Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

CDC37: Interactions, Overview & Domain architecture

Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene. This protein is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a HSP90 Co-chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

CDC37 topic overview

The analysis highlights Interactions, Overview and Domain architecture as prominent areas in the source structure around CDC37.

Related topics
24
Source areas
3
Connected nodes
27
Extracted relationships
99
Concept neighborhoods
15
Bridge connections
27

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 14 topics
Interactions · 6 topics
Domain architecture · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CDC37, P50cell division cycle 37, cell division cycle 37, HSP90 cochaperone
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1US7, 2K5B, 2W0G, 2N5X, 2NCA, 5FWM, 5FWL, 5FWK
Band
19p13.2 · 9|9 A3
Bgee
sural nerve · apex of heart · granulocyte · body of uterus · left uterine tube
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 9 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Domain architecture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CDC37 connects Entity context

The extracted context around CDC37 shows recurring relationship patterns in the source. For example, CDC37 → chaperone binding, chaperone complex, cytoplasm, cytosol, ERBB2 signaling pathway, extracellular exosome, heat shock protein binding, Hsp90 protein binding, HSP90-CDC37 chaperone complex, kinase binding, peptidyl-tyrosine phosphorylation, positive regulation of mitophagy in response to mitochondrial depolarization, posttranscriptional regulation of gene expression, protein binding, protein folding, protein kinase binding, protein kinase regulator activity, protein stabilization, protein targeting, protein tyrosine kinase activity Another extracted example is CDC37 → abdominal wall, apex of heart, body of uterus, canal of the cervix, dentate gyrus of hippocampal formation granule cell, efferent ductule, epiblast, gastric mucosa, granulocyte, left lobe of thyroid gland, left uterine tube, mandibular prominence, maxillary prominence, neural layer of retina, neural tube, right uterine tube, right ventricle, somite, sural nerve, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

CDC37

Top relations

Gene ontology · 26
CDC37 → chaperone binding, chaperone complex, cytoplasm, cytosol, ERBB2 signaling pathway, extracellular exosome, heat shock protein binding, Hsp90 protein binding, HSP90-CDC37 chaperone complex, kinase binding, peptidyl-tyrosine phosphorylation, positive regulation of mitophagy in response to mitochondrial depolarization, posttranscriptional regulation of gene expression, protein binding, protein folding, protein kinase binding, protein kinase regulator activity, protein stabilization, protein targeting, protein tyrosine kinase activity
Bgee · 20
CDC37 → abdominal wall, apex of heart, body of uterus, canal of the cervix, dentate gyrus of hippocampal formation granule cell, efferent ductule, epiblast, gastric mucosa, granulocyte, left lobe of thyroid gland, left uterine tube, mandibular prominence, maxillary prominence, neural layer of retina, neural tube, right uterine tube, right ventricle, somite, sural nerve, upper lobe of left lung
RNA expression pattern · 20
CDC37 → abdominal wall, apex of heart, body of uterus, canal of the cervix, dentate gyrus of hippocampal formation granule cell, efferent ductule, epiblast, gastric mucosa, granulocyte, left lobe of thyroid gland, left uterine tube, mandibular prominence, maxillary prominence, neural layer of retina, neural tube, right uterine tube, right ventricle, somite, sural nerve, upper lobe of left lung
related to Domain architecture · 4
CDC37 → C-terminal, Hsp90, The, The N-terminal
related to Interactions · 3
CDC37 → CDK4, HSP90AA1IKBKG, IKK2
Band · 2
CDC37 → 19p13.2, 9|9 A3
Chr. · 2
CDC37 → Chromosome 19 (human), Chromosome 9 (mouse)
End · 2
CDC37 → 10,420,121 bp, 21,061,278 bp
related to External links · 2
CDC37 → Human CDC37, UCSC Genome Browser
Aliases · 1
CDC37 → CDC37, P50cell division cycle 37, cell division cycle 37, HSP90 cochaperone

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

hsp90 protein bp human gene chr band cell chromosome 19 location kinases domain co-chaperone function mouse cdk4 37 division cycle

CDC37 relationships Subject–Predicate–Object triples

TTTA extracted 99 structured relationships around CDC37. Examples in this analysis include CDC37 → Aliases → CDC37, P50cell division cycle 37, cell division cycle 37, HSP90 cochaperone and CDC37 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1US7, 2K5B, 2W0G, 2N5X, 2NCA, 5FWM, 5FWL, 5FWK. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CDC37AliasesCDC37, P50cell division cycle 37, cell division cycle 37, HSP90 cochaperone1.00infobox
CDC37Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1US7, 2K5B, 2W0G, 2N5X, 2NCA, 5FWM, 5FWL, 5FWK1.00infobox
CDC37Band19p13.21.00infobox
CDC37Band9|9 A31.00infobox
CDC37Bgeesural nerve1.00infobox
CDC37Bgeeapex of heart1.00infobox
CDC37Bgeegranulocyte1.00infobox
CDC37Bgeebody of uterus1.00infobox
CDC37Bgeeleft uterine tube1.00infobox
CDC37Bgeeupper lobe of left lung1.00infobox
CDC37Bgeeleft lobe of thyroid gland1.00infobox
CDC37Bgeegastric mucosa1.00infobox
CDC37Bgeeright uterine tube1.00infobox
CDC37Bgeecanal of the cervix1.00infobox
CDC37Bgeemaxillary prominence1.00infobox
CDC37Bgeemandibular prominence1.00infobox
CDC37Bgeeright ventricle1.00infobox
CDC37Bgeeneural layer of retina1.00infobox
CDC37Bgeesomite1.00infobox
CDC37Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
CDC37Bgeeepiblast1.00infobox
CDC37Bgeeabdominal wall1.00infobox
CDC37Bgeeefferent ductule1.00infobox
CDC37Bgeeneural tube1.00infobox
CDC37BioGPSMore reference expression data1.00infobox
CDC37Chr.Chromosome 19 (human)1.00infobox
CDC37Chr.Chromosome 9 (mouse)1.00infobox
CDC37DatabasesNCBI: entry; OMA: entry1.00infobox
CDC37End10,420,121 bp1.00infobox
CDC37End21,061,278 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CDC37 bring nearby vocabulary together. In this analysis, examples include Gene, Location and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CDC37
    • Gene
    • Location
    • Human
    • Search
    • Ucsc
    • Hsp90
    • Cell
    • Chromosome
    • Bp
    • Chr
    • External
    • Protein
  • cdc37
    • Gene
    • Location
    • Human
    • Search
    • Ucsc
    • Hsp90
    • Cell
    • Chromosome
    • Bp
    • Chr
    • External
    • Protein
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • End
    • Mouse
    • Search
    • Ucsc
    • Hsp90
    • Band
    • Cell
  • cell division cycle
    • Cycle
    • Division
    • External
    • Search
    • Function
    • Hsp90
    • Protein
    • Chromosome
    • Location
    • Bp
    • Chr
    • Gene
  • hsp90
    • Protein
    • Cell
    • Gene
    • Binding
    • Cdk4
    • Chaperone
    • Complex
    • Heat
    • Search
    • Shock
    • Shown
    • Function
  • cdk4
    • Complex
    • Shown
    • Cdk6
    • Mok
    • Raf1
    • Src
    • Binding
    • Chaperone
    • End
    • Heat
    • Mouse
    • Search
  • protein kinases
    • Cdk6
    • Mok
    • Raf1
    • Src
    • Binding
    • Cdk4
    • Chaperone
    • Heat
    • Shock
    • Shown
    • Kinases
    • Protein
  • protein
    • Binding
    • Cdk4
    • Chaperone
    • Heat
    • Shock
    • Shown
    • Kinases
    • Domain
    • Cdk6
    • Mok
    • Raf1
    • Src

Connections between topic areas Semantic bridges

For CDC37, one of the stronger structural bridges in this analysis connects CDC37 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CDC37Overview · splits 13 ⟂ 15
CDC37Interactions · splits 21 ⟂ 7
CDC37Domain architecture · splits 23 ⟂ 5

Map overview Semantic statistics

CDC37

Nodes28
Edges27
Triples99
Avg. degree1.93
Density0.071429
Components1

Source & methodology

TTTA analyzes the structure around CDC37 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Overview & Domain architecture, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CDC37 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.