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Granulocyte-macrophage colony-stimulating factor: History & Regions

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and…

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Granulocyte-macrophage colony-stimulating factor topic overview

The analysis highlights History and Regions as prominent areas in the source structure around Granulocyte-macrophage colony-stimulating factor.

Related topics
59
Source areas
6
Connected nodes
65
Extracted relationships
123
Concept neighborhoods
22
Bridge connections
65

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 15 topics
Overview · 15 topics
Clinical significance · 10 topics
History · 10 topics
Genetics · 7 topics
Clinical trials · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CSF2, GMCSF, colony stimulating factor 2, CSF
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CSG, 2GMF, 4NKQ, 5C7X, 5D70, 5D71, 5D72, 4RS1
Band
5q31.1 · 11 B1.3|11 32.13 cM
Bgee
cartilage tissue · upper lobe of left lung · gallbladder · stromal cell of endometrium · appendix
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Genetics

History

Clinical significance

Clinical trials

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Granulocyte-macrophage colony-stimulating factor connects Entity context

The extracted context around Granulocyte-macrophage colony-stimulating factor shows recurring relationship patterns in the source. For example, Granulocyte-macrophage colony-stimulating factor → cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to lipopolysaccharide, cytokine activity, cytokine-mediated signaling pathway, dendritic cell differentiation, embryonic placenta development, epithelial fluid transport, extracellular region, extracellular space, granulocyte macrophage colony-stimulating factor receptor binding, growth factor activity, histamine secretion, immune response, intracellular membrane-bounded organelle, macrophage activation, macrophage differentiation, MAPK cascade, monocyte differentiation, myeloid dendritic cell differentiation, negative regulation of cytolysis Another extracted example is Granulocyte-macrophage colony-stimulating factor → appendix, artery, carotid body, cartilage tissue, colon, duodenum, gallbladder, granulocyte, haematopoietic system, islet of Langerhans, jejunum, left lung lobe, muscle tissue, piriform cortex, rectum, right lung lobe, smooth muscle tissue, stromal cell of endometrium, thymus, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

Granulocyte-macrophage colony-stimulating factor

Top relations

Gene ontology · 39
Granulocyte-macrophage colony-stimulating factor → cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to lipopolysaccharide, cytokine activity, cytokine-mediated signaling pathway, dendritic cell differentiation, embryonic placenta development, epithelial fluid transport, extracellular region, extracellular space, granulocyte macrophage colony-stimulating factor receptor binding, growth factor activity, histamine secretion, immune response, intracellular membrane-bounded organelle, macrophage activation, macrophage differentiation, MAPK cascade, monocyte differentiation, myeloid dendritic cell differentiation, negative regulation of cytolysis
Bgee · 20
Granulocyte-macrophage colony-stimulating factor → appendix, artery, carotid body, cartilage tissue, colon, duodenum, gallbladder, granulocyte, haematopoietic system, islet of Langerhans, jejunum, left lung lobe, muscle tissue, piriform cortex, rectum, right lung lobe, smooth muscle tissue, stromal cell of endometrium, thymus, upper lobe of left lung
RNA expression pattern · 20
Granulocyte-macrophage colony-stimulating factor → appendix, artery, carotid body, cartilage tissue, colon, duodenum, gallbladder, granulocyte, haematopoietic system, islet of Langerhans, jejunum, left lung lobe, muscle tissue, piriform cortex, rectum, right lung lobe, smooth muscle tissue, stromal cell of endometrium, thymus, upper lobe of left lung
related to External links · 14
Granulocyte-macrophage colony-stimulating factor → Colony-Stimulating, Factor, Granulocyte-macrophage, Leukine, Macrophage, Medicine Medical Subject Headings, MeSH, National Library, Official, Overview, P04141, PDB, PDBe-KB, UniProt
see also · 6
Granulocyte-macrophage colony-stimulating factor → CFU-GMFilgrastim, G-CSF, Granulocyte-macrophage, Neulasta, Neupogen, PEGylated
Band · 2
Granulocyte-macrophage colony-stimulating factor → 11 B1.3|11 32.13 cM, 5q31.1
Chr. · 2
Granulocyte-macrophage colony-stimulating factor → Chromosome 11 (mouse), Chromosome 5 (human)
End · 2
Granulocyte-macrophage colony-stimulating factor → 132,076,170 bp, 54,140,493 bp
Aliases · 1
Granulocyte-macrophage colony-stimulating factor → CSF2, GMCSF, colony stimulating factor 2, CSF
Available structures · 1
Granulocyte-macrophage colony-stimulating factor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CSG, 2GMF, 4NKQ, 5C7X, 5D70, 5D71, 5D72, 4RS1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gm-csf macrophages factor human bp colony-stimulating cells cytokine chr band chromosome also cell neutrophil sargramostim molgramostim csf2 gene granulocyte-macrophage granulocyte

Granulocyte-macrophage colony-stimulating factor relationships Subject–Predicate–Object triples

TTTA extracted 123 structured relationships around Granulocyte-macrophage colony-stimulating factor. Examples in this analysis include Granulocyte-macrophage colony-stimulating factor → Aliases → CSF2, GMCSF, colony stimulating factor 2, CSF and Granulocyte-macrophage colony-stimulating factor → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CSG, 2GMF, 4NKQ, 5C7X, 5D70, 5D71, 5D72, 4RS1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Granulocyte-macrophage colony-stimulating factorAliasesCSF2, GMCSF, colony stimulating factor 2, CSF1.00infobox
Granulocyte-macrophage colony-stimulating factorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CSG, 2GMF, 4NKQ, 5C7X, 5D70, 5D71, 5D72, 4RS11.00infobox
Granulocyte-macrophage colony-stimulating factorBand5q31.11.00infobox
Granulocyte-macrophage colony-stimulating factorBand11 B1.3|11 32.13 cM1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeecartilage tissue1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeupper lobe of left lung1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeegallbladder1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeestromal cell of endometrium1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeappendix1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeislet of Langerhans1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeemuscle tissue1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeesmooth muscle tissue1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeegranulocyte1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeerectum1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeleft lung lobe1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeright lung lobe1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeejejunum1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeduodenum1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeepiriform cortex1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeartery1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeehaematopoietic system1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeethymus1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeecolon1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeecarotid body1.00infobox
Granulocyte-macrophage colony-stimulating factorBioGPSMore reference expression data1.00infobox
Granulocyte-macrophage colony-stimulating factorChr.Chromosome 5 (human)1.00infobox
Granulocyte-macrophage colony-stimulating factorChr.Chromosome 11 (mouse)1.00infobox
Granulocyte-macrophage colony-stimulating factorDatabasesNCBI: entry; OMA: entry1.00infobox
Granulocyte-macrophage colony-stimulating factorEnd132,076,170 bp1.00infobox
Granulocyte-macrophage colony-stimulating factorEnd54,140,493 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Granulocyte-macrophage colony-stimulating factor bring nearby vocabulary together. In this analysis, examples include Factor, Granulocyte-macrophage and Proliferation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Granulocyte-macrophage colony-stimulating factor
    • Factor
    • Granulocyte-macrophage
    • Proliferation
    • Csf2
    • Cell
    • Location
    • Neutrophil
    • Cells
    • Gene
    • Also
    • Bp
    • Chr
  • granulocyte-macrophage colony-stimulating factor
    • Factor
    • Granulocyte-macrophage
    • Granulocyte
    • Csf2
    • Glycoprotein
    • Monomeric
    • P04141
    • Proliferation
    • Uniprot
    • Functions
    • Pdb
    • Human
  • glycoprotein
    • Monomeric
    • Functions
    • Cytokine
    • Mouse
    • P04141
    • Proliferation
    • Uniprot
    • Function
    • Granulocyte
    • Immune
    • Location
    • Region
  • cytokine
    • Glycoprotein
    • Monomeric
    • Functions
    • Region
    • Gene
    • Chromosome
    • Factor
    • Human
    • Macrophages
    • Mouse
    • P04141
    • Proliferation
  • granulocyte colony-stimulating factor
    • Factor
    • Granulocyte-macrophage
    • Proliferation
    • Granulocyte
    • Csf2
    • Cell
    • Neutrophil
    • Glycoprotein
    • Monomeric
    • P04141
    • Uniprot
    • Functions
  • white blood cell
    • Cell
    • White
    • Proliferation
    • Granulocyte
    • Neutrophil
    • Colony-stimulating
    • Glycoprotein
    • Monomeric
    • Mouse
    • P04141
    • Uniprot
    • Factor
  • growth factor
    • Granulocyte-macrophage
    • Csf2
    • Granulocyte
    • Glycoprotein
    • Monomeric
    • P04141
    • Pdb
    • Proliferation
    • Uniprot
    • Human
    • Function
    • Functions
  • function
    • Location
    • Gene
    • Neutrophil
    • Bp
    • Chr
    • Chromosome
    • External
    • Glycoprotein
    • Human
    • Monomeric
    • Mouse
    • P04141

Connections between topic areas Semantic bridges

For Granulocyte-macrophage colony-stimulating factor, one of the stronger structural bridges in this analysis connects Granulocyte-macrophage colony-stimulating factor with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Granulocyte-macrophage colony-stimulating factorOverview · splits 50 ⟂ 16
Granulocyte-macrophage colony-stimulating factorFunction · splits 50 ⟂ 16
Granulocyte-macrophage colony-stimulating factorHistory · splits 55 ⟂ 11
Granulocyte-macrophage colony-stimulating factorClinical significance · splits 55 ⟂ 11
Granulocyte-macrophage colony-stimulating factorGenetics · splits 58 ⟂ 8
Granulocyte-macrophage colony-stimulating factorClinical trials · splits 63 ⟂ 3

Map overview Semantic statistics

Granulocyte-macrophage colony-stimulating factor

Nodes66
Edges65
Triples123
Avg. degree1.97
Density0.030303
Components1

Source & methodology

TTTA analyzes the structure around Granulocyte-macrophage colony-stimulating factor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Granulocyte-macrophage colony-stimulating factor · EN edition · Analysis: TopicsToTalkAbout

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