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Granulocyte-macrophage colony-stimulating factor

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and…

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Aliases
CSF2, GMCSF, colony stimulating factor 2, CSF
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CSG, 2GMF, 4NKQ, 5C7X, 5D70, 5D71, 5D72, 4RS1
Band
5q31.1 · 11 B1.3|11 32.13 cM
Bgee
cartilage tissue · upper lobe of left lung · gallbladder · stromal cell of endometrium · appendix
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 11 (mouse)

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Genetics

History

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Map overview Semantic statistics

Granulocyte-macrophage colony-stimulating factor

Nodes66
Edges65
Triples123
Avg. degree1.97
Density0.030303
Components1

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Granulocyte-macrophage colony-stimulating factor

Top relations

Gene ontology · 39
Granulocyte-macrophage colony-stimulating factor → cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to lipopolysaccharide, cytokine activity, cytokine-mediated signaling pathway, dendritic cell differentiation, embryonic placenta development, epithelial fluid transport, extracellular region, extracellular space, granulocyte macrophage colony-stimulating factor receptor binding, growth factor activity, histamine secretion, immune response, intracellular membrane-bounded organelle, macrophage activation, macrophage differentiation, MAPK cascade, monocyte differentiation, myeloid dendritic cell differentiation, negative regulation of cytolysis
Bgee · 20
Granulocyte-macrophage colony-stimulating factor → appendix, artery, carotid body, cartilage tissue, colon, duodenum, gallbladder, granulocyte, haematopoietic system, islet of Langerhans, jejunum, left lung lobe, muscle tissue, piriform cortex, rectum, right lung lobe, smooth muscle tissue, stromal cell of endometrium, thymus, upper lobe of left lung
RNA expression pattern · 20
Granulocyte-macrophage colony-stimulating factor → appendix, artery, carotid body, cartilage tissue, colon, duodenum, gallbladder, granulocyte, haematopoietic system, islet of Langerhans, jejunum, left lung lobe, muscle tissue, piriform cortex, rectum, right lung lobe, smooth muscle tissue, stromal cell of endometrium, thymus, upper lobe of left lung
related to External links · 14
Granulocyte-macrophage colony-stimulating factor → Colony-Stimulating, Factor, Granulocyte-macrophage, Leukine, Macrophage, Medicine Medical Subject Headings, MeSH, National Library, Official, Overview, P04141, PDB, PDBe-KB, UniProt
see also · 6
Granulocyte-macrophage colony-stimulating factor → CFU-GMFilgrastim, G-CSF, Granulocyte-macrophage, Neulasta, Neupogen, PEGylated
Band · 2
Granulocyte-macrophage colony-stimulating factor → 11 B1.3|11 32.13 cM, 5q31.1
Chr. · 2
Granulocyte-macrophage colony-stimulating factor → Chromosome 11 (mouse), Chromosome 5 (human)
End · 2
Granulocyte-macrophage colony-stimulating factor → 132,076,170 bp, 54,140,493 bp
Aliases · 1
Granulocyte-macrophage colony-stimulating factor → CSF2, GMCSF, colony stimulating factor 2, CSF
Available structures · 1
Granulocyte-macrophage colony-stimulating factor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CSG, 2GMF, 4NKQ, 5C7X, 5D70, 5D71, 5D72, 4RS1

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Important terminology

gm-csf macrophages factor human bp colony-stimulating cells cytokine chr band chromosome also cell neutrophil sargramostim molgramostim csf2 gene granulocyte-macrophage granulocyte

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Granulocyte-macrophage colony-stimulating factorAliasesCSF2, GMCSF, colony stimulating factor 2, CSF1.00infobox
Granulocyte-macrophage colony-stimulating factorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CSG, 2GMF, 4NKQ, 5C7X, 5D70, 5D71, 5D72, 4RS11.00infobox
Granulocyte-macrophage colony-stimulating factorBand5q31.11.00infobox
Granulocyte-macrophage colony-stimulating factorBand11 B1.3|11 32.13 cM1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeecartilage tissue1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeupper lobe of left lung1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeegallbladder1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeestromal cell of endometrium1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeappendix1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeislet of Langerhans1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeemuscle tissue1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeesmooth muscle tissue1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeegranulocyte1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeerectum1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeleft lung lobe1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeright lung lobe1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeejejunum1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeduodenum1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeepiriform cortex1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeeartery1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeehaematopoietic system1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeethymus1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeecolon1.00infobox
Granulocyte-macrophage colony-stimulating factorBgeecarotid body1.00infobox
Granulocyte-macrophage colony-stimulating factorBioGPSMore reference expression data1.00infobox
Granulocyte-macrophage colony-stimulating factorChr.Chromosome 5 (human)1.00infobox
Granulocyte-macrophage colony-stimulating factorChr.Chromosome 11 (mouse)1.00infobox
Granulocyte-macrophage colony-stimulating factorDatabasesNCBI: entry; OMA: entry1.00infobox
Granulocyte-macrophage colony-stimulating factorEnd132,076,170 bp1.00infobox
Granulocyte-macrophage colony-stimulating factorEnd54,140,493 bp1.00infobox

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