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Somatic hypermutation

Somatic hypermutation (SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes). A major component of the process of affinity maturation, SHM diversifies B cell receptors used to recognize foreign elements (antigens) and allows the immune system to adapt its response to new threats during…

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Somatic hypermutation

Nodes42
Edges41
Triples17
Avg. degree1.95
Density0.047619
Components1

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Somatic hypermutation

Top relations

related to Targeting · 14
Somatic hypermutation → A/G, B-cell, C/T A/T, DNA, During, RGYW, The, These, This, TW, Variation, WA, When, WRCY

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Important terminology

somatic hypermutation dna process immune mutations shm cells also mutation immunoglobulin antigen uracil mechanism system new foreign gene conversion affinity

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
cattleinstance ofThe bird genomes have a large number of pseudogenic V segments which are effectively used by this additional recombination process.Mammals0.80text
sheepinstance ofThe bird genomes have a large number of pseudogenic V segments which are effectively used by this additional recombination process.Mammals0.80text
and horses have a sufficiently large selection for Vinstance ofThe bird genomes have a large number of pseudogenic V segments which are effectively used by this additional recombination process.Mammals0.80text
Somatic hypermutationrelated to TargetingWhen0.60section
Somatic hypermutationrelated to TargetingDuring0.60section
Somatic hypermutationrelated to TargetingB-cell0.60section
Somatic hypermutationrelated to TargetingVariation0.60section
Somatic hypermutationrelated to TargetingThese0.60section
Somatic hypermutationrelated to TargetingDNA0.60section
Somatic hypermutationrelated to TargetingThe0.60section
Somatic hypermutationrelated to TargetingRGYW0.60section
Somatic hypermutationrelated to TargetingA/G0.60section

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