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IRF8: Research, Clinical significance & Function
Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to…
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IRF8 topic overview
The analysis highlights Research, Clinical significance and Function as prominent areas in the source structure around IRF8.
Related topics
35
Source areas
5
Connected nodes
40
Extracted relationships
106
Concept neighborhoods
14
Bridge connections
40
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Clinical significance · 11 topics
Function · 8 topics
Overview · 7 topics
Knockout studies · 6 topics
Interactions · 3 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How IRF8 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around IRF8 shows recurring relationship patterns in the source. For example, IRF8 → autophagy, cellular response to interferon-gamma, cellular response to lipopolysaccharide, cytoplasm, cytosol, defense response to bacterium, defense response to protozoan, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, immune response, immune system process, interferon-gamma-mediated signaling pathway, myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, nucleoplasm, nucleus, phagocytosis, positive regulation of interferon-gamma production Another extracted example is IRF8 → appendix, blood, bone marrow, crypt of lieberkuhn of small intestine, epithelium of colon, granulocyte, Ileal epithelium, jejunum, lymph node, mesenteric lymph nodes, monocyte, rectum, secondary oocyte, spleen, stroma of bone marrow, subcutaneous adipose tissue, submandibular gland, tibiofemoral joint. Use these groups to spot repeated connection types before inspecting the individual relationships.
IRF8
Top relations
Gene ontology· 32
IRF8 → autophagy, cellular response to interferon-gamma, cellular response to lipopolysaccharide, cytoplasm, cytosol, defense response to bacterium, defense response to protozoan, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, immune response, immune system process, interferon-gamma-mediated signaling pathway, myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, nucleoplasm, nucleus, phagocytosis, positive regulation of interferon-gamma production
Bgee· 18
IRF8 → appendix, blood, bone marrow, crypt of lieberkuhn of small intestine, epithelium of colon, granulocyte, Ileal epithelium, jejunum, lymph node, mesenteric lymph nodes, monocyte, rectum, secondary oocyte, spleen, stroma of bone marrow, subcutaneous adipose tissue, submandibular gland, tibiofemoral joint
RNA expression pattern· 18
IRF8 → appendix, blood, bone marrow, crypt of lieberkuhn of small intestine, epithelium of colon, granulocyte, Ileal epithelium, jejunum, lymph node, mesenteric lymph nodes, monocyte, rectum, secondary oocyte, spleen, stroma of bone marrow, subcutaneous adipose tissue, submandibular gland, tibiofemoral joint
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 106 structured relationships around IRF8. Examples in this analysis include IRF8 → Aliases → IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8, interferon regulatory factor 8 and IRF8 → Band → 16q24.1. The table shows each extracted connection, where it came from and its confidence.
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around IRF8 bring nearby vocabulary together. In this analysis, examples include Cells, Human and Myeloid. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
IRF8
Cells
Human
Myeloid
Regulatory
Expression
Apoptosis
Cancer
Protein
Transcription
Cell
Critical
Function
irf8
Cells
Human
Myeloid
Regulatory
Expression
Apoptosis
Cancer
Protein
Transcription
Cell
Critical
Function
gene
Location
Chromosome
Human
Interferon
Bp
Chr
Regulatory
Function
Mouse
Sequence-binding
Icsbp
Protein
transcription factor
Transcription
Cell
Interferon
Myeloid
Gene
Regulatory
Consensus
Critical
Function
Monocyte
Regulation
Sequence-binding
cell
Expressed
Transcription
Myeloid
Critical
Factor
Monocyte
Regulation
Irf8
Consensus
Function
Mouse
Sequence-binding
interferon consensus sequence-binding protein
Sequence-binding
Regulatory
Protein
Consensus
Factor
Function
Gene
Interferon
Icsbp
Location
Human
Chromosome
interferon
Regulatory
Protein
Consensus
Factor
Function
Gene
Sequence-binding
Icsbp
Location
Human
Chromosome
Irf8
function
Location
Chromosome
Interferon
Bp
Chr
Gene
Regulatory
Icsbp
Monocyte
Mouse
Regulation
Sequence-binding
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For IRF8, one of the stronger structural bridges in this analysis connects IRF8 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
IRF8
Nodes41
Edges40
Triples106
Avg. degree1.95
Density0.04878
Components1
Source & methodology
TTTA analyzes the structure around IRF8 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — IRF8 · EN edition · Analysis: TopicsToTalkAbout
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