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IRF8

Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to…

Research, Clinical significance & Function

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Clinical significance

11 related topics

Function

8 related topics

Knockout studies

6 related topics

Interactions

3 related topics

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Aliases
IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8, interferon regulatory factor 8
Band
16q24.1 · 8 E1|8 70.05 cM
Bgee
monocyte · lymph node · spleen · secondary oocyte · appendix
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Function

Knockout studies

Clinical significance

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

IRF8

Nodes41
Edges40
Triples106
Avg. degree1.95
Density0.04878
Components1

How this topic connects Entity context

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IRF8

Top relations

Gene ontology · 32
IRF8 → autophagy, cellular response to interferon-gamma, cellular response to lipopolysaccharide, cytoplasm, cytosol, defense response to bacterium, defense response to protozoan, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, immune response, immune system process, interferon-gamma-mediated signaling pathway, myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, nucleoplasm, nucleus, phagocytosis, positive regulation of interferon-gamma production
Bgee · 18
IRF8 → appendix, blood, bone marrow, crypt of lieberkuhn of small intestine, epithelium of colon, granulocyte, Ileal epithelium, jejunum, lymph node, mesenteric lymph nodes, monocyte, rectum, secondary oocyte, spleen, stroma of bone marrow, subcutaneous adipose tissue, submandibular gland, tibiofemoral joint
RNA expression pattern · 18
IRF8 → appendix, blood, bone marrow, crypt of lieberkuhn of small intestine, epithelium of colon, granulocyte, Ileal epithelium, jejunum, lymph node, mesenteric lymph nodes, monocyte, rectum, secondary oocyte, spleen, stroma of bone marrow, subcutaneous adipose tissue, submandibular gland, tibiofemoral joint
related to Clinical significance · 9
IRF8 → Bax, CML, Fas, FLIP, Furthermore, IFN-γ, In, Jak1, STAT1
related to External links · 6
IRF8 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
Band · 2
IRF8 → 16q24.1, 8 E1|8 70.05 cM
Chr. · 2
IRF8 → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
IRF8 → 121,483,433 bp, 85,922,606 bp
related to Interactions · 2
IRF8 → COPS2, IRF1
Aliases · 1
IRF8 → IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8, interferon regulatory factor 8

Important terminology Word statistics

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Important terminology

human factor bp regulatory interferon gene also icsbp chr band cells expression chromosome 16 protein myeloid cell transcription location family

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
IRF8AliasesIRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8, interferon regulatory factor 81.00infobox
IRF8Band16q24.11.00infobox
IRF8Band8 E1|8 70.05 cM1.00infobox
IRF8Bgeemonocyte1.00infobox
IRF8Bgeelymph node1.00infobox
IRF8Bgeespleen1.00infobox
IRF8Bgeesecondary oocyte1.00infobox
IRF8Bgeeappendix1.00infobox
IRF8Bgeegranulocyte1.00infobox
IRF8Bgeeblood1.00infobox
IRF8Bgeeepithelium of colon1.00infobox
IRF8Bgeebone marrow1.00infobox
IRF8Bgeerectum1.00infobox
IRF8BgeeIleal epithelium1.00infobox
IRF8Bgeemesenteric lymph nodes1.00infobox
IRF8Bgeetibiofemoral joint1.00infobox
IRF8Bgeesubmandibular gland1.00infobox
IRF8Bgeecrypt of lieberkuhn of small intestine1.00infobox
IRF8Bgeejejunum1.00infobox
IRF8Bgeestroma of bone marrow1.00infobox
IRF8Bgeesubcutaneous adipose tissue1.00infobox
IRF8BioGPSMore reference expression data1.00infobox
IRF8Chr.Chromosome 16 (human)1.00infobox
IRF8Chr.Chromosome 8 (mouse)1.00infobox
IRF8DatabasesNCBI: entry; OMA: entry1.00infobox
IRF8End85,922,606 bp1.00infobox
IRF8End121,483,433 bp1.00infobox
IRF8EnsemblENSG000001409681.00infobox
IRF8Entrez33941.00infobox
IRF8External IDsOMIM: 601565; MGI: 96395; GeneCards: IRF81.00infobox

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