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Induced pluripotent stem cell

Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. The iPSC technology was pioneered by Shinya Yamanaka and Kazutoshi Takahashi in Kyoto, Japan, who together showed in 2006 that the introduction of four specific genes (named c-Myc, Oct4, Sox2 and KLF4)…

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Induced pluripotent stem cell

Nodes173
Edges172
Triples99
Avg. degree1.99
Density0.011561
Components1

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Induced pluripotent stem cell

Top relations

related to Safety · 29
Induced pluripotent stem cell → All, An, Araki, Concern, ES, ESC, FDA, Findings, Furthermore, However, In, IPS, IPSC, Much, Myc, Nevertheless, Other, Since, Some, Stem Cells
related to External links · 25
Induced pluripotent stem cell → Application, April, Archived, BSCRF, Cell Research, Cells, Center, Forced Expression, Future, Induced Pluripotent Stem, Induced Pluripotent Stem Cells, Klf42 Minute Video, Kyoto UniversityWith, MEFS, Myc, Oct-4, Oxford, SCNT, Sox-2, The Discovery
related to First generation (mouse) · 18
Induced pluripotent stem cell → By, ESC, ESC-like, ESC-specific, ESCs, Fbx15, Induced, Japan, Kazutoshi Takahashi, Klf4, Kyoto University, Oct4, Shinya Yamanaka, Sox2, The, They, To, Upon
related to Organ synthesis · 7
Induced pluripotent stem cell → After, Further, Human, Japan, LBs, Most, This
related to Identity · 6
Induced pluripotent stem cell → ES, Gene, H3K27me3, H3K4me3, Induced, The

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Important terminology

cells ipscs cell stem ips reprogramming genes human pluripotent factors sox2 et al mouse used using yamanaka also efficiency expression

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
lineage specifiersinstance ofor even non-related genes0.80text
C-MYC/L-MYC or repression of cell cycle checkpointsinstance ofIt is also clear that pro-mitotic factors0.80text
such as p53instance ofIt is also clear that pro-mitotic factors0.80text
are conduits to creating a compliant cellular state for iPSC reprogramming.iPSC derivation is typically a slowinstance ofIt is also clear that pro-mitotic factors0.80text
inefficient processinstance ofIt is also clear that pro-mitotic factors0.80text
taking oneinstance ofIt is also clear that pro-mitotic factors0.80text
tumorgenesisinstance ofAlternate vectorsAnother key strategy for avoiding problems0.80text
low throughput has been to use alternate forms of vectorsinstance ofAlternate vectorsAnother key strategy for avoiding problems0.80text
using adenoviruses or plasmids are generally thought to be safer than retroviral methods.An important area for future studies in the iPSC field is directly testing iPSC tumorigenicity using methods that mimic the approaches that would be used for regenerative medicine therapiesinstance ofOther approaches0.80text
Down syndromeinstance ofincluding common disorders0.80text
polycystic kidney diseaseinstance ofincluding common disorders0.80text
PD-L1instance ofwhile expressing immune-modulatory genes0.80text

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