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LIN28: Function, Overview & Structure

Lin-28 homolog A is a protein that in humans is encoded by the LIN28 gene.

Language: English [EN]
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LIN28 topic overview

The analysis highlights Function, Overview and Structure as prominent areas in the source structure around LIN28.

Related topics
36
Source areas
3
Connected nodes
39
Extracted relationships
124
Concept neighborhoods
16
Bridge connections
39

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 20 topics
Overview · 13 topics
Structure · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
LIN28A, CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A, lin-28 homolog A, Lin28a, LIN28A (gene), Lin-28 homolog A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CQF, 2LI8
Band
1p36.11 · 4|4 D2.3
Bgee
oocyte · secondary oocyte · sperm · gonad · buccal mucosa cell
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How LIN28 connects Entity context

The extracted context around LIN28 shows recurring relationship patterns in the source. For example, LIN28 → cellular response to glucose stimulus, cytoplasm, cytoplasmic stress granule, cytosol, DNA binding, endoplasmic reticulum, G-quadruplex RNA binding, gene silencing, germ cell development, metal ion binding, miRNA binding, miRNA catabolic process, miRNA metabolic process, mRNA binding, negative regulation of glial cell differentiation, negative regulation of translation, nucleic acid binding, nucleolus, nucleus, P-body Another extracted example is LIN28 → Achilles tendon, buccal mucosa cell, embryo, epiblast, gonad, granulocyte, left testis, oocyte, otic placode, otic vesicle, primitive streak, right testis, secondary oocyte, somite, sperm, tail of embryo, testicle, yolk sac, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

LIN28

Top relations

Gene ontology · 43
LIN28 → cellular response to glucose stimulus, cytoplasm, cytoplasmic stress granule, cytosol, DNA binding, endoplasmic reticulum, G-quadruplex RNA binding, gene silencing, germ cell development, metal ion binding, miRNA binding, miRNA catabolic process, miRNA metabolic process, mRNA binding, negative regulation of glial cell differentiation, negative regulation of translation, nucleic acid binding, nucleolus, nucleus, P-body
Bgee · 19
LIN28 → Achilles tendon, buccal mucosa cell, embryo, epiblast, gonad, granulocyte, left testis, oocyte, otic placode, otic vesicle, primitive streak, right testis, secondary oocyte, somite, sperm, tail of embryo, testicle, yolk sac, zygote
RNA expression pattern · 19
LIN28 → Achilles tendon, buccal mucosa cell, embryo, epiblast, gonad, granulocyte, left testis, oocyte, otic placode, otic vesicle, primitive streak, right testis, secondary oocyte, somite, sperm, tail of embryo, testicle, yolk sac, zygote
related to Structure · 6
LIN28 → Lin28/let-7, Models, NMR, RNA, The, X-ray
related to Stem cell expression · 5
LIN28 → In, In Caenorhabditis, Lin28a, Lin28b, VPCs
related to Tissue regeneration · 5
LIN28 → Appropriate, Lin28a, Mice, The, While
related to Puberty · 4
LIN28 → Aberrant, LIN28B, Mutations, PI3K-mTOR
Band · 2
LIN28 → 1p36.11, 4|4 D2.3
Chr. · 2
LIN28 → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
LIN28 → 133,746,152 bp, 26,429,728 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human stem gene cells bp chr band protein mouse homolog chromosome lin28a lin-28 mice embryonic expressed location let-7 puberty expression

LIN28 relationships Subject–Predicate–Object triples

TTTA extracted 124 structured relationships around LIN28. Examples in this analysis include LIN28 → Aliases → LIN28A, CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A, lin-28 homolog A, Lin28a, LIN28A (gene), Lin-28 homolog A and LIN28 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CQF, 2LI8. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
LIN28AliasesLIN28A, CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A, lin-28 homolog A, Lin28a, LIN28A (gene), Lin-28 homolog A1.00infobox
LIN28Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CQF, 2LI81.00infobox
LIN28Band1p36.111.00infobox
LIN28Band4|4 D2.31.00infobox
LIN28Bgeeoocyte1.00infobox
LIN28Bgeesecondary oocyte1.00infobox
LIN28Bgeesperm1.00infobox
LIN28Bgeegonad1.00infobox
LIN28Bgeebuccal mucosa cell1.00infobox
LIN28Bgeetesticle1.00infobox
LIN28Bgeeleft testis1.00infobox
LIN28Bgeeright testis1.00infobox
LIN28Bgeeembryo1.00infobox
LIN28BgeeAchilles tendon1.00infobox
LIN28Bgeeprimitive streak1.00infobox
LIN28Bgeetail of embryo1.00infobox
LIN28Bgeeepiblast1.00infobox
LIN28Bgeeotic placode1.00infobox
LIN28Bgeesomite1.00infobox
LIN28Bgeeotic vesicle1.00infobox
LIN28Bgeeyolk sac1.00infobox
LIN28Bgeezygote1.00infobox
LIN28Bgeegranulocyte1.00infobox
LIN28BioGPSMore reference expression data1.00infobox
LIN28Chr.Chromosome 1 (human)1.00infobox
LIN28Chr.Chromosome 4 (mouse)1.00infobox
LIN28DatabasesNCBI: entry; OMA: entry1.00infobox
LIN28End26,429,728 bp1.00infobox
LIN28End133,746,152 bp1.00infobox
LIN28EnsemblENSG000001319141.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around LIN28 bring nearby vocabulary together. In this analysis, examples include Stem, Cells and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • LIN28
    • Stem
    • Cells
    • Human
    • Embryonic
    • Expressed
    • Expression
    • Regulate
    • Lin28a
    • Mouse
    • Protein
    • Mice
    • Binds
  • lin28
    • Stem
    • Cells
    • Human
    • Embryonic
    • Expressed
    • Expression
    • Regulate
    • Lin28a
    • Mouse
    • Protein
    • Mice
    • Binds
  • gene
    • Location
    • Human
    • Chromosome
    • Homolog
    • Lin-28
    • Lin28
    • Lin28a
    • Bp
    • Chr
    • Cell
    • Function
    • Expression
  • let-7
    • Production
    • Mouse
    • Cell
    • Function
    • Mrna
    • Q9h9z2
    • Stress
    • Translation
    • Uniprot
    • Stem
    • Expression
    • Location
  • embryonic stem cells
    • Stem
    • Cells
    • Embryonic
    • Lin28
    • Human
    • Expressed
    • Mouse
    • Pluripotent
    • Location
    • Lin28a
    • Production
    • Let-7
  • stem cells
    • Stem
    • Embryonic
    • Lin28
    • Human
    • Expressed
    • Pluripotent
    • Location
    • Mouse
    • Lin28a
    • Production
    • Stress
    • Let-7
  • function
    • Cell
    • Expression
    • Location
    • Chromosome
    • External
    • Lin28a
    • Bp
    • Chr
    • Mrna
    • Pdb
    • Production
    • Q9h9z2
  • protein
    • Mrna
    • Q9h9z2
    • Translation
    • Uniprot
    • Cell
    • Function
    • Pdb
    • Production
    • Stress
    • Expression
    • Let-7
    • Location

Connections between topic areas Semantic bridges

For LIN28, one of the stronger structural bridges in this analysis connects LIN28 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
LIN28Function · splits 19 ⟂ 21
LIN28Overview · splits 26 ⟂ 14
LIN28Structure · splits 36 ⟂ 4

Map overview Semantic statistics

LIN28

Nodes40
Edges39
Triples124
Avg. degree1.95
Density0.05
Components1

Source & methodology

TTTA analyzes the structure around LIN28 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Overview & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — LIN28 · EN edition · Analysis: TopicsToTalkAbout

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