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KLF2

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic…

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Aliases
KLF2, LKLF, Kruppel-like factor 2, Kruppel like factor 2
Band
19p13.11 · 8|8 B3.3
Bgee
urethra · vena cava · trachea · saphenous vein · gastric mucosa
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

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Mouse knockout

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Map overview Semantic statistics

KLF2

Nodes128
Edges127
Triples161
Avg. degree1.98
Density0.015625
Components1

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KLF2

Top relations

Gene ontology · 35
KLF2 → cell morphogenesis, cellular response to cycloheximide, cellular response to fluid shear stress, cellular response to hydrogen peroxide, cellular response to interleukin-1, cellular response to laminar fluid shear stress, cellular response to organic cyclic compound, cellular response to peptide, cellular response to tumor necrosis factor, cellular stress response to acid chemical, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, erythrocyte homeostasis, erythrocyte maturation, in utero embryonic development, metal ion binding, multicellular organism growth, negative regulation of interleukin-6 production, negative regulation of sprouting angiogenesis
Bgee · 19
KLF2 → ankle, ankle joint, cardia, endocardial cushion, gastric mucosa, granulocyte, left lung, mesenteric lymph nodes, nipple, pericardium, pylorus, right lung, right lung lobe, saphenous vein, spleen, subcutaneous adipose tissue, trachea, urethra, vena cava
RNA expression pattern · 19
KLF2 → ankle, ankle joint, cardia, endocardial cushion, gastric mucosa, granulocyte, left lung, mesenteric lymph nodes, nipple, pericardium, pylorus, right lung, right lung lobe, saphenous vein, spleen, subcutaneous adipose tissue, trachea, urethra, vena cava
related to Discovery · 13
KLF2 → By, CACCC, EKLF, EKLF-deficient, Erythroid Krüppel-like Factor, Hemoglobin, However, It, KLF, KLF1, Krüppel-like, Krüppel-like Factor, Since
related to Structure · 10
KLF2 → C-terminus, CACCC, Cysteine2/Histidine2, EKLF, KLF, N-terminus, TGEKP, The, These, Y/F
related to Endothelial physiology · 7
KLF2 → Binding, IL-1β, MEF2, MEK5/ERK5, PI3K, This, TNFα
related to External links · 7
KLF2 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, UCSC Genome Browser, United States National Library
related to Mouse knockout · 7
KLF2 → Aortic, Both, Due, Homologous, KLF2-deficient, The, These KLF2-deficient
related to Embryonic erythropoiesis · 6
KLF2 → EKLF, However, In, It, KLF2-deficient, The
related to Lung development · 6
KLF2 → In, KLF2-deficient, Lung, These, These KLF2-deficient, This

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Important terminology

embryonic gene expression lung factor eklf human mouse also development transcription embryos cells klf2-deficient krüppel-like bp differentiation zinc chromosome 19

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
KLF2AliasesKLF2, LKLF, Kruppel-like factor 2, Kruppel like factor 21.00infobox
KLF2Band19p13.111.00infobox
KLF2Band8|8 B3.31.00infobox
KLF2Bgeeurethra1.00infobox
KLF2Bgeevena cava1.00infobox
KLF2Bgeetrachea1.00infobox
KLF2Bgeesaphenous vein1.00infobox
KLF2Bgeegastric mucosa1.00infobox
KLF2Bgeegranulocyte1.00infobox
KLF2Bgeenipple1.00infobox
KLF2Bgeepericardium1.00infobox
KLF2Bgeecardia1.00infobox
KLF2Bgeepylorus1.00infobox
KLF2Bgeeright lung1.00infobox
KLF2Bgeeankle joint1.00infobox
KLF2Bgeeright lung lobe1.00infobox
KLF2Bgeemesenteric lymph nodes1.00infobox
KLF2Bgeespleen1.00infobox
KLF2Bgeesubcutaneous adipose tissue1.00infobox
KLF2Bgeeankle1.00infobox
KLF2Bgeeendocardial cushion1.00infobox
KLF2Bgeeleft lung1.00infobox
KLF2BioGPSMore reference expression data1.00infobox
KLF2Chr.Chromosome 19 (human)1.00infobox
KLF2Chr.Chromosome 8 (mouse)1.00infobox
KLF2DatabasesNCBI: entry; OMA: entry1.00infobox
KLF2End16,328,685 bp1.00infobox
KLF2End73,075,500 bp1.00infobox
KLF2EnsemblENSG000001275281.00infobox
KLF2Entrez103651.00infobox

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