Dopamine receptor D2

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Explore the main themes, entities and connections around Dopamine receptor D2. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Ligands

Chlorpromazine Haloperidol Serotonin Histamine Bromocriptine

64 related topics

Genetics

Allelic A-241G C132T G423A T765C

15 related topics

Protein–protein interactions

Interact EPB41L1 PPP1R9B NCS-1 Receptor heterodimers

15 related topics

Function

Gi G protein G protein-coupled receptor Adenylyl cyclase Neuronal calcium sensor-1

12 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: DRD2, D2DR, D2R, dopamine receptor D2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes6CM4
Band: 11q23.2 · 9 A5.3|9 26.72 cM
Bgee: putamen · nucleus accumbens · testicle · pituitary gland · caudate nucleus
BioGPS: More reference expression data
Chr.: Chromosome 11 (human) · Chromosome 9 (mouse)

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Overview

Function

Isoforms

Active and inactive forms

Antagonist Antagonism (chemistry)
PDB Protein Data Bank
Homology modeling
Transmembrane domains Transmembrane domain
Binding affinities Binding affinity
Schizophrenia
Autism

Genetics

Allelic Allele
A-241G A-241G?action=edit&redlink=1
C132T C132T?action=edit&redlink=1
G423A G423A?action=edit&redlink=1
T765C T765C?action=edit&redlink=1
C939T C939T?action=edit&redlink=1
C957T
G1101A G1101A?action=edit&redlink=1
Cys311Ser Cys311Ser?action=edit&redlink=1
Polymorphism Polymorphism (biology)
Rs1800497 Rs1800497?action=edit&redlink=1
Exon
ANKK1
Tardive dyskinesia
Positive and Negative Syndrome Scale

Ligands

Chlorpromazine
Haloperidol
Serotonin
Histamine
Bromocriptine
Cabergoline
Ligands Ligand (biochemistry)
N,N-Propyldihydrexidine N,N-Propyldihydrexidine?action=edit&redlink=1
Dihydrexidine
Piribedil
Α2–adrenergic antagonist Α2-adrenergic receptor
Pramipexole
Quinagolide
Quinelorane
Quinpirole
Ropinirole
Sumanirole
Talipexole
Aplindore
Aripiprazole
Armodafinil
Modafinil
Brexpiprazole
Cariprazine
Cannabidiol
Ketamine
LSD
OSU-6162
Roxindole
Brilaroxazine

Protein–protein interactions

Interact Protein–protein interaction
EPB41L1
PPP1R9B
NCS-1
Receptor heterodimers GPCR oligomer
In vivo
G protein-coupled receptors
D1–D2 dopamine receptor heteromer
Adenosine A2A Adenosine A2A receptor
Ghrelin receptor
TAAR1
In vitro
DRD3 Dopamine D3 receptor
DRD5 Dopamine receptor D5
5-HT2A 5-HT2A receptor

Advanced semantic analysis

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Map overview Semantic statistics

Nodes136

Edges135

Triples221

Avg. degree1.99

Density0.014706

Components1

How this topic connects Entity context

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Dopamine receptor D2

Top relations

Gene ontology · 144

Dopamine receptor D2 → acid secretion, acrosomal vesicle, activation of protein kinase activity, adenohypophysis development, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-inhibiting dopamine receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, adrenergic receptor activity, adrenergic receptor signaling pathway, adult behavior, adult walking behavior, arachidonic acid secretion, associative learning, auditory behavior, autophagy, axon, axon terminus, axonogenesis, behavioral response to cocaine, behavioral response to ethanol

Bgee · 19

Dopamine receptor D2 → ankle joint, anterior pituitary, caudate nucleus, dorsal striatum, embryo, lumbar subsegment of spinal cord, neural layer of retina, nucleus accumbens, olfactory epithelium, olfactory tubercle, pars compacta, pars reticulata, pituitary gland, putamen, striatum of neuraxis, superior frontal gyrus, testicle, triceps brachii muscle, ventral tegmental area

RNA expression pattern · 19

related to Protein–protein interactions · 5

Dopamine receptor D2 → D2, EPB41L1, NCS-1, PPP1R9B, The

Band · 2

Dopamine receptor D2 → 11q23.2, 9 A5.3|9 26.72 cM

Chr. · 2

Dopamine receptor D2 → Chromosome 11 (human), Chromosome 9 (mouse)

End · 2

Dopamine receptor D2 → 113,475,691 bp, 49,319,477 bp

Aliases · 1

Dopamine receptor D2 → DRD2, D2DR, D2R, dopamine receptor D2

Available structures · 1

Dopamine receptor D2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes6CM4

BioGPS · 1

Dopamine receptor D2 → More reference expression data

Important terminology Word statistics

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Important terminology

dopamine d2 receptor d2r agonist also antipsychotic antagonist receptors gene drd2 bp form selective chr protein human band ligands active

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Dopamine receptor D2	Aliases	DRD2, D2DR, D2R, dopamine receptor D2	1.00	infobox
Dopamine receptor D2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes6CM4	1.00	infobox
Dopamine receptor D2	Band	11q23.2	1.00	infobox
Dopamine receptor D2	Band	9 A5.3\|9 26.72 cM	1.00	infobox
Dopamine receptor D2	Bgee	putamen	1.00	infobox
Dopamine receptor D2	Bgee	nucleus accumbens	1.00	infobox
Dopamine receptor D2	Bgee	testicle	1.00	infobox
Dopamine receptor D2	Bgee	pituitary gland	1.00	infobox
Dopamine receptor D2	Bgee	caudate nucleus	1.00	infobox
Dopamine receptor D2	Bgee	anterior pituitary	1.00	infobox
Dopamine receptor D2	Bgee	triceps brachii muscle	1.00	infobox
Dopamine receptor D2	Bgee	pars compacta	1.00	infobox
Dopamine receptor D2	Bgee	pars reticulata	1.00	infobox
Dopamine receptor D2	Bgee	ventral tegmental area	1.00	infobox
Dopamine receptor D2	Bgee	superior frontal gyrus	1.00	infobox
Dopamine receptor D2	Bgee	striatum of neuraxis	1.00	infobox
Dopamine receptor D2	Bgee	dorsal striatum	1.00	infobox
Dopamine receptor D2	Bgee	olfactory epithelium	1.00	infobox
Dopamine receptor D2	Bgee	lumbar subsegment of spinal cord	1.00	infobox
Dopamine receptor D2	Bgee	neural layer of retina	1.00	infobox
Dopamine receptor D2	Bgee	olfactory tubercle	1.00	infobox
Dopamine receptor D2	Bgee	embryo	1.00	infobox
Dopamine receptor D2	Bgee	ankle joint	1.00	infobox
Dopamine receptor D2	BioGPS	More reference expression data	1.00	infobox
Dopamine receptor D2	Chr.	Chromosome 11 (human)	1.00	infobox
Dopamine receptor D2	Chr.	Chromosome 9 (mouse)	1.00	infobox
Dopamine receptor D2	Databases	NCBI: entry; OMA: entry	1.00	infobox
Dopamine receptor D2	End	113,475,691 bp	1.00	infobox
Dopamine receptor D2	End	49,319,477 bp	1.00	infobox
Dopamine receptor D2	Ensembl	ENSG00000149295	1.00	infobox

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