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CARM1: Clinical significance & Overview

CARM1 (coactivator-associated arginine methyltransferase 1), also known as PRMT4 (protein arginine N-methyltransferase 4), is an enzyme (EC 2.1.1.125) encoded by the CARM1 gene found in human beings, as well as many other mammals. It has a polypeptide (L) chain type that is 348 residues long, and is made up of alpha helices and beta sheets. Its main…

Language: English [EN]
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CARM1 topic overview

The analysis highlights Clinical significance and Overview as prominent areas in the source structure around CARM1.

Related topics
14
Source areas
2
Connected nodes
16
Extracted relationships
17
Concept neighborhoods
11
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics
Clinical significance · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Domains
InterPro
EC number
2.1.1.125
HGNC
23393
Locus
Chr. 19 p13.2
NCBI gene
10498
OMIM
603934

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CARM1 connects Entity context

The extracted context around CARM1 shows recurring relationship patterns in the source. For example, CARM1 → BAF155, CARM1-mediated MDH1, In, MDH1, NADPH Another extracted example is CARM1 → InterPro. Use these groups to spot repeated connection types before inspecting the individual relationships.

CARM1

Top relations

related to Clinical significance · 5
CARM1 → BAF155, CARM1-mediated MDH1, In, MDH1, NADPH
Domains · 1
CARM1 → InterPro
EC number · 1
CARM1 → 2.1.1.125
HGNC · 1
CARM1 → 23393
Locus · 1
CARM1 → Chr. 19 p13.2
NCBI gene · 1
CARM1 → 10498
OMIM · 1
CARM1 → 603934
RefSeq · 1
CARM1 → XM_032719
Search for · 1
CARM1 → Search forStructuresSwiss-modelDomainsInterPro
Structures · 1
CARM1 → Swiss-model

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

arginine methyltransferase chain residues coactivator also 125 gene cancer coactivator-associated n-methyltransferase cells cell chr 19 p13 mdh1 enzyme s-adenosyl-l-homocysteine src-1

CARM1 relationships Subject–Predicate–Object triples

TTTA extracted 17 structured relationships around CARM1. Examples in this analysis include CARM1 → Domains → InterPro and CARM1 → EC number → 2.1.1.125. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CARM1DomainsInterPro1.00infobox
CARM1EC number2.1.1.1251.00infobox
CARM1HGNC233931.00infobox
CARM1LocusChr. 19 p13.21.00infobox
CARM1NCBI gene104981.00infobox
CARM1OMIM6039341.00infobox
CARM1RefSeqXM_0327191.00infobox
CARM1Search forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
CARM1StructuresSwiss-model1.00infobox
CARM1SymbolCARM11.00infobox
CARM1UniProtQ86X551.00infobox
CARM1is asecondary coactivator through its association with p160 family0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around CARM1 bring nearby vocabulary together. In this analysis, examples include Cancer, Also and Coactivator. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CARM1
    • Cancer
    • Also
    • Coactivator
    • Gene
    • Methylates
    • Progression
    • Methyltransferase
    • Arginine
    • Aib
    • Beings
    • Ec2
    • Encoded
  • carm1
    • Cancer
    • Also
    • Coactivator
    • Gene
    • Methylates
    • Progression
    • Methyltransferase
    • Arginine
    • Aib
    • Beings
    • Ec2
    • Encoded
  • arginine
    • Methyltransferase
    • Also
    • Coactivator-associated
    • Gene
    • N-methyltransferase
    • Beings
    • Ec2
    • Encoded
    • Enzyme
    • Found
    • Human
    • Known
  • enzyme
    • Ec2
    • Encoded
    • Found
    • Human
    • Known
    • Mammals
    • Many
    • Prmt4
    • Protein
    • Well
    • Gene
    • N-methyltransferase
  • coactivator
    • Grip1
    • Src-1
    • Chr
    • Gene
    • Methyltransferase
  • pancreatic cancer
    • Methylates
    • Progression
    • Carm1
    • Mdh1
    • P13
  • src-1
    • Aib
    • Grip1
    • Coactivator
    • Carm1
  • aib
    • Grip1
    • Src-1
    • Coactivator
    • Carm1

Connections between topic areas Semantic bridges

For CARM1, one of the stronger structural bridges in this analysis connects CARM1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CARM1 — Overview · splits 7 ⟂ 10
CARM1 — Clinical significance · splits 11 ⟂ 6

Map overview Semantic statistics

CARM1

Nodes17
Edges16
Triples17
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around CARM1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CARM1 · EN edition · Analysis: TopicsToTalkAbout

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