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KDM1A: Clinical significance, Mechanism of catalysis and protein function & Interactions
Lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in humans is encoded by the KDM1A gene. LSD1 is a flavin-dependent monoamine oxidase, which can demethylate mono- and di-methylated lysines, specifically histone 3, lysine 4 (H3K4). Other reported methylated lysine substrates such as…
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KDM1A topic overview
The analysis highlights Clinical significance, Mechanism of catalysis and protein function and Interactions as prominent areas in the source structure around KDM1A.
Related topics
27
Source areas
6
Connected nodes
33
Extracted relationships
155
Concept neighborhoods
11
Bridge connections
33
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Overview · 9 topics
Clinical significance · 5 topics
Interactions · 4 topics
Mechanism of catalysis and protein function · 4 topics
Structure · 3 topics
Role in development · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COM, 2DW4, 2EJR, 2H94, 2HKO, 2IW5, 2L3D, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48,…
Band
1p36.12 · 4 D3|4 68.8 cM
Bgee
ganglionic eminence · ventricular zone · right testis · left testis · beta cell
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How KDM1A connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around KDM1A shows recurring relationship patterns in the source. For example, KDM1A → alternative mRNA splicing, via spliceosome, androgen receptor binding, blood coagulation, cellular response to cAMP, cellular response to gamma radiation, cellular response to UV, cerebral cortex development, chromatin binding, chromatin organization, demethylase activity, DNA binding, DNA repair complex, enzyme binding, flavin adenine dinucleotide binding, guanine metabolic process, histone deacetylase activity, histone deacetylation, histone demethylase activity, histone H3-K4 demethylation, histone H3-K9 demethylation Another extracted example is KDM1A → anterior pituitary, beta cell, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, ganglionic eminence, genital tubercle, Gonadal ridge, left ovary, left testis, male urethra, right ovary, right testis, right uterine tube, stromal cell of endometrium, tail of embryo, urethra, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
KDM1A
Top relations
Gene ontology· 63
KDM1A → alternative mRNA splicing, via spliceosome, androgen receptor binding, blood coagulation, cellular response to cAMP, cellular response to gamma radiation, cellular response to UV, cerebral cortex development, chromatin binding, chromatin organization, demethylase activity, DNA binding, DNA repair complex, enzyme binding, flavin adenine dinucleotide binding, guanine metabolic process, histone deacetylase activity, histone deacetylation, histone demethylase activity, histone H3-K4 demethylation, histone H3-K9 demethylation
Bgee· 19
KDM1A → anterior pituitary, beta cell, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, ganglionic eminence, genital tubercle, Gonadal ridge, left ovary, left testis, male urethra, right ovary, right testis, right uterine tube, stromal cell of endometrium, tail of embryo, urethra, ventricular zone
RNA expression pattern· 19
KDM1A → anterior pituitary, beta cell, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, ganglionic eminence, genital tubercle, Gonadal ridge, left ovary, left testis, male urethra, right ovary, right testis, right uterine tube, stromal cell of endometrium, tail of embryo, urethra, ventricular zone
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 155 structured relationships around KDM1A. Examples in this analysis include KDM1A → 1.14.11.65 → ↗ and KDM1A → Aliases → KDM1A, AOF2, BHC110, KDM1, LSD1, CPRF, lysine demethylase 1A. The table shows each extracted connection, where it came from and its confidence.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COM, 2DW4, 2EJR, 2H94, 2HKO, 2IW5, 2L3D, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48,…
1.00
infobox
KDM1A
Band
1p36.12
1.00
infobox
KDM1A
Band
4 D3|4 68.8 cM
1.00
infobox
KDM1A
Bgee
ganglionic eminence
1.00
infobox
KDM1A
Bgee
ventricular zone
1.00
infobox
KDM1A
Bgee
right testis
1.00
infobox
KDM1A
Bgee
left testis
1.00
infobox
KDM1A
Bgee
beta cell
1.00
infobox
KDM1A
Bgee
stromal cell of endometrium
1.00
infobox
KDM1A
Bgee
anterior pituitary
1.00
infobox
KDM1A
Bgee
right ovary
1.00
infobox
KDM1A
Bgee
right uterine tube
1.00
infobox
KDM1A
Bgee
left ovary
1.00
infobox
KDM1A
Bgee
urethra
1.00
infobox
KDM1A
Bgee
epithelium of urethra
1.00
infobox
KDM1A
Bgee
male urethra
1.00
infobox
KDM1A
Bgee
tail of embryo
1.00
infobox
KDM1A
Bgee
epithelium of male urethra
1.00
infobox
KDM1A
Bgee
female urethra
1.00
infobox
KDM1A
Bgee
Gonadal ridge
1.00
infobox
KDM1A
Bgee
epithelium of female urethra
1.00
infobox
KDM1A
Bgee
genital tubercle
1.00
infobox
KDM1A
BioGPS
n/a
1.00
infobox
KDM1A
Chr.
Chromosome 1 (human)
1.00
infobox
KDM1A
Chr.
Chromosome 4 (mouse)
1.00
infobox
KDM1A
Databases
NCBI: entry; OMA: entry
1.00
infobox
KDM1A
End
23,083,689 bp
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around KDM1A bring nearby vocabulary together. In this analysis, examples include Protein, Function and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
KDM1A
Protein
Function
Gene
Enzyme
Location
Mouse
Chromosome
Development
Stem
Bp
Chr
Human
kdm1a
Protein
Function
Gene
Enzyme
Location
Mouse
Chromosome
Development
Stem
Bp
Chr
Human
gene
Location
Protein
Chromosome
Bp
Chr
Human
Enzyme
Mouse
Kdm1a
Band
Complex
Development
histone
Demethylase
Lysine
Lysine-specific
Transcription
Gene
Protein
Kdm1a
1a
Specifically
Complex
Lsd1
H3k4
histone deacetylase
Demethylase
Lysine
Lysine-specific
Transcription
Gene
Protein
Kdm1a
1a
Specifically
Complex
Lsd1
H3k4
mechanism of catalysis and protein function
Activity
Protein
Location
Kdm1a
Chromosome
Complex
Development
Enzymatic
Maturation
Stem
Binding
Bp
role in development
Enzyme
Location
Chromosome
Maturation
Treatment
Bp
Chr
Human
Inhibitors
Function
Gene
Protein
nurd complex
Enzymatic
Transcription
Function
Gene
Enzyme
Location
Mouse
Nuclear
Specifically
Development
Histone
Maturation
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For KDM1A, one of the stronger structural bridges in this analysis connects KDM1A with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Min side: 3
KDM1A — Overview· splits 24 ⟂ 10KDM1A — Clinical significance· splits 28 ⟂ 6KDM1A — Mechanism of catalysis and protein function· splits 29 ⟂ 5KDM1A — Interactions· splits 29 ⟂ 5KDM1A — Structure· splits 30 ⟂ 4KDM1A — Role in development· splits 31 ⟂ 3
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
KDM1A
Nodes34
Edges33
Triples155
Avg. degree1.94
Density0.058824
Components1
Source & methodology
TTTA analyzes the structure around KDM1A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Mechanism of catalysis and protein function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — KDM1A · EN edition · Analysis: TopicsToTalkAbout
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