Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

KDM1A: Mechanism of catalysis and protein function, Interactions & Structure

Lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in humans is encoded by the KDM1A gene. LSD1 is a flavin-dependent monoamine oxidase, which can demethylate mono- and di-methylated lysines, specifically histone 3, lysine 4 (H3K4). Other reported methylated lysine substrates such as…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

KDM1A topic overview

The analysis highlights Mechanism of catalysis and protein function, Interactions and Structure as prominent areas in the source structure around KDM1A.

Related topics
25
Source areas
6
Connected nodes
31
Extracted relationships
153
Related term clusters
11
Bridge connections
31

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics
Interactions · 4 topics
Mechanism of catalysis and protein function · 4 topics
Clinical significance · 3 topics
Structure · 3 topics
Role in development · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.14.11.65
↗
1.14.99.66
↗
Aliases
KDM1A, AOF2, BHC110, KDM1, LSD1, CPRF, lysine demethylase 1A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COM, 2DW4, 2EJR, 2H94, 2HKO, 2IW5, 2L3D, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48,…
Band
1p36.12 · 4 D3|4 68.8 cM
Bgee
ganglionic eminence · ventricular zone · right testis · left testis · beta cell

Start with your topic. Discover where to go next.

Explore different angles and find fresh ideas to shape your next piece of content.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Mechanism of catalysis and protein function

Interactions

Role in development

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How KDM1A connects Entity context

The extracted context around KDM1A shows recurring relationship patterns in the source. For example, KDM1A → alternative mRNA splicing, via spliceosome, androgen receptor binding, blood coagulation, cellular response to cAMP, cellular response to gamma radiation, cellular response to UV, cerebral cortex development, chromatin binding, chromatin organization, demethylase activity, DNA binding, DNA repair complex, enzyme binding, flavin adenine dinucleotide binding, guanine metabolic process, histone deacetylase activity, histone deacetylation, histone demethylase activity, histone H3-K4 demethylation, histone H3-K9 demethylation Another extracted example is KDM1A → anterior pituitary, beta cell, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, ganglionic eminence, genital tubercle, Gonadal ridge, left ovary, left testis, male urethra, right ovary, right testis, right uterine tube, stromal cell of endometrium, tail of embryo, urethra, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

KDM1A

Top relations

Gene ontology · 63
KDM1A → alternative mRNA splicing, via spliceosome, androgen receptor binding, blood coagulation, cellular response to cAMP, cellular response to gamma radiation, cellular response to UV, cerebral cortex development, chromatin binding, chromatin organization, demethylase activity, DNA binding, DNA repair complex, enzyme binding, flavin adenine dinucleotide binding, guanine metabolic process, histone deacetylase activity, histone deacetylation, histone demethylase activity, histone H3-K4 demethylation, histone H3-K9 demethylation
Bgee · 19
KDM1A → anterior pituitary, beta cell, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, ganglionic eminence, genital tubercle, Gonadal ridge, left ovary, left testis, male urethra, right ovary, right testis, right uterine tube, stromal cell of endometrium, tail of embryo, urethra, ventricular zone
RNA expression pattern · 19
KDM1A → anterior pituitary, beta cell, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, ganglionic eminence, genital tubercle, Gonadal ridge, left ovary, left testis, male urethra, right ovary, right testis, right uterine tube, stromal cell of endometrium, tail of embryo, urethra, ventricular zone
related to Clinical significance · 6
KDM1A → Catalytic, Given LSD1, Imago BioSciences, Inc, Inhibitors, LSD1
related to Mutations · 4
KDM1A → De, H3K4, LSD1, SETD1A
related to Role in development · 3
KDM1A → Day, Deletion, LSD1
Band · 2
KDM1A → 1p36.12, 4 D3|4 68.8 cM
Chr. · 2
KDM1A → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
KDM1A → 136,330,034 bp, 23,083,689 bp
1.14.11.65 · 1
KDM1A → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

lsd1 histone demethylase lysine gene protein bp human activity chr band function h3k4 chromosome inhibitors binding transcription development interaction cells

KDM1A relationships Subject–Predicate–Object triples

TTTA extracted 153 structured relationships around KDM1A. Examples in this analysis include KDM1A → 1.14.11.65 → ↗ and KDM1A → Aliases → KDM1A, AOF2, BHC110, KDM1, LSD1, CPRF, lysine demethylase 1A. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
KDM1A1.14.11.65↗1.00infobox
KDM1A1.14.99.66↗1.00infobox
KDM1AAliasesKDM1A, AOF2, BHC110, KDM1, LSD1, CPRF, lysine demethylase 1A1.00infobox
KDM1AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COM, 2DW4, 2EJR, 2H94, 2HKO, 2IW5, 2L3D, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48,…1.00infobox
KDM1ABand1p36.121.00infobox
KDM1ABand4 D3|4 68.8 cM1.00infobox
KDM1ABgeeganglionic eminence1.00infobox
KDM1ABgeeventricular zone1.00infobox
KDM1ABgeeright testis1.00infobox
KDM1ABgeeleft testis1.00infobox
KDM1ABgeebeta cell1.00infobox
KDM1ABgeestromal cell of endometrium1.00infobox
KDM1ABgeeanterior pituitary1.00infobox
KDM1ABgeeright ovary1.00infobox
KDM1ABgeeright uterine tube1.00infobox
KDM1ABgeeleft ovary1.00infobox
KDM1ABgeeurethra1.00infobox
KDM1ABgeeepithelium of urethra1.00infobox
KDM1ABgeemale urethra1.00infobox
KDM1ABgeetail of embryo1.00infobox
KDM1ABgeeepithelium of male urethra1.00infobox
KDM1ABgeefemale urethra1.00infobox
KDM1ABgeeGonadal ridge1.00infobox
KDM1ABgeeepithelium of female urethra1.00infobox
KDM1ABgeegenital tubercle1.00infobox
KDM1ABioGPSn/a1.00infobox
KDM1AChr.Chromosome 1 (human)1.00infobox
KDM1AChr.Chromosome 4 (mouse)1.00infobox
KDM1ADatabasesNCBI: entry; OMA: entry1.00infobox
KDM1AEnd23,083,689 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around KDM1A bring nearby vocabulary together. In this analysis, examples include Protein, Function and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • KDM1A
    • Protein
    • Function
    • Gene
    • Enzyme
    • Location
    • Mouse
    • Chromosome
    • Development
    • Stem
    • Bp
    • Chr
    • Human
  • kdm1a
    • Protein
    • Function
    • Gene
    • Enzyme
    • Location
    • Mouse
    • Chromosome
    • Development
    • Stem
    • Bp
    • Chr
    • Human
  • gene
    • Location
    • Protein
    • Chromosome
    • Bp
    • Chr
    • Human
    • Enzyme
    • Mouse
    • Kdm1a
    • Band
    • Complex
    • Development
  • histone
    • Demethylase
    • Lysine
    • Lysine-specific
    • Transcription
    • Gene
    • Protein
    • Kdm1a
    • 1a
    • Specifically
    • Complex
    • Lsd1
    • H3k4
  • histone deacetylase
    • Demethylase
    • Lysine
    • Lysine-specific
    • Transcription
    • Gene
    • Protein
    • Kdm1a
    • 1a
    • Specifically
    • Complex
    • Lsd1
    • H3k4
  • mechanism of catalysis and protein function
    • Activity
    • Protein
    • Location
    • Kdm1a
    • Chromosome
    • Complex
    • Development
    • Enzymatic
    • Maturation
    • Stem
    • Binding
    • Bp
  • role in development
    • Enzyme
    • Location
    • Chromosome
    • Maturation
    • Treatment
    • Bp
    • Chr
    • Human
    • Inhibitors
    • Function
    • Gene
    • Protein
  • nurd complex
    • Enzymatic
    • Transcription
    • Function
    • Gene
    • Enzyme
    • Location
    • Mouse
    • Nuclear
    • Specifically
    • Development
    • Histone
    • Maturation

Connections between topic areas Semantic bridges

For KDM1A, one of the stronger structural bridges in this analysis connects KDM1A with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
KDM1A — Overview · splits 22 ⟂ 10
KDM1A — Mechanism of catalysis and protein function · splits 27 ⟂ 5
KDM1A — Interactions · splits 27 ⟂ 5
KDM1A — Structure · splits 28 ⟂ 4
KDM1A — Clinical significance · splits 28 ⟂ 4
KDM1A — Role in development · splits 29 ⟂ 3

Map overview Semantic statistics

KDM1A

Nodes32
Edges31
Triples153
Avg. degree1.94
Density0.0625
Components1

Source & methodology

TTTA analyzes the structure around KDM1A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Mechanism of catalysis and protein function, Interactions & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — KDM1A · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.

Monitor your Domain Rating with FrogDR