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KDM1A

Lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) is a protein that in humans is encoded by the KDM1A gene. LSD1 is a flavin-dependent monoamine oxidase, which can demethylate mono- and di-methylated lysines, specifically histone 3, lysine 4 (H3K4). Other reported methylated lysine substrates such as…

Clinical significance, Mechanism of catalysis and protein function & Interactions

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Clinical significance

IadademstatPhenelzinePulrodemstatSeclidemstatTranylcypromine
5 related topics

Mechanism of catalysis and protein function

H3K4me1FormaldehydeGFI1BBomedemstat
4 related topics

Interactions

Acute myeloid leukemiaNuRD complexGSK3βGlioblastoma
4 related topics

Structure

FADAmine oxidaseHistone deacetylase
3 related topics

Key facts & relationships

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1.14.11.65
↗
1.14.99.66
↗
Aliases
KDM1A, AOF2, BHC110, KDM1, LSD1, CPRF, lysine demethylase 1A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COM, 2DW4, 2EJR, 2H94, 2HKO, 2IW5, 2L3D, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48,…
Band
1p36.12 · 4 D3|4 68.8 cM
Bgee
ganglionic eminence · ventricular zone · right testis · left testis · beta cell

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Overview

Structure

Mechanism of catalysis and protein function

Interactions

Role in development

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

KDM1A

Nodes34
Edges33
Triples155
Avg. degree1.94
Density0.058824
Components1

How this topic connects Entity context

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KDM1A

Top relations

Gene ontology · 63
KDM1A → alternative mRNA splicing, via spliceosome, androgen receptor binding, blood coagulation, cellular response to cAMP, cellular response to gamma radiation, cellular response to UV, cerebral cortex development, chromatin binding, chromatin organization, demethylase activity, DNA binding, DNA repair complex, enzyme binding, flavin adenine dinucleotide binding, guanine metabolic process, histone deacetylase activity, histone deacetylation, histone demethylase activity, histone H3-K4 demethylation, histone H3-K9 demethylation
Bgee · 19
KDM1A → anterior pituitary, beta cell, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, ganglionic eminence, genital tubercle, Gonadal ridge, left ovary, left testis, male urethra, right ovary, right testis, right uterine tube, stromal cell of endometrium, tail of embryo, urethra, ventricular zone
RNA expression pattern · 19
KDM1A → anterior pituitary, beta cell, epithelium of female urethra, epithelium of male urethra, epithelium of urethra, female urethra, ganglionic eminence, genital tubercle, Gonadal ridge, left ovary, left testis, male urethra, right ovary, right testis, right uterine tube, stromal cell of endometrium, tail of embryo, urethra, ventricular zone
related to Clinical significance · 7
KDM1A → As, Catalytic, Given LSD1, Imago BioSciences, Inc, Inhibitors, LSD1
related to Mutations · 5
KDM1A → All, De, H3K4, LSD1, SETD1A
related to Role in development · 3
KDM1A → Day, Deletion, LSD1
Band · 2
KDM1A → 1p36.12, 4 D3|4 68.8 cM
Chr. · 2
KDM1A → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
KDM1A → 136,330,034 bp, 23,083,689 bp
1.14.11.65 · 1
KDM1A → ↗

Important terminology Word statistics

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Important terminology

lsd1 histone demethylase lysine gene protein bp human activity chr band function h3k4 chromosome inhibitors binding transcription development interaction cells

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
KDM1A1.14.11.65↗1.00infobox
KDM1A1.14.99.66↗1.00infobox
KDM1AAliasesKDM1A, AOF2, BHC110, KDM1, LSD1, CPRF, lysine demethylase 1A1.00infobox
KDM1AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COM, 2DW4, 2EJR, 2H94, 2HKO, 2IW5, 2L3D, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48,…1.00infobox
KDM1ABand1p36.121.00infobox
KDM1ABand4 D3|4 68.8 cM1.00infobox
KDM1ABgeeganglionic eminence1.00infobox
KDM1ABgeeventricular zone1.00infobox
KDM1ABgeeright testis1.00infobox
KDM1ABgeeleft testis1.00infobox
KDM1ABgeebeta cell1.00infobox
KDM1ABgeestromal cell of endometrium1.00infobox
KDM1ABgeeanterior pituitary1.00infobox
KDM1ABgeeright ovary1.00infobox
KDM1ABgeeright uterine tube1.00infobox
KDM1ABgeeleft ovary1.00infobox
KDM1ABgeeurethra1.00infobox
KDM1ABgeeepithelium of urethra1.00infobox
KDM1ABgeemale urethra1.00infobox
KDM1ABgeetail of embryo1.00infobox
KDM1ABgeeepithelium of male urethra1.00infobox
KDM1ABgeefemale urethra1.00infobox
KDM1ABgeeGonadal ridge1.00infobox
KDM1ABgeeepithelium of female urethra1.00infobox
KDM1ABgeegenital tubercle1.00infobox
KDM1ABioGPSn/a1.00infobox
KDM1AChr.Chromosome 1 (human)1.00infobox
KDM1AChr.Chromosome 4 (mouse)1.00infobox
KDM1ADatabasesNCBI: entry; OMA: entry1.00infobox
KDM1AEnd23,083,689 bp1.00infobox

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