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SOD1

Superoxide dismutase also known as superoxide dismutase 1 or hSod1 is an enzyme that in humans is encoded by the SOD1 gene, located on chromosome 21. SOD1 is one of three human superoxide dismutases. It is implicated in apoptosis, familial amyotrophic lateral sclerosis and Parkinson's disease.

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1.15.1.1
Aliases
SOD1, ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer, superoxide dismutase 1, soluble, superoxide dismutase 1, STAHP
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AZV, 1BA9, 1DSW, 1FUN, 1HL4, 1HL5, 1KMG, 1L3N, 1MFM, 1N18, 1N19, 1OEZ, 1OZT, 1OZU, 1P1V, 1PTZ, 1PU0, 1RK7,…
Band
21q22.11 · 16 C3.3|16 51.56 cM
Bgee
pons · pars compacta · spinal ganglia · lateral nuclear group of thalamus · superior vestibular nucleus
BioGPS
More reference expression data

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SOD1

Nodes76
Edges75
Triples217
Avg. degree1.97
Density0.026316
Components1

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SOD1

Top relations

Gene ontology · 99
SOD1 → ageing, anterograde axonal transport, antioxidant activity, auditory receptor cell stereocilium organization, axon cytoplasm, cellular iron ion homeostasis, cellular response to ATP, cellular response to cadmium ion, cellular response to oxidative stress, cellular response to potassium ion, chaperone binding, copper ion binding, cytoplasm, cytoplasmic vesicle, cytosol, dendrite cytoplasm, dense core granule, embryo implantation, enzyme binding, extracellular exosome
Bgee · 20
SOD1 → Brodmann area 10, condyle, cumulus cell, Epithelium of choroid plexus, facial motor nucleus, fossa, hypothalamus, lateral nuclear group of thalamus, otolith organ, Paneth cell, pars compacta, pars reticulata, pons, primary oocyte, right adrenal cortex, right lobe of liver, spinal ganglia, superior vestibular nucleus, utricle, vestibular sensory epithelium
RNA expression pattern · 20
SOD1 → Brodmann area 10, condyle, cumulus cell, Epithelium of choroid plexus, facial motor nucleus, fossa, hypothalamus, lateral nuclear group of thalamus, otolith organ, Paneth cell, pars compacta, pars reticulata, pons, primary oocyte, right adrenal cortex, right lobe of liver, spinal ganglia, superior vestibular nucleus, utricle, vestibular sensory epithelium
related to Amyotrophic lateral sclerosis (Lou Gehrig's disease) · 14
SOD1 → A4V, ALS, ALS-causing SOD1, G93A, H46R, However, In Iceland, It, Japan, Mutations, Rare, SOD1-G93S, The, Virtually
related to Role in oxidative stress · 10
SOD1 → Although, As, During, In, Ischemic, It, Mice, Most, Research, ROS
related to Structure · 10
SOD1 → Although SOD1, CCS, Cu/Zn, Cys-146, Cys-57, Moreover, The, There, This, This Cu/Zn
related to Down syndrome · 9
SOD1 → DNA, Down, DS, DS-related, Increased, OHdG, Oxidative, The, These
related to Function · 6
SOD1 → BCL-2, Hydrogen, OMM, The, Two, Wildtype SOD1
Band · 2
SOD1 → 16 C3.3|16 51.56 cM, 21q22.11
Chr. · 2
SOD1 → Chromosome 16 (mouse), Chromosome 21 (human)

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Important terminology

als g93a gene a4v superoxide disease mutation human chromosome 21 mitochondrial oxidative bp mouse enzyme h46r mutations one chr band

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SOD11.15.1.11.00infobox
SOD1AliasesSOD1, ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer, superoxide dismutase 1, soluble, superoxide dismutase 1, STAHP1.00infobox
SOD1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AZV, 1BA9, 1DSW, 1FUN, 1HL4, 1HL5, 1KMG, 1L3N, 1MFM, 1N18, 1N19, 1OEZ, 1OZT, 1OZU, 1P1V, 1PTZ, 1PU0, 1RK7,…1.00infobox
SOD1Band21q22.111.00infobox
SOD1Band16 C3.3|16 51.56 cM1.00infobox
SOD1Bgeepons1.00infobox
SOD1Bgeepars compacta1.00infobox
SOD1Bgeespinal ganglia1.00infobox
SOD1Bgeelateral nuclear group of thalamus1.00infobox
SOD1Bgeesuperior vestibular nucleus1.00infobox
SOD1Bgeepars reticulata1.00infobox
SOD1Bgeeright lobe of liver1.00infobox
SOD1BgeeBrodmann area 101.00infobox
SOD1Bgeeright adrenal cortex1.00infobox
SOD1Bgeehypothalamus1.00infobox
SOD1Bgeeotolith organ1.00infobox
SOD1Bgeeutricle1.00infobox
SOD1BgeePaneth cell1.00infobox
SOD1Bgeecumulus cell1.00infobox
SOD1Bgeefossa1.00infobox
SOD1Bgeeprimary oocyte1.00infobox
SOD1Bgeevestibular sensory epithelium1.00infobox
SOD1BgeeEpithelium of choroid plexus1.00infobox
SOD1Bgeefacial motor nucleus1.00infobox
SOD1Bgeecondyle1.00infobox
SOD1BioGPSMore reference expression data1.00infobox
SOD1Chr.Chromosome 21 (human)1.00infobox
SOD1Chr.Chromosome 16 (mouse)1.00infobox
SOD1DatabasesNCBI: entry; OMA: entry1.00infobox
SOD1End31,668,931 bp1.00infobox

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