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SOD1: Clinical significance, Structure & Function

Superoxide dismutase also known as superoxide dismutase 1 or hSod1 is an enzyme that in humans is encoded by the SOD1 gene, located on chromosome 21. SOD1 is one of three human superoxide dismutases. It is implicated in apoptosis, familial amyotrophic lateral sclerosis and Parkinson's disease.

Language: English [EN]
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SOD1 topic overview

The analysis highlights Clinical significance, Structure and Function as prominent areas in the source structure around SOD1. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
69
Source areas
5
Connected nodes
75
Extracted relationships
217
Concept neighborhoods
26
Bridge connections
75

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 36 topics
Overview · 15 topics
Function · 8 topics
Structure · 8 topics
Interactions · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.15.1.1
Aliases
SOD1, ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer, superoxide dismutase 1, soluble, superoxide dismutase 1, STAHP
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AZV, 1BA9, 1DSW, 1FUN, 1HL4, 1HL5, 1KMG, 1L3N, 1MFM, 1N18, 1N19, 1OEZ, 1OZT, 1OZU, 1P1V, 1PTZ, 1PU0, 1RK7,…
Band
21q22.11 · 16 C3.3|16 51.56 cM
Bgee
pons · pars compacta · spinal ganglia · lateral nuclear group of thalamus · superior vestibular nucleus
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SOD1 connects Entity context

The extracted context around SOD1 shows recurring relationship patterns in the source. For example, SOD1 → ageing, anterograde axonal transport, antioxidant activity, auditory receptor cell stereocilium organization, axon cytoplasm, cellular iron ion homeostasis, cellular response to ATP, cellular response to cadmium ion, cellular response to oxidative stress, cellular response to potassium ion, chaperone binding, copper ion binding, cytoplasm, cytoplasmic vesicle, cytosol, dendrite cytoplasm, dense core granule, embryo implantation, enzyme binding, extracellular exosome Another extracted example is SOD1 → Brodmann area 10, condyle, cumulus cell, Epithelium of choroid plexus, facial motor nucleus, fossa, hypothalamus, lateral nuclear group of thalamus, otolith organ, Paneth cell, pars compacta, pars reticulata, pons, primary oocyte, right adrenal cortex, right lobe of liver, spinal ganglia, superior vestibular nucleus, utricle, vestibular sensory epithelium. Use these groups to spot repeated connection types before inspecting the individual relationships.

SOD1

Top relations

Gene ontology · 99
SOD1 → ageing, anterograde axonal transport, antioxidant activity, auditory receptor cell stereocilium organization, axon cytoplasm, cellular iron ion homeostasis, cellular response to ATP, cellular response to cadmium ion, cellular response to oxidative stress, cellular response to potassium ion, chaperone binding, copper ion binding, cytoplasm, cytoplasmic vesicle, cytosol, dendrite cytoplasm, dense core granule, embryo implantation, enzyme binding, extracellular exosome
Bgee · 20
SOD1 → Brodmann area 10, condyle, cumulus cell, Epithelium of choroid plexus, facial motor nucleus, fossa, hypothalamus, lateral nuclear group of thalamus, otolith organ, Paneth cell, pars compacta, pars reticulata, pons, primary oocyte, right adrenal cortex, right lobe of liver, spinal ganglia, superior vestibular nucleus, utricle, vestibular sensory epithelium
RNA expression pattern · 20
SOD1 → Brodmann area 10, condyle, cumulus cell, Epithelium of choroid plexus, facial motor nucleus, fossa, hypothalamus, lateral nuclear group of thalamus, otolith organ, Paneth cell, pars compacta, pars reticulata, pons, primary oocyte, right adrenal cortex, right lobe of liver, spinal ganglia, superior vestibular nucleus, utricle, vestibular sensory epithelium
related to Amyotrophic lateral sclerosis (Lou Gehrig's disease) · 14
SOD1 → A4V, ALS, ALS-causing SOD1, G93A, H46R, However, In Iceland, It, Japan, Mutations, Rare, SOD1-G93S, The, Virtually
related to Role in oxidative stress · 10
SOD1 → Although, As, During, In, Ischemic, It, Mice, Most, Research, ROS
related to Structure · 10
SOD1 → Although SOD1, CCS, Cu/Zn, Cys-146, Cys-57, Moreover, The, There, This, This Cu/Zn
related to Down syndrome · 9
SOD1 → DNA, Down, DS, DS-related, Increased, OHdG, Oxidative, The, These
related to Function · 6
SOD1 → BCL-2, Hydrogen, OMM, The, Two, Wildtype SOD1
Band · 2
SOD1 → 16 C3.3|16 51.56 cM, 21q22.11
Chr. · 2
SOD1 → Chromosome 16 (mouse), Chromosome 21 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

als g93a gene a4v superoxide disease mutation human chromosome 21 mitochondrial oxidative bp mouse enzyme h46r mutations one chr band

SOD1 relationships Subject–Predicate–Object triples

TTTA extracted 217 structured relationships around SOD1. Examples in this analysis include SOD1 → 1.15.1.1 → ↗ and SOD1 → Aliases → SOD1, ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer, superoxide dismutase 1, soluble, superoxide dismutase 1, STAHP. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SOD11.15.1.11.00infobox
SOD1AliasesSOD1, ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer, superoxide dismutase 1, soluble, superoxide dismutase 1, STAHP1.00infobox
SOD1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AZV, 1BA9, 1DSW, 1FUN, 1HL4, 1HL5, 1KMG, 1L3N, 1MFM, 1N18, 1N19, 1OEZ, 1OZT, 1OZU, 1P1V, 1PTZ, 1PU0, 1RK7,…1.00infobox
SOD1Band21q22.111.00infobox
SOD1Band16 C3.3|16 51.56 cM1.00infobox
SOD1Bgeepons1.00infobox
SOD1Bgeepars compacta1.00infobox
SOD1Bgeespinal ganglia1.00infobox
SOD1Bgeelateral nuclear group of thalamus1.00infobox
SOD1Bgeesuperior vestibular nucleus1.00infobox
SOD1Bgeepars reticulata1.00infobox
SOD1Bgeeright lobe of liver1.00infobox
SOD1BgeeBrodmann area 101.00infobox
SOD1Bgeeright adrenal cortex1.00infobox
SOD1Bgeehypothalamus1.00infobox
SOD1Bgeeotolith organ1.00infobox
SOD1Bgeeutricle1.00infobox
SOD1BgeePaneth cell1.00infobox
SOD1Bgeecumulus cell1.00infobox
SOD1Bgeefossa1.00infobox
SOD1Bgeeprimary oocyte1.00infobox
SOD1Bgeevestibular sensory epithelium1.00infobox
SOD1BgeeEpithelium of choroid plexus1.00infobox
SOD1Bgeefacial motor nucleus1.00infobox
SOD1Bgeecondyle1.00infobox
SOD1BioGPSMore reference expression data1.00infobox
SOD1Chr.Chromosome 21 (human)1.00infobox
SOD1Chr.Chromosome 16 (mouse)1.00infobox
SOD1DatabasesNCBI: entry; OMA: entry1.00infobox
SOD1End31,668,931 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SOD1 bring nearby vocabulary together. In this analysis, examples include Gene, Als and Superoxide. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • SOD1
    • Gene
    • Als
    • Superoxide
    • Disease
    • Increased
    • Stress
    • Mitochondrial
    • Mutations
    • Oxidative
    • Copper
    • Human
    • Motor
  • sod1
    • Gene
    • Als
    • Superoxide
    • Disease
    • Increased
    • Stress
    • Mitochondrial
    • Mutations
    • Oxidative
    • Copper
    • Human
    • Motor
  • enzyme
    • Activity
    • Chromosome
    • Superoxide
    • Lateral
    • Mutation
    • Bp
    • Chr
    • Hydrogen
    • Peroxide
    • G93a
    • Gene
    • Human
  • gene
    • Chromosome
    • Human
    • Lateral
    • Bp
    • Chr
    • Stress
    • Mitochondrial
    • Mouse
    • Sod1
    • Oxidative
    • Superoxide
    • Activity
  • chromosome 21
    • Bp
    • Chr
    • Human
    • Gene
    • Band
    • Enzyme
    • Stress
    • Oxidative
    • Superoxide
    • Activity
    • Lateral
    • Mouse
  • superoxide dismutases
    • Hydrogen
    • Peroxide
    • Copper
    • Enzyme
    • Human
    • Chromosome
    • Mitochondrial
    • Activity
    • Lateral
    • Gene
    • Bp
    • Chr
  • familial amyotrophic lateral sclerosis
    • Activity
    • Lateral
    • Bp
    • Chr
    • Stress
    • Mutations
    • Oxidative
    • Superoxide
    • Gene
    • Band
    • Disulfide
    • Hydrogen
  • parkinson's disease
    • Mutations
    • Mutation
    • Sod1
    • Lateral
    • Als
    • Known
    • Enzyme
    • H46r
    • Stress
    • Oxidative
    • A4v
    • G93a

Connections between topic areas Semantic bridges

For SOD1, one of the stronger structural bridges in this analysis connects SOD1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SOD1Clinical significance · splits 39 ⟂ 37
SOD1Overview · splits 60 ⟂ 16
SOD1Structure · splits 67 ⟂ 9
SOD1Function · splits 67 ⟂ 9
SOD1Interactions · splits 72 ⟂ 4

Map overview Semantic statistics

SOD1

Nodes76
Edges75
Triples217
Avg. degree1.97
Density0.026316
Components1

Source & methodology

TTTA analyzes the structure around SOD1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Structure & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SOD1 · EN edition · Analysis: TopicsToTalkAbout

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