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Bcl-2 homologous antagonist killer: Interactions, Clinical significance & Function

Bcl-2 homologous antagonist/killer is a protein which in humans is encoded by the BAK1 gene on chromosome 6. It belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and…

Language: English [EN]
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Bcl-2 homologous antagonist killer topic overview

The analysis highlights Interactions, Clinical significance and Function as prominent areas in the source structure around Bcl-2 homologous antagonist killer.

Related topics
15
Source areas
4
Connected nodes
19
Extracted relationships
117
Related term clusters
11
Bridge connections
19

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 5 topics
Overview · 5 topics
Clinical significance · 4 topics
Function · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
BAK1, BAK, BAK-LIKE, BCL2L7, CDN1, BCL2 antagonist/killer 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AJK, 1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2LP8, 2M5B, 2XPX, 3I1H, 3QBR, 4D2L, 4U2U, 4U2V, 4UF1, 5FMK, 5FMI
Band
6p21.31
Bgee
mucosa of transverse colon · granulocyte · left adrenal gland · left adrenal cortex · right adrenal gland
BioGPS
More reference expression data
Chr.
Chromosome 6 (human)

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Bcl-2 homologous antagonist killer

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Bcl-2 homologous antagonist killer connects Entity context

The extracted context around Bcl-2 homologous antagonist killer shows recurring relationship patterns in the source. For example, Bcl-2 homologous antagonist killer → activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, ageing, animal organ regeneration, apoptotic process, apoptotic process involved in blood vessel morphogenesis, apoptotic signaling pathway, B cell apoptotic process, B cell homeostasis, B cell negative selection, BAK complex, BH domain binding, blood vessel remodeling, brain development, cell population proliferation, cellular response to mechanical stimulus, cellular response to UV, chaperone binding, cytosol Another extracted example is Bcl-2 homologous antagonist killer → apex of heart, duodenum, granulocyte, left adrenal cortex, left adrenal gland, monocyte, mucosa of transverse colon, rectum, right adrenal cortex, right adrenal gland. Use these groups to spot repeated connection types before inspecting the individual relationships.

Bcl-2 homologous antagonist killer

Top relations

Gene ontology · 78
Bcl-2 homologous antagonist killer → activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, ageing, animal organ regeneration, apoptotic process, apoptotic process involved in blood vessel morphogenesis, apoptotic signaling pathway, B cell apoptotic process, B cell homeostasis, B cell negative selection, BAK complex, BH domain binding, blood vessel remodeling, brain development, cell population proliferation, cellular response to mechanical stimulus, cellular response to UV, chaperone binding, cytosol
Bgee · 10
Bcl-2 homologous antagonist killer → apex of heart, duodenum, granulocyte, left adrenal cortex, left adrenal gland, monocyte, mucosa of transverse colon, rectum, right adrenal cortex, right adrenal gland
RNA expression pattern · 10
Bcl-2 homologous antagonist killer → apex of heart, duodenum, granulocyte, left adrenal cortex, left adrenal gland, monocyte, mucosa of transverse colon, rectum, right adrenal cortex, right adrenal gland
Aliases · 1
Bcl-2 homologous antagonist killer → BAK1, BAK, BAK-LIKE, BCL2L7, CDN1, BCL2 antagonist/killer 1
Available structures · 1
Bcl-2 homologous antagonist killer → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AJK, 1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2LP8, 2M5B, 2XPX, 3I1H, 3QBR, 4D2L, 4U2U, 4U2V, 4UF1, 5FMK, 5FMI
Band · 1
Bcl-2 homologous antagonist killer → 6p21.31
BioGPS · 1
Bcl-2 homologous antagonist killer → More reference expression data
Chr. · 1
Bcl-2 homologous antagonist killer → Chromosome 6 (human)
Databases · 1
Bcl-2 homologous antagonist killer → NCBI: entry; OMA: entry
End · 1
Bcl-2 homologous antagonist killer → 33,580,293 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bak1 protein gene chromosome bcl2 human bcl-2 pro-apoptotic family mitochondria membrane involved mitochondrial bp form bak cells cellular release cytochrome

Bcl-2 homologous antagonist killer relationships Subject–Predicate–Object triples

TTTA extracted 117 structured relationships around Bcl-2 homologous antagonist killer. Examples in this analysis include Bcl-2 homologous antagonist killer → Aliases → BAK1, BAK, BAK-LIKE, BCL2L7, CDN1, BCL2 antagonist/killer 1 and Bcl-2 homologous antagonist killer → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AJK, 1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2LP8, 2M5B, 2XPX, 3I1H, 3QBR, 4D2L, 4U2U, 4U2V, 4UF1, 5FMK, 5FMI. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Bcl-2 homologous antagonist killerAliasesBAK1, BAK, BAK-LIKE, BCL2L7, CDN1, BCL2 antagonist/killer 11.00infobox
Bcl-2 homologous antagonist killerAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AJK, 1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2LP8, 2M5B, 2XPX, 3I1H, 3QBR, 4D2L, 4U2U, 4U2V, 4UF1, 5FMK, 5FMI1.00infobox
Bcl-2 homologous antagonist killerBand6p21.311.00infobox
Bcl-2 homologous antagonist killerBgeemucosa of transverse colon1.00infobox
Bcl-2 homologous antagonist killerBgeegranulocyte1.00infobox
Bcl-2 homologous antagonist killerBgeeleft adrenal gland1.00infobox
Bcl-2 homologous antagonist killerBgeeleft adrenal cortex1.00infobox
Bcl-2 homologous antagonist killerBgeeright adrenal gland1.00infobox
Bcl-2 homologous antagonist killerBgeemonocyte1.00infobox
Bcl-2 homologous antagonist killerBgeeapex of heart1.00infobox
Bcl-2 homologous antagonist killerBgeeduodenum1.00infobox
Bcl-2 homologous antagonist killerBgeeright adrenal cortex1.00infobox
Bcl-2 homologous antagonist killerBgeerectum1.00infobox
Bcl-2 homologous antagonist killerBioGPSMore reference expression data1.00infobox
Bcl-2 homologous antagonist killerChr.Chromosome 6 (human)1.00infobox
Bcl-2 homologous antagonist killerDatabasesNCBI: entry; OMA: entry1.00infobox
Bcl-2 homologous antagonist killerEnd33,580,293 bp1.00infobox
Bcl-2 homologous antagonist killerEnsemblENSG000000301101.00infobox
Bcl-2 homologous antagonist killerEntrez5781.00infobox
Bcl-2 homologous antagonist killerExternal IDsOMIM: 600516; MGI: 1097161; GeneCards: BAK11.00infobox
Bcl-2 homologous antagonist killerGene location (Human)Gene location (Human)Chr.Chromosome 6 (human)Band6p21.31Start33,572,547 bpEnd33,580,293 bp1.00infobox
Bcl-2 homologous antagonist killerGene ontologytransmembrane transporter binding1.00infobox
Bcl-2 homologous antagonist killerGene ontologymetal ion binding1.00infobox
Bcl-2 homologous antagonist killerGene ontologyprotein binding1.00infobox
Bcl-2 homologous antagonist killerGene ontologyidentical protein binding1.00infobox
Bcl-2 homologous antagonist killerGene ontologyprotein homodimerization activity1.00infobox
Bcl-2 homologous antagonist killerGene ontologymolecular function1.00infobox
Bcl-2 homologous antagonist killerGene ontologyheat shock protein binding1.00infobox
Bcl-2 homologous antagonist killerGene ontologyprotein heterodimerization activity1.00infobox
Bcl-2 homologous antagonist killerGene ontologychaperone binding1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Bcl-2 homologous antagonist killer bring nearby vocabulary together. In this analysis, examples include External, Chromosome and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Bcl-2 homologous antagonist killer
    • External
    • Chromosome
    • Gene
    • Protein
    • Bak
    • Band
    • Bcl-2
    • Killer
    • P53
    • Potential
    • Stress
    • Structure
  • bcl-2 homologous antagonist killer
    • Killer
    • External
    • Chromosome
    • Gene
    • Structure
    • Bp
    • Chr
    • Function
    • Location
    • Protein
    • Bak
    • Band
  • gene
    • Chromosome
    • Human
    • Location
    • Bak
    • Killer
    • Structure
    • Bp
    • Chr
    • Function
    • Cells
    • Protein
    • External
  • bcl-2
    • Chromosome
    • Gene
    • Protein
    • Band
    • Killer
    • P53
    • Potential
    • Stress
    • Structure
    • Bak1
    • Bp
    • Cell
  • mitochondria
    • Apoptosis
    • Cytochrome
    • Functions
    • Release
    • Mitochondrial
    • Protein
    • Band
    • Potential
    • Stress
    • Structure
    • Bp
    • Cell
  • cytochrome c
    • Release
    • Mitochondrial
    • Potential
    • Membrane
    • Mitochondria
    • Band
    • Interacts
    • Stress
    • Structure
    • Bp
    • Cell
    • Chr
  • function
    • Structure
    • Bp
    • Chr
    • Location
    • Bak
    • External
    • Human
    • Pro-apoptotic
    • Gene
    • Band
    • Killer
    • Potential
  • protein
    • Stress
    • Band
    • Structure
    • Wide
    • Bp
    • Chr
    • Function
    • Location
    • Permeabilization
    • Release
    • Vdac2
    • Bak

Connections between topic areas Semantic bridges

For Bcl-2 homologous antagonist killer, one of the stronger structural bridges in this analysis connects Bcl-2 homologous antagonist killer with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Bcl-2 homologous antagonist killer — Overview · splits 14 ⟂ 6
Bcl-2 homologous antagonist killer — Interactions · splits 14 ⟂ 6
Bcl-2 homologous antagonist killer — Clinical significance · splits 15 ⟂ 5

Map overview Semantic statistics

Bcl-2 homologous antagonist killer

Nodes20
Edges19
Triples117
Avg. degree1.9
Density0.1
Components1

Source & methodology

TTTA analyzes the structure around Bcl-2 homologous antagonist killer to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Bcl-2 homologous antagonist killer · EN edition · Analysis: TopicsToTalkAbout

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