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Aptamer

Aptamers are oligomers of artificial ssDNA, RNA, XNA, or peptide that bind a specific target molecule, or family of target molecules. They exhibit a range of affinities (KD in the pM to μM range), with variable levels of off-target binding and are sometimes classified as chemical antibodies. Aptamers and antibodies can be used in many of the same…

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Overview

Etymology

Classification

History

Properties

Structure

Peptide Aptamers

Industry and Research Community

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Map overview Semantic statistics

Aptamer

Nodes163
Edges162
Triples116
Avg. degree1.99
Density0.01227
Components1

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Aptamer

Top relations

related to history · 18
Aptamer → Colin Cox, DNA, Early, Ellington, EXponential, Gilead Sciences, In, Jack Szostak, Larry Gold, Ligands, Qbeta, RNA, SELEX, Since, Systematic Evolution, Szostak, T4 DNA, Two
related to Structure · 16
Aptamer → As, Chemical, Derivatives, DNA, Most, PCR, Peptide, Polymerase Chain Reaction, RNA, RNA-based, Some, The, This, Typically, XNA, XNA-based
related to Targets · 12
Aptamer → Aptamers, HIV TAR, HSF1, PSA, Respiratory, RSV, SARS, SARS-CoV, SARS-CoV-2, These, VEGF, Viral
related to Etymology · 11
Aptamer → Andrew, BC, Ellington, Greek, Homer, Jack Szostak, Latin, RNA, The, They, We
related to Antibody replacement · 9
Aptamer → Aptamers, As, ELISA, However, IHC, In, Unlike, When, While
related to Industry and Research Community · 7
Aptamer → Apta-index, Aptamers, Commercial, INSOAP, Macugen, SomaLogic, The International Society
related to Classification · 5
Aptamer → Aptamers, DNA, However, RNA, XNA
related to Selection · 5
Aptamer → All, MimoDB, Peptide, The, These
has application · 4
Aptamer → In, Libraries, Such, The
related to Peptide Aptamers · 4
Aptamer → DNA, RNA, While, XNA

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Important terminology

aptamers proteins peptide antibodies target dna binding used molecular specific rna also selection applications research serum bind selex molecules useful

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Aptameris asynthetically generated ligand exploiting the combinatorial diversity of DNA0.90text
proteinsinstance oflarger ligands0.80text
and even whole cellsinstance oflarger ligands0.80text
proteins has generated increasing interest in using them to facilitate controlled release of therapeutic biomoleculesinstance ofavoiding the use of animals entirely.Controlled release of therapeuticsThe ability of aptamers to reversibly bind molecules0.80text
such as growth factorsinstance ofavoiding the use of animals entirely.Controlled release of therapeuticsThe ability of aptamers to reversibly bind molecules0.80text
hybridization of the aptamer with complementary oligonucleotides or unfolding of the aptamer due to cellular traction forces.Tissue Engineering ApplicationAptamerinstance ofalong with active release via mechanisms0.80text
known for their ability to bind specific molecules reversiblyinstance ofalong with active release via mechanisms0.80text
have been used in 3D bioprinting tissues to precisely deliver growth factors to promote vascularizationinstance ofalong with active release via mechanisms0.80text
proteins has generated increasing interest in using them to facilitate controlled release of therapeutic biomoleculesinstance ofControlled release of therapeuticsThe ability of aptamers to reversibly bind molecules0.80text
such as growth factorsinstance ofControlled release of therapeuticsThe ability of aptamers to reversibly bind molecules0.80text
hybridization of the aptamer with complementary oligonucleotides or unfolding of the aptamer due to cellular traction forcesinstance ofalong with active release via mechanisms0.80text
mRNA displayinstance ofPeptide aptamers can also be selected from combinatorial peptide libraries constructed by phage display and other surface display technologies0.80text

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