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Nuclease

In biochemistry, a nuclease (also archaically known as nucleodepolymerase or polynucleotidase) is an enzyme capable of cleaving the phosphodiester bonds that link nucleotides together to form nucleic acids. Nucleases variously affect single and double stranded breaks in their target molecules. In living organisms, they are essential machinery for many…

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Overview

History

Numerical Classification System

Structure

Site recognition

Endonucleases

Role in nature

Meganucleases

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Map overview Semantic statistics

Nuclease

Nodes128
Edges127
Triples103
Avg. degree1.98
Density0.015625
Components1

How this topic connects Entity context

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Nuclease

Top relations

related to history · 18
Nuclease → An, DNA, Escherichia, Haemophilus, HindII, In, Johns Hopkins University, Kelly, One, Smith, Stuart Linn, The, These, They, Werner Arber, What, Wilcox, Working
related to Staggered cutting · 18
Nuclease → AATT, Any, DNA, Each, EcoRI, For, GAATTC, HindII, In, Ligase, Many, Not, Once, Other, Protruding, The, TTAA, When
related to Sequence specific nuclease · 12
Nuclease → EcoRI, EcoRII, Escherichia, For, Haemophilus, HindII, Numbers, Rd, RY13, The, There, These
related to Site recognition · 12
Nuclease → B-form, BamHI, Both, DNA, EcoRV, In, Nonspecific, Nucleases, PvuII, Such, That, This
related to Numerical Classification System · 9
Nuclease → Biochemistry, EC-number, EC-numbers, Enzyme Commission, International Union, Molecular Biology, Most, Nomenclature Committee, The
related to DNA repair · 7
Nuclease → DNA, Many, Most, These, They, Ubiquitous, With
related to Meganucleases · 6
Nuclease → DNA, For, Genome, One, The, These
related to External links · 5
Nuclease → Action, EcoRIEnzyme, Examples, Main, Restriction Enzymes ChartRestriction Enzyme
related to Endonucleases · 4
Nuclease → Different, DNA, Once, The
see also · 2
Nuclease → HindIIILigaseMicrococcal, S1

Important terminology Word statistics

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Important terminology

dna nucleases repair endonucleases sequence base two molecules recognition enzyme damage restriction enzymes molecule cuts 3' strand breaks ends specific

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EcoRVinstance ofIn the case of endonucleases0.80text
BamHIinstance ofIn the case of endonucleases0.80text
and PvuIIinstance ofIn the case of endonucleases0.80text
this nonspecific binding involves electrostatic interactions between minimal surface area of the proteininstance ofIn the case of endonucleases0.80text
the DNAinstance ofIn the case of endonucleases0.80text
plantsinstance ofThese nucleases are particularly useful for genetic engineering and Genome engineering applications in complex organisms0.80text
mammalsinstance ofThese nucleases are particularly useful for genetic engineering and Genome engineering applications in complex organisms0.80text
where typically larger genomesinstance ofThese nucleases are particularly useful for genetic engineering and Genome engineering applications in complex organisms0.80text
Nucleaserelated to DNA repairWith0.60section
Nucleaserelated to DNA repairDNA0.60section
Nucleaserelated to DNA repairUbiquitous0.60section
Nucleaserelated to DNA repairMany0.60section

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