Find related topics. | Discover entities. | See connections. | Build a topical map.
Building topical map: Starting…
TGF beta 1: Function, Interactions & Overview
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene.
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
More settings
TGF beta 1 topic overview
The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around TGF beta 1.
Related topics
52
Source areas
3
Connected nodes
55
Extracted relationships
288
Concept neighborhoods
25
Bridge connections
55
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Function · 39 topics
Overview · 7 topics
Interactions · 6 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How TGF beta 1 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around TGF beta 1 shows recurring relationship patterns in the source. For example, TGF beta 1 → adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ageing, animal organ regeneration, antigen binding, apoptotic process, ATP biosynthetic process, axon, blood microparticle, BMP signaling pathway, branch elongation involved in mammary gland duct branching, cell activation, cell development, cell growth, cell migration, cell population proliferation, cell surface, cell-cell junction organization, cellular calcium ion homeostasis, cellular response to dexamethasone stimulus, cellular response to growth factor stimulus Another extracted example is TGF beta 1 → ascending aorta, blood, body of femur, calvaria, canal of the cervix, Descending thoracic aorta, granulocyte, lower jaw, mesenteric lymph nodes, molar, monocyte, right coronary artery, right lung, spleen, stroma of bone marrow, stromal cell of endometrium, thymus, tibiofemoral joint. Use these groups to spot repeated connection types before inspecting the individual relationships.
TGF beta 1
Top relations
Gene ontology· 226
TGF beta 1 → adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, ageing, animal organ regeneration, antigen binding, apoptotic process, ATP biosynthetic process, axon, blood microparticle, BMP signaling pathway, branch elongation involved in mammary gland duct branching, cell activation, cell development, cell growth, cell migration, cell population proliferation, cell surface, cell-cell junction organization, cellular calcium ion homeostasis, cellular response to dexamethasone stimulus, cellular response to growth factor stimulus
Bgee· 18
TGF beta 1 → ascending aorta, blood, body of femur, calvaria, canal of the cervix, Descending thoracic aorta, granulocyte, lower jaw, mesenteric lymph nodes, molar, monocyte, right coronary artery, right lung, spleen, stroma of bone marrow, stromal cell of endometrium, thymus, tibiofemoral joint
RNA expression pattern· 18
TGF beta 1 → ascending aorta, blood, body of femur, calvaria, canal of the cervix, Descending thoracic aorta, granulocyte, lower jaw, mesenteric lymph nodes, molar, monocyte, right coronary artery, right lung, spleen, stroma of bone marrow, stromal cell of endometrium, thymus, tibiofemoral joint
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 288 structured relationships around TGF beta 1. Examples in this analysis include TGF beta 1 → Aliases → TGFB1, CED, DPD1, LAP, TGFB, TGFbeta, transforming growth factor beta 1, IBDIMDE, TGF-beta1 and TGF beta 1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KLA, 1KLC, 1KLD, 3KFD, 4KV5. The table shows each extracted connection, where it came from and its confidence.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1KLA, 1KLC, 1KLD, 3KFD, 4KV5
1.00
infobox
TGF beta 1
Band
19q13.2
1.00
infobox
TGF beta 1
Band
7 A3|7 13.98 cM
1.00
infobox
TGF beta 1
Bgee
granulocyte
1.00
infobox
TGF beta 1
Bgee
monocyte
1.00
infobox
TGF beta 1
Bgee
stromal cell of endometrium
1.00
infobox
TGF beta 1
Bgee
ascending aorta
1.00
infobox
TGF beta 1
Bgee
Descending thoracic aorta
1.00
infobox
TGF beta 1
Bgee
right coronary artery
1.00
infobox
TGF beta 1
Bgee
spleen
1.00
infobox
TGF beta 1
Bgee
right lung
1.00
infobox
TGF beta 1
Bgee
canal of the cervix
1.00
infobox
TGF beta 1
Bgee
blood
1.00
infobox
TGF beta 1
Bgee
molar
1.00
infobox
TGF beta 1
Bgee
tibiofemoral joint
1.00
infobox
TGF beta 1
Bgee
stroma of bone marrow
1.00
infobox
TGF beta 1
Bgee
calvaria
1.00
infobox
TGF beta 1
Bgee
mesenteric lymph nodes
1.00
infobox
TGF beta 1
Bgee
lower jaw
1.00
infobox
TGF beta 1
Bgee
thymus
1.00
infobox
TGF beta 1
Bgee
body of femur
1.00
infobox
TGF beta 1
BioGPS
More reference expression data
1.00
infobox
TGF beta 1
Chr.
Chromosome 19 (human)
1.00
infobox
TGF beta 1
Chr.
Chromosome 7 (mouse)
1.00
infobox
TGF beta 1
Databases
NCBI: entry; OMA: entry
1.00
infobox
TGF beta 1
End
41,353,922 bp
1.00
infobox
TGF beta 1
End
25,404,502 bp
1.00
infobox
TGF beta 1
Ensembl
ENSG00000105329
1.00
infobox
TGF beta 1
Entrez
7040
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around TGF beta 1 bring nearby vocabulary together. In this analysis, examples include Factor, Superfamily and Transforming. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
TGF beta 1
Factor
Superfamily
Transforming
Function
Location
Myeloid
Tgfb1
Growth
Chromosome
Gene
Receptor
Bp
tgf beta 1
Factor
Superfamily
Transforming
Function
Location
Myeloid
Tgfb1
Growth
Chromosome
Gene
Receptor
Bp
transforming growth factor beta superfamily
Factor
Growth
Transforming
Beta
Superfamily
Function
Location
Myeloid
Pdb
Tgfb1
Cellular
Chromosome
cell growth
Factor
Transforming
Differentiation
Beta
Cellular
Ii
Myeloid
Pdb
Superfamily
Cells
Activation
Function
cell proliferation
Differentiation
Expression
Cellular
Apoptosis
Cytokine
Ii
Myeloid
Cells
Activation
Many
Protein
Also
cell differentiation
Differentiation
Many
Protein
Cellular
Ii
Myeloid
Proliferation
Cells
Activation
Growth
Mouse
Superfamily
gene
Location
Tgfb1
Chromosome
Bp
Chr
Human
Mouse
Function
Myeloid
Band
Transforming
External
differentiation
Many
Protein
Proliferation
Growth
Mouse
Superfamily
Activity
Apoptosis
Cytokine
Function
Ii
Location
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For TGF beta 1, one of the stronger structural bridges in this analysis connects TGF beta 1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
TGF beta 1
Nodes56
Edges55
Triples288
Avg. degree1.96
Density0.035714
Components1
Source & methodology
TTTA analyzes the structure around TGF beta 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
