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Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.
The analysis highlights Functions and interactions, Clinical significance and Gene as prominent areas in the source structure around SMAD3.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around SMAD3 shows recurring relationship patterns in the source. For example, SMAD3 → activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, activin receptor signaling pathway, adrenal gland development, beta-catenin binding, bHLH transcription factor binding, canonical Wnt signaling pathway, cell-cell junction organization, cellular response to cytokine stimulus, cellular response to transforming growth factor beta stimulus, chromatin binding, chromatin DNA binding, cis-regulatory region sequence-specific DNA binding, co-SMAD binding, collagen binding, cytoplasm, cytosol, DEAD/H-box RNA helicase binding, developmental growth, DNA binding Another extracted example is SMAD3 → AC, C-terminus, CAG, CC, CG, Da, DNA, GC, GGC, It, LDTFs, MH1, Once SMAD3, Receptor Activation, SARA, SBEs, SMAD, SMAD Anchor, SMAD-binding, SMAD-bound. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
cancer smad also activity gene tgf-β complex signaling smad4 human pathway cell growth protein transcriptional role binding genes bp dna
TTTA extracted 316 structured relationships around SMAD3. Examples in this analysis include SMAD3 → Aliases → SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3 and SMAD3 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| SMAD3 | Aliases | SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3 | 1.00 | infobox |
| SMAD3 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG | 1.00 | infobox |
| SMAD3 | Band | 15q22.33 | 1.00 | infobox |
| SMAD3 | Band | 9|9 C | 1.00 | infobox |
| SMAD3 | Bgee | tendon of biceps brachii | 1.00 | infobox |
| SMAD3 | Bgee | cartilage tissue | 1.00 | infobox |
| SMAD3 | Bgee | muscle of thigh | 1.00 | infobox |
| SMAD3 | Bgee | mucosa of esophagus | 1.00 | infobox |
| SMAD3 | Bgee | epithelium of colon | 1.00 | infobox |
| SMAD3 | Bgee | gastrocnemius muscle | 1.00 | infobox |
| SMAD3 | Bgee | synovial joint | 1.00 | infobox |
| SMAD3 | Bgee | Skeletal muscle tissue of biceps brachii | 1.00 | infobox |
| SMAD3 | Bgee | mucosa of urinary bladder | 1.00 | infobox |
| SMAD3 | Bgee | olfactory zone of nasal mucosa | 1.00 | infobox |
| SMAD3 | Bgee | genital tubercle | 1.00 | infobox |
| SMAD3 | Bgee | temporal muscle | 1.00 | infobox |
| SMAD3 | Bgee | triceps brachii muscle | 1.00 | infobox |
| SMAD3 | Bgee | molar | 1.00 | infobox |
| SMAD3 | Bgee | ankle | 1.00 | infobox |
| SMAD3 | Bgee | sternocleidomastoid muscle | 1.00 | infobox |
| SMAD3 | Bgee | tail of embryo | 1.00 | infobox |
| SMAD3 | Bgee | internal carotid artery | 1.00 | infobox |
| SMAD3 | Bgee | external carotid artery | 1.00 | infobox |
| SMAD3 | Bgee | fossa | 1.00 | infobox |
| SMAD3 | BioGPS | More reference expression data | 1.00 | infobox |
| SMAD3 | Chr. | Chromosome 15 (human) | 1.00 | infobox |
| SMAD3 | Chr. | Chromosome 9 (mouse) | 1.00 | infobox |
| SMAD3 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| SMAD3 | End | 67,195,173 bp | 1.00 | infobox |
| SMAD3 | End | 63,665,276 bp | 1.00 | infobox |
The concept neighborhoods around SMAD3 bring nearby vocabulary together. In this analysis, examples include Activity, Complex and Transcriptional. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For SMAD3, one of the stronger structural bridges in this analysis connects SMAD3 with Functions and interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around SMAD3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Functions and interactions, Clinical significance & Gene, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — SMAD3 · EN edition · Analysis: TopicsToTalkAbout