Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

SMAD3

Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.

Functions and interactions, Clinical significance & Gene

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around SMAD3. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG
Band
15q22.33 · 9|9 C
Bgee
tendon of biceps brachii · cartilage tissue · muscle of thigh · mucosa of esophagus · epithelium of colon
BioGPS
More reference expression data
Chr.
Chromosome 15 (human) · Chromosome 9 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Gene

Protein

Functions and interactions

Clinical significance

Nomenclature

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

SMAD3

Nodes48
Edges47
Triples316
Avg. degree1.96
Density0.041667
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

SMAD3

Top relations

Gene ontology · 134
SMAD3 → activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway, activin receptor signaling pathway, adrenal gland development, beta-catenin binding, bHLH transcription factor binding, canonical Wnt signaling pathway, cell-cell junction organization, cellular response to cytokine stimulus, cellular response to transforming growth factor beta stimulus, chromatin binding, chromatin DNA binding, cis-regulatory region sequence-specific DNA binding, co-SMAD binding, collagen binding, cytoplasm, cytosol, DEAD/H-box RNA helicase binding, developmental growth, DNA binding
related to Protein · 29
SMAD3 → AC, C-terminus, CAG, CC, CG, Da, DNA, GC, GGC, It, LDTFs, MH1, Once SMAD3, Receptor Activation, SARA, SBEs, SMAD, SMAD Anchor, SMAD-binding, SMAD-bound
related to MH1 domain · 25
SMAD3 → Arg74, Cys109, Cys121, Cys64, DNA, DNA-binding, DNAs, GCGCC, GGCGC, Gln76, GTCT DNA, His126, In, It, Lys81, MH1, R-SMADS, Several, SMAD3 MH1, SMAD4
Bgee · 20
SMAD3 → ankle, cartilage tissue, epithelium of colon, external carotid artery, fossa, gastrocnemius muscle, genital tubercle, internal carotid artery, molar, mucosa of esophagus, mucosa of urinary bladder, muscle of thigh, olfactory zone of nasal mucosa, Skeletal muscle tissue of biceps brachii, sternocleidomastoid muscle, synovial joint, tail of embryo, temporal muscle, tendon of biceps brachii, triceps brachii muscle
RNA expression pattern · 20
SMAD3 → ankle, cartilage tissue, epithelium of colon, external carotid artery, fossa, gastrocnemius muscle, genital tubercle, internal carotid artery, molar, mucosa of esophagus, mucosa of urinary bladder, muscle of thigh, olfactory zone of nasal mucosa, Skeletal muscle tissue of biceps brachii, sternocleidomastoid muscle, synovial joint, tail of embryo, temporal muscle, tendon of biceps brachii, triceps brachii muscle
related to TGF-β/SMAD signaling pathway · 17
SMAD3 → AP-1/SMAD, CD34, CXCR4, FGF1, Fos, NGF, SMAD3-mediated TGFβ, SMAD4, Some, TGF-β, TGF-β-inducible, TGF-β/SMAD, The, TPA, TRE, TRIM33-SMAD2/3, WNT11
related to TGF-β/SMAD3-induced repression · 10
SMAD3 → Besides, E2F, E2F4, RSBE, SMAD, SMAD4, TGF-β, TGF-β-induced, The, TIE
related to Nomenclature · 9
SMAD3 → Drosophila, During Drosophila, MAD, MADD, Mothers, Mothers Against Drunk Driving, SMA, The, The SMAD
related to MH2 domain · 8
SMAD3 → DNA-binding, R-SMADS, Ser-X-Ser, SMAD4, SMAD4 MH2, TGF-β, The, The MH2
related to Diseases · 7
SMAD3 → AOS, Despite, II-infused, Increased SMAD3, Loeys-Dietz Syndrome, Macrophage, SMAD3-knockout

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer smad also activity gene tgf-β complex signaling smad4 human pathway cell growth protein transcriptional role binding genes bp dna

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SMAD3AliasesSMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 31.00infobox
SMAD3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LB2, 1MHD, 1MJS, 1MK2, 1OZJ, 1U7F, 2LAJ, 5OD6, 5ODG1.00infobox
SMAD3Band15q22.331.00infobox
SMAD3Band9|9 C1.00infobox
SMAD3Bgeetendon of biceps brachii1.00infobox
SMAD3Bgeecartilage tissue1.00infobox
SMAD3Bgeemuscle of thigh1.00infobox
SMAD3Bgeemucosa of esophagus1.00infobox
SMAD3Bgeeepithelium of colon1.00infobox
SMAD3Bgeegastrocnemius muscle1.00infobox
SMAD3Bgeesynovial joint1.00infobox
SMAD3BgeeSkeletal muscle tissue of biceps brachii1.00infobox
SMAD3Bgeemucosa of urinary bladder1.00infobox
SMAD3Bgeeolfactory zone of nasal mucosa1.00infobox
SMAD3Bgeegenital tubercle1.00infobox
SMAD3Bgeetemporal muscle1.00infobox
SMAD3Bgeetriceps brachii muscle1.00infobox
SMAD3Bgeemolar1.00infobox
SMAD3Bgeeankle1.00infobox
SMAD3Bgeesternocleidomastoid muscle1.00infobox
SMAD3Bgeetail of embryo1.00infobox
SMAD3Bgeeinternal carotid artery1.00infobox
SMAD3Bgeeexternal carotid artery1.00infobox
SMAD3Bgeefossa1.00infobox
SMAD3BioGPSMore reference expression data1.00infobox
SMAD3Chr.Chromosome 15 (human)1.00infobox
SMAD3Chr.Chromosome 9 (mouse)1.00infobox
SMAD3DatabasesNCBI: entry; OMA: entry1.00infobox
SMAD3End67,195,173 bp1.00infobox
SMAD3End63,665,276 bp1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.