Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

SMAD7

Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene.

Function, Interactions & Role in cancer

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around SMAD7. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SMAD7, CRCS3, MADH7, MADH8, SMAD family member 7
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ
Band
18q21.1 · 18|18 E3
Bgee
popliteal artery · tibial arteries · saphenous vein · Descending thoracic aorta · right auricle of heart
BioGPS
More reference expression data
Chr.
Chromosome 18 (human) · Chromosome 18 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Role in cancer

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

SMAD7

Nodes55
Edges54
Triples177
Avg. degree1.96
Density0.036364
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

SMAD7

Top relations

Gene ontology · 61
SMAD7 → activin binding, adherens junction assembly, artery morphogenesis, beta-catenin binding, BMP signaling pathway, catenin complex, cellular response to leukemia inhibitory factor, cellular response to transforming growth factor beta stimulus, centrosome, collagen binding, cytoplasm, cytosol, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, fibrillar center, I-SMAD binding, intracellular anatomical structure, metal ion binding, negative regulation of BMP signaling pathway
related to Structure · 23
SMAD7 → Between, C-terminal, Ca2, CamKII, DNA, E3, Erk-family MAP, II, It, Mad Homology, MAPKs, MH1, MH2, N-terminal, PKC, PY, Smad, Smurf2, TGF-β, The
Bgee · 20
SMAD7 → ascending aorta, blood, cardiac muscle tissue of right atrium, cumulus cell, decidua, Descending thoracic aorta, gastrula, Gonadal ridge, left coronary artery, left lung lobe, lumbar subsegment of spinal cord, molar, popliteal artery, pyloric antrum, right auricle of heart, right coronary artery, right lung, saphenous vein, substantia nigra, tibial arteries
RNA expression pattern · 20
SMAD7 → ascending aorta, blood, cardiac muscle tissue of right atrium, cumulus cell, decidua, Descending thoracic aorta, gastrula, Gonadal ridge, left coronary artery, left lung lobe, lumbar subsegment of spinal cord, molar, popliteal artery, pyloric antrum, right auricle of heart, right coronary artery, right lung, saphenous vein, substantia nigra, tibial arteries
related to Function · 13
SMAD7 → Activin, BMP, By, IRAK1-mediated IL-1R/TLR, It, NF-κB, Pellino-1, Smad MH2, Smad2, Smad2/Smad4, TGF-β, The, Upon TGF
related to Role in cancer · 9
SMAD7 → Asian, By, Case, CRC, European, Perturbation, Some, TGF-β, The
related to Use in Pharmacology · 5
SMAD7 → Celgene Phase III, Crohn's, Mongersen, NCT ID, This
Band · 2
SMAD7 → 18q21.1, 18|18 E3
Chr. · 2
SMAD7 → Chromosome 18 (human), Chromosome 18 (mouse)
End · 2
SMAD7 → 48,950,965 bp, 75,529,006 bp

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

smad gene bp protein tgf-β cancer signaling receptor chr human band tgfβ type chromosome 18 family activin mothers decapentaplegic homolog

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SMAD7AliasesSMAD7, CRCS3, MADH7, MADH8, SMAD family member 71.00infobox
SMAD7Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ1.00infobox
SMAD7Band18q21.11.00infobox
SMAD7Band18|18 E31.00infobox
SMAD7Bgeepopliteal artery1.00infobox
SMAD7Bgeetibial arteries1.00infobox
SMAD7Bgeesaphenous vein1.00infobox
SMAD7BgeeDescending thoracic aorta1.00infobox
SMAD7Bgeeright auricle of heart1.00infobox
SMAD7Bgeeascending aorta1.00infobox
SMAD7Bgeecardiac muscle tissue of right atrium1.00infobox
SMAD7Bgeeright lung1.00infobox
SMAD7Bgeeleft coronary artery1.00infobox
SMAD7Bgeeright coronary artery1.00infobox
SMAD7Bgeemolar1.00infobox
SMAD7Bgeegastrula1.00infobox
SMAD7Bgeeleft lung lobe1.00infobox
SMAD7Bgeepyloric antrum1.00infobox
SMAD7BgeeGonadal ridge1.00infobox
SMAD7Bgeedecidua1.00infobox
SMAD7Bgeecumulus cell1.00infobox
SMAD7Bgeelumbar subsegment of spinal cord1.00infobox
SMAD7Bgeesubstantia nigra1.00infobox
SMAD7Bgeeblood1.00infobox
SMAD7BioGPSMore reference expression data1.00infobox
SMAD7Chr.Chromosome 18 (human)1.00infobox
SMAD7Chr.Chromosome 18 (mouse)1.00infobox
SMAD7DatabasesNCBI: entry; OMA: entry1.00infobox
SMAD7End48,950,965 bp1.00infobox
SMAD7End75,529,006 bp1.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.