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Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene.
The analysis highlights Function, Interactions and Role in cancer as prominent areas in the source structure around SMAD7.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around SMAD7 shows recurring relationship patterns in the source. For example, SMAD7 → activin binding, adherens junction assembly, artery morphogenesis, beta-catenin binding, BMP signaling pathway, catenin complex, cellular response to leukemia inhibitory factor, cellular response to transforming growth factor beta stimulus, centrosome, collagen binding, cytoplasm, cytosol, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, fibrillar center, I-SMAD binding, intracellular anatomical structure, metal ion binding, negative regulation of BMP signaling pathway Another extracted example is SMAD7 → Between, C-terminal, Ca2, CamKII, DNA, E3, Erk-family MAP, II, It, Mad Homology, MAPKs, MH1, MH2, N-terminal, PKC, PY, Smad, Smurf2, TGF-β, The. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
smad gene bp protein tgf-β cancer signaling receptor chr human band tgfβ type chromosome 18 family activin mothers decapentaplegic homolog
TTTA extracted 177 structured relationships around SMAD7. Examples in this analysis include SMAD7 → Aliases → SMAD7, CRCS3, MADH7, MADH8, SMAD family member 7 and SMAD7 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| SMAD7 | Aliases | SMAD7, CRCS3, MADH7, MADH8, SMAD family member 7 | 1.00 | infobox |
| SMAD7 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ | 1.00 | infobox |
| SMAD7 | Band | 18q21.1 | 1.00 | infobox |
| SMAD7 | Band | 18|18 E3 | 1.00 | infobox |
| SMAD7 | Bgee | popliteal artery | 1.00 | infobox |
| SMAD7 | Bgee | tibial arteries | 1.00 | infobox |
| SMAD7 | Bgee | saphenous vein | 1.00 | infobox |
| SMAD7 | Bgee | Descending thoracic aorta | 1.00 | infobox |
| SMAD7 | Bgee | right auricle of heart | 1.00 | infobox |
| SMAD7 | Bgee | ascending aorta | 1.00 | infobox |
| SMAD7 | Bgee | cardiac muscle tissue of right atrium | 1.00 | infobox |
| SMAD7 | Bgee | right lung | 1.00 | infobox |
| SMAD7 | Bgee | left coronary artery | 1.00 | infobox |
| SMAD7 | Bgee | right coronary artery | 1.00 | infobox |
| SMAD7 | Bgee | molar | 1.00 | infobox |
| SMAD7 | Bgee | gastrula | 1.00 | infobox |
| SMAD7 | Bgee | left lung lobe | 1.00 | infobox |
| SMAD7 | Bgee | pyloric antrum | 1.00 | infobox |
| SMAD7 | Bgee | Gonadal ridge | 1.00 | infobox |
| SMAD7 | Bgee | decidua | 1.00 | infobox |
| SMAD7 | Bgee | cumulus cell | 1.00 | infobox |
| SMAD7 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| SMAD7 | Bgee | substantia nigra | 1.00 | infobox |
| SMAD7 | Bgee | blood | 1.00 | infobox |
| SMAD7 | BioGPS | More reference expression data | 1.00 | infobox |
| SMAD7 | Chr. | Chromosome 18 (human) | 1.00 | infobox |
| SMAD7 | Chr. | Chromosome 18 (mouse) | 1.00 | infobox |
| SMAD7 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| SMAD7 | End | 48,950,965 bp | 1.00 | infobox |
| SMAD7 | End | 75,529,006 bp | 1.00 | infobox |
The concept neighborhoods around SMAD7 bring nearby vocabulary together. In this analysis, examples include Signaling, Pathway and Tgf-β. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For SMAD7, one of the stronger structural bridges in this analysis connects SMAD7 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around SMAD7 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Role in cancer, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — SMAD7 · EN edition · Analysis: TopicsToTalkAbout