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SMAD2

Mothers against decapentaplegic homolog 2, also known as SMAD family member 2 or SMAD2, is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal…

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Aliases
SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2, LDS6, CHTD8
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DEV, 1KHX, 1U7V, 2LB3
Band
18q21.1 · 18 E3|18 51.42 cM
Bgee
Achilles tendon · sperm · secondary oocyte · germinal epithelium · monocyte
BioGPS
More reference expression data
Chr.
Chromosome 18 (human) · Chromosome 18 (mouse)

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SMAD2

Nodes47
Edges46
Triples168
Avg. degree1.96
Density0.042553
Components1

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SMAD2

Top relations

Gene ontology · 88
SMAD2 → activin receptor signaling pathway, activin responsive factor complex, adrenal gland development, anterior/posterior pattern specification, cell fate commitment, chromatin binding, co-SMAD binding, common-partner SMAD protein phosphorylation, cytoplasm, cytosol, development of the heart, developmental growth, disordered domain specific binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, double-stranded DNA binding, embryonic cranial skeleton morphogenesis, embryonic foregut morphogenesis
Bgee · 19
SMAD2 → Achilles tendon, amniotic fluid, epithelium of colon, genital tubercle, germinal epithelium, hair follicle, islet of Langerhans, lumbar spinal ganglion, monocyte, otic placode, otic vesicle, primary oocyte, saccule, secondary oocyte, sperm, tail of embryo, tendon of biceps brachii, transitional epithelium of urinary bladder, zygote
RNA expression pattern · 19
SMAD2 → Achilles tendon, amniotic fluid, epithelium of colon, genital tubercle, germinal epithelium, hair follicle, islet of Langerhans, lumbar spinal ganglion, monocyte, otic placode, otic vesicle, primary oocyte, saccule, secondary oocyte, sperm, tail of embryo, tendon of biceps brachii, transitional epithelium of urinary bladder, zygote
related to Function · 19
SMAD2 → Alternatively, Binding, C-terminus, In, Like, Phosphorylated SMAD2, SARA, Serine-Serine-Methionine-Serine, SMAD, SMAD4, SMADs, SSMS, TGF, TGF-beta, TGFβ, The, These, This, Transforming Growth Factor
Band · 2
SMAD2 → 18 E3|18 51.42 cM, 18q21.1
Chr. · 2
SMAD2 → Chromosome 18 (human), Chromosome 18 (mouse)
End · 2
SMAD2 → 47,931,146 bp, 76,444,034 bp
Aliases · 1
SMAD2 → SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2, LDS6, CHTD8
Available structures · 1
SMAD2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DEV, 1KHX, 1U7V, 2LB3
BioGPS · 1
SMAD2 → More reference expression data

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Important terminology

gene protein smad bp chr human band signal family decapentaplegic chromosome 18 cell mothers homolog proteins drosophila nucleus receptor member

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SMAD2AliasesSMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2, LDS6, CHTD81.00infobox
SMAD2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DEV, 1KHX, 1U7V, 2LB31.00infobox
SMAD2Band18q21.11.00infobox
SMAD2Band18 E3|18 51.42 cM1.00infobox
SMAD2BgeeAchilles tendon1.00infobox
SMAD2Bgeesperm1.00infobox
SMAD2Bgeesecondary oocyte1.00infobox
SMAD2Bgeegerminal epithelium1.00infobox
SMAD2Bgeemonocyte1.00infobox
SMAD2Bgeeislet of Langerhans1.00infobox
SMAD2Bgeeamniotic fluid1.00infobox
SMAD2Bgeetendon of biceps brachii1.00infobox
SMAD2Bgeehair follicle1.00infobox
SMAD2Bgeeepithelium of colon1.00infobox
SMAD2Bgeesaccule1.00infobox
SMAD2Bgeeotic placode1.00infobox
SMAD2Bgeezygote1.00infobox
SMAD2Bgeegenital tubercle1.00infobox
SMAD2Bgeeotic vesicle1.00infobox
SMAD2Bgeetail of embryo1.00infobox
SMAD2Bgeelumbar spinal ganglion1.00infobox
SMAD2Bgeetransitional epithelium of urinary bladder1.00infobox
SMAD2Bgeeprimary oocyte1.00infobox
SMAD2BioGPSMore reference expression data1.00infobox
SMAD2Chr.Chromosome 18 (human)1.00infobox
SMAD2Chr.Chromosome 18 (mouse)1.00infobox
SMAD2DatabasesNCBI: entry; OMA: entry1.00infobox
SMAD2End47,931,146 bp1.00infobox
SMAD2End76,444,034 bp1.00infobox
SMAD2EnsemblENSG000001753871.00infobox

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