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SMAD4

SMAD4, also called SMAD family member 4, Mothers against decapentaplegic homolog 4, or DPC4 (deleted in pancreatic cancer 4) is a highly conserved protein present in all metazoans. It belongs to the SMAD family of transcription factor proteins, which act as mediators of TGF-β signal transduction. The TGFβ family of cytokines regulates critical processes…

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Aliases
SMAD4, DPC4, JIP, MADH4, MYHRS, SMAD family member 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DD1, 1G88, 1MR1, 1U7F, 1U7V, 1YGS, 5MEY, 5MEZ, 5MF0
Band
18q21.2 · 18 E2|18 49.51 cM
Bgee
ventricular zone · ganglionic eminence · Achilles tendon · epithelium of colon · stromal cell of endometrium
BioGPS
More reference expression data
Chr.
Chromosome 18 (human) · Chromosome 18 (mouse)

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Overview

Protein

  • Polypeptide
  • Da Dalton (unit)
  • MH1 MH1 domain?action=edit&redlink=1
  • MH2 MH2 domain?action=edit&redlink=1

Structures

Nomenclature and origin of name

Function and action mechanism

Clinical significance

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Map overview Semantic statistics

SMAD4

Nodes75
Edges74
Triples285
Avg. degree1.97
Density0.026667
Components1

How this topic connects Entity context

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SMAD4

Top relations

Gene ontology · 115
SMAD4 → activin responsive factor complex, anatomical structure morphogenesis, anterior/posterior pattern specification, atrioventricular canal development, atrioventricular valve formation, axon guidance, BMP signaling pathway, brainstem development, branching involved in ureteric bud morphogenesis, cardiac septum development, cell differentiation, cell population proliferation, cellular iron ion homeostasis, cellular response to BMP stimulus, centrosome, chromatin binding, cis-regulatory region sequence-specific DNA binding, collagen binding, cytoplasm, cytosol
related to Protein · 26
SMAD4 → AC, CAG, CAGCC, CC, CG, Da, DNA, Early, GC, GGC, GTCTAGAC, LDTFs, MH1, MH2, Other, Smad, SMAD-bound, SMAD2, SMAD3, SMAD3/SMAD4
Bgee · 20
SMAD4 → Achilles tendon, ciliary body, conjunctival fornix, epithelium of colon, gallbladder, ganglionic eminence, human fetus, left ovary, medial ganglionic eminence, medullary collecting duct, Paneth cell, popliteal artery, rectum, renal corpuscle, retinal pigment epithelium, Rostral migratory stream, stromal cell of endometrium, tibial arteries, vas deferens, ventricular zone
RNA expression pattern · 20
SMAD4 → Achilles tendon, ciliary body, conjunctival fornix, epithelium of colon, gallbladder, ganglionic eminence, human fetus, left ovary, medial ganglionic eminence, medullary collecting duct, Paneth cell, popliteal artery, rectum, renal corpuscle, retinal pigment epithelium, Rostral migratory stream, stromal cell of endometrium, tibial arteries, vas deferens, ventricular zone
related to MH1 domain complexes with DNA motifs · 18
SMAD4 → Arg81, DNA, Efficient, GC-sites, GGCGC, Gln83, GTCTAGAC, In, Lys88, MH1, Other, Recently, Smad DNA-binding, SMAD4 MH1, The, The X-ray, This, Trichoplax
related to Nomenclature and origin of name · 15
SMAD4 → DPC4, Drosophila, During Drosophila, JIP, MAD, MADD, MADH4, MH1, MH2, Mothers, Mothers Against Drunk Driving, SMA, SMADs, The, The SMAD
related to Function and action mechanism · 14
SMAD4 → II, In, Once, R-SMADS, SMAD, SMAD2, SMAD3, SMADS, TGF-β, TGFβ, The, The R-SMADs-SMAD4, This, Type
related to Clinical significance · 10
SMAD4 → BMP-7, Experiments, FSHR, Genetic, It, KO, LHR, Mus, SMAD, This
related to MH2 domain complexes · 8
SMAD4 → C-terminus, It, MH1, MH2, R-SMADS MH2, SMADs, Some, The MH2
is a · 3
SMAD4 → homolog of the Drosophila protein, only known co-SMAD in most metazoans, substrate of the Erk/MAPK kinase and GSK3

Important terminology Word statistics

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Important terminology

smad also family protein mh1 gene pathway growth dna cells complex r-smads bp tgfβ smad3 domain complexes cell human mh2

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SMAD4AliasesSMAD4, DPC4, JIP, MADH4, MYHRS, SMAD family member 41.00infobox
SMAD4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DD1, 1G88, 1MR1, 1U7F, 1U7V, 1YGS, 5MEY, 5MEZ, 5MF01.00infobox
SMAD4Band18q21.21.00infobox
SMAD4Band18 E2|18 49.51 cM1.00infobox
SMAD4Bgeeventricular zone1.00infobox
SMAD4Bgeeganglionic eminence1.00infobox
SMAD4BgeeAchilles tendon1.00infobox
SMAD4Bgeeepithelium of colon1.00infobox
SMAD4Bgeestromal cell of endometrium1.00infobox
SMAD4Bgeeleft ovary1.00infobox
SMAD4Bgeegallbladder1.00infobox
SMAD4Bgeerectum1.00infobox
SMAD4Bgeepopliteal artery1.00infobox
SMAD4Bgeetibial arteries1.00infobox
SMAD4BgeeRostral migratory stream1.00infobox
SMAD4Bgeeciliary body1.00infobox
SMAD4BgeePaneth cell1.00infobox
SMAD4Bgeevas deferens1.00infobox
SMAD4Bgeehuman fetus1.00infobox
SMAD4Bgeerenal corpuscle1.00infobox
SMAD4Bgeemedullary collecting duct1.00infobox
SMAD4Bgeeconjunctival fornix1.00infobox
SMAD4Bgeemedial ganglionic eminence1.00infobox
SMAD4Bgeeretinal pigment epithelium1.00infobox
SMAD4BioGPSMore reference expression data1.00infobox
SMAD4Chr.Chromosome 18 (human)1.00infobox
SMAD4Chr.Chromosome 18 (mouse)1.00infobox
SMAD4DatabasesNCBI: entry; OMA: entry1.00infobox
SMAD4End51,085,045 bp1.00infobox
SMAD4End73,836,851 bp1.00infobox

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