SMAD4

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SMAD4 topic overview

The analysis highlights Function and action mechanism, Clinical significance and Overview as prominent areas in the source structure around SMAD4.

Related topics: 68
Source areas: 6
Connected nodes: 74
Extracted relationships: 285
Concept neighborhoods: 22
Bridge connections: 74

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function and action mechanism · 23 topics

Clinical significance · 16 topics

Overview · 16 topics

Structures · 5 topics

Nomenclature and origin of name · 4 topics

Protein · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SMAD4, DPC4, JIP, MADH4, MYHRS, SMAD family member 4
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DD1, 1G88, 1MR1, 1U7F, 1U7V, 1YGS, 5MEY, 5MEZ, 5MF0
Band: 18q21.2 · 18 E2|18 49.51 cM
Bgee: ventricular zone · ganglionic eminence · Achilles tendon · epithelium of colon · stromal cell of endometrium
BioGPS: More reference expression data
Chr.: Chromosome 18 (human) · Chromosome 18 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Metazoans
Dwarfin family SMAD (protein)
Transcription factor
TGFβ Transforming growth factor beta
Co-SMAD Co-SMAD?action=edit&redlink=1
Homolog Homology (biology)
Drosophila
Mothers against decapentaplegic
SMAD2
SMAD3
SMAD1
SMAD5
SMAD9
WWTR1 (TAZ) WWTR1
DNA
TGFβ

Protein

Polypeptide
Da Dalton (unit)
MH1 MH1 domain?action=edit&redlink=1
MH2 MH2 domain?action=edit&redlink=1

Structures

Β-hairpin
Trichoplax adhaerens
C-terminus
Heterodimers
Heterotrimers Heterotrimers?action=edit&redlink=1

Nomenclature and origin of name

N terminal N terminus
C. elegans Caenorhabditis elegans
Dpp Decapentaplegic
Mothers Against Drunk Driving

Function and action mechanism

Nucleus Cell nucleus
Cell surface receptor
Heteromeric
Erk Extracellular signal-regulated kinases
MAPK
GSK3
Fibroblast Growth Factor
Phosphorylation
Growth factor
E3 ligase
Beta-TrCP BTRC (gene)
Proteasome
Colon cancer
AP-1 AP-1 (transcription factor)
TFE3
FoxG1 FoxG1?action=edit&redlink=1
Gene expression
Pathway TGFβ signaling pathway
Differentiation Cellular differentiation
Apoptosis
Gastrulation
Embryonic development
Cell cycle

Clinical significance

Gene knockout
Mus musculus
Granulosa cells
Oocyte
Follicle-stimulating hormone receptors FSH receptor
Luteinizing hormone receptors LH-receptor
Bone morphogenetic protein-7 BMP7
Somatic Somatic (biology)
Fibroblasts
Extracellular matrix
Colorectal cancer
Pancreatic carcinoma
Autosomal dominant
Juvenile polyposis syndrome
Gastrointestinal cancers Gastrointestinal cancer
Myhre syndrome

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SMAD4 connects Entity context

The extracted context around SMAD4 shows recurring relationship patterns in the source. For example, SMAD4 → activin responsive factor complex, anatomical structure morphogenesis, anterior/posterior pattern specification, atrioventricular canal development, atrioventricular valve formation, axon guidance, BMP signaling pathway, brainstem development, branching involved in ureteric bud morphogenesis, cardiac septum development, cell differentiation, cell population proliferation, cellular iron ion homeostasis, cellular response to BMP stimulus, centrosome, chromatin binding, cis-regulatory region sequence-specific DNA binding, collagen binding, cytoplasm, cytosol Another extracted example is SMAD4 → AC, CAG, CAGCC, CC, CG, Da, DNA, Early, GC, GGC, GTCTAGAC, LDTFs, MH1, MH2, Other, Smad, SMAD-bound, SMAD2, SMAD3, SMAD3/SMAD4. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 115

SMAD4 → activin responsive factor complex, anatomical structure morphogenesis, anterior/posterior pattern specification, atrioventricular canal development, atrioventricular valve formation, axon guidance, BMP signaling pathway, brainstem development, branching involved in ureteric bud morphogenesis, cardiac septum development, cell differentiation, cell population proliferation, cellular iron ion homeostasis, cellular response to BMP stimulus, centrosome, chromatin binding, cis-regulatory region sequence-specific DNA binding, collagen binding, cytoplasm, cytosol

related to Protein · 26

SMAD4 → AC, CAG, CAGCC, CC, CG, Da, DNA, Early, GC, GGC, GTCTAGAC, LDTFs, MH1, MH2, Other, Smad, SMAD-bound, SMAD2, SMAD3, SMAD3/SMAD4

Bgee · 20

SMAD4 → Achilles tendon, ciliary body, conjunctival fornix, epithelium of colon, gallbladder, ganglionic eminence, human fetus, left ovary, medial ganglionic eminence, medullary collecting duct, Paneth cell, popliteal artery, rectum, renal corpuscle, retinal pigment epithelium, Rostral migratory stream, stromal cell of endometrium, tibial arteries, vas deferens, ventricular zone

RNA expression pattern · 20

related to MH1 domain complexes with DNA motifs · 18

SMAD4 → Arg81, DNA, Efficient, GC-sites, GGCGC, Gln83, GTCTAGAC, In, Lys88, MH1, Other, Recently, Smad DNA-binding, SMAD4 MH1, The, The X-ray, This, Trichoplax

related to Nomenclature and origin of name · 15

SMAD4 → DPC4, Drosophila, During Drosophila, JIP, MAD, MADD, MADH4, MH1, MH2, Mothers, Mothers Against Drunk Driving, SMA, SMADs, The, The SMAD

related to Function and action mechanism · 14

SMAD4 → II, In, Once, R-SMADS, SMAD, SMAD2, SMAD3, SMADS, TGF-β, TGFβ, The, The R-SMADs-SMAD4, This, Type

related to Clinical significance · 10

SMAD4 → BMP-7, Experiments, FSHR, Genetic, It, KO, LHR, Mus, SMAD, This

related to MH2 domain complexes · 8

SMAD4 → C-terminus, It, MH1, MH2, R-SMADS MH2, SMADs, Some, The MH2

is a · 3

SMAD4 → homolog of the Drosophila protein, only known co-SMAD in most metazoans, substrate of the Erk/MAPK kinase and GSK3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

smad also family protein mh1 gene pathway growth dna cells complex r-smads bp tgfβ smad3 domain complexes cell human mh2

SMAD4 relationships Subject–Predicate–Object triples

TTTA extracted 285 structured relationships around SMAD4. Examples in this analysis include SMAD4 → Aliases → SMAD4, DPC4, JIP, MADH4, MYHRS, SMAD family member 4 and SMAD4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DD1, 1G88, 1MR1, 1U7F, 1U7V, 1YGS, 5MEY, 5MEZ, 5MF0. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
SMAD4	Aliases	SMAD4, DPC4, JIP, MADH4, MYHRS, SMAD family member 4	1.00	infobox
SMAD4	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DD1, 1G88, 1MR1, 1U7F, 1U7V, 1YGS, 5MEY, 5MEZ, 5MF0	1.00	infobox
SMAD4	Band	18q21.2	1.00	infobox
SMAD4	Band	18 E2\|18 49.51 cM	1.00	infobox
SMAD4	Bgee	ventricular zone	1.00	infobox
SMAD4	Bgee	ganglionic eminence	1.00	infobox
SMAD4	Bgee	Achilles tendon	1.00	infobox
SMAD4	Bgee	epithelium of colon	1.00	infobox
SMAD4	Bgee	stromal cell of endometrium	1.00	infobox
SMAD4	Bgee	left ovary	1.00	infobox
SMAD4	Bgee	gallbladder	1.00	infobox
SMAD4	Bgee	rectum	1.00	infobox
SMAD4	Bgee	popliteal artery	1.00	infobox
SMAD4	Bgee	tibial arteries	1.00	infobox
SMAD4	Bgee	Rostral migratory stream	1.00	infobox
SMAD4	Bgee	ciliary body	1.00	infobox
SMAD4	Bgee	Paneth cell	1.00	infobox
SMAD4	Bgee	vas deferens	1.00	infobox
SMAD4	Bgee	human fetus	1.00	infobox
SMAD4	Bgee	renal corpuscle	1.00	infobox
SMAD4	Bgee	medullary collecting duct	1.00	infobox
SMAD4	Bgee	conjunctival fornix	1.00	infobox
SMAD4	Bgee	medial ganglionic eminence	1.00	infobox
SMAD4	Bgee	retinal pigment epithelium	1.00	infobox
SMAD4	BioGPS	More reference expression data	1.00	infobox
SMAD4	Chr.	Chromosome 18 (human)	1.00	infobox
SMAD4	Chr.	Chromosome 18 (mouse)	1.00	infobox
SMAD4	Databases	NCBI: entry; OMA: entry	1.00	infobox
SMAD4	End	51,085,045 bp	1.00	infobox
SMAD4	End	73,836,851 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SMAD4 bring nearby vocabulary together. In this analysis, examples include Mh1, Domains and Pathway. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

dwarfin family
- Tgfβ
- Factors
- Protein
- Metazoans
- Regulation
- Smad
- Transcription
- Gene
- Growth
- Smad4
- Chromosome
- Factor
transcription factor
- Intracellular
- Pathway
- Growth
- Factor
- Transcription
- Factors
- Tgf-β
- Cell
- Gene
- Family
- Smad
- Band
dna
- Mh1
- Chromosome
- Function
- Binding
- Bp
- Chr
- Human
- Nucleus
- Smad
- Domains
- Smad3
- Smad4
cell surface receptor
- Smads
- Growth
- Tgf-β
- Factors
- Nucleus
- Tgfβ
- Transcription
- Receptor
- Pathway
- Regulation
- Chromosome
- Factor
fibroblast growth factor
- Intracellular
- Pathway
- Growth
- Transcription
- Factors
- Tgf-β
- Cell
- Regulation
- Smad
- Nucleus
- Tgfβ
- Smad4
growth factor
- Intracellular
- Pathway
- Growth
- Transcription
- Factors
- Tgf-β
- Cell
- Regulation
- Smad
- Nucleus
- Tgfβ
- Smad4
cell cycle
- Growth
- Factors
- Nucleus
- Tgfβ
- Transcription
- Receptor
- Pathway
- Chromosome
- Factor
- Function
- Intracellular
- Regulation
protein
- Smad
- Chromosome
- Function
- Regulation
- Binding
- Bp
- Chr
- Human
- Smad4
- Complexes
- Dna
- Gene

Connections between topic areas Semantic bridges

For SMAD4, one of the stronger structural bridges in this analysis connects SMAD4 with Function and action mechanism. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

SMAD4 — Function and action mechanism · splits 51 ⟂ 24

SMAD4 — Overview · splits 58 ⟂ 17

SMAD4 — Clinical significance · splits 58 ⟂ 17

SMAD4 — Structures · splits 69 ⟂ 6

SMAD4 — Protein · splits 70 ⟂ 5

SMAD4 — Nomenclature and origin of name · splits 70 ⟂ 5

Map overview Semantic statistics

SMAD4

Nodes75

Edges74

Triples285

Avg. degree1.97

Density0.026667

Components1

Source & methodology

TTTA analyzes the structure around SMAD4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function and action mechanism, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SMAD4 · EN edition · Analysis: TopicsToTalkAbout