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TGF beta receptor 1: Research, Interactions & Inhibitors

Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGF beta receptor protein of the TGF-beta receptor family for the TGF beta superfamily of signaling ligands. TGFBR1 is its human gene.

Language: English [EN]
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TGF beta receptor 1 topic overview

The analysis highlights Research, Interactions and Inhibitors as prominent areas in the source structure around TGF beta receptor 1.

Related topics
27
Source areas
5
Connected nodes
32
Extracted relationships
185
Concept neighborhoods
11
Bridge connections
32

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 10 topics
Inhibitors · 7 topics
Overview · 4 topics
Animal studies · 3 topics
Function · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.30
Aliases
TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I, transforming growth factor beta receptor 1, TBRI, TBR-i
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B6C, 1IAS, 1PY5, 1RW8, 1VJY, 2L5S, 2PJY, 2WOT, 2WOU, 2X7O, 3FAA, 3GXL, 3HMM, 3KCF, 3KFD, 3TZM, 4X0M, 4X2J,…
Band
9q22.33 · 4 B1|4 26.02 cM
Bgee
saphenous vein · tibia · visceral pleura · Achilles tendon · synovial joint
BioGPS
n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Inhibitors

Animal studies

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TGF beta receptor 1 connects Entity context

The extracted context around TGF beta receptor 1 shows recurring relationship patterns in the source. For example, TGF beta receptor 1 → activin binding, activin receptor complex, activin receptor signaling pathway, angiogenesis, angiogenesis involved in coronary vascular morphogenesis, anterior/posterior pattern specification, apoptotic process, artery morphogenesis, ATP binding, bicellular tight junction, blastocyst development, cardiac epithelial to mesenchymal transition, cell differentiation, cell junction, cell motility, cell surface, cellular response to transforming growth factor beta stimulus, collagen fibril organization, coronary artery morphogenesis, development of the heart Another extracted example is TGF beta receptor 1 → abdominal wall, Achilles tendon, cumulus cell, efferent ductule, ganglionic eminence, lactiferous duct, mandibular prominence, maxillary prominence, medial ganglionic eminence, medullary collecting duct, molar, mucosa of paranasal sinus, saphenous vein, superficial temporal artery, superior cervical ganglion, synovial joint, tibia, tunica media of zone of aorta, ventricular zone, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

TGF beta receptor 1

Top relations

Gene ontology · 111
TGF beta receptor 1 → activin binding, activin receptor complex, activin receptor signaling pathway, angiogenesis, angiogenesis involved in coronary vascular morphogenesis, anterior/posterior pattern specification, apoptotic process, artery morphogenesis, ATP binding, bicellular tight junction, blastocyst development, cardiac epithelial to mesenchymal transition, cell differentiation, cell junction, cell motility, cell surface, cellular response to transforming growth factor beta stimulus, collagen fibril organization, coronary artery morphogenesis, development of the heart
Bgee · 20
TGF beta receptor 1 → abdominal wall, Achilles tendon, cumulus cell, efferent ductule, ganglionic eminence, lactiferous duct, mandibular prominence, maxillary prominence, medial ganglionic eminence, medullary collecting duct, molar, mucosa of paranasal sinus, saphenous vein, superficial temporal artery, superior cervical ganglion, synovial joint, tibia, tunica media of zone of aorta, ventricular zone, visceral pleura
RNA expression pattern · 20
TGF beta receptor 1 → abdominal wall, Achilles tendon, cumulus cell, efferent ductule, ganglionic eminence, lactiferous duct, mandibular prominence, maxillary prominence, medial ganglionic eminence, medullary collecting duct, molar, mucosa of paranasal sinus, saphenous vein, superficial temporal artery, superior cervical ganglion, synovial joint, tibia, tunica media of zone of aorta, ventricular zone, visceral pleura
related to Interactions · 9
TGF beta receptor 1 → A1Mothers, Caveolin, Endoglin, FKBP1A, FNTA, Heat, PPP2R2A, STRAP, TGF
Band · 2
TGF beta receptor 1 → 4 B1|4 26.02 cM, 9q22.33
Chr. · 2
TGF beta receptor 1 → Chromosome 4 (mouse), Chromosome 9 (human)
End · 2
TGF beta receptor 1 → 47,414,931 bp, 99,154,192 bp
2.7.11.30 · 1
TGF beta receptor 1 → ↗
Aliases · 1
TGF beta receptor 1 → TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I, transforming growth factor beta receptor 1, TBRI, TBR-i
Available structures · 1
TGF beta receptor 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B6C, 1IAS, 1PY5, 1RW8, 1VJY, 2L5S, 2PJY, 2WOT, 2WOU, 2X7O, 3FAA, 3GXL, 3HMM, 3KCF, 3KFD, 3TZM, 4X0M, 4X2J,…

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp chr band receptor protein beta chromosome mouse tgfbr1 tgfbr-1 transforming growth factor type kinase location function external

TGF beta receptor 1 relationships Subject–Predicate–Object triples

TTTA extracted 185 structured relationships around TGF beta receptor 1. Examples in this analysis include TGF beta receptor 1 → 2.7.11.30 → ↗ and TGF beta receptor 1 → Aliases → TGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I, transforming growth factor beta receptor 1, TBRI, TBR-i. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TGF beta receptor 12.7.11.301.00infobox
TGF beta receptor 1AliasesTGFBR1, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I, transforming growth factor beta receptor 1, TBRI, TBR-i1.00infobox
TGF beta receptor 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B6C, 1IAS, 1PY5, 1RW8, 1VJY, 2L5S, 2PJY, 2WOT, 2WOU, 2X7O, 3FAA, 3GXL, 3HMM, 3KCF, 3KFD, 3TZM, 4X0M, 4X2J,…1.00infobox
TGF beta receptor 1Band9q22.331.00infobox
TGF beta receptor 1Band4 B1|4 26.02 cM1.00infobox
TGF beta receptor 1Bgeesaphenous vein1.00infobox
TGF beta receptor 1Bgeetibia1.00infobox
TGF beta receptor 1Bgeevisceral pleura1.00infobox
TGF beta receptor 1BgeeAchilles tendon1.00infobox
TGF beta receptor 1Bgeesynovial joint1.00infobox
TGF beta receptor 1Bgeelactiferous duct1.00infobox
TGF beta receptor 1Bgeeventricular zone1.00infobox
TGF beta receptor 1Bgeemucosa of paranasal sinus1.00infobox
TGF beta receptor 1Bgeeganglionic eminence1.00infobox
TGF beta receptor 1Bgeesuperficial temporal artery1.00infobox
TGF beta receptor 1Bgeemedullary collecting duct1.00infobox
TGF beta receptor 1Bgeesuperior cervical ganglion1.00infobox
TGF beta receptor 1Bgeecumulus cell1.00infobox
TGF beta receptor 1Bgeemedial ganglionic eminence1.00infobox
TGF beta receptor 1Bgeemandibular prominence1.00infobox
TGF beta receptor 1Bgeeefferent ductule1.00infobox
TGF beta receptor 1Bgeeabdominal wall1.00infobox
TGF beta receptor 1Bgeetunica media of zone of aorta1.00infobox
TGF beta receptor 1Bgeemaxillary prominence1.00infobox
TGF beta receptor 1Bgeemolar1.00infobox
TGF beta receptor 1BioGPSn/a1.00infobox
TGF beta receptor 1Chr.Chromosome 9 (human)1.00infobox
TGF beta receptor 1Chr.Chromosome 4 (mouse)1.00infobox
TGF beta receptor 1DatabasesNCBI: entry; OMA: entry1.00infobox
TGF beta receptor 1End99,154,192 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TGF beta receptor 1 bring nearby vocabulary together. In this analysis, examples include Receptor, Factor and Growth. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TGF beta receptor 1
    • Receptor
    • Factor
    • Growth
    • Activin
    • Activity
    • Protein
    • Search
    • Tgf
    • Function
    • Kinase
    • Location
    • Tgfbr1
  • tgf beta receptor 1
    • Receptor
    • Factor
    • Growth
    • Transforming
    • Function
    • Protein
    • Activin
    • Activity
    • Search
    • Signaling
    • Tgf
    • Type
  • tgf beta receptor
    • Receptor
    • Factor
    • Growth
    • Transforming
    • Function
    • Protein
    • Activin
    • Activity
    • Search
    • Signaling
    • Tgf
    • Type
  • tgf-beta receptor family
    • Function
    • Transforming
    • Protein
    • Activin
    • Activity
    • Search
    • Signaling
    • Tgf
    • Type
    • Kinase
    • Location
    • Tgfbr1
  • tgf beta superfamily of signaling ligands
    • Type
    • Receptor
    • Factor
    • Growth
    • Transforming
    • Protein
    • Activin
    • Activity
    • Search
    • Signaling
    • Tgf
    • Function
  • gene
    • Human
    • Tgfbr-1
    • Location
    • Tgfbr1
    • Chromosome
    • Mouse
    • Bp
    • Chr
    • Activity
    • B1
    • End
    • External
  • type ii tgf-β receptors
    • Activin
    • Signaling
    • Factor
    • Growth
    • Kinase
    • Transforming
    • Beta
    • Protein
    • Receptor
    • Activity
    • B1
    • End
  • serine/threonine protein kinase
    • Protein
    • Signaling
    • Type
    • Receptor
    • Tgf
    • Transforming
    • Activity
    • B1
    • End
    • Entry
    • Ncbi
    • Search

Connections between topic areas Semantic bridges

For TGF beta receptor 1, one of the stronger structural bridges in this analysis connects TGF beta receptor 1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TGF beta receptor 1Interactions · splits 22 ⟂ 11
TGF beta receptor 1Inhibitors · splits 25 ⟂ 8
TGF beta receptor 1Overview · splits 28 ⟂ 5
TGF beta receptor 1Function · splits 29 ⟂ 4
TGF beta receptor 1Animal studies · splits 29 ⟂ 4

Map overview Semantic statistics

TGF beta receptor 1

Nodes33
Edges32
Triples185
Avg. degree1.94
Density0.060606
Components1

Source & methodology

TTTA analyzes the structure around TGF beta receptor 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Interactions & Inhibitors, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TGF beta receptor 1 · EN edition · Analysis: TopicsToTalkAbout

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