Research any topic before you write.
Find related topics. | Discover entities. | See connections. | Build a topical map.
E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene which is located at chromosome 17q23.3-q24.1.
The analysis highlights Interactions and Overview as prominent areas in the source structure around SMURF2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around SMURF2 shows recurring relationship patterns in the source. For example, SMURF2 → BMP signaling pathway, cytoplasm, cytosol, identical protein binding, membrane, membrane raft, negative regulation of BMP signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, negative regulation of transforming growth factor beta receptor signaling pathway, nuclear speck, nucleoplasm, nucleus, plasma membrane, positive regulation of canonical Wnt signaling pathway, positive regulation of protein catabolic process, positive regulation of trophoblast cell migration, proteasome-mediated ubiquitin-dependent protein catabolic process, protein binding, protein deubiquitination Another extracted example is SMURF2 → Achilles tendon, amniotic fluid, buccal mucosa cell, caput epididymis, endothelial cell of lymphatic vessel, genital tubercle, hand, lactiferous duct, left lung lobe, otolith organ, pericardium, pylorus, right lung lobe, saphenous vein, secondary oocyte, superior cervical ganglion, utricle, visceral pleura, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
bp chromosome chr human band gene 17 ligase 3-q24 location ubiquitin enzyme mouse e3 ubiquitin-protein 17q23 smad protein search activity
TTTA extracted 99 structured relationships around SMURF2. Examples in this analysis include SMURF2 → 2.3.2.26 → ↗ and SMURF2 → Aliases → SMURF2, SMAD specific E3 ubiquitin protein ligase 2. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| SMURF2 | 2.3.2.26 | ↗ | 1.00 | infobox |
| SMURF2 | Aliases | SMURF2, SMAD specific E3 ubiquitin protein ligase 2 | 1.00 | infobox |
| SMURF2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZVD, 2DJY, 2JQZ, 2KXQ, 2LTZ | 1.00 | infobox |
| SMURF2 | Band | 17q23.3-q24.1 | 1.00 | infobox |
| SMURF2 | Band | 11|11 E1 | 1.00 | infobox |
| SMURF2 | Bgee | buccal mucosa cell | 1.00 | infobox |
| SMURF2 | Bgee | secondary oocyte | 1.00 | infobox |
| SMURF2 | Bgee | amniotic fluid | 1.00 | infobox |
| SMURF2 | Bgee | pylorus | 1.00 | infobox |
| SMURF2 | Bgee | saphenous vein | 1.00 | infobox |
| SMURF2 | Bgee | lactiferous duct | 1.00 | infobox |
| SMURF2 | Bgee | visceral pleura | 1.00 | infobox |
| SMURF2 | Bgee | pericardium | 1.00 | infobox |
| SMURF2 | Bgee | caput epididymis | 1.00 | infobox |
| SMURF2 | Bgee | Achilles tendon | 1.00 | infobox |
| SMURF2 | Bgee | hand | 1.00 | infobox |
| SMURF2 | Bgee | otolith organ | 1.00 | infobox |
| SMURF2 | Bgee | utricle | 1.00 | infobox |
| SMURF2 | Bgee | zygote | 1.00 | infobox |
| SMURF2 | Bgee | left lung lobe | 1.00 | infobox |
| SMURF2 | Bgee | right lung lobe | 1.00 | infobox |
| SMURF2 | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| SMURF2 | Bgee | genital tubercle | 1.00 | infobox |
| SMURF2 | Bgee | superior cervical ganglion | 1.00 | infobox |
| SMURF2 | BioGPS | More reference expression data | 1.00 | infobox |
| SMURF2 | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| SMURF2 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| SMURF2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| SMURF2 | End | 64,662,307 bp | 1.00 | infobox |
| SMURF2 | End | 106,811,541 bp | 1.00 | infobox |
The concept neighborhoods around SMURF2 bring nearby vocabulary together. In this analysis, examples include Gene, Activity and Enzyme. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For SMURF2, one of the stronger structural bridges in this analysis connects SMURF2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around SMURF2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — SMURF2 · EN edition · Analysis: TopicsToTalkAbout