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SKP2

S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene.

Structure, Clinical significance & Function

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Aliases
SKP2, FBL1, FBXL1, FLB1, p45, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase, S-phase kinase associated protein 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FQV, 1FS1, 1FS2, 1LDK, 2ASS, 2AST
Band
5p13.2 · 15|15 A1
Bgee
oocyte · secondary oocyte · placenta · ventricular zone · embryo
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 15 (mouse)

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Overview

Structure

Function

Clinical significance

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Map overview Semantic statistics

SKP2

Nodes58
Edges57
Triples171
Avg. degree1.97
Density0.034483
Components1

How this topic connects Entity context

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SKP2

Top relations

Gene ontology · 31
SKP2 → cell population proliferation, cellular response to cell-matrix adhesion, cytoplasm, cytosol, defense response to virus, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, identical protein binding, immune system process, innate immune response, nucleolus, nucleoplasm, nucleus, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of protein polyubiquitination, positive regulation of smooth muscle cell proliferation, post-translational protein modification, proteasome-mediated ubiquitin-dependent protein catabolic process, protein binding, protein deubiquitination
Bgee · 20
SKP2 → abdominal wall, buccal mucosa cell, dermis, embryo, endothelial cell, ganglionic eminence, gingival epithelium, hand, human fetus, mandibular prominence, maxillary prominence, oocyte, otic placode, otic vesicle, placenta, primitive streak, Rostral migratory stream, secondary oocyte, tibia, ventricular zone
RNA expression pattern · 20
SKP2 → abdominal wall, buccal mucosa cell, dermis, embryo, endothelial cell, ganglionic eminence, gingival epithelium, hand, human fetus, mandibular prominence, maxillary prominence, oocyte, otic placode, otic vesicle, placenta, primitive streak, Rostral migratory stream, secondary oocyte, tibia, ventricular zone
related to F-box domain · 18
SKP2 → A-CDK2 S-phase, After, Alternative, C-terminal, CDKN1B, F-box, Fbxls, Fbxos, Fbxws, G2, In, It, KIP1, LRR, LRRs, The, The F-box, WD40
related to Function · 13
SKP2 → CDK, CDKs, CKIs, E1, E2s, E3, G1/S, Here, Progression, Relative, SCFSkp2, The, These
related to Clinical significance · 10
SKP2 → CDK, CKIs, D-CDK4, E-CDK2, G0, It, Levels, One, Robust, SCFSkp2
related to Overexpression · 9
SKP2 → Additionally, ARF, As, By, Her2/Neu, Overexpression, PTEN, This, Using
related to Structure · 9
SKP2 → C-terminal, F-box, In, LRRs, N-terminal, SCF, SCFs, SKP1-cullin-F-box, The F-box
related to Potential use as a clinical target · 8
SKP2 → Akt-mediated, Although Skp2, Another, As Skp2, SCF, Skp1/Skp2, Skp2-dependent, Small
related to Interactions · 6
SKP2 → CCNA2, CDK2, CDKN1ACDKN1BCKS1B, CDT1, CUL1E2F1, ORC1L

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Important terminology

p27 cancer protein complex bp gene cell human cycle chr band ligase ubiquitin f-box overexpression scf inhibitors chromosome mouse enzyme

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SKP2AliasesSKP2, FBL1, FBXL1, FLB1, p45, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase, S-phase kinase associated protein 21.00infobox
SKP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FQV, 1FS1, 1FS2, 1LDK, 2ASS, 2AST1.00infobox
SKP2Band5p13.21.00infobox
SKP2Band15|15 A11.00infobox
SKP2Bgeeoocyte1.00infobox
SKP2Bgeesecondary oocyte1.00infobox
SKP2Bgeeplacenta1.00infobox
SKP2Bgeeventricular zone1.00infobox
SKP2Bgeeembryo1.00infobox
SKP2Bgeegingival epithelium1.00infobox
SKP2Bgeebuccal mucosa cell1.00infobox
SKP2Bgeeganglionic eminence1.00infobox
SKP2Bgeetibia1.00infobox
SKP2Bgeeendothelial cell1.00infobox
SKP2Bgeemaxillary prominence1.00infobox
SKP2Bgeemandibular prominence1.00infobox
SKP2Bgeeprimitive streak1.00infobox
SKP2Bgeeabdominal wall1.00infobox
SKP2Bgeehand1.00infobox
SKP2Bgeeotic vesicle1.00infobox
SKP2BgeeRostral migratory stream1.00infobox
SKP2Bgeeotic placode1.00infobox
SKP2Bgeedermis1.00infobox
SKP2Bgeehuman fetus1.00infobox
SKP2BioGPSMore reference expression data1.00infobox
SKP2Chr.Chromosome 5 (human)1.00infobox
SKP2Chr.Chromosome 15 (mouse)1.00infobox
SKP2DatabasesNCBI: entry; OMA: entry1.00infobox
SKP2End36,196,849 bp1.00infobox
SKP2End9,155,512 bp1.00infobox

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