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S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene.
The analysis highlights Structure, Clinical significance and Function as prominent areas in the source structure around SKP2. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around SKP2 shows recurring relationship patterns in the source. For example, SKP2 → cell population proliferation, cellular response to cell-matrix adhesion, cytoplasm, cytosol, defense response to virus, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, identical protein binding, immune system process, innate immune response, nucleolus, nucleoplasm, nucleus, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of protein polyubiquitination, positive regulation of smooth muscle cell proliferation, post-translational protein modification, proteasome-mediated ubiquitin-dependent protein catabolic process, protein binding, protein deubiquitination Another extracted example is SKP2 → abdominal wall, buccal mucosa cell, dermis, embryo, endothelial cell, ganglionic eminence, gingival epithelium, hand, human fetus, mandibular prominence, maxillary prominence, oocyte, otic placode, otic vesicle, placenta, primitive streak, Rostral migratory stream, secondary oocyte, tibia, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
p27 cancer protein complex bp gene cell human cycle chr band ligase ubiquitin f-box overexpression scf inhibitors chromosome mouse enzyme
TTTA extracted 171 structured relationships around SKP2. Examples in this analysis include SKP2 → Aliases → SKP2, FBL1, FBXL1, FLB1, p45, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase, S-phase kinase associated protein 2 and SKP2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FQV, 1FS1, 1FS2, 1LDK, 2ASS, 2AST. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| SKP2 | Aliases | SKP2, FBL1, FBXL1, FLB1, p45, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase, S-phase kinase associated protein 2 | 1.00 | infobox |
| SKP2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FQV, 1FS1, 1FS2, 1LDK, 2ASS, 2AST | 1.00 | infobox |
| SKP2 | Band | 5p13.2 | 1.00 | infobox |
| SKP2 | Band | 15|15 A1 | 1.00 | infobox |
| SKP2 | Bgee | oocyte | 1.00 | infobox |
| SKP2 | Bgee | secondary oocyte | 1.00 | infobox |
| SKP2 | Bgee | placenta | 1.00 | infobox |
| SKP2 | Bgee | ventricular zone | 1.00 | infobox |
| SKP2 | Bgee | embryo | 1.00 | infobox |
| SKP2 | Bgee | gingival epithelium | 1.00 | infobox |
| SKP2 | Bgee | buccal mucosa cell | 1.00 | infobox |
| SKP2 | Bgee | ganglionic eminence | 1.00 | infobox |
| SKP2 | Bgee | tibia | 1.00 | infobox |
| SKP2 | Bgee | endothelial cell | 1.00 | infobox |
| SKP2 | Bgee | maxillary prominence | 1.00 | infobox |
| SKP2 | Bgee | mandibular prominence | 1.00 | infobox |
| SKP2 | Bgee | primitive streak | 1.00 | infobox |
| SKP2 | Bgee | abdominal wall | 1.00 | infobox |
| SKP2 | Bgee | hand | 1.00 | infobox |
| SKP2 | Bgee | otic vesicle | 1.00 | infobox |
| SKP2 | Bgee | Rostral migratory stream | 1.00 | infobox |
| SKP2 | Bgee | otic placode | 1.00 | infobox |
| SKP2 | Bgee | dermis | 1.00 | infobox |
| SKP2 | Bgee | human fetus | 1.00 | infobox |
| SKP2 | BioGPS | More reference expression data | 1.00 | infobox |
| SKP2 | Chr. | Chromosome 5 (human) | 1.00 | infobox |
| SKP2 | Chr. | Chromosome 15 (mouse) | 1.00 | infobox |
| SKP2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| SKP2 | End | 36,196,849 bp | 1.00 | infobox |
| SKP2 | End | 9,155,512 bp | 1.00 | infobox |
The concept neighborhoods around SKP2 bring nearby vocabulary together. In this analysis, examples include Cancer, P27 and Complex. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For SKP2, one of the stronger structural bridges in this analysis connects SKP2 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around SKP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — SKP2 · EN edition · Analysis: TopicsToTalkAbout