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PSMD2: Measurement, Clinical significance & Structure

26S proteasome non-ATPase regulatory subunit 2, also as known as 26S Proteasome Regulatory Subunit Rpn1 (systematic nomenclature), is an enzyme that in humans is encoded by the PSMD2 gene.

Language: English [EN]
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PSMD2 topic overview

The analysis highlights Measurement, Clinical significance and Structure as prominent areas in the source structure around PSMD2.

Related topics
68
Source areas
4
Connected nodes
72
Extracted relationships
113
Concept neighborhoods
10
Bridge connections
72

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 59 topics
Structure · 4 topics
Interactions · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PSMD2, P97, RPN1, S2, TRAP2, proteasome 26S subunit, non-ATPase 2, proteasome 26S subunit ubiquitin receptor, non-ATPase 2
Band
3q27.1 · 16|16 A3
Bgee
secondary oocyte · endothelial cell · stromal cell of endometrium · right testis · gastrocnemius muscle
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PSMD2 connects Entity context

The extracted context around PSMD2 shows recurring relationship patterns in the source. For example, PSMD2 → anaphase-promoting complex-dependent catabolic process, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, cytosol, endopeptidase activity, enzyme regulator activity, extracellular exosome, extracellular region, Fc-epsilon receptor signaling pathway, ficolin-1-rich granule lumen, interleukin-1-mediated signaling pathway, MAPK cascade, membrane, negative regulation of canonical Wnt signaling pathway, negative regulation of G2/M transition of mitotic cell cycle, neutrophil degranulation, NIK/NF-kappaB signaling, nucleoplasm, nucleus, positive regulation of canonical Wnt signaling pathway, post-translational protein modification Another extracted example is PSMD2 → blastocyst, dentate gyrus of hippocampal formation granule cell, endothelial cell, esophagus, gastrocnemius muscle, genital tubercle, glutes, islet of Langerhans, left testis, morula, muscle of thigh, right adrenal gland, right testis, secondary oocyte, spermatocyte, stromal cell of endometrium, tail of embryo, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

PSMD2

Top relations

Gene ontology · 43
PSMD2 → anaphase-promoting complex-dependent catabolic process, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, cytosol, endopeptidase activity, enzyme regulator activity, extracellular exosome, extracellular region, Fc-epsilon receptor signaling pathway, ficolin-1-rich granule lumen, interleukin-1-mediated signaling pathway, MAPK cascade, membrane, negative regulation of canonical Wnt signaling pathway, negative regulation of G2/M transition of mitotic cell cycle, neutrophil degranulation, NIK/NF-kappaB signaling, nucleoplasm, nucleus, positive regulation of canonical Wnt signaling pathway, post-translational protein modification
Bgee · 19
PSMD2 → blastocyst, dentate gyrus of hippocampal formation granule cell, endothelial cell, esophagus, gastrocnemius muscle, genital tubercle, glutes, islet of Langerhans, left testis, morula, muscle of thigh, right adrenal gland, right testis, secondary oocyte, spermatocyte, stromal cell of endometrium, tail of embryo, ventricular zone, yolk sac
RNA expression pattern · 19
PSMD2 → blastocyst, dentate gyrus of hippocampal formation granule cell, endothelial cell, esophagus, gastrocnemius muscle, genital tubercle, glutes, islet of Langerhans, left testis, morula, muscle of thigh, right adrenal gland, right testis, secondary oocyte, spermatocyte, stromal cell of endometrium, tail of embryo, ventricular zone, yolk sac
related to Gene expression · 5
PSMD2 → ATPase, In, The, TNF, Two
Band · 2
PSMD2 → 16|16 A3, 3q27.1
Chr. · 2
PSMD2 → Chromosome 16 (mouse), Chromosome 3 (human)
End · 2
PSMD2 → 184,309,050 bp, 20,482,164 bp
related to Interactions · 2
PSMD2 → PSMC1, TNFRSF1A
Aliases · 1
PSMD2 → PSMD2, P97, RPN1, S2, TRAP2, proteasome 26S subunit, non-ATPase 2, proteasome 26S subunit ubiquitin receptor, non-ATPase 2
BioGPS · 1
PSMD2 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

proteasome protein 19s gene complex regulatory subunit rpn1 base non-atpase human ups bp particle 26s band subunits degradation chromosome chr

PSMD2 relationships Subject–Predicate–Object triples

TTTA extracted 113 structured relationships around PSMD2. Examples in this analysis include PSMD2 → Aliases → PSMD2, P97, RPN1, S2, TRAP2, proteasome 26S subunit, non-ATPase 2, proteasome 26S subunit ubiquitin receptor, non-ATPase 2 and PSMD2 → Band → 3q27.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PSMD2AliasesPSMD2, P97, RPN1, S2, TRAP2, proteasome 26S subunit, non-ATPase 2, proteasome 26S subunit ubiquitin receptor, non-ATPase 21.00infobox
PSMD2Band3q27.11.00infobox
PSMD2Band16|16 A31.00infobox
PSMD2Bgeesecondary oocyte1.00infobox
PSMD2Bgeeendothelial cell1.00infobox
PSMD2Bgeestromal cell of endometrium1.00infobox
PSMD2Bgeeright testis1.00infobox
PSMD2Bgeegastrocnemius muscle1.00infobox
PSMD2Bgeeleft testis1.00infobox
PSMD2Bgeemuscle of thigh1.00infobox
PSMD2Bgeeglutes1.00infobox
PSMD2Bgeeislet of Langerhans1.00infobox
PSMD2Bgeeright adrenal gland1.00infobox
PSMD2Bgeeyolk sac1.00infobox
PSMD2Bgeeventricular zone1.00infobox
PSMD2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
PSMD2Bgeegenital tubercle1.00infobox
PSMD2Bgeeblastocyst1.00infobox
PSMD2Bgeetail of embryo1.00infobox
PSMD2Bgeeesophagus1.00infobox
PSMD2Bgeespermatocyte1.00infobox
PSMD2Bgeemorula1.00infobox
PSMD2BioGPSMore reference expression data1.00infobox
PSMD2Chr.Chromosome 3 (human)1.00infobox
PSMD2Chr.Chromosome 16 (mouse)1.00infobox
PSMD2DatabasesNCBI: entry; OMA: entry1.00infobox
PSMD2End184,309,050 bp1.00infobox
PSMD2End20,482,164 bp1.00infobox
PSMD2EnsemblENSG000001751661.00infobox
PSMD2Entrez57081.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PSMD2 bring nearby vocabulary together. In this analysis, examples include Chromosome, Expression and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PSMD2
    • Chromosome
    • Expression
    • Human
    • Subunit
    • Rpn1
    • Function
    • Receptor
    • Regulatory
    • Band
    • Bp
    • Chr
    • Complex
  • psmd2
    • Chromosome
    • Expression
    • Human
    • Subunit
    • Rpn1
    • Function
    • Receptor
    • Regulatory
    • Band
    • Bp
    • Chr
    • Complex
  • gene
    • Chromosome
    • Human
    • Psmd2
    • Non-atpase
    • Band
    • Bp
    • Chr
    • Expression
    • Degradation
    • Tumor
    • Function
    • Receptor
  • proteasome
    • Subunit
    • Protein
    • Psmd2
    • Regulatory
    • Complex
    • Function
    • Gene
    • Rpn1
    • Receptor
    • Ubiquitin
    • Assembly
    • Clinical
  • ubiquitin–proteasome system
    • Subunit
    • Protein
    • Psmd2
    • Regulatory
    • Complex
    • Function
    • Ups
    • Gene
    • Rpn1
    • Receptor
    • Ubiquitin
    • Assembly
  • rpn1
    • Subunit
    • Base
    • Receptor
    • Subcomplex
    • Rpn2
    • Particle
    • Complex
    • 19s
    • Function
    • Protein
    • Ubiquitin
    • Assembly
  • clinical significance
    • Proteasome
    • Complex
    • Function
    • Receptor
    • Ubiquitin
    • Bp
    • Chr
    • Chromosome
    • Expression
    • Human
    • Two
    • Non-atpase
  • von hippel–lindau tumor suppressor
    • Via
    • Substrate
    • Degradation
    • Ups

Connections between topic areas Semantic bridges

For PSMD2, one of the stronger structural bridges in this analysis connects PSMD2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PSMD2Clinical significance · splits 13 ⟂ 60
PSMD2Structure · splits 68 ⟂ 5
PSMD2Interactions · splits 69 ⟂ 4
PSMD2Overview · splits 70 ⟂ 3

Map overview Semantic statistics

PSMD2

Nodes73
Edges72
Triples113
Avg. degree1.97
Density0.027397
Components1

Source & methodology

TTTA analyzes the structure around PSMD2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PSMD2 · EN edition · Analysis: TopicsToTalkAbout

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