ICAM-1 (intercellular adhesion molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also…
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ICAM-1 topic overview
The analysis highlights Function, Clinical significance and Structure as prominent areas in the source structure around ICAM-1.
Related topics
56
Source areas
5
Connected nodes
61
Extracted relationships
183
Concept neighborhoods
18
Bridge connections
61
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Function · 22 topics
Clinical significance · 12 topics
Overview · 12 topics
Structure · 8 topics
Interactions · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX
Band
19p13.2 · 9 A3|9 7.69 cM
Bgee
vena cava · upper lobe of left lung · cartilage tissue · right lung · beta cell
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 9 (mouse)
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How ICAM-1 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around ICAM-1 shows recurring relationship patterns in the source. For example, ICAM-1 → acute inflammatory response to antigenic stimulus, cell adhesion, cell adhesion mediated by integrin, cell surface, cell-cell adhesion, cellular response to alkaloid, cellular response to amyloid-beta, cellular response to dexamethasone stimulus, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to interleukin-6, cellular response to leukemia inhibitory factor, cellular response to lipopolysaccharide, cellular response to nutrient levels, cellular response to organic substance, cellular response to tumor necrosis factor, collagen-containing extracellular matrix, cytokine-mediated signaling pathway Another extracted example is ICAM-1 → ankle joint, aortic valve, beta cell, cartilage tissue, decidua, gallbladder, gastrula, left lung, left lung lobe, lower lobe of lung, lymph node, mesenteric lymph nodes, monocyte, right lung, right lung lobe, spleen, thymus, upper lobe of left lung, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.
ICAM-1
Top relations
Gene ontology· 81
ICAM-1 → acute inflammatory response to antigenic stimulus, cell adhesion, cell adhesion mediated by integrin, cell surface, cell-cell adhesion, cellular response to alkaloid, cellular response to amyloid-beta, cellular response to dexamethasone stimulus, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to interleukin-6, cellular response to leukemia inhibitory factor, cellular response to lipopolysaccharide, cellular response to nutrient levels, cellular response to organic substance, cellular response to tumor necrosis factor, collagen-containing extracellular matrix, cytokine-mediated signaling pathway
Bgee· 19
ICAM-1 → ankle joint, aortic valve, beta cell, cartilage tissue, decidua, gallbladder, gastrula, left lung, left lung lobe, lower lobe of lung, lymph node, mesenteric lymph nodes, monocyte, right lung, right lung lobe, spleen, thymus, upper lobe of left lung, vena cava
RNA expression pattern· 19
ICAM-1 → ankle joint, aortic valve, beta cell, cartilage tissue, decidua, gallbladder, gastrula, left lung, left lung lobe, lower lobe of lung, lymph node, mesenteric lymph nodes, monocyte, right lung, right lung lobe, spleen, thymus, upper lobe of left lung, vena cava
related to Other functions· 8
ICAM-1 → As, ITGAM, ITGB2, LFA-1, Mac-1, Notably, The, These
related to Function· 7
ICAM-1 → ICAM-1/LFA-1, IL-1, LFA-1, The, TNF, Upon, When
is a· 3
ICAM-1 → ligand for LFA-1, primary entry receptor for Coxsackievirus A21, transmembrane protein possessing an amino-terminus extracellular domain
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 183 structured relationships around ICAM-1. Examples in this analysis include ICAM-1 → Aliases → ICAM1, BB2, CD54, P3.58, intercellular adhesion molecule 1 and ICAM-1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX. The table shows each extracted connection, where it came from and its confidence.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX
1.00
infobox
ICAM-1
Band
19p13.2
1.00
infobox
ICAM-1
Band
9 A3|9 7.69 cM
1.00
infobox
ICAM-1
Bgee
vena cava
1.00
infobox
ICAM-1
Bgee
upper lobe of left lung
1.00
infobox
ICAM-1
Bgee
cartilage tissue
1.00
infobox
ICAM-1
Bgee
right lung
1.00
infobox
ICAM-1
Bgee
beta cell
1.00
infobox
ICAM-1
Bgee
gallbladder
1.00
infobox
ICAM-1
Bgee
lower lobe of lung
1.00
infobox
ICAM-1
Bgee
spleen
1.00
infobox
ICAM-1
Bgee
monocyte
1.00
infobox
ICAM-1
Bgee
lymph node
1.00
infobox
ICAM-1
Bgee
right lung lobe
1.00
infobox
ICAM-1
Bgee
left lung
1.00
infobox
ICAM-1
Bgee
left lung lobe
1.00
infobox
ICAM-1
Bgee
mesenteric lymph nodes
1.00
infobox
ICAM-1
Bgee
decidua
1.00
infobox
ICAM-1
Bgee
ankle joint
1.00
infobox
ICAM-1
Bgee
gastrula
1.00
infobox
ICAM-1
Bgee
thymus
1.00
infobox
ICAM-1
Bgee
aortic valve
1.00
infobox
ICAM-1
BioGPS
More reference expression data
1.00
infobox
ICAM-1
Chr.
Chromosome 19 (human)
1.00
infobox
ICAM-1
Chr.
Chromosome 9 (mouse)
1.00
infobox
ICAM-1
Databases
NCBI: entry; OMA: entry
1.00
infobox
ICAM-1
End
10,286,615 bp
1.00
infobox
ICAM-1
End
20,940,113 bp
1.00
infobox
ICAM-1
Ensembl
ENSG00000090339
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around ICAM-1 bring nearby vocabulary together. In this analysis, examples include Protein, Signaling and Adhesion. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
ICAM-1
Protein
Signaling
Adhesion
Binding
Also
Role
Endothelial
Cells
Found
Leukocyte
Signal
Transduction
icam-1
Protein
Signaling
Adhesion
Binding
Also
Role
Endothelial
Cells
Found
Leukocyte
Signal
Transduction
intercellular adhesion molecule
Molecule
Intercellular
Cell
Function
Entry
External
Gene
Icam1
Role
Human
Location
Chromosome
gene
Icam1
Location
Molecule
Cell
Chromosome
Bp
Chr
Intercellular
External
Human
Surface
Endothelial
endothelial
Cells
Surface
Leukocytes
Leukocyte
Expressed
Gene
Expression
Protein
Immune
Receptor
Inflammatory
Molecule
endothelial cells
Cells
Endothelial
Surface
Expressed
Leukocytes
Leukocyte
Gene
Immune
Inflammatory
Expression
Protein
Type
soluble icam-1
Protein
Signaling
Adhesion
Binding
Also
Role
Endothelial
Cells
Found
Leukocyte
Signal
Transduction
adhesion
Molecule
Intercellular
Function
Gene
Role
Icam1
Cell
Binding
Entry
Human
External
Location
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For ICAM-1, one of the stronger structural bridges in this analysis connects ICAM-1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
ICAM-1
Nodes62
Edges61
Triples183
Avg. degree1.97
Density0.032258
Components1
Source & methodology
TTTA analyzes the structure around ICAM-1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
