Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

PSMD4: Measurement, Clinical significance & Complex assembly

26S proteasome non-ATPase regulatory subunit 4, also as known as 26S Proteasome Regulatory Subunit Rpn10 (systematic nomenclature), is an enzyme that in humans is encoded by the PSMD4 gene. This protein is one of the 19 essential subunits that contributes to the complete assembly of 19S proteasome complex.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

PSMD4 topic overview

The analysis highlights Measurement, Clinical significance and Complex assembly as prominent areas in the source structure around PSMD4.

Related topics
60
Source areas
4
Connected nodes
64
Extracted relationships
108
Concept neighborhoods
9
Bridge connections
64

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 51 topics
Complex assembly · 4 topics
Interactions · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, proteasome 26S subunit, non-ATPase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P9C, 1P9D, 1UEL, 1YX4, 1YX5, 1YX6, 2KDE, 2KDF
Band
1q21.3 · 3 F2.1|3 40.74 cM
Bgee
apex of heart · left testis · right testis · gastrocnemius muscle · muscle of thigh
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Complex assembly

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PSMD4 connects Entity context

The extracted context around PSMD4 shows recurring relationship patterns in the source. For example, PSMD4 → anaphase-promoting complex-dependent catabolic process, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, cytosol, Fc-epsilon receptor signaling pathway, identical protein binding, interleukin-1-mediated signaling pathway, MAPK cascade, negative regulation of canonical Wnt signaling pathway, negative regulation of G2/M transition of mitotic cell cycle, NIK/NF-kappaB signaling, nucleoplasm, nucleus, polyubiquitin modification-dependent protein binding, positive regulation of canonical Wnt signaling pathway, post-translational protein modification, proteasome accessory complex, proteasome assembly, proteasome complex, proteasome regulatory particle, base subcomplex, proteasome-mediated ubiquitin-dependent protein catabolic process Another extracted example is PSMD4 → abdominal wall, amygdala, apex of heart, C1 segment, choroid plexus of fourth ventricle, facial motor nucleus, gastrocnemius muscle, left testis, lens, mandibular prominence, maxillary prominence, medial head of gastrocnemius muscle, monocyte, muscle layer of sigmoid colon, muscle of thigh, right frontal lobe, right testis, temporal muscle, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

PSMD4

Top relations

Gene ontology · 36
PSMD4 → anaphase-promoting complex-dependent catabolic process, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, cytosol, Fc-epsilon receptor signaling pathway, identical protein binding, interleukin-1-mediated signaling pathway, MAPK cascade, negative regulation of canonical Wnt signaling pathway, negative regulation of G2/M transition of mitotic cell cycle, NIK/NF-kappaB signaling, nucleoplasm, nucleus, polyubiquitin modification-dependent protein binding, positive regulation of canonical Wnt signaling pathway, post-translational protein modification, proteasome accessory complex, proteasome assembly, proteasome complex, proteasome regulatory particle, base subcomplex, proteasome-mediated ubiquitin-dependent protein catabolic process
Bgee · 19
PSMD4 → abdominal wall, amygdala, apex of heart, C1 segment, choroid plexus of fourth ventricle, facial motor nucleus, gastrocnemius muscle, left testis, lens, mandibular prominence, maxillary prominence, medial head of gastrocnemius muscle, monocyte, muscle layer of sigmoid colon, muscle of thigh, right frontal lobe, right testis, temporal muscle, yolk sac
RNA expression pattern · 19
PSMD4 → abdominal wall, amygdala, apex of heart, C1 segment, choroid plexus of fourth ventricle, facial motor nucleus, gastrocnemius muscle, left testis, lens, mandibular prominence, maxillary prominence, medial head of gastrocnemius muscle, monocyte, muscle layer of sigmoid colon, muscle of thigh, right frontal lobe, right testis, temporal muscle, yolk sac
related to Gene · 4
PSMD4 → ATPase, Pseudogenes, Rpn10, The
Band · 2
PSMD4 → 1q21.3, 3 F2.1|3 40.74 cM
Chr. · 2
PSMD4 → Chromosome 1 (human), Chromosome 3 (mouse)
End · 2
PSMD4 → 151,267,479 bp, 94,949,925 bp
related to Interactions · 2
PSMD4 → RAD23A, RAD23B
Aliases · 1
PSMD4 → PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, proteasome 26S subunit, non-ATPase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4
Available structures · 1
PSMD4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P9C, 1P9D, 1UEL, 1YX4, 1YX5, 1YX6, 2KDE, 2KDF

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein proteasome complex gene 19s regulatory base subunit rpn10 subunits human assembly ups bp particle band degradation 26s non-atpase chr

PSMD4 relationships Subject–Predicate–Object triples

TTTA extracted 108 structured relationships around PSMD4. Examples in this analysis include PSMD4 → Aliases → PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, proteasome 26S subunit, non-ATPase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4 and PSMD4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P9C, 1P9D, 1UEL, 1YX4, 1YX5, 1YX6, 2KDE, 2KDF. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PSMD4AliasesPSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, proteasome 26S subunit, non-ATPase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 41.00infobox
PSMD4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P9C, 1P9D, 1UEL, 1YX4, 1YX5, 1YX6, 2KDE, 2KDF1.00infobox
PSMD4Band1q21.31.00infobox
PSMD4Band3 F2.1|3 40.74 cM1.00infobox
PSMD4Bgeeapex of heart1.00infobox
PSMD4Bgeeleft testis1.00infobox
PSMD4Bgeeright testis1.00infobox
PSMD4Bgeegastrocnemius muscle1.00infobox
PSMD4Bgeemuscle of thigh1.00infobox
PSMD4Bgeeright frontal lobe1.00infobox
PSMD4Bgeemuscle layer of sigmoid colon1.00infobox
PSMD4Bgeeamygdala1.00infobox
PSMD4BgeeC1 segment1.00infobox
PSMD4Bgeemonocyte1.00infobox
PSMD4Bgeeyolk sac1.00infobox
PSMD4Bgeeabdominal wall1.00infobox
PSMD4Bgeefacial motor nucleus1.00infobox
PSMD4Bgeemandibular prominence1.00infobox
PSMD4Bgeemaxillary prominence1.00infobox
PSMD4Bgeetemporal muscle1.00infobox
PSMD4Bgeelens1.00infobox
PSMD4Bgeemedial head of gastrocnemius muscle1.00infobox
PSMD4Bgeechoroid plexus of fourth ventricle1.00infobox
PSMD4BioGPSMore reference expression data1.00infobox
PSMD4Chr.Chromosome 1 (human)1.00infobox
PSMD4Chr.Chromosome 3 (mouse)1.00infobox
PSMD4DatabasesNCBI: entry; OMA: entry1.00infobox
PSMD4End151,267,479 bp1.00infobox
PSMD4End94,949,925 bp1.00infobox
PSMD4EnsemblENSG000001593521.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PSMD4 bring nearby vocabulary together. In this analysis, examples include Chromosome, Human and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PSMD4
    • Chromosome
    • Human
    • Function
    • Location
    • Rpn10
    • Subunit
    • Band
    • Bp
    • Chr
    • Assembly
    • Regulatory
    • Amino
  • psmd4
    • Chromosome
    • Human
    • Function
    • Location
    • Rpn10
    • Subunit
    • Band
    • Bp
    • Chr
    • Assembly
    • Regulatory
    • Amino
  • gene
    • Chromosome
    • Psmd4
    • Human
    • Location
    • Expression
    • Band
    • Bp
    • Chr
    • Non-atpase
    • Degradation
    • Function
    • Proteasome
  • proteasome
    • Protein
    • Complex
    • Assembly
    • Subunit
    • Regulatory
    • Function
    • Gene
    • One
    • Ubiquitin
    • Clinical
    • Psmd4
    • 19s
  • ubiquitin–proteasome system
    • Protein
    • Complex
    • Assembly
    • Subunit
    • Regulatory
    • Function
    • Gene
    • One
    • Ubiquitin
    • Ups
    • Clinical
    • Psmd4
  • complex assembly
    • Complex
    • Function
    • One
    • Proteasome
    • Rpn10
    • Subunits
    • 19s
    • Location
    • Subunit
    • Essential
    • Protein
    • Ubiquitin
  • clinical significance
    • Proteasome
    • Function
    • Location
    • Complex
    • Ubiquitin
    • Bp
    • Chr
    • Chromosome
    • Psmd4
    • Human
    • Non-atpase
    • Gene
  • rpn1
    • Subunit
    • Rpn10
    • Subcomplex
    • Subunits

Connections between topic areas Semantic bridges

For PSMD4, one of the stronger structural bridges in this analysis connects PSMD4 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PSMD4Clinical significance · splits 13 ⟂ 52
PSMD4Complex assembly · splits 60 ⟂ 5
PSMD4Interactions · splits 61 ⟂ 4
PSMD4Overview · splits 62 ⟂ 3

Map overview Semantic statistics

PSMD4

Nodes65
Edges64
Triples108
Avg. degree1.97
Density0.030769
Components1

Source & methodology

TTTA analyzes the structure around PSMD4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Clinical significance & Complex assembly, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PSMD4 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.