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PSMD4

26S proteasome non-ATPase regulatory subunit 4, also as known as 26S Proteasome Regulatory Subunit Rpn10 (systematic nomenclature), is an enzyme that in humans is encoded by the PSMD4 gene. This protein is one of the 19 essential subunits that contributes to the complete assembly of 19S proteasome complex.

Measurement, Clinical significance & Complex assembly

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Clinical significance

51 related topics

Complex assembly

4 related topics

Interactions

3 related topics

Overview

2 related topics

Key facts & relationships

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Aliases
PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, proteasome 26S subunit, non-ATPase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P9C, 1P9D, 1UEL, 1YX4, 1YX5, 1YX6, 2KDE, 2KDF
Band
1q21.3 · 3 F2.1|3 40.74 cM
Bgee
apex of heart · left testis · right testis · gastrocnemius muscle · muscle of thigh
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)

Topics to explore

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Overview

Complex assembly

Clinical significance

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

PSMD4

Nodes65
Edges64
Triples108
Avg. degree1.97
Density0.030769
Components1

How this topic connects Entity context

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PSMD4

Top relations

Gene ontology · 36
PSMD4 → anaphase-promoting complex-dependent catabolic process, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, cytosol, Fc-epsilon receptor signaling pathway, identical protein binding, interleukin-1-mediated signaling pathway, MAPK cascade, negative regulation of canonical Wnt signaling pathway, negative regulation of G2/M transition of mitotic cell cycle, NIK/NF-kappaB signaling, nucleoplasm, nucleus, polyubiquitin modification-dependent protein binding, positive regulation of canonical Wnt signaling pathway, post-translational protein modification, proteasome accessory complex, proteasome assembly, proteasome complex, proteasome regulatory particle, base subcomplex, proteasome-mediated ubiquitin-dependent protein catabolic process
Bgee · 19
PSMD4 → abdominal wall, amygdala, apex of heart, C1 segment, choroid plexus of fourth ventricle, facial motor nucleus, gastrocnemius muscle, left testis, lens, mandibular prominence, maxillary prominence, medial head of gastrocnemius muscle, monocyte, muscle layer of sigmoid colon, muscle of thigh, right frontal lobe, right testis, temporal muscle, yolk sac
RNA expression pattern · 19
PSMD4 → abdominal wall, amygdala, apex of heart, C1 segment, choroid plexus of fourth ventricle, facial motor nucleus, gastrocnemius muscle, left testis, lens, mandibular prominence, maxillary prominence, medial head of gastrocnemius muscle, monocyte, muscle layer of sigmoid colon, muscle of thigh, right frontal lobe, right testis, temporal muscle, yolk sac
related to Gene · 4
PSMD4 → ATPase, Pseudogenes, Rpn10, The
Band · 2
PSMD4 → 1q21.3, 3 F2.1|3 40.74 cM
Chr. · 2
PSMD4 → Chromosome 1 (human), Chromosome 3 (mouse)
End · 2
PSMD4 → 151,267,479 bp, 94,949,925 bp
related to Interactions · 2
PSMD4 → RAD23A, RAD23B
Aliases · 1
PSMD4 → PSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, proteasome 26S subunit, non-ATPase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4
Available structures · 1
PSMD4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P9C, 1P9D, 1UEL, 1YX4, 1YX5, 1YX6, 2KDE, 2KDF

Important terminology Word statistics

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Important terminology

protein proteasome complex gene 19s regulatory base subunit rpn10 subunits human assembly ups bp particle band degradation 26s non-atpase chr

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PSMD4AliasesPSMD4, AF, AF-1, ASF, MCB1, Rpn10, S5A, pUB-R5, proteasome 26S subunit, non-ATPase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 41.00infobox
PSMD4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1P9C, 1P9D, 1UEL, 1YX4, 1YX5, 1YX6, 2KDE, 2KDF1.00infobox
PSMD4Band1q21.31.00infobox
PSMD4Band3 F2.1|3 40.74 cM1.00infobox
PSMD4Bgeeapex of heart1.00infobox
PSMD4Bgeeleft testis1.00infobox
PSMD4Bgeeright testis1.00infobox
PSMD4Bgeegastrocnemius muscle1.00infobox
PSMD4Bgeemuscle of thigh1.00infobox
PSMD4Bgeeright frontal lobe1.00infobox
PSMD4Bgeemuscle layer of sigmoid colon1.00infobox
PSMD4Bgeeamygdala1.00infobox
PSMD4BgeeC1 segment1.00infobox
PSMD4Bgeemonocyte1.00infobox
PSMD4Bgeeyolk sac1.00infobox
PSMD4Bgeeabdominal wall1.00infobox
PSMD4Bgeefacial motor nucleus1.00infobox
PSMD4Bgeemandibular prominence1.00infobox
PSMD4Bgeemaxillary prominence1.00infobox
PSMD4Bgeetemporal muscle1.00infobox
PSMD4Bgeelens1.00infobox
PSMD4Bgeemedial head of gastrocnemius muscle1.00infobox
PSMD4Bgeechoroid plexus of fourth ventricle1.00infobox
PSMD4BioGPSMore reference expression data1.00infobox
PSMD4Chr.Chromosome 1 (human)1.00infobox
PSMD4Chr.Chromosome 3 (mouse)1.00infobox
PSMD4DatabasesNCBI: entry; OMA: entry1.00infobox
PSMD4End151,267,479 bp1.00infobox
PSMD4End94,949,925 bp1.00infobox
PSMD4EnsemblENSG000001593521.00infobox

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