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Butriptyline: History, Community, Culture & Regions

Butriptyline, sold under the brand name Evadyne among others, is a tricyclic antidepressant (TCA) that has been used in the United Kingdom and several other European countries for the treatment of depression but appears to no longer be marketed. Along with trimipramine, iprindole, and amoxapine, it has been described as an "atypical" or…

Language: English [EN]
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Butriptyline topic overview

The analysis highlights History, Community, Culture and Regions as prominent areas in the source structure around Butriptyline.

Related topics
78
Source areas
6
Connected nodes
84
Extracted relationships
71
Concept neighborhoods
26
Bridge connections
84

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Chemistry · 22 topics
Side effects · 17 topics
Pharmacology · 14 topics
Society and culture · 14 topics
Overview · 10 topics
History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
N06AA15 (WHO)
Bioavailability
?
CAS Number
35941-65-2 Y · HCl: 5585-73-9 Y
ChEBI
CHEBI:135227 Y
ChEMBL
ChEMBL2110816 N

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Side effects

Pharmacology

Chemistry

History

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Butriptyline connects Entity context

The extracted context around Butriptyline shows recurring relationship patterns in the source. For example, Butriptyline → BANMTooltip British Approved Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, English, French, German, INNTooltip International Nonproprietary Name, Its, Latin, Name, Spanish, USANTooltip United States Adopted Another extracted example is Butriptyline → C21H27N, It, Other, TCA, TCAs, The, The CAS Registry Number. Use these groups to spot repeated connection types before inspecting the individual relationships.

Butriptyline

Top relations

related to Generic names · 12
Butriptyline → BANMTooltip British Approved Name, BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, English, French, German, INNTooltip International Nonproprietary Name, Its, Latin, Name, Spanish, USANTooltip United States Adopted
related to Chemistry · 7
Butriptyline → C21H27N, It, Other, TCA, TCAs, The, The CAS Registry Number
related to Availability · 6
Butriptyline → Austria, Belgium, Europe, Italy, Luxembourg, United Kingdom
related to Pharmacodynamics · 6
Butriptyline → As, However, HT2, In, TCAs, These
related to Brand names · 4
Butriptyline → Centrolese, Evadene, Evadyne, Evasidol
has effect · 3
Butriptyline → It, TCAs, The
CAS Number · 2
Butriptyline → 35941-65-2 Y, HCl: 5585-73-9 Y
Legal status · 2
Butriptyline → BR: Class C1 (Other controlled substances), In general: ℞ (Prescription only)
UNII · 2
Butriptyline → HCl: LIJ2H8658W Y, Z22441975X
is a · 2
Butriptyline → analogue of amitriptyline with an isobutyl side chain instead of a propylidene side chain, strong antihistamine and anticholinergic

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

side effects name amitriptyline tcas used united tca trimipramine brand evadyne number names kingdom marketed hydrochloride pharmacology generic depression iprindole

Butriptyline relationships Subject–Predicate–Object triples

TTTA extracted 71 structured relationships around Butriptyline. Examples in this analysis include Butriptyline → 3D model (JSmol) → Interactive image and Butriptyline → ATC code → N06AA15 (WHO). The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Butriptyline3D model (JSmol)Interactive image1.00infobox
ButriptylineATC codeN06AA15 (WHO)1.00infobox
ButriptylineBioavailability?1.00infobox
ButriptylineCAS Number35941-65-2 Y1.00infobox
ButriptylineCAS NumberHCl: 5585-73-9 Y1.00infobox
ButriptylineChEBICHEBI:135227 Y1.00infobox
ButriptylineChEMBLChEMBL2110816 N1.00infobox
ButriptylineChemSpider20462 Y1.00infobox
ButriptylineChiralityRacemic mixture1.00infobox
ButriptylineCompTox Dashboard (EPA)DTXSID60227151.00infobox
ButriptylineDrugBankDB09016 N1.00infobox
ButriptylineElimination half-life20 hours1.00infobox
ButriptylineFormulaC21H27N1.00infobox
ButriptylineKEGGD07601 Y1.00infobox
ButriptylineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
ButriptylineLegal statusIn general: ℞ (Prescription only)1.00infobox
ButriptylineMetabolismHepatic (N-demethylation)1.00infobox
ButriptylineMetabolitesNorbutriptyline1.00infobox
ButriptylineMolar mass293.454 g·mol−11.00infobox
ButriptylineOther namesAY-620141.00infobox
ButriptylineProtein binding>90%1.00infobox
ButriptylinePubChem CID217721.00infobox
ButriptylineRoutes of administrationOral1.00infobox
ButriptylineTrade namesEvadyne, others1.00infobox
ButriptylineUNIIZ22441975X1.00infobox
ButriptylineUNIIHCl: LIJ2H8658W Y1.00infobox
Butriptylineis astrong antihistamine and anticholinergic0.90text
Butriptylineis aanalogue of amitriptyline with an isobutyl side chain instead of a propylidene side chain0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Butriptyline bring nearby vocabulary together. In this analysis, examples include Side, United and Name. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Butriptyline
    • Side
    • United
    • Name
    • Effects
    • Evadyne
    • Kingdom
    • Marketed
    • Amitriptyline
    • 5-ht2
    • Antidepressant
    • Antihistamine
    • Depression
  • butriptyline
    • Side
    • United
    • Name
    • Effects
    • Evadyne
    • Kingdom
    • Marketed
    • Amitriptyline
    • 5-ht2
    • Antidepressant
    • Antihistamine
    • Depression
  • side effects
    • Side
    • Anticholinergic
    • Antihistamine
    • Sedation
    • Similar
    • 5-ht2
    • Iprindole
    • Names
    • Others
    • Pharmacodynamics
    • Pharmacology
    • Relatively
  • generic name
    • Depression
    • Treatment
    • Generic
    • Name
    • United
    • Used
    • Names
    • Others
    • Pharmacodynamics
    • Pharmacology
    • Drug
    • Hydrochloride
  • tricyclic antidepressant
    • 5-ht2
    • Depression
    • Dibenzocycloheptadiene
    • Imipramine
    • Others
    • Treatment
    • Tricyclic
    • Brand
    • Evadyne
    • Kingdom
    • Marketed
    • Similar
  • chemical name
    • Depression
    • Treatment
    • Generic
    • United
    • Used
    • 5585-73-9
    • Others
    • Protein
    • Tricyclic
    • Base
    • Drug
    • Free
  • depression
    • Treatment
    • Used
    • Name
    • 5585-73-9
    • Others
    • Protein
    • Tricyclic
    • Evadyne
    • Kingdom
    • Marketed
    • Number
    • Tca
  • united kingdom
    • United
    • Marketed
    • Depression
    • Others
    • Treatment
    • Tricyclic
    • Tca
    • Drug
    • Generic
    • Hydrochloride
    • Used
    • Name

Connections between topic areas Semantic bridges

For Butriptyline, one of the stronger structural bridges in this analysis connects Butriptyline with Chemistry. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ButriptylineChemistry · splits 62 ⟂ 23
ButriptylineSide effects · splits 67 ⟂ 18
ButriptylinePharmacology · splits 70 ⟂ 15
ButriptylineSociety and culture · splits 70 ⟂ 15
ButriptylineOverview · splits 74 ⟂ 11

Map overview Semantic statistics

Butriptyline

Nodes85
Edges84
Triples71
Avg. degree1.98
Density0.023529
Components1

Source & methodology

TTTA analyzes the structure around Butriptyline to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Butriptyline · EN edition · Analysis: TopicsToTalkAbout

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