MDC1

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Map view:

Zoom: 100%

More settings

Connection length 100% Label size 100% Node size 100% Line width 100% Label width 100%

Export map as:

MDC1 topic overview

The analysis highlights Function, Interactions and Regulation as prominent areas in the source structure around MDC1.

Related topics: 62
Source areas: 6
Connected nodes: 68
Extracted relationships: 163
Concept neighborhoods: 23
Bridge connections: 68

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 31 topics

Interactions · 9 topics

Regulation · 6 topics

Role in cancer · 6 topics

Overview · 5 topics

Protein structure · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: MDC1, NFBD1, mediator of DNA damage checkpoint 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ADO, 2AZM, 2ETX, 3K05, 3UEO, 3UMZ, 3UN0, 3UNM, 3UNN, 3UOT
Band: 6p21.33 · 17|17 B1
Bgee: right testis · left testis · right lobe of thyroid gland · ventricular zone · left lobe of thyroid gland
BioGPS: More reference expression data
Chr.: Chromosome 6 (human) · Chromosome 17 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Nuclear protein
Double-strand breaks
Ionizing radiation
Clastogens Clastogen
Kinases
DNA damage
Cell cycle checkpoints Cell cycle checkpoint
Chromatin
DSB DNA repair
MRN complex
ATM kinase Ataxia telangiectasia mutated
H2AX H2AFX
Histone
Phosphorylates Phosphorylation
C-terminus
Epigenetic Epigenetics
Apoptotic Apoptosis
Chk2
MDM2
A549 cells A549 cell
Genotoxic
Meiosis
Prophase
Oocytes Oocyte
DNA double-strand breaks DNA damage (naturally occurring)
Microtubule
CIP2A KIAA1524
TOPBP1
Spindle pole Spindle pole body
Chromosomes
SiRNA

Interactions

Interact Protein-protein interaction
APC/C Anaphase-promoting complex
CHEK2
H2AX
MRE11A
NBS1
RAD51
RNF8
TOPOα TOP2A

Protein structure

Regulation

Role in cancer

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MDC1 connects Entity context

The extracted context around MDC1 shows recurring relationship patterns in the source. For example, MDC1 → ATM, BRCT, C-terminus, CK2, DDR, DNA, DSB, E3, G2/M, H2AX, In, MRN, PST, RNF8, The, The DDR, The MDC1, The MDC1s, The SDT, This Another extracted example is MDC1 → body of uterus, cumulus cell, gastric mucosa, genital tubercle, hand, left lobe of thyroid gland, left ovary, left testis, neural layer of retina, pituitary gland, right lobe of thyroid gland, right ovary, right testis, spermatid, spermatocyte, tail of embryo, ventricular zone, yolk sac, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Role in DNA damage response · 22

MDC1 → ATM, BRCT, C-terminus, CK2, DDR, DNA, DSB, E3, G2/M, H2AX, In, MRN, PST, RNF8, The, The DDR, The MDC1, The MDC1s, The SDT, This

Bgee · 19

MDC1 → body of uterus, cumulus cell, gastric mucosa, genital tubercle, hand, left lobe of thyroid gland, left ovary, left testis, neural layer of retina, pituitary gland, right lobe of thyroid gland, right ovary, right testis, spermatid, spermatocyte, tail of embryo, ventricular zone, yolk sac, zygote

RNA expression pattern · 19

Gene ontology · 14

MDC1 → cell cycle, cellular response to DNA damage stimulus, chromosome, DNA repair, double-strand break repair via nonhomologous end joining, FHA domain binding, focal adhesion, identical protein binding, mitotic intra-S DNA damage checkpoint signaling, nuclear body, nucleoplasm, nucleus, protein binding, protein C-terminus binding

related to Role in cancer · 13

MDC1 → A549, Because, CaSki, DDR, HeLa, Knockout, MDC1s, Reduction, Several, SiHa, TE11, YES2, YES5

related to Protein structure · 12

MDC1 → BRCA, BRCT, C-terminal, C-terminus, FHA, N-terminal, N-terminus, PST- This, SDTD, The MDC1, This, TQXF- This

related to Role in apoptosis · 11

MDC1 → A549, ATM, BRC1, Chk2, DNA, E3, MDM2, Ser-15, Ser-20, Studies, The MDC1

related to Loss of MDC1 protein · 10

MDC1 → ATM, CHK1, CHK2, DRR, G2/M, Human, Inhibition, Intra-S, Knock, Mice

related to Interactions · 9

MDC1 → APC/C, ATM, CHEK2, H2AFX, MRE11A, NBS1, RAD51, RNF8, TOPOα

related to Role in meiosis · 3

MDC1 → CIP2A-MDC1-TOPBP1, DNA, In

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein dna damage domain cell p53 human chromosome atm cells bp ddr gene chr band mediator cycle response amino checkpoints

MDC1 relationships Subject–Predicate–Object triples

TTTA extracted 163 structured relationships around MDC1. Examples in this analysis include MDC1 → Aliases → MDC1, NFBD1, mediator of DNA damage checkpoint 1 and MDC1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ADO, 2AZM, 2ETX, 3K05, 3UEO, 3UMZ, 3UN0, 3UNM, 3UNN, 3UOT. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
MDC1	Aliases	MDC1, NFBD1, mediator of DNA damage checkpoint 1	1.00	infobox
MDC1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ADO, 2AZM, 2ETX, 3K05, 3UEO, 3UMZ, 3UN0, 3UNM, 3UNN, 3UOT	1.00	infobox
MDC1	Band	6p21.33	1.00	infobox
MDC1	Band	17\|17 B1	1.00	infobox
MDC1	Bgee	right testis	1.00	infobox
MDC1	Bgee	left testis	1.00	infobox
MDC1	Bgee	right lobe of thyroid gland	1.00	infobox
MDC1	Bgee	ventricular zone	1.00	infobox
MDC1	Bgee	left lobe of thyroid gland	1.00	infobox
MDC1	Bgee	right ovary	1.00	infobox
MDC1	Bgee	left ovary	1.00	infobox
MDC1	Bgee	gastric mucosa	1.00	infobox
MDC1	Bgee	body of uterus	1.00	infobox
MDC1	Bgee	pituitary gland	1.00	infobox
MDC1	Bgee	tail of embryo	1.00	infobox
MDC1	Bgee	spermatocyte	1.00	infobox
MDC1	Bgee	genital tubercle	1.00	infobox
MDC1	Bgee	zygote	1.00	infobox
MDC1	Bgee	cumulus cell	1.00	infobox
MDC1	Bgee	spermatid	1.00	infobox
MDC1	Bgee	hand	1.00	infobox
MDC1	Bgee	yolk sac	1.00	infobox
MDC1	Bgee	neural layer of retina	1.00	infobox
MDC1	BioGPS	More reference expression data	1.00	infobox
MDC1	Chr.	Chromosome 6 (human)	1.00	infobox
MDC1	Chr.	Chromosome 17 (mouse)	1.00	infobox
MDC1	Databases	NCBI: entry; OMA: entry	1.00	infobox
MDC1	End	30,717,447 bp	1.00	infobox
MDC1	End	36,170,562 bp	1.00	infobox
MDC1	Ensembl	ENSG00000224587 ENSG00000237095 ENSG00000137337 ENSG00000206481 ENSG00000234012 ENSG00000231135 ENSG00000228575 ENSG00000225589	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MDC1 bring nearby vocabulary together. In this analysis, examples include Protein, Human and P53. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

MDC1
- Protein
- Human
- P53
- Cells
- Cell
- Domain
- Cancer
- Tumor
- Atm
- Ddr
- Mrna
- Also
mdc1
- Protein
- Human
- P53
- Cells
- Cell
- Domain
- Cancer
- Tumor
- Atm
- Ddr
- Mrna
- Also
protein
- Domain
- Response
- Human
- P53
- Apoptosis
- Cancer
- Function
- Site
- Cells
- Nuclear
- Brct
- Location
gene
- Chromosome
- Location
- Bp
- Chr
- Band
- Function
- Human
- Response
- Mediator
- Nuclear
- C-terminus
- Meiosis
chromosome 6
- Gene
- Bp
- Chr
- Location
- Band
- Human
- Function
- Response
- Mediator
- Damage
- Dna
- Nuclear
nuclear protein
- Domain
- Brct
- C-terminus
- Location
- Mrna
- Repair
- Response
- Band
- Function
- Ionizing
- Human
- P53
dna damage
- Damage
- Dna
- Site
- Protein
- Ddr
- Function
- Complex
- Cycle
- Mediator
- Cell
- Atm
- Checkpoint
cell cycle checkpoints
- Checkpoints
- Cycle
- Repair
- Intra-s
- Damage
- Ddr
- Cancer
- Protein
- Response
- Dna
- Cells
- Function

Connections between topic areas Semantic bridges

For MDC1, one of the stronger structural bridges in this analysis connects MDC1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

MDC1 — Function · splits 37 ⟂ 32

MDC1 — Interactions · splits 59 ⟂ 10

MDC1 — Regulation · splits 62 ⟂ 7

MDC1 — Role in cancer · splits 62 ⟂ 7

MDC1 — Overview · splits 63 ⟂ 6

MDC1 — Protein structure · splits 63 ⟂ 6

Map overview Semantic statistics

MDC1

Nodes69

Edges68

Triples163

Avg. degree1.97

Density0.028986

Components1

Source & methodology

TTTA analyzes the structure around MDC1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Regulation, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MDC1 · EN edition · Analysis: TopicsToTalkAbout