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MDC1

Mediator of DNA damage checkpoint protein 1 is a 2080 amino acid long protein that in humans is encoded by the MDC1 gene located on the short arm (p) of chromosome 6. MDC1 protein is a regulator of the Intra-S phase and the G2/M cell cycle checkpoints and recruits repair proteins to the site of DNA damage. It is involved in determining cell survival fate…

Function, Interactions & Regulation

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Key facts & relationships

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Aliases
MDC1, NFBD1, mediator of DNA damage checkpoint 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ADO, 2AZM, 2ETX, 3K05, 3UEO, 3UMZ, 3UN0, 3UNM, 3UNN, 3UOT
Band
6p21.33 · 17|17 B1
Bgee
right testis · left testis · right lobe of thyroid gland · ventricular zone · left lobe of thyroid gland
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 17 (mouse)

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Overview

Function

Interactions

Protein structure

Regulation

Role in cancer

Advanced semantic analysis

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Map overview Semantic statistics

MDC1

Nodes69
Edges68
Triples163
Avg. degree1.97
Density0.028986
Components1

How this topic connects Entity context

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MDC1

Top relations

related to Role in DNA damage response · 22
MDC1 → ATM, BRCT, C-terminus, CK2, DDR, DNA, DSB, E3, G2/M, H2AX, In, MRN, PST, RNF8, The, The DDR, The MDC1, The MDC1s, The SDT, This
Bgee · 19
MDC1 → body of uterus, cumulus cell, gastric mucosa, genital tubercle, hand, left lobe of thyroid gland, left ovary, left testis, neural layer of retina, pituitary gland, right lobe of thyroid gland, right ovary, right testis, spermatid, spermatocyte, tail of embryo, ventricular zone, yolk sac, zygote
RNA expression pattern · 19
MDC1 → body of uterus, cumulus cell, gastric mucosa, genital tubercle, hand, left lobe of thyroid gland, left ovary, left testis, neural layer of retina, pituitary gland, right lobe of thyroid gland, right ovary, right testis, spermatid, spermatocyte, tail of embryo, ventricular zone, yolk sac, zygote
Gene ontology · 14
MDC1 → cell cycle, cellular response to DNA damage stimulus, chromosome, DNA repair, double-strand break repair via nonhomologous end joining, FHA domain binding, focal adhesion, identical protein binding, mitotic intra-S DNA damage checkpoint signaling, nuclear body, nucleoplasm, nucleus, protein binding, protein C-terminus binding
related to Role in cancer · 13
MDC1 → A549, Because, CaSki, DDR, HeLa, Knockout, MDC1s, Reduction, Several, SiHa, TE11, YES2, YES5
related to Protein structure · 12
MDC1 → BRCA, BRCT, C-terminal, C-terminus, FHA, N-terminal, N-terminus, PST- This, SDTD, The MDC1, This, TQXF- This
related to Role in apoptosis · 11
MDC1 → A549, ATM, BRC1, Chk2, DNA, E3, MDM2, Ser-15, Ser-20, Studies, The MDC1
related to Loss of MDC1 protein · 10
MDC1 → ATM, CHK1, CHK2, DRR, G2/M, Human, Inhibition, Intra-S, Knock, Mice
related to Interactions · 9
MDC1 → APC/C, ATM, CHEK2, H2AFX, MRE11A, NBS1, RAD51, RNF8, TOPOα
related to Role in meiosis · 3
MDC1 → CIP2A-MDC1-TOPBP1, DNA, In

Important terminology Word statistics

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Important terminology

protein dna damage domain cell p53 human chromosome atm cells bp ddr gene chr band mediator cycle response amino checkpoints

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MDC1AliasesMDC1, NFBD1, mediator of DNA damage checkpoint 11.00infobox
MDC1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ADO, 2AZM, 2ETX, 3K05, 3UEO, 3UMZ, 3UN0, 3UNM, 3UNN, 3UOT1.00infobox
MDC1Band6p21.331.00infobox
MDC1Band17|17 B11.00infobox
MDC1Bgeeright testis1.00infobox
MDC1Bgeeleft testis1.00infobox
MDC1Bgeeright lobe of thyroid gland1.00infobox
MDC1Bgeeventricular zone1.00infobox
MDC1Bgeeleft lobe of thyroid gland1.00infobox
MDC1Bgeeright ovary1.00infobox
MDC1Bgeeleft ovary1.00infobox
MDC1Bgeegastric mucosa1.00infobox
MDC1Bgeebody of uterus1.00infobox
MDC1Bgeepituitary gland1.00infobox
MDC1Bgeetail of embryo1.00infobox
MDC1Bgeespermatocyte1.00infobox
MDC1Bgeegenital tubercle1.00infobox
MDC1Bgeezygote1.00infobox
MDC1Bgeecumulus cell1.00infobox
MDC1Bgeespermatid1.00infobox
MDC1Bgeehand1.00infobox
MDC1Bgeeyolk sac1.00infobox
MDC1Bgeeneural layer of retina1.00infobox
MDC1BioGPSMore reference expression data1.00infobox
MDC1Chr.Chromosome 6 (human)1.00infobox
MDC1Chr.Chromosome 17 (mouse)1.00infobox
MDC1DatabasesNCBI: entry; OMA: entry1.00infobox
MDC1End30,717,447 bp1.00infobox
MDC1End36,170,562 bp1.00infobox
MDC1EnsemblENSG00000224587 ENSG00000237095 ENSG00000137337 ENSG00000206481 ENSG00000234012 ENSG00000231135 ENSG00000228575 ENSG000002255891.00infobox

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