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MRN complex: Role in human cancer, Biological function & Overview

The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin in humans and as Xrs2 in yeast). In eukaryotes, the MRN/X complex plays an important role in the initial processing of double-strand DNA breaks prior to repair by homologous recombination or non-homologous end joining. The MRN complex…

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MRN complex topic overview

The analysis highlights Role in human cancer, Biological function and Overview as prominent areas in the source structure around MRN complex.

Related topics
42
Source areas
5
Connected nodes
47
Extracted relationships
62
Concept neighborhoods
20
Bridge connections
47

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Role in human cancer · 21 topics
Overview · 13 topics
Biological function · 6 topics
Evolutionary ancestry and biologic function · 1 topics
Role in human disease · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Evolutionary ancestry and biologic function

Biological function

Role in human disease

Role in human cancer

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MRN complex connects Entity context

The extracted context around MRN complex shows recurring relationship patterns in the source. For example, MRN complex → ADP-ribose, ATM, BRCA, BRCA-proficient, Cancer, DNA, G2-M DNA, HNSCC, In, Likewise, Mirin, MRE11, MRN, MRN's, Nbs1, Overall, PARP, PARPi, PI3K/AKT, Specifically Another extracted example is MRN complex → All, ATLD, DNA, MRE11, MRN, Mutations, NBN, Nbs1, NBSLD, Nijmegen Breakage Syndrome, Nijmegen Breakage Syndrome-like, RAD50. Use these groups to spot repeated connection types before inspecting the individual relationships.

MRN complex

Top relations

related to Aggression · 24
MRN complex → ADP-ribose, ATM, BRCA, BRCA-proficient, Cancer, DNA, G2-M DNA, HNSCC, In, Likewise, Mirin, MRE11, MRN, MRN's, Nbs1, Overall, PARP, PARPi, PI3K/AKT, Specifically
related to Role in human disease · 12
MRN complex → All, ATLD, DNA, MRE11, MRN, Mutations, NBN, Nbs1, NBSLD, Nijmegen Breakage Syndrome, Nijmegen Breakage Syndrome-like, RAD50
related to Evolutionary ancestry and biologic function · 11
MRN complex → DNA, However, In, Mre11, MRN, Rad50, Similarly, Sulfolobus, Tetrahymena Mre11, The MRN, This
related to Repair of double-strand DNA breaks · 9
MRN complex → ATM, DNA, In, Initial, Likewise, MRE11, MRN, Nbs1, Rad50
related to Role in human cancer · 6
MRN complex → DNA, Double-strand DNA, However, MRN, Since, The MRN

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mrn dna mre11 complex nbs1 cancer repair cells cell telomere also double-strand breaks tumor rad50 role human atm protein homologous

MRN complex relationships Subject–Predicate–Object triples

TTTA extracted 62 structured relationships around MRN complex. Examples in this analysis include MRN complex → related to Aggression → Cancer and MRN complex → related to Aggression → The MRN. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MRN complexrelated to AggressionCancer0.60section
MRN complexrelated to AggressionThe MRN0.60section
MRN complexrelated to AggressionMRN0.60section
MRN complexrelated to AggressionIn0.60section
MRN complexrelated to AggressionHNSCC0.60section
MRN complexrelated to AggressionNbs10.60section
MRN complexrelated to AggressionDNA0.60section
MRN complexrelated to AggressionWhen0.60section
MRN complexrelated to AggressionPARP0.60section
MRN complexrelated to AggressionADP-ribose0.60section
MRN complexrelated to AggressionPARPi0.60section
MRN complexrelated to AggressionWhile0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around MRN complex bring nearby vocabulary together. In this analysis, examples include Mrn, Dna and Cancer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • MRN complex
    • Mrn
    • Dna
    • Cancer
    • Cell
    • Cells
    • Breaks
    • Double-strand
    • Telomere
    • Homologous
    • Recombination
    • Repair
    • Nbs1
  • mrn complex
    • Mrn
    • Dna
    • Also
    • Cancer
    • Cell
    • Cells
    • Breaks
    • Double-strand
    • End
    • Eukaryotes
    • Joining
    • Non-homologous
  • mrx complex
    • Mrn
    • Dna
    • Also
    • Breaks
    • Double-strand
    • End
    • Eukaryotes
    • Joining
    • Non-homologous
    • Homologous
    • Recombination
    • Repair
  • protein complex
    • Mrn
    • Dna
    • Rad50
    • Also
    • Breaks
    • Double-strand
    • End
    • Eukaryotes
    • Joining
    • Non-homologous
    • Homologous
    • Recombination
  • mre11
    • Protein
    • Rad50
    • Atm
    • Known
    • Repair
    • Also
    • Dna
    • Cell
    • Checkpoint
    • Nbs1
    • Pathway
    • Expression
  • double-strand dna breaks
    • Breaks
    • Double-strand
    • Repair
    • Dna
    • Homologous
    • Recombination
    • End
    • Eukaryotes
    • Joining
    • Non-homologous
    • Ends
    • Damage
  • dna end resection
    • Joining
    • Non-homologous
    • Repair
    • Homologous
    • Recombination
    • Eukaryotes
    • Breaks
    • Double-strand
    • Ends
    • Damage
    • Mrn
    • Radiation
  • cell cycle checkpoint
    • Atm
    • Lines
    • Damage
    • Human
    • Cells
    • Mrn
    • Tumor
    • Role
    • Dna
    • Telomere
    • Pathway
    • Repair

Connections between topic areas Semantic bridges

For MRN complex, one of the stronger structural bridges in this analysis connects MRN complex with Role in human cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MRN complex — Role in human cancer · splits 26 ⟂ 22
MRN complex — Overview · splits 34 ⟂ 14
MRN complex — Biological function · splits 41 ⟂ 7

Map overview Semantic statistics

MRN complex

Nodes48
Edges47
Triples62
Avg. degree1.96
Density0.041667
Components1

Source & methodology

TTTA analyzes the structure around MRN complex to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Role in human cancer, Biological function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MRN complex · EN edition · Analysis: TopicsToTalkAbout

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