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MRN complex

The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin in humans and as Xrs2 in yeast). In eukaryotes, the MRN/X complex plays an important role in the initial processing of double-strand DNA breaks prior to repair by homologous recombination or non-homologous end joining. The MRN complex…

Role in human cancer, Biological function & Overview

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Role in human cancer

HomeostasisCarcinogenesisMetastasisP53T-cell lymphomas
21 related topics

Biological function

Cell cycle checkpointTelomeresTERF2ShelterinT-loop
6 related topics

Overview

MRX complexProtein complexMre11Rad50Nbs1
13 related topics

Evolutionary ancestry and biologic function

Tetrahymena
1 related topics

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Overview

Evolutionary ancestry and biologic function

Biological function

Role in human disease

Role in human cancer

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Map overview Semantic statistics

MRN complex

Nodes48
Edges47
Triples62
Avg. degree1.96
Density0.041667
Components1

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MRN complex

Top relations

related to Aggression · 24
MRN complex → ADP-ribose, ATM, BRCA, BRCA-proficient, Cancer, DNA, G2-M DNA, HNSCC, In, Likewise, Mirin, MRE11, MRN, MRN's, Nbs1, Overall, PARP, PARPi, PI3K/AKT, Specifically
related to Role in human disease · 12
MRN complex → All, ATLD, DNA, MRE11, MRN, Mutations, NBN, Nbs1, NBSLD, Nijmegen Breakage Syndrome, Nijmegen Breakage Syndrome-like, RAD50
related to Evolutionary ancestry and biologic function · 11
MRN complex → DNA, However, In, Mre11, MRN, Rad50, Similarly, Sulfolobus, Tetrahymena Mre11, The MRN, This
related to Repair of double-strand DNA breaks · 9
MRN complex → ATM, DNA, In, Initial, Likewise, MRE11, MRN, Nbs1, Rad50
related to Role in human cancer · 6
MRN complex → DNA, Double-strand DNA, However, MRN, Since, The MRN

Important terminology Word statistics

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Important terminology

mrn dna mre11 complex nbs1 cancer repair cells cell telomere also double-strand breaks tumor rad50 role human atm protein homologous

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MRN complexrelated to AggressionCancer0.60section
MRN complexrelated to AggressionThe MRN0.60section
MRN complexrelated to AggressionMRN0.60section
MRN complexrelated to AggressionIn0.60section
MRN complexrelated to AggressionHNSCC0.60section
MRN complexrelated to AggressionNbs10.60section
MRN complexrelated to AggressionDNA0.60section
MRN complexrelated to AggressionWhen0.60section
MRN complexrelated to AggressionPARP0.60section
MRN complexrelated to AggressionADP-ribose0.60section
MRN complexrelated to AggressionPARPi0.60section
MRN complexrelated to AggressionWhile0.60section

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