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CIB1: Clinical significance, Interactions & Function

Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene and is located in chromosome 15. The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase…

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CIB1 topic overview

The analysis highlights Clinical significance, Interactions and Function as prominent areas in the source structure around CIB1.

Related topics
34
Source areas
5
Connected nodes
39
Extracted relationships
172
Concept neighborhoods
17
Bridge connections
39

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 14 topics
Overview · 7 topics
Interactions · 6 topics
Function · 4 topics
Structure · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CIB1, CIB, CIBP, KIP1, PRKDCIP, SIP2-28, calcium and integrin binding 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DGU, 1DGV, 1XO5, 1Y1A, 2L4H, 2L4I, 2LM5
Band
15q26.1 · 7|7 D2
Bgee
bronchial epithelial cell · mucosa of transverse colon · right uterine tube · olfactory zone of nasal mucosa · body of pancreas
BioGPS
More reference expression data
Chr.
Chromosome 15 (human) · Chromosome 7 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CIB1 connects Entity context

The extracted context around CIB1 shows recurring relationship patterns in the source. For example, CIB1 → angiogenesis, apical plasma membrane, apoptotic process, axon, calcium ion binding, calcium-dependent protein kinase inhibitor activity, cell adhesion, cell cycle, cell differentiation, cell division, cell periphery, cell projection, cellular response to DNA damage stimulus, cellular response to growth factor stimulus, cellular response to nerve growth factor stimulus, cellular response to tumor necrosis factor, centrosome, cytoplasm, cytoplasmic microtubule organization, cytoskeleton Another extracted example is CIB1 → body of pancreas, bronchial epithelial cell, crypt of lieberkuhn of small intestine, duodenum, epithelium of stomach, granulocyte, jejunum, left adrenal cortex, left adrenal gland, mucosa of transverse colon, nasal epithelium, olfactory zone of nasal mucosa, pyloric antrum, right adrenal gland, right kidney, right uterine tube, seminiferous tubule, spermatid, spermatocyte, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

CIB1

Top relations

Gene ontology · 80
CIB1 → angiogenesis, apical plasma membrane, apoptotic process, axon, calcium ion binding, calcium-dependent protein kinase inhibitor activity, cell adhesion, cell cycle, cell differentiation, cell division, cell periphery, cell projection, cellular response to DNA damage stimulus, cellular response to growth factor stimulus, cellular response to nerve growth factor stimulus, cellular response to tumor necrosis factor, centrosome, cytoplasm, cytoplasmic microtubule organization, cytoskeleton
Bgee · 20
CIB1 → body of pancreas, bronchial epithelial cell, crypt of lieberkuhn of small intestine, duodenum, epithelium of stomach, granulocyte, jejunum, left adrenal cortex, left adrenal gland, mucosa of transverse colon, nasal epithelium, olfactory zone of nasal mucosa, pyloric antrum, right adrenal gland, right kidney, right uterine tube, seminiferous tubule, spermatid, spermatocyte, yolk sac
RNA expression pattern · 20
CIB1 → body of pancreas, bronchial epithelial cell, crypt of lieberkuhn of small intestine, duodenum, epithelium of stomach, granulocyte, jejunum, left adrenal cortex, left adrenal gland, mucosa of transverse colon, nasal epithelium, olfactory zone of nasal mucosa, pyloric antrum, right adrenal gland, right kidney, right uterine tube, seminiferous tubule, spermatid, spermatocyte, yolk sac
related to Cancer · 8
CIB1 → High, In, It, Silencing CIB1, Small, Targeting CIB1, The, Upregulation
related to Interactions · 5
CIB1 → CD61, DNA-PKcs, PSEN2, RAC3, UBR5
related to Structure · 5
CIB1 → C-terminal, EF, In, It, N-terminus
related to Male infertility · 4
CIB1 → CatSper, In, Male, Studies
related to Spermatogenesis · 4
CIB1 → In, Spermatogenesis, Studies, This
Band · 2
CIB1 → 15q26.1, 7|7 D2
Chr. · 2
CIB1 → Chromosome 15 (human), Chromosome 7 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cancer shown protein gene sperm human also bp spermatogenesis expression differentiation chromosome 15 cell chr band function role calcium male

CIB1 relationships Subject–Predicate–Object triples

TTTA extracted 172 structured relationships around CIB1. Examples in this analysis include CIB1 → Aliases → CIB1, CIB, CIBP, KIP1, PRKDCIP, SIP2-28, calcium and integrin binding 1 and CIB1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DGU, 1DGV, 1XO5, 1Y1A, 2L4H, 2L4I, 2LM5. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CIB1AliasesCIB1, CIB, CIBP, KIP1, PRKDCIP, SIP2-28, calcium and integrin binding 11.00infobox
CIB1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DGU, 1DGV, 1XO5, 1Y1A, 2L4H, 2L4I, 2LM51.00infobox
CIB1Band15q26.11.00infobox
CIB1Band7|7 D21.00infobox
CIB1Bgeebronchial epithelial cell1.00infobox
CIB1Bgeemucosa of transverse colon1.00infobox
CIB1Bgeeright uterine tube1.00infobox
CIB1Bgeeolfactory zone of nasal mucosa1.00infobox
CIB1Bgeebody of pancreas1.00infobox
CIB1Bgeenasal epithelium1.00infobox
CIB1Bgeegranulocyte1.00infobox
CIB1Bgeeright adrenal gland1.00infobox
CIB1Bgeeleft adrenal gland1.00infobox
CIB1Bgeeleft adrenal cortex1.00infobox
CIB1Bgeespermatocyte1.00infobox
CIB1Bgeespermatid1.00infobox
CIB1Bgeeright kidney1.00infobox
CIB1Bgeeduodenum1.00infobox
CIB1Bgeeepithelium of stomach1.00infobox
CIB1Bgeeyolk sac1.00infobox
CIB1Bgeepyloric antrum1.00infobox
CIB1Bgeejejunum1.00infobox
CIB1Bgeecrypt of lieberkuhn of small intestine1.00infobox
CIB1Bgeeseminiferous tubule1.00infobox
CIB1BioGPSMore reference expression data1.00infobox
CIB1Chr.Chromosome 15 (human)1.00infobox
CIB1Chr.Chromosome 7 (mouse)1.00infobox
CIB1DatabasesNCBI: entry; OMA: entry1.00infobox
CIB1End90,234,047 bp1.00infobox
CIB1End79,882,561 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CIB1 bring nearby vocabulary together. In this analysis, examples include Shown, Cancer and Sperm. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CIB1
    • Shown
    • Cancer
    • Sperm
    • Expression
    • Also
    • Motility
    • Cell
    • Breast
    • Important
    • Involved
    • Male
    • Proliferation
  • cib1
    • Shown
    • Cancer
    • Sperm
    • Expression
    • Also
    • Motility
    • Cell
    • Breast
    • Important
    • Involved
    • Male
    • Proliferation
  • protein
    • Integrin
    • Cellular
    • Involved
    • Also
    • Adhesion
    • Band
    • Location
    • Migration
    • Process
    • Processes
    • Regulating
    • Signaling
  • calcium-binding protein
    • Integrin
    • Cellular
    • Involved
    • Also
    • Adhesion
    • Band
    • Location
    • Migration
    • Process
    • Processes
    • Regulating
    • Signaling
  • protein kinase
    • Integrin
    • Cellular
    • Involved
    • Also
    • Adhesion
    • Band
    • Location
    • Migration
    • Process
    • Processes
    • Regulating
    • Signaling
  • cell adhesion
    • Cellular
    • Migration
    • Adhesion
    • Cell
    • Involved
    • Proliferation
    • Signaling
    • Processes
    • Differentiation
    • Important
    • Including
    • Spermatogenesis
  • cancer
    • Cib1
    • Breast
    • Expression
    • Shown
    • Several
    • Including
    • Cellular
    • Migration
    • Processes
    • Function
    • Important
    • Involved
  • cell proliferation
    • Adhesion
    • Migration
    • Involved
    • Proliferation
    • Cellular
    • Signaling
    • Differentiation
    • Shown
    • Processes
    • Spermatogenesis
    • Important
    • Including

Connections between topic areas Semantic bridges

For CIB1, one of the stronger structural bridges in this analysis connects CIB1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CIB1 — Clinical significance · splits 25 ⟂ 15
CIB1 — Overview · splits 32 ⟂ 8
CIB1 — Interactions · splits 33 ⟂ 7
CIB1 — Function · splits 35 ⟂ 5
CIB1 — Structure · splits 36 ⟂ 4

Map overview Semantic statistics

CIB1

Nodes40
Edges39
Triples172
Avg. degree1.95
Density0.05
Components1

Source & methodology

TTTA analyzes the structure around CIB1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CIB1 · EN edition · Analysis: TopicsToTalkAbout

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