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Amphotericin B: History & Applications

Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. It is sometimes used as a drug of last resort for primary amoebic meningoencephalitis. For certain infections it…

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Amphotericin B topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Amphotericin B.

Related topics
116
Source areas
8
Connected nodes
124
Extracted relationships
99
Concept neighborhoods
20
Bridge connections
124

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 37 topics
Side effects · 34 topics
Interactions · 11 topics
Mechanism of action · 11 topics
Available formulations · 8 topics
History · 8 topics
Medical uses · 6 topics
Biosynthesis · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A01AB04 (WHO) A07AA07 (WHO), G01AA03 (WHO), J02AA01 (WHO)
Bioavailability
100% (IV) low (oral)
CAS Number
1397-89-3 Y
ChEBI
CHEBI:2682 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Available formulations

Side effects

Interactions

Mechanism of action

Biosynthesis

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Amphotericin B connects Entity context

The extracted context around Amphotericin B shows recurring relationship patterns in the source. For example, Amphotericin B → ABD, AmBisome, Amphotericin, Deoxycholate, Intravenously, Kidney, Less, Paracetamol, Reactions, The, This, To, Type, Very Another extracted example is Amphotericin B → Amphotericin, B's, B/ergosterol, Cl, It, Na, Researchers, Scedosporium, The, This, Two, Van, Waals. Use these groups to spot repeated connection types before inspecting the individual relationships.

Amphotericin B

Top relations

has effect · 14
Amphotericin B → ABD, AmBisome, Amphotericin, Deoxycholate, Intravenously, Kidney, Less, Paracetamol, Reactions, The, This, To, Type, Very
related to Mechanism of action · 13
Amphotericin B → Amphotericin, B's, B/ergosterol, Cl, It, Na, Researchers, Scedosporium, The, This, Two, Van, Waals
related to By mouth · 7
Amphotericin B → AmbiOnp, An, GI, However, In, Matinas Biopharma, The
related to External links · 7
Amphotericin B → AmBisome Summaries, Amphotericin, Lipid Complex Injection, Liposomal Injection, MedlinePlus, Product Characteristics, United Kingdom
related to Mechanism of toxicity · 7
Amphotericin B → Amphotericin, Bacteria, Because, Ergosterol, Mammalian, Reactivity, This
related to Intravenous · 3
Amphotericin B → Amphotericin, Lipid-based, Therefore
Elimination half-life · 2
Amphotericin B → Initial phase: 24 hours, Second phase: approximately 15 days
Excretion · 2
Amphotericin B → 40% found in urine after single cumulated over several days, Biliary excretion is also important
Legal status · 2
Amphotericin B → In general: ℞ (Prescription only), US: ℞-only
3D model (JSmol) · 1
Amphotericin B → Interactive image

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

amphotericin drug fungal effects may side also used infections toxicity lipid deoxycholate formulations liposomal cell membrane serious complex kidney low

Amphotericin B relationships Subject–Predicate–Object triples

TTTA extracted 99 structured relationships around Amphotericin B. Examples in this analysis include Amphotericin B → 3D model (JSmol) → Interactive image and Amphotericin B → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Amphotericin B3D model (JSmol)Interactive image1.00infobox
Amphotericin BAHFS/Drugs.comMonograph1.00infobox
Amphotericin BATC codeA01AB04 (WHO) A07AA07 (WHO), G01AA03 (WHO), J02AA01 (WHO)1.00infobox
Amphotericin BBioavailability100% (IV) low (oral)1.00infobox
Amphotericin BCAS Number1397-89-3 Y1.00infobox
Amphotericin BChEBICHEBI:2682 Y1.00infobox
Amphotericin BChEMBLChEMBL267345 Y1.00infobox
Amphotericin BChemSpider10237579 Y1.00infobox
Amphotericin BCompTox Dashboard (EPA)DTXSID90226011.00infobox
Amphotericin BDrugBankDB00681 Y1.00infobox
Amphotericin BECHA InfoCard100.014.3111.00infobox
Amphotericin BElimination half-lifeInitial phase: 24 hours1.00infobox
Amphotericin BElimination half-lifeSecond phase: approximately 15 days1.00infobox
Amphotericin BExcretion40% found in urine after single cumulated over several days1.00infobox
Amphotericin BExcretionBiliary excretion is also important1.00infobox
Amphotericin BFormulaC47H73NO171.00infobox
Amphotericin BKEGGD00203 Y1.00infobox
Amphotericin BLegal statusUS: ℞-only1.00infobox
Amphotericin BLegal statusIn general: ℞ (Prescription only)1.00infobox
Amphotericin BLicense dataUS DailyMed: Amphotericin_B1.00infobox
Amphotericin BMedlinePlusa6826431.00infobox
Amphotericin BMelting point170 °C (338 °F)1.00infobox
Amphotericin BMetabolismkidney1.00infobox
Amphotericin BMolar mass924.091 g·mol−11.00infobox
Amphotericin BNIAID ChemDB0000961.00infobox
Amphotericin BPregnancy categoryAU: B21.00infobox
Amphotericin BPubChem CID52809651.00infobox
Amphotericin BRoutes of administrationIntravenous infusion1.00infobox
Amphotericin BTrade namesFungizone, Mysteclin-F, AmBisome and other1.00infobox
Amphotericin BUNII7XU7A7DROE1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Amphotericin B bring nearby vocabulary together. In this analysis, examples include Fungal, Toxicity and Effects. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Amphotericin B
    • Fungal
    • Toxicity
    • Effects
    • May
    • Antifungal
    • Cell
    • Lipid
    • Also
    • Oral
    • Complex
    • Membrane
    • Formulations
  • amphotericin b
    • Fungal
    • Toxicity
    • Effects
    • May
    • Antifungal
    • Cell
    • Lipid
    • Also
    • Oral
    • Complex
    • Membrane
    • Formulations
  • fungal infections
    • Used
    • Cell
    • Membrane
    • Infections
    • Also
    • Side
    • Effects
    • Include
    • Medication
    • Toxicity
    • Given
    • Primary
  • side effects
    • Side
    • Kidney
    • Include
    • Risk
    • Low
    • Membrane
    • Toxicity
    • Formulations
    • Infections
    • Lipid
    • May
    • Fungal
  • antifungal
    • Infections
    • Medication
    • Fungal
    • Primary
    • Ambisome
    • Available
    • Effect
    • Oral
    • Two
    • Kidney
    • Liposomal
    • Low
  • kidney problems
    • Side
    • Renal
    • Risk
    • Toxicity
    • Ambisome
    • Liposomal
    • Low
    • Increased
    • Formulations
    • Medication
    • Blood
    • Reaction
  • low blood potassium
    • Serious
    • Blood
    • Low
    • Oral
    • Increased
    • Include
    • Side
    • Risk
    • Including
    • Renal
    • Kidney
    • Several
  • kidney damage
    • Side
    • Renal
    • Risk
    • Toxicity
    • Ambisome
    • Liposomal
    • Low
    • Increased
    • Formulations
    • Medication
    • Blood
    • Reaction

Connections between topic areas Semantic bridges

For Amphotericin B, one of the stronger structural bridges in this analysis connects Amphotericin B with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Amphotericin B — Overview · splits 87 ⟂ 38
Amphotericin B — Side effects · splits 90 ⟂ 35
Amphotericin B — Interactions · splits 113 ⟂ 12
Amphotericin B — Mechanism of action · splits 113 ⟂ 12
Amphotericin B — Available formulations · splits 116 ⟂ 9
Amphotericin B — History · splits 116 ⟂ 9
Amphotericin B — Medical uses · splits 118 ⟂ 7

Map overview Semantic statistics

Amphotericin B

Nodes125
Edges124
Triples99
Avg. degree1.98
Density0.016
Components1

Source & methodology

TTTA analyzes the structure around Amphotericin B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Amphotericin B · EN edition · Analysis: TopicsToTalkAbout

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