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IQGAP1: History, Key pathways & Clinical significance

Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene. IQGAP1 is a scaffold protein involved in regulating various cellular processes ranging from organization of the actin cytoskeleton, transcription, and cellular adhesion to regulating the cell cycle.

Language: English [EN]
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IQGAP1 topic overview

The analysis highlights History, Key pathways and Clinical significance as prominent areas in the source structure around IQGAP1.

Related topics
85
Source areas
10
Connected nodes
95
Extracted relationships
221
Concept neighborhoods
35
Bridge connections
95

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Key pathways · 17 topics
Clinical significance · 12 topics
Domains · 11 topics
Interactions · 10 topics
Function · 9 topics
Function as a Scaffold · 7 topics
Overview · 7 topics
History · 6 topics
Expression · 4 topics
Related Proteins · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IQGAP1, HUMORFA01, SAR1, p195, IQ motif containing GTPase activating protein 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X0H, 2RR8, 3FAY, 3I6X
Band
15q26.1 · 7 D3|7 45.68 cM
Bgee
Achilles tendon · epithelium of colon · monocyte · skin of hip · skin of thigh
BioGPS
More reference expression data
Chr.
Chromosome 15 (human) · Chromosome 7 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Expression

Domains

Related Proteins

Function

Interactions

Function as a Scaffold

Key pathways

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How IQGAP1 connects Entity context

The extracted context around IQGAP1 shows recurring relationship patterns in the source. For example, IQGAP1 → actin cytoskeleton, actin filament, axon, cadherin binding, calcium ion binding, calmodulin binding, cell leading edge, cell migration, cell-cell junction, cellular response to calcium ion, cellular response to epidermal growth factor stimulus, cellular response to fibroblast growth factor stimulus, cellular response to platelet-derived growth factor stimulus, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, epidermal growth factor receptor signaling pathway, extracellular exosome, extrinsic component of cytoplasmic side of plasma membrane, fibroblast growth factor receptor signaling pathway Another extracted example is IQGAP1 → Achilles tendon, body of uterus, carotid body, conjunctival fornix, corneal stroma, Descending thoracic aorta, epithelium of colon, granulocyte, left colon, left lung lobe, lower lobe of lung, monocyte, right coronary artery, right lung lobe, secondary oocyte, skin of hip, skin of thigh, stria vascularis, tibiofemoral joint, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.

IQGAP1

Top relations

Gene ontology · 69
IQGAP1 → actin cytoskeleton, actin filament, axon, cadherin binding, calcium ion binding, calmodulin binding, cell leading edge, cell migration, cell-cell junction, cellular response to calcium ion, cellular response to epidermal growth factor stimulus, cellular response to fibroblast growth factor stimulus, cellular response to platelet-derived growth factor stimulus, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, epidermal growth factor receptor signaling pathway, extracellular exosome, extrinsic component of cytoplasmic side of plasma membrane, fibroblast growth factor receptor signaling pathway
Bgee · 20
IQGAP1 → Achilles tendon, body of uterus, carotid body, conjunctival fornix, corneal stroma, Descending thoracic aorta, epithelium of colon, granulocyte, left colon, left lung lobe, lower lobe of lung, monocyte, right coronary artery, right lung lobe, secondary oocyte, skin of hip, skin of thigh, stria vascularis, tibiofemoral joint, vestibular membrane of cochlear duct
RNA expression pattern · 20
IQGAP1 → Achilles tendon, body of uterus, carotid body, conjunctival fornix, corneal stroma, Descending thoracic aorta, epithelium of colon, granulocyte, left colon, left lung lobe, lower lobe of lung, monocyte, right coronary artery, right lung lobe, secondary oocyte, skin of hip, skin of thigh, stria vascularis, tibiofemoral joint, vestibular membrane of cochlear duct
related to history · 18
IQGAP1 → Cdc42, GAP, GDP-bound, GRD, GTP, GTP-bound, GTPase, GTPases, However, Instead, IQGAP, IQGAP’s GAP, It, Its, RAC1, RasGAP-related, Rho GTPases Rac1, Sar1 GTPase
related to Function · 13
IQGAP1 → CAMs, Dia1, Expression, For, IQ, IQGAP, It, PTPmu, PTPRM, Ras-GAP, The, This, WW
related to ERK MAPK · 12
IQGAP1 → EGF, ERK MAPK, For, IGF-1, MEK, NGF, PDGF, Raf, The, The Ras, This, Various
related to Adhesion · 8
IQGAP1 → Actin, Active RAC1, Cadherins, E-cadherin, E-cadherins, IQGAP, Rac1, When IQGAP1
related to Cytoskeletal control (actin dynamics) · 7
IQGAP1 → Actin, Cdc42, Despite, GAP, RAC1, Rho GTPases CDC42, This
related to Function as a Scaffold · 6
IQGAP1 → As, Does, Far, Generally, Protein, Scaffolds
related to Domains · 5
IQGAP1 → CHD, It, N-terminus, Since, Starting

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

actin cell protein adhesion pathway cytoskeleton cellular binds signaling expression rac1 cdc42 cancer binding domain function cells mapk cycle human

IQGAP1 relationships Subject–Predicate–Object triples

TTTA extracted 221 structured relationships around IQGAP1. Examples in this analysis include IQGAP1 → Aliases → IQGAP1, HUMORFA01, SAR1, p195, IQ motif containing GTPase activating protein 1 and IQGAP1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X0H, 2RR8, 3FAY, 3I6X. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
IQGAP1AliasesIQGAP1, HUMORFA01, SAR1, p195, IQ motif containing GTPase activating protein 11.00infobox
IQGAP1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X0H, 2RR8, 3FAY, 3I6X1.00infobox
IQGAP1Band15q26.11.00infobox
IQGAP1Band7 D3|7 45.68 cM1.00infobox
IQGAP1BgeeAchilles tendon1.00infobox
IQGAP1Bgeeepithelium of colon1.00infobox
IQGAP1Bgeemonocyte1.00infobox
IQGAP1Bgeeskin of hip1.00infobox
IQGAP1Bgeeskin of thigh1.00infobox
IQGAP1Bgeeright coronary artery1.00infobox
IQGAP1Bgeebody of uterus1.00infobox
IQGAP1Bgeesecondary oocyte1.00infobox
IQGAP1BgeeDescending thoracic aorta1.00infobox
IQGAP1Bgeelower lobe of lung1.00infobox
IQGAP1Bgeeleft lung lobe1.00infobox
IQGAP1Bgeeright lung lobe1.00infobox
IQGAP1Bgeeleft colon1.00infobox
IQGAP1Bgeestria vascularis1.00infobox
IQGAP1Bgeetibiofemoral joint1.00infobox
IQGAP1Bgeevestibular membrane of cochlear duct1.00infobox
IQGAP1Bgeecorneal stroma1.00infobox
IQGAP1Bgeegranulocyte1.00infobox
IQGAP1Bgeeconjunctival fornix1.00infobox
IQGAP1Bgeecarotid body1.00infobox
IQGAP1BioGPSMore reference expression data1.00infobox
IQGAP1Chr.Chromosome 15 (human)1.00infobox
IQGAP1Chr.Chromosome 7 (mouse)1.00infobox
IQGAP1DatabasesNCBI: entry; OMA: entry1.00infobox
IQGAP1End90,502,239 bp1.00infobox
IQGAP1End80,475,722 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around IQGAP1 bring nearby vocabulary together. In this analysis, examples include Actin, Cellular and Adhesion. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • IQGAP1
    • Actin
    • Cellular
    • Adhesion
    • Expression
    • Protein
    • Cells
    • Cell
    • Binds
    • Rac1
    • Pathway
    • Cdc42
    • Signaling
  • iqgap1
    • Actin
    • Cellular
    • Adhesion
    • Expression
    • Protein
    • Cells
    • Cell
    • Binds
    • Rac1
    • Pathway
    • Cdc42
    • Signaling
  • protein
    • Domain
    • Function
    • Domains
    • Scaffold
    • Transcription
    • Pathways
    • Proteins
    • Many
    • Binding
    • Expression
    • Signaling
    • Binds
  • gene
    • Bp
    • Chr
    • Human
    • Band
    • Expression
    • Protein
    • Function
    • Adhesion
    • Domains
    • Dynamics
    • Erk
    • Extracellular
  • scaffold protein
    • Transcription
    • Domain
    • Human
    • Function
    • Pathways
    • Proteins
    • Domains
    • Scaffold
    • Expression
    • Many
    • Binding
    • Signaling
  • actin
    • Cytoskeleton
    • Cycle
    • Adhesion
    • Cell
    • Dynamics
    • Iqgap1
    • Cellular
    • Scaffold
    • Transcription
    • Binds
    • Cdc42
    • Rac1
  • cytoskeleton
    • Cycle
    • Adhesion
    • Cell
    • Scaffold
    • Signaling
    • Transcription
    • Protein
    • Binding
    • Iqgap1
    • Band
    • Bp
    • Chr
  • cellular adhesion
    • Cell
    • Cycle
    • Adhesion
    • Cellular
    • Cytoskeleton
    • Transcription
    • Scaffold
    • Signaling
    • Iqgap1
    • Actin
    • Protein
    • Dynamics

Connections between topic areas Semantic bridges

For IQGAP1, one of the stronger structural bridges in this analysis connects IQGAP1 with Key pathways. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
IQGAP1 — Key pathways · splits 78 ⟂ 18
IQGAP1 — Clinical significance · splits 83 ⟂ 13
IQGAP1 — Domains · splits 84 ⟂ 12
IQGAP1 — Interactions · splits 85 ⟂ 11
IQGAP1 — Function · splits 86 ⟂ 10
IQGAP1 — Overview · splits 88 ⟂ 8
IQGAP1 — Function as a Scaffold · splits 88 ⟂ 8
IQGAP1 — History · splits 89 ⟂ 7
IQGAP1 — Expression · splits 91 ⟂ 5
IQGAP1 — Related Proteins · splits 93 ⟂ 3

Map overview Semantic statistics

IQGAP1

Nodes96
Edges95
Triples221
Avg. degree1.98
Density0.020833
Components1

Source & methodology

TTTA analyzes the structure around IQGAP1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Key pathways & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — IQGAP1 · EN edition · Analysis: TopicsToTalkAbout

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