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IQGAP1

Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene. IQGAP1 is a scaffold protein involved in regulating various cellular processes ranging from organization of the actin cytoskeleton, transcription, and cellular adhesion to regulating the cell cycle.

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Aliases
IQGAP1, HUMORFA01, SAR1, p195, IQ motif containing GTPase activating protein 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X0H, 2RR8, 3FAY, 3I6X
Band
15q26.1 · 7 D3|7 45.68 cM
Bgee
Achilles tendon · epithelium of colon · monocyte · skin of hip · skin of thigh
BioGPS
More reference expression data
Chr.
Chromosome 15 (human) · Chromosome 7 (mouse)

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Overview

History

Expression

Domains

Related Proteins

Function

Interactions

Function as a Scaffold

Key pathways

Clinical significance

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Map overview Semantic statistics

IQGAP1

Nodes96
Edges95
Triples221
Avg. degree1.98
Density0.020833
Components1

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IQGAP1

Top relations

Gene ontology · 69
IQGAP1 → actin cytoskeleton, actin filament, axon, cadherin binding, calcium ion binding, calmodulin binding, cell leading edge, cell migration, cell-cell junction, cellular response to calcium ion, cellular response to epidermal growth factor stimulus, cellular response to fibroblast growth factor stimulus, cellular response to platelet-derived growth factor stimulus, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, epidermal growth factor receptor signaling pathway, extracellular exosome, extrinsic component of cytoplasmic side of plasma membrane, fibroblast growth factor receptor signaling pathway
Bgee · 20
IQGAP1 → Achilles tendon, body of uterus, carotid body, conjunctival fornix, corneal stroma, Descending thoracic aorta, epithelium of colon, granulocyte, left colon, left lung lobe, lower lobe of lung, monocyte, right coronary artery, right lung lobe, secondary oocyte, skin of hip, skin of thigh, stria vascularis, tibiofemoral joint, vestibular membrane of cochlear duct
RNA expression pattern · 20
IQGAP1 → Achilles tendon, body of uterus, carotid body, conjunctival fornix, corneal stroma, Descending thoracic aorta, epithelium of colon, granulocyte, left colon, left lung lobe, lower lobe of lung, monocyte, right coronary artery, right lung lobe, secondary oocyte, skin of hip, skin of thigh, stria vascularis, tibiofemoral joint, vestibular membrane of cochlear duct
related to history · 18
IQGAP1 → Cdc42, GAP, GDP-bound, GRD, GTP, GTP-bound, GTPase, GTPases, However, Instead, IQGAP, IQGAP’s GAP, It, Its, RAC1, RasGAP-related, Rho GTPases Rac1, Sar1 GTPase
related to Function · 13
IQGAP1 → CAMs, Dia1, Expression, For, IQ, IQGAP, It, PTPmu, PTPRM, Ras-GAP, The, This, WW
related to ERK MAPK · 12
IQGAP1 → EGF, ERK MAPK, For, IGF-1, MEK, NGF, PDGF, Raf, The, The Ras, This, Various
related to Adhesion · 8
IQGAP1 → Actin, Active RAC1, Cadherins, E-cadherin, E-cadherins, IQGAP, Rac1, When IQGAP1
related to Cytoskeletal control (actin dynamics) · 7
IQGAP1 → Actin, Cdc42, Despite, GAP, RAC1, Rho GTPases CDC42, This
related to Function as a Scaffold · 6
IQGAP1 → As, Does, Far, Generally, Protein, Scaffolds
related to Domains · 5
IQGAP1 → CHD, It, N-terminus, Since, Starting

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Important terminology

actin cell protein adhesion pathway cytoskeleton cellular binds signaling expression rac1 cdc42 cancer binding domain function cells mapk cycle human

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
IQGAP1AliasesIQGAP1, HUMORFA01, SAR1, p195, IQ motif containing GTPase activating protein 11.00infobox
IQGAP1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1X0H, 2RR8, 3FAY, 3I6X1.00infobox
IQGAP1Band15q26.11.00infobox
IQGAP1Band7 D3|7 45.68 cM1.00infobox
IQGAP1BgeeAchilles tendon1.00infobox
IQGAP1Bgeeepithelium of colon1.00infobox
IQGAP1Bgeemonocyte1.00infobox
IQGAP1Bgeeskin of hip1.00infobox
IQGAP1Bgeeskin of thigh1.00infobox
IQGAP1Bgeeright coronary artery1.00infobox
IQGAP1Bgeebody of uterus1.00infobox
IQGAP1Bgeesecondary oocyte1.00infobox
IQGAP1BgeeDescending thoracic aorta1.00infobox
IQGAP1Bgeelower lobe of lung1.00infobox
IQGAP1Bgeeleft lung lobe1.00infobox
IQGAP1Bgeeright lung lobe1.00infobox
IQGAP1Bgeeleft colon1.00infobox
IQGAP1Bgeestria vascularis1.00infobox
IQGAP1Bgeetibiofemoral joint1.00infobox
IQGAP1Bgeevestibular membrane of cochlear duct1.00infobox
IQGAP1Bgeecorneal stroma1.00infobox
IQGAP1Bgeegranulocyte1.00infobox
IQGAP1Bgeeconjunctival fornix1.00infobox
IQGAP1Bgeecarotid body1.00infobox
IQGAP1BioGPSMore reference expression data1.00infobox
IQGAP1Chr.Chromosome 15 (human)1.00infobox
IQGAP1Chr.Chromosome 7 (mouse)1.00infobox
IQGAP1DatabasesNCBI: entry; OMA: entry1.00infobox
IQGAP1End90,502,239 bp1.00infobox
IQGAP1End80,475,722 bp1.00infobox

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