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PRKACA: Measurement, Clinical significance & Discovery

The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the PRKACA gene. This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity. Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family (protein kinases A, G, and C), and contributes to the…

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PRKACA topic overview

The analysis highlights Measurement, Clinical significance and Discovery as prominent areas in the source structure around PRKACA.

Related topics
37
Source areas
5
Connected nodes
42
Extracted relationships
171
Concept neighborhoods
16
Bridge connections
42

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 14 topics
Discovery · 10 topics
Overview · 8 topics
Catalytic subunits · 4 topics
Signaling · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.11
Aliases
PRKACA, PKACA, PPNAD4, protein kinase cAMP-activated catalytic subunit alpha, CAFD1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GU8, 3AGL, 3AGM, 3AMA, 3AMB, 3L9L, 3L9M, 3L9N, 3MVJ, 3NX8, 3OOG, 3OVV, 3OWP, 3OXT, 3P0M, 3POO, 3VQH, 4AE6,…
Band
19p13.12 · 8|8 C2
Bgee
gastrocnemius muscle · apex of heart · left ventricle · right auricle of heart · skeletal muscle tissue
BioGPS
n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Catalytic subunits

Signaling

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PRKACA connects Entity context

The extracted context around PRKACA shows recurring relationship patterns in the source. For example, PRKACA → acrosomal vesicle, activation of protein kinase A activity, ATP binding, axoneme, blood coagulation, calcium channel complex, calcium-mediated signaling using intracellular calcium source, cAMP-dependent protein kinase activity, cAMP-dependent protein kinase complex, cell communication by electrical coupling involved in cardiac conduction, cell projection, cellular response to epinephrine stimulus, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to heat, cellular response to parathyroid hormone stimulus, centrosome, ciliary basal body-plasma membrane docking, ciliary base, cilium Another extracted example is PRKACA → apex of heart, brown adipose tissue, central gray substance of midbrain, dentate gyrus of hippocampal formation granule cell, dorsomedial hypothalamic nucleus, entorhinal cortex, gastrocnemius muscle, left adrenal cortex, left adrenal gland, left ventricle, medulla oblongata, muscle of thigh, perirhinal cortex, primary visual cortex, right adrenal cortex, right auricle of heart, skeletal muscle tissue, smooth muscle tissue, superior frontal gyrus. Use these groups to spot repeated connection types before inspecting the individual relationships.

PRKACA

Top relations

Gene ontology · 83
PRKACA → acrosomal vesicle, activation of protein kinase A activity, ATP binding, axoneme, blood coagulation, calcium channel complex, calcium-mediated signaling using intracellular calcium source, cAMP-dependent protein kinase activity, cAMP-dependent protein kinase complex, cell communication by electrical coupling involved in cardiac conduction, cell projection, cellular response to epinephrine stimulus, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to heat, cellular response to parathyroid hormone stimulus, centrosome, ciliary basal body-plasma membrane docking, ciliary base, cilium
Bgee · 19
PRKACA → apex of heart, brown adipose tissue, central gray substance of midbrain, dentate gyrus of hippocampal formation granule cell, dorsomedial hypothalamic nucleus, entorhinal cortex, gastrocnemius muscle, left adrenal cortex, left adrenal gland, left ventricle, medulla oblongata, muscle of thigh, perirhinal cortex, primary visual cortex, right adrenal cortex, right auricle of heart, skeletal muscle tissue, smooth muscle tissue, superior frontal gyrus
RNA expression pattern · 19
PRKACA → apex of heart, brown adipose tissue, central gray substance of midbrain, dentate gyrus of hippocampal formation granule cell, dorsomedial hypothalamic nucleus, entorhinal cortex, gastrocnemius muscle, left adrenal cortex, left adrenal gland, left ventricle, medulla oblongata, muscle of thigh, perirhinal cortex, primary visual cortex, right adrenal cortex, right auricle of heart, skeletal muscle tissue, smooth muscle tissue, superior frontal gyrus
related to Clinical significance · 12
PRKACA → Cushing's, It, Long QT, Mutations, One, Other, PKA, Protein, Several, The Cα, There, This
related to Catalytic subunits · 10
PRKACA → Another, Cα, Cα1, Cα2, Cβ, Cγ, In, PKA, The, There
related to External links · 3
PRKACA → Human, PDB, PDBe-KB
Band · 2
PRKACA → 19p13.12, 8|8 C2
Chr. · 2
PRKACA → Chromosome 19 (human), Chromosome 8 (mouse)
End · 2
PRKACA → 14,118,084 bp, 84,723,072 bp
2.7.11.11 · 1
PRKACA → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pka kinase protein catalytic gene enzyme subunit subunits human proteins activity bp chromosome 19 chr band found two cell

PRKACA relationships Subject–Predicate–Object triples

TTTA extracted 171 structured relationships around PRKACA. Examples in this analysis include PRKACA → 2.7.11.11 → ↗ and PRKACA → Aliases → PRKACA, PKACA, PPNAD4, protein kinase cAMP-activated catalytic subunit alpha, CAFD1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PRKACA2.7.11.111.00infobox
PRKACAAliasesPRKACA, PKACA, PPNAD4, protein kinase cAMP-activated catalytic subunit alpha, CAFD11.00infobox
PRKACAAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GU8, 3AGL, 3AGM, 3AMA, 3AMB, 3L9L, 3L9M, 3L9N, 3MVJ, 3NX8, 3OOG, 3OVV, 3OWP, 3OXT, 3P0M, 3POO, 3VQH, 4AE6,…1.00infobox
PRKACABand19p13.121.00infobox
PRKACABand8|8 C21.00infobox
PRKACABgeegastrocnemius muscle1.00infobox
PRKACABgeeapex of heart1.00infobox
PRKACABgeeleft ventricle1.00infobox
PRKACABgeeright auricle of heart1.00infobox
PRKACABgeeskeletal muscle tissue1.00infobox
PRKACABgeemuscle of thigh1.00infobox
PRKACABgeeleft adrenal gland1.00infobox
PRKACABgeeleft adrenal cortex1.00infobox
PRKACABgeeright adrenal cortex1.00infobox
PRKACABgeesmooth muscle tissue1.00infobox
PRKACABgeedentate gyrus of hippocampal formation granule cell1.00infobox
PRKACABgeedorsomedial hypothalamic nucleus1.00infobox
PRKACABgeeentorhinal cortex1.00infobox
PRKACABgeeperirhinal cortex1.00infobox
PRKACABgeesuperior frontal gyrus1.00infobox
PRKACABgeeprimary visual cortex1.00infobox
PRKACABgeebrown adipose tissue1.00infobox
PRKACABgeemedulla oblongata1.00infobox
PRKACABgeecentral gray substance of midbrain1.00infobox
PRKACABioGPSn/a1.00infobox
PRKACAChr.Chromosome 19 (human)1.00infobox
PRKACAChr.Chromosome 8 (mouse)1.00infobox
PRKACADatabasesNCBI: entry; OMA: entry1.00infobox
PRKACAEnd14,118,084 bp1.00infobox
PRKACAEnd84,723,072 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PRKACA bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Subunit. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PRKACA
    • Gene
    • Protein
    • Subunit
    • Signaling
    • Activity
    • Chromosome
    • Human
    • Found
    • Location
    • Phosphorylation
    • Adrenal
    • Camp-dependent
  • prkaca
    • Gene
    • Protein
    • Subunit
    • Signaling
    • Activity
    • Chromosome
    • Human
    • Found
    • Location
    • Phosphorylation
    • Adrenal
    • Camp-dependent
  • enzyme
    • Activity
    • Key
    • Proteins
    • Kinase
    • Subunit
    • Gene
    • Prkaca
    • Regulatory
    • Protein
    • Pka
    • Subunits
    • Responsible
  • gene
    • Prkaca
    • Location
    • Adrenal
    • Signaling
    • Bp
    • Chr
    • Activity
    • Chromosome
    • Human
    • Protein
    • Mouse
    • Subunit
  • protein kinase a
    • Kinase
    • Protein
    • Camp-dependent
    • Subunit
    • Prkaca
    • Enzyme
    • Gene
    • Cell
    • Human
    • Cellular
    • Complex
    • Location
  • agc kinase family
    • Protein
    • Subunit
    • Camp-dependent
    • Enzyme
    • Prkaca
    • Cell
    • Human
    • Gene
    • Pka
    • Cellular
    • Key
    • Location
  • cell division
    • Cellular
    • Kinase
    • Proteins
    • Subunit
    • Mouse
    • Complex
    • Contributes
    • Expressed
    • Location
    • Phosphorylation
    • Protein
    • Adrenal
  • adrenal cortex
    • Disease
    • Gene
    • Mouse
    • Cellular
    • Complex
    • Expressed
    • Location
    • Phosphorylation
    • Prkaca
    • Also
    • Band
    • Camp-dependent

Connections between topic areas Semantic bridges

For PRKACA, one of the stronger structural bridges in this analysis connects PRKACA with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PRKACAClinical significance · splits 28 ⟂ 15
PRKACADiscovery · splits 32 ⟂ 11
PRKACAOverview · splits 34 ⟂ 9
PRKACACatalytic subunits · splits 38 ⟂ 5

Map overview Semantic statistics

PRKACA

Nodes43
Edges42
Triples171
Avg. degree1.95
Density0.046512
Components1

Source & methodology

TTTA analyzes the structure around PRKACA to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Clinical significance & Discovery, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PRKACA · EN edition · Analysis: TopicsToTalkAbout

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