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PRKACA

The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the PRKACA gene. This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity. Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family (protein kinases A, G, and C), and contributes to the…

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2.7.11.11
Aliases
PRKACA, PKACA, PPNAD4, protein kinase cAMP-activated catalytic subunit alpha, CAFD1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GU8, 3AGL, 3AGM, 3AMA, 3AMB, 3L9L, 3L9M, 3L9N, 3MVJ, 3NX8, 3OOG, 3OVV, 3OWP, 3OXT, 3P0M, 3POO, 3VQH, 4AE6,…
Band
19p13.12 · 8|8 C2
Bgee
gastrocnemius muscle · apex of heart · left ventricle · right auricle of heart · skeletal muscle tissue
BioGPS
n/a

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Overview

Discovery

Catalytic subunits

Signaling

Clinical significance

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Map overview Semantic statistics

PRKACA

Nodes43
Edges42
Triples171
Avg. degree1.95
Density0.046512
Components1

How this topic connects Entity context

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PRKACA

Top relations

Gene ontology · 83
PRKACA → acrosomal vesicle, activation of protein kinase A activity, ATP binding, axoneme, blood coagulation, calcium channel complex, calcium-mediated signaling using intracellular calcium source, cAMP-dependent protein kinase activity, cAMP-dependent protein kinase complex, cell communication by electrical coupling involved in cardiac conduction, cell projection, cellular response to epinephrine stimulus, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to heat, cellular response to parathyroid hormone stimulus, centrosome, ciliary basal body-plasma membrane docking, ciliary base, cilium
Bgee · 19
PRKACA → apex of heart, brown adipose tissue, central gray substance of midbrain, dentate gyrus of hippocampal formation granule cell, dorsomedial hypothalamic nucleus, entorhinal cortex, gastrocnemius muscle, left adrenal cortex, left adrenal gland, left ventricle, medulla oblongata, muscle of thigh, perirhinal cortex, primary visual cortex, right adrenal cortex, right auricle of heart, skeletal muscle tissue, smooth muscle tissue, superior frontal gyrus
RNA expression pattern · 19
PRKACA → apex of heart, brown adipose tissue, central gray substance of midbrain, dentate gyrus of hippocampal formation granule cell, dorsomedial hypothalamic nucleus, entorhinal cortex, gastrocnemius muscle, left adrenal cortex, left adrenal gland, left ventricle, medulla oblongata, muscle of thigh, perirhinal cortex, primary visual cortex, right adrenal cortex, right auricle of heart, skeletal muscle tissue, smooth muscle tissue, superior frontal gyrus
related to Clinical significance · 12
PRKACA → Cushing's, It, Long QT, Mutations, One, Other, PKA, Protein, Several, The Cα, There, This
related to Catalytic subunits · 10
PRKACA → Another, Cα, Cα1, Cα2, Cβ, Cγ, In, PKA, The, There
related to External links · 3
PRKACA → Human, PDB, PDBe-KB
Band · 2
PRKACA → 19p13.12, 8|8 C2
Chr. · 2
PRKACA → Chromosome 19 (human), Chromosome 8 (mouse)
End · 2
PRKACA → 14,118,084 bp, 84,723,072 bp
2.7.11.11 · 1
PRKACA → ↗

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Important terminology

pka kinase protein catalytic gene enzyme subunit subunits human proteins activity bp chromosome 19 chr band found two cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PRKACA2.7.11.111.00infobox
PRKACAAliasesPRKACA, PKACA, PPNAD4, protein kinase cAMP-activated catalytic subunit alpha, CAFD11.00infobox
PRKACAAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GU8, 3AGL, 3AGM, 3AMA, 3AMB, 3L9L, 3L9M, 3L9N, 3MVJ, 3NX8, 3OOG, 3OVV, 3OWP, 3OXT, 3P0M, 3POO, 3VQH, 4AE6,…1.00infobox
PRKACABand19p13.121.00infobox
PRKACABand8|8 C21.00infobox
PRKACABgeegastrocnemius muscle1.00infobox
PRKACABgeeapex of heart1.00infobox
PRKACABgeeleft ventricle1.00infobox
PRKACABgeeright auricle of heart1.00infobox
PRKACABgeeskeletal muscle tissue1.00infobox
PRKACABgeemuscle of thigh1.00infobox
PRKACABgeeleft adrenal gland1.00infobox
PRKACABgeeleft adrenal cortex1.00infobox
PRKACABgeeright adrenal cortex1.00infobox
PRKACABgeesmooth muscle tissue1.00infobox
PRKACABgeedentate gyrus of hippocampal formation granule cell1.00infobox
PRKACABgeedorsomedial hypothalamic nucleus1.00infobox
PRKACABgeeentorhinal cortex1.00infobox
PRKACABgeeperirhinal cortex1.00infobox
PRKACABgeesuperior frontal gyrus1.00infobox
PRKACABgeeprimary visual cortex1.00infobox
PRKACABgeebrown adipose tissue1.00infobox
PRKACABgeemedulla oblongata1.00infobox
PRKACABgeecentral gray substance of midbrain1.00infobox
PRKACABioGPSn/a1.00infobox
PRKACAChr.Chromosome 19 (human)1.00infobox
PRKACAChr.Chromosome 8 (mouse)1.00infobox
PRKACADatabasesNCBI: entry; OMA: entry1.00infobox
PRKACAEnd14,118,084 bp1.00infobox
PRKACAEnd84,723,072 bp1.00infobox

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