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The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the PRKACA gene. This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity. Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family (protein kinases A, G, and C), and contributes to the…
The analysis highlights Measurement, Clinical significance and Discovery as prominent areas in the source structure around PRKACA.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around PRKACA shows recurring relationship patterns in the source. For example, PRKACA → acrosomal vesicle, activation of protein kinase A activity, ATP binding, axoneme, blood coagulation, calcium channel complex, calcium-mediated signaling using intracellular calcium source, cAMP-dependent protein kinase activity, cAMP-dependent protein kinase complex, cell communication by electrical coupling involved in cardiac conduction, cell projection, cellular response to epinephrine stimulus, cellular response to glucagon stimulus, cellular response to glucose stimulus, cellular response to heat, cellular response to parathyroid hormone stimulus, centrosome, ciliary basal body-plasma membrane docking, ciliary base, cilium Another extracted example is PRKACA → apex of heart, brown adipose tissue, central gray substance of midbrain, dentate gyrus of hippocampal formation granule cell, dorsomedial hypothalamic nucleus, entorhinal cortex, gastrocnemius muscle, left adrenal cortex, left adrenal gland, left ventricle, medulla oblongata, muscle of thigh, perirhinal cortex, primary visual cortex, right adrenal cortex, right auricle of heart, skeletal muscle tissue, smooth muscle tissue, superior frontal gyrus. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
pka kinase protein catalytic gene enzyme subunit subunits human proteins activity bp chromosome 19 chr band found two cα cell
TTTA extracted 171 structured relationships around PRKACA. Examples in this analysis include PRKACA → 2.7.11.11 → ↗ and PRKACA → Aliases → PRKACA, PKACA, PPNAD4, protein kinase cAMP-activated catalytic subunit alpha, CAFD1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| PRKACA | 2.7.11.11 | ↗ | 1.00 | infobox |
| PRKACA | Aliases | PRKACA, PKACA, PPNAD4, protein kinase cAMP-activated catalytic subunit alpha, CAFD1 | 1.00 | infobox |
| PRKACA | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GU8, 3AGL, 3AGM, 3AMA, 3AMB, 3L9L, 3L9M, 3L9N, 3MVJ, 3NX8, 3OOG, 3OVV, 3OWP, 3OXT, 3P0M, 3POO, 3VQH, 4AE6,… | 1.00 | infobox |
| PRKACA | Band | 19p13.12 | 1.00 | infobox |
| PRKACA | Band | 8|8 C2 | 1.00 | infobox |
| PRKACA | Bgee | gastrocnemius muscle | 1.00 | infobox |
| PRKACA | Bgee | apex of heart | 1.00 | infobox |
| PRKACA | Bgee | left ventricle | 1.00 | infobox |
| PRKACA | Bgee | right auricle of heart | 1.00 | infobox |
| PRKACA | Bgee | skeletal muscle tissue | 1.00 | infobox |
| PRKACA | Bgee | muscle of thigh | 1.00 | infobox |
| PRKACA | Bgee | left adrenal gland | 1.00 | infobox |
| PRKACA | Bgee | left adrenal cortex | 1.00 | infobox |
| PRKACA | Bgee | right adrenal cortex | 1.00 | infobox |
| PRKACA | Bgee | smooth muscle tissue | 1.00 | infobox |
| PRKACA | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| PRKACA | Bgee | dorsomedial hypothalamic nucleus | 1.00 | infobox |
| PRKACA | Bgee | entorhinal cortex | 1.00 | infobox |
| PRKACA | Bgee | perirhinal cortex | 1.00 | infobox |
| PRKACA | Bgee | superior frontal gyrus | 1.00 | infobox |
| PRKACA | Bgee | primary visual cortex | 1.00 | infobox |
| PRKACA | Bgee | brown adipose tissue | 1.00 | infobox |
| PRKACA | Bgee | medulla oblongata | 1.00 | infobox |
| PRKACA | Bgee | central gray substance of midbrain | 1.00 | infobox |
| PRKACA | BioGPS | n/a | 1.00 | infobox |
| PRKACA | Chr. | Chromosome 19 (human) | 1.00 | infobox |
| PRKACA | Chr. | Chromosome 8 (mouse) | 1.00 | infobox |
| PRKACA | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| PRKACA | End | 14,118,084 bp | 1.00 | infobox |
| PRKACA | End | 84,723,072 bp | 1.00 | infobox |
The concept neighborhoods around PRKACA bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Subunit. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For PRKACA, one of the stronger structural bridges in this analysis connects PRKACA with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around PRKACA to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Clinical significance & Discovery, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — PRKACA · EN edition · Analysis: TopicsToTalkAbout