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Intermediate filament: Structure, Types & Function

Intermediate filaments (IFs) are cytoskeletal structural components found in the cells of vertebrates, and many invertebrates. Homologues of the IF protein have been noted in an invertebrate, the cephalochordate Branchiostoma.

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Intermediate filament topic overview

The analysis highlights Structure, Types and Function as prominent areas in the source structure around Intermediate filament.

Related topics
95
Source areas
7
Connected nodes
102
Extracted relationships
48
Concept neighborhoods
28
Bridge connections
102

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Types · 37 topics
Structure · 21 topics
Overview · 15 topics
Function · 10 topics
Diseases arising from mutations in IF genes · 6 topics
In other organisms · 5 topics
Biomechanical properties · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR001322 · PF00932
Available protein structures:
IPR001322 · PF00932
InterPro
IPR001322
PDB
IPR001322 PF00932 (ECOD; PDBsum)
Pfam
PF00932
PROSITE
PDOC00198

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Biomechanical properties

Types

Function

Diseases arising from mutations in IF genes

In other organisms

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Intermediate filament connects Entity context

The extracted context around Intermediate filament shows recurring relationship patterns in the source. For example, Intermediate filament → Bilateria, Cytoplasmic IFs, Functionally-similar, IF, IF-like, In, IV, The Hydra, There, They, VI, With Another extracted example is Intermediate filament → Desmin IFs, GFAP, Glial, IF, III, III IF, Peripherin, Syncoilin, There, They, Vimentin. Use these groups to spot repeated connection types before inspecting the individual relationships.

Intermediate filament

Top relations

related to In other organisms · 12
Intermediate filament → Bilateria, Cytoplasmic IFs, Functionally-similar, IF, IF-like, In, IV, The Hydra, There, They, VI, With
related to Type III · 11
Intermediate filament → Desmin IFs, GFAP, Glial, IF, III, III IF, Peripherin, Syncoilin, There, They, Vimentin
related to Structure · 6
Intermediate filament → Analysis, As, IF, Structural, The, This
related to Types · 5
Intermediate filament → Animal IFs, However, IFs, In, There
related to Type IV · 3
Intermediate filament → Alpha-internexinNeurofilaments, IV, SyneminSyncoilin
AlphaFold · 2
Intermediate filament → IPR001322, PF00932
Available protein structures: · 2
Intermediate filament → IPR001322, PF00932
InterPro · 1
Intermediate filament → IPR001322
PDB · 1
Intermediate filament → IPR001322 PF00932 (ECOD; PDBsum)
Pfam · 1
Intermediate filament → PF00932

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

proteins protein intermediate filaments type lamins nuclear cells structure lamin ifs types filament citation needed found sequence keratin keratins microtubules

Intermediate filament relationships Subject–Predicate–Object triples

TTTA extracted 48 structured relationships around Intermediate filament. Examples in this analysis include Intermediate filament → AlphaFold → IPR001322 and Intermediate filament → AlphaFold → PF00932. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Intermediate filamentAlphaFoldIPR0013221.00infobox
Intermediate filamentAlphaFoldPF009321.00infobox
Intermediate filamentAvailable protein structures:IPR0013221.00infobox
Intermediate filamentAvailable protein structures:PF009321.00infobox
Intermediate filamentInterProIPR0013221.00infobox
Intermediate filamentPDBIPR001322 PF00932 (ECOD; PDBsum)1.00infobox
Intermediate filamentPfamPF009321.00infobox
Intermediate filamentPROSITEPDOC001981.00infobox
Intermediate filamentSCOP21ivt / SCOPe / SUPFAM1.00infobox
Intermediate filamentSymbolIF_tail1.00infobox
Intermediate filamentis apair of two intertwined proteins that is called a coiled-coil structure0.90text
Intermediate filamentrelated to In other organismsIF0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Intermediate filament bring nearby vocabulary together. In this analysis, examples include Filament, Intermediate and Proteins. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Intermediate filament
    • Filament
    • Intermediate
    • Proteins
    • Found
    • Sequence
    • Structure
    • Actin
    • Cells
    • Microfilaments
    • Protein
    • Acid
    • Family
  • intermediate filament
    • Filament
    • Intermediate
    • Proteins
    • Found
    • Sequence
    • Form
    • Pair
    • Structure
    • Actin
    • Cells
    • Microfilaments
    • Protein
  • amino acid sequence
    • Acid
    • Amino
    • Sequence
    • Types
    • Structure
    • Basic
    • Acidic
    • Keratin
    • Protein
    • Keratins
    • Type
    • Lamin
  • type i (acidic)
    • Basic
    • Keratins
    • Lamin
    • Amino
    • Form
    • Keratin
    • Sequence
    • Types
    • Protein
    • Nuclear
    • Lamins
    • Citation
  • type ii (basic)
    • Keratins
    • Form
    • Lamin
    • Keratin
    • Sequence
    • Types
    • Nuclear
    • Lamins
    • Structure
    • Citation
    • Needed
    • Nm
  • glial fibrillary acidic protein
    • Basic
    • Keratins
    • Types
    • Amino
    • Form
    • Structure
    • Keratin
    • Sequence
    • Acidic
    • Protein
    • Type
    • Citation
  • endothelial cells
    • Citation
    • Needed
    • Structural
    • Found
    • Filaments
    • Cell
    • Intermediate
    • Microtubules
    • Keratin
    • Ifs
    • Proteins
    • Type
  • animal cells
    • Citation
    • Needed
    • Structural
    • Found
    • Filaments
    • Cell
    • Intermediate
    • Microtubules
    • Keratin
    • Ifs
    • Proteins
    • Type

Connections between topic areas Semantic bridges

For Intermediate filament, one of the stronger structural bridges in this analysis connects Intermediate filament with Types. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Intermediate filamentTypes · splits 65 ⟂ 38
Intermediate filamentStructure · splits 81 ⟂ 22
Intermediate filamentOverview · splits 87 ⟂ 16
Intermediate filamentFunction · splits 92 ⟂ 11
Intermediate filamentDiseases arising from mutations in IF genes · splits 96 ⟂ 7
Intermediate filamentIn other organisms · splits 97 ⟂ 6

Map overview Semantic statistics

Intermediate filament

Nodes103
Edges102
Triples48
Avg. degree1.98
Density0.019417
Components1

Source & methodology

TTTA analyzes the structure around Intermediate filament to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Types & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Intermediate filament · EN edition · Analysis: TopicsToTalkAbout

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