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Plectin: Structure, Function & Clinical significance

Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. By holding these…

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Plectin topic overview

The analysis highlights Structure, Function and Clinical significance as prominent areas in the source structure around Plectin.

Related topics
36
Source areas
4
Connected nodes
40
Extracted relationships
130
Concept neighborhoods
16
Bridge connections
40

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 13 topics
Overview · 10 topics
Function · 9 topics
Clinical significance · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PLEC, EBS1, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN, plectin, LGMDR17, EBS5D, EBS5C, EBS5B, EBS5A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MB8, 2ODU, 2ODV, 3F7P, 3PDY, 3PE0, 4GDO, 4Q58, 4Q59, 2N03, 5J1H, 5J1G, 5J1I
Band
8q24.3 · 15 D3|15 35.48 cM
Bgee
sural nerve · muscle of thigh · gastrocnemius muscle · stromal cell of endometrium · apex of heart
BioGPS
n/a
Chr.
Chromosome 8 (human) · Chromosome 15 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Plectin connects Entity context

The extracted context around Plectin shows recurring relationship patterns in the source. For example, Plectin → actin binding, ankyrin binding, brush border, cadherin binding, cell junction, contractile fiber, costamere, cytoplasm, cytoskeletal protein binding, cytoskeleton, cytoskeleton organization, cytosol, extracellular exosome, extracellular matrix, focal adhesion, hemidesmosome, hemidesmosome assembly, intermediate filament, intermediate filament cytoskeleton, intermediate filament cytoskeleton organization Another extracted example is Plectin → ankle, apex of heart, body of tongue, digastric muscle, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, gastrocnemius muscle, internal carotid artery, muscle of thigh, nipple, right coronary artery, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, stromal cell of endometrium, sural nerve, temporal muscle, triceps brachii muscle, vastus lateralis muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

Plectin

Top relations

Gene ontology · 31
Plectin → actin binding, ankyrin binding, brush border, cadherin binding, cell junction, contractile fiber, costamere, cytoplasm, cytoskeletal protein binding, cytoskeleton, cytoskeleton organization, cytosol, extracellular exosome, extracellular matrix, focal adhesion, hemidesmosome, hemidesmosome assembly, intermediate filament, intermediate filament cytoskeleton, intermediate filament cytoskeleton organization
Bgee · 20
Plectin → ankle, apex of heart, body of tongue, digastric muscle, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, gastrocnemius muscle, internal carotid artery, muscle of thigh, nipple, right coronary artery, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, stromal cell of endometrium, sural nerve, temporal muscle, triceps brachii muscle, vastus lateralis muscle
RNA expression pattern · 20
Plectin → ankle, apex of heart, body of tongue, digastric muscle, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, gastrocnemius muscle, internal carotid artery, muscle of thigh, nipple, right coronary artery, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, stromal cell of endometrium, sural nerve, temporal muscle, triceps brachii muscle, vastus lateralis muscle
related to Structure · 11
Plectin → ABD, At, CH, DES, In, ITGB4, N-terminal, SPTAN1, The, These, Z-discs
related to Function · 10
Plectin → Cardiac, Expression, In, Pups, Skeletal, Studies, This, Through, Z-disc, Z-discs
related to External links · 9
Plectin → Edinburgh, Epidermolysis Bullosa, GeneReviews/NCBI/NIH/UW, Medicine Medical Subject Headings, MeSH, National Library, Pyloric Atresiaplectin, Retrieved, The University
related to Clinical significance · 5
Plectin → Although, Isolated, Mutations, PDAC, PLEC
Band · 2
Plectin → 15 D3|15 35.48 cM, 8q24.3
Chr. · 2
Plectin → Chromosome 15 (mouse), Chromosome 8 (human)
End · 2
Plectin → 143,976,734 bp, 76,116,774 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

intermediate bp cells cytoskeleton protein chr human band also actin chromosome plec muscle filaments found membrane external mouse filament gene

Plectin relationships Subject–Predicate–Object triples

TTTA extracted 130 structured relationships around Plectin. Examples in this analysis include Plectin → Aliases → PLEC, EBS1, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN, plectin, LGMDR17, EBS5D, EBS5C, EBS5B, EBS5A and Plectin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MB8, 2ODU, 2ODV, 3F7P, 3PDY, 3PE0, 4GDO, 4Q58, 4Q59, 2N03, 5J1H, 5J1G, 5J1I. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PlectinAliasesPLEC, EBS1, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN, plectin, LGMDR17, EBS5D, EBS5C, EBS5B, EBS5A1.00infobox
PlectinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MB8, 2ODU, 2ODV, 3F7P, 3PDY, 3PE0, 4GDO, 4Q58, 4Q59, 2N03, 5J1H, 5J1G, 5J1I1.00infobox
PlectinBand8q24.31.00infobox
PlectinBand15 D3|15 35.48 cM1.00infobox
PlectinBgeesural nerve1.00infobox
PlectinBgeemuscle of thigh1.00infobox
PlectinBgeegastrocnemius muscle1.00infobox
PlectinBgeestromal cell of endometrium1.00infobox
PlectinBgeeapex of heart1.00infobox
PlectinBgeebody of tongue1.00infobox
PlectinBgeeright coronary artery1.00infobox
PlectinBgeegastric mucosa1.00infobox
PlectinBgeenipple1.00infobox
PlectinBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
PlectinBgeeankle1.00infobox
PlectinBgeeinternal carotid artery1.00infobox
PlectinBgeeexternal carotid artery1.00infobox
PlectinBgeesoleus muscle1.00infobox
PlectinBgeetemporal muscle1.00infobox
PlectinBgeeendothelial cell of lymphatic vessel1.00infobox
PlectinBgeedigastric muscle1.00infobox
PlectinBgeetriceps brachii muscle1.00infobox
PlectinBgeevastus lateralis muscle1.00infobox
PlectinBgeesternocleidomastoid muscle1.00infobox
PlectinBioGPSn/a1.00infobox
PlectinChr.Chromosome 8 (human)1.00infobox
PlectinChr.Chromosome 15 (mouse)1.00infobox
PlectinDatabasesNCBI: entry; OMA: entry1.00infobox
PlectinEnd143,976,734 bp1.00infobox
PlectinEnd76,116,774 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Plectin bring nearby vocabulary together. In this analysis, examples include Intermediate, Cytoskeleton and Cells. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Plectin
    • Intermediate
    • Cytoskeleton
    • Cells
    • Protein
    • Filament
    • Expressed
    • Found
    • Function
    • Link
    • Membrane
    • Z-discs
    • Actin
  • plectin
    • Intermediate
    • Cytoskeleton
    • Cells
    • Protein
    • Filament
    • Expressed
    • Found
    • Function
    • Link
    • Membrane
    • Z-discs
    • Actin
  • cells
    • Cytoskeleton
    • Membrane
    • Plasma
    • Protein
    • Expressed
    • Found
    • Link
    • Intermediate
    • Actin
    • Filament
    • Plectin
    • Muscle
  • cytoskeleton
    • Found
    • Plasma
    • Link
    • Membrane
    • Intermediate
    • Actin
    • Filament
    • Plectin
    • Protein
    • Different
    • External
    • Links
  • actin
    • Protein
    • End
    • Cytoskeleton
    • Cells
    • External
    • Intermediate
    • Mammalian
    • Plasma
    • Components
    • Expressed
    • Found
    • Function
  • intermediate filaments
    • Filament
    • Filaments
    • Intermediate
    • Protein
    • Link
    • Plectin
    • Function
    • Shown
    • Z-discs
    • Mammalian
    • Muscle
    • Also
  • function
    • External
    • Gene
    • Location
    • Chromosome
    • Filament
    • Human
    • Plec
    • Bp
    • Chr
    • Links
    • Plasma
    • Intermediate
  • plasma membrane
    • Membrane
    • Plasma
    • Expressed
    • Different
    • External
    • Protein
    • End
    • Function
    • Gene
    • Location
    • Mouse
    • Skeletal

Connections between topic areas Semantic bridges

For Plectin, one of the stronger structural bridges in this analysis connects Plectin with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PlectinStructure · splits 27 ⟂ 14
PlectinOverview · splits 30 ⟂ 11
PlectinFunction · splits 31 ⟂ 10
PlectinClinical significance · splits 36 ⟂ 5

Map overview Semantic statistics

Plectin

Nodes41
Edges40
Triples130
Avg. degree1.95
Density0.04878
Components1

Source & methodology

TTTA analyzes the structure around Plectin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Plectin · EN edition · Analysis: TopicsToTalkAbout

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