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Plectin

Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. By holding these…

Structure, Function & Clinical significance

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Aliases
PLEC, EBS1, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN, plectin, LGMDR17, EBS5D, EBS5C, EBS5B, EBS5A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MB8, 2ODU, 2ODV, 3F7P, 3PDY, 3PE0, 4GDO, 4Q58, 4Q59, 2N03, 5J1H, 5J1G, 5J1I
Band
8q24.3 · 15 D3|15 35.48 cM
Bgee
sural nerve · muscle of thigh · gastrocnemius muscle · stromal cell of endometrium · apex of heart
BioGPS
n/a
Chr.
Chromosome 8 (human) · Chromosome 15 (mouse)

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Overview

Structure

Function

Clinical significance

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Map overview Semantic statistics

Plectin

Nodes41
Edges40
Triples130
Avg. degree1.95
Density0.04878
Components1

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Plectin

Top relations

Gene ontology · 31
Plectin → actin binding, ankyrin binding, brush border, cadherin binding, cell junction, contractile fiber, costamere, cytoplasm, cytoskeletal protein binding, cytoskeleton, cytoskeleton organization, cytosol, extracellular exosome, extracellular matrix, focal adhesion, hemidesmosome, hemidesmosome assembly, intermediate filament, intermediate filament cytoskeleton, intermediate filament cytoskeleton organization
Bgee · 20
Plectin → ankle, apex of heart, body of tongue, digastric muscle, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, gastrocnemius muscle, internal carotid artery, muscle of thigh, nipple, right coronary artery, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, stromal cell of endometrium, sural nerve, temporal muscle, triceps brachii muscle, vastus lateralis muscle
RNA expression pattern · 20
Plectin → ankle, apex of heart, body of tongue, digastric muscle, endothelial cell of lymphatic vessel, external carotid artery, gastric mucosa, gastrocnemius muscle, internal carotid artery, muscle of thigh, nipple, right coronary artery, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, stromal cell of endometrium, sural nerve, temporal muscle, triceps brachii muscle, vastus lateralis muscle
related to Structure · 11
Plectin → ABD, At, CH, DES, In, ITGB4, N-terminal, SPTAN1, The, These, Z-discs
related to Function · 10
Plectin → Cardiac, Expression, In, Pups, Skeletal, Studies, This, Through, Z-disc, Z-discs
related to External links · 9
Plectin → Edinburgh, Epidermolysis Bullosa, GeneReviews/NCBI/NIH/UW, Medicine Medical Subject Headings, MeSH, National Library, Pyloric Atresiaplectin, Retrieved, The University
related to Clinical significance · 5
Plectin → Although, Isolated, Mutations, PDAC, PLEC
Band · 2
Plectin → 15 D3|15 35.48 cM, 8q24.3
Chr. · 2
Plectin → Chromosome 15 (mouse), Chromosome 8 (human)
End · 2
Plectin → 143,976,734 bp, 76,116,774 bp

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Important terminology

intermediate bp cells cytoskeleton protein chr human band also actin chromosome plec muscle filaments found membrane external mouse filament gene

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PlectinAliasesPLEC, EBS1, EBSMD, EBSND, EBSO, EBSOG, EBSPA, HD1, LGMD2Q, PCN, PLEC1, PLEC1b, PLTN, plectin, LGMDR17, EBS5D, EBS5C, EBS5B, EBS5A1.00infobox
PlectinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MB8, 2ODU, 2ODV, 3F7P, 3PDY, 3PE0, 4GDO, 4Q58, 4Q59, 2N03, 5J1H, 5J1G, 5J1I1.00infobox
PlectinBand8q24.31.00infobox
PlectinBand15 D3|15 35.48 cM1.00infobox
PlectinBgeesural nerve1.00infobox
PlectinBgeemuscle of thigh1.00infobox
PlectinBgeegastrocnemius muscle1.00infobox
PlectinBgeestromal cell of endometrium1.00infobox
PlectinBgeeapex of heart1.00infobox
PlectinBgeebody of tongue1.00infobox
PlectinBgeeright coronary artery1.00infobox
PlectinBgeegastric mucosa1.00infobox
PlectinBgeenipple1.00infobox
PlectinBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
PlectinBgeeankle1.00infobox
PlectinBgeeinternal carotid artery1.00infobox
PlectinBgeeexternal carotid artery1.00infobox
PlectinBgeesoleus muscle1.00infobox
PlectinBgeetemporal muscle1.00infobox
PlectinBgeeendothelial cell of lymphatic vessel1.00infobox
PlectinBgeedigastric muscle1.00infobox
PlectinBgeetriceps brachii muscle1.00infobox
PlectinBgeevastus lateralis muscle1.00infobox
PlectinBgeesternocleidomastoid muscle1.00infobox
PlectinBioGPSn/a1.00infobox
PlectinChr.Chromosome 8 (human)1.00infobox
PlectinChr.Chromosome 15 (mouse)1.00infobox
PlectinDatabasesNCBI: entry; OMA: entry1.00infobox
PlectinEnd143,976,734 bp1.00infobox
PlectinEnd76,116,774 bp1.00infobox

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