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Lamin: History, Clinical significance & Overview

Lamins, also known as nuclear lamins, are fibrous proteins in type V intermediate filaments, providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope. Lamins have elastic and mechanosensitive properties…

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Lamin topic overview

The analysis highlights History, Clinical significance and Overview as prominent areas in the source structure around Lamin.

Related topics
52
Source areas
6
Connected nodes
58
Extracted relationships
106
Concept neighborhoods
25
Bridge connections
58

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 17 topics
Clinical significance · 15 topics
A- and B-types · 7 topics
Function · 7 topics
History · 4 topics
Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Structure

A- and B-types

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Lamin connects Entity context

The extracted context around Lamin shows recurring relationship patterns in the source. For example, Lamin → A-type, CaaX, Due, Expressed, Furthermore, Here, Isoform, LMNA, Prelamin, Some, The, These, This, Two, Unlike Another extracted example is Lamin → A-type, As, B-type, B1, B2, CaaX, Further, Furthermore, LMNB1, LMNB2, Other, Similar, They, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Lamin

Top relations

related to A-type lamins · 15
Lamin → A-type, CaaX, Due, Expressed, Furthermore, Here, Isoform, LMNA, Prelamin, Some, The, These, This, Two, Unlike
related to B-type lamins · 14
Lamin → A-type, As, B-type, B1, B2, CaaX, Further, Furthermore, LMNB1, LMNB2, Other, Similar, They, This
related to history · 12
Lamin → After, Current, During, Further, Furthermore, However, IF, It, Lamins, Later, Studies, This
related to Hutchinson-Gilford progeria syndrome · 11
Lamin → Because, Current, FTIs, Furthermore, HGPS, Hutchinson-Gilford, LMNA, One, The, This, Those
related to Structure · 11
Lamin → As, C-terminal, However, IF, Lamins, NLS, Similar, The, The N-terminal, These, While
related to Apoptosis · 10
Lamin → Apoptosis, Apoptotic, As, B-type, B-types, DNA, Finally, Lamins, Studies, This
related to Maintenance of nuclear shape · 7
Lamin → Due, IF, Nuclei, SUN1/SUN2, These, They, This
related to Lamin A/C heart disease · 5
Lamin → As, Lamin A/C, Laminopathies, Some, These
related to Mitosis · 5
Lamin → After, DNA, During, MPF, This
related to Clinical significance · 4
Lamin → Collectively, Lamins, LMNA, Mutations

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

lamins nuclear proteins prelamin b-type cell found envelope laminopathies nucleus gene apoptosis structure a-type heart mitosis a- lmna studies posttranslational

Lamin relationships Subject–Predicate–Object triples

TTTA extracted 106 structured relationships around Lamin. Examples in this analysis include atherosclerosis → instance of → health problems usually seen in older persons and sinus node dysfunction → instance of → Laminopathies frequently cause heart rhythm problems at an early stage in the disease process including abnormally slow heart rhythms. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
atherosclerosisinstance ofhealth problems usually seen in older persons0.80text
high blood pressure occur at a much younger ageinstance ofhealth problems usually seen in older persons0.80text
sinus node dysfunctioninstance ofLaminopathies frequently cause heart rhythm problems at an early stage in the disease process including abnormally slow heart rhythms0.80text
atrioventricular blockinstance ofLaminopathies frequently cause heart rhythm problems at an early stage in the disease process including abnormally slow heart rhythms0.80text
and abnormally rapid heart rhythms such as ventricular tachycardiainstance ofLaminopathies frequently cause heart rhythm problems at an early stage in the disease process including abnormally slow heart rhythms0.80text
Laminrelated to A- and B-typesLamins0.60section
Laminrelated to A- and B-typesB-types0.60section
Laminrelated to A- and B-typesThese0.60section
Laminrelated to A-type laminsA-type0.60section
Laminrelated to A-type laminsExpressed0.60section
Laminrelated to A-type laminsLMNA0.60section
Laminrelated to A-type laminsTwo0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Lamin bring nearby vocabulary together. In this analysis, examples include Prelamin, B-type and Common. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • inner nuclear membrane proteins
    • Envelope
    • Lamina
    • Membrane
    • Mitosis
    • Nuclear
    • Proteins
    • Chromatin
    • Sequence
    • Nucleus
    • Form
    • Found
    • Posttranslational
  • nuclear lamina
    • Envelope
    • Lamina
    • Membrane
    • Mitosis
    • Nuclear
    • Proteins
    • Chromatin
    • Nucleus
    • Lmna
    • Studies
    • Gene
    • Shape
  • nuclear envelope
    • Envelope
    • Nuclear
    • Lamina
    • Membrane
    • Mitosis
    • Proteins
    • Chromatin
    • Nucleus
    • Lamins
    • Form
    • Process
    • Shape
  • nuclear pores
    • Envelope
    • Lamina
    • Membrane
    • Mitosis
    • Proteins
    • Chromatin
    • Nucleus
    • Shape
    • Structural
    • Apoptosis
    • Lamin
    • Contain
  • nuclear localization sequence
    • Envelope
    • Lamina
    • Membrane
    • Mitosis
    • Proteins
    • Chromatin
    • Nucleus
    • Posttranslational
    • Shape
    • Structural
    • Structure
    • Apoptosis
  • Lamin
    • Prelamin
    • B-type
    • Common
    • Disease
    • Furthermore
    • Mitosis
    • Nuclear
    • Posttranslational
    • A-type
    • Heart
    • Structure
    • Proteins
  • lamin
    • Prelamin
    • B-type
    • Common
    • Disease
    • Furthermore
    • Mitosis
    • Nuclear
    • Posttranslational
    • A-type
    • Heart
    • Structure
    • Proteins
  • lamin b1
    • Prelamin
    • B-type
    • Common
    • Disease
    • Furthermore
    • Mitosis
    • Nuclear
    • Posttranslational
    • A-type
    • Heart
    • Structure
    • Proteins

Connections between topic areas Semantic bridges

For Lamin, one of the stronger structural bridges in this analysis connects Lamin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
LaminOverview · splits 41 ⟂ 18
LaminClinical significance · splits 43 ⟂ 16
LaminA- and B-types · splits 51 ⟂ 8
LaminFunction · splits 51 ⟂ 8
LaminHistory · splits 54 ⟂ 5
LaminStructure · splits 56 ⟂ 3

Map overview Semantic statistics

Lamin

Nodes59
Edges58
Triples106
Avg. degree1.97
Density0.033898
Components1

Source & methodology

TTTA analyzes the structure around Lamin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Lamin · EN edition · Analysis: TopicsToTalkAbout

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