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Lamin

Lamins, also known as nuclear lamins, are fibrous proteins in type V intermediate filaments, providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope. Lamins have elastic and mechanosensitive properties…

History, Clinical significance & Overview

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Overview

History

Structure

A- and B-types

Function

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

Lamin

Nodes59
Edges58
Triples106
Avg. degree1.97
Density0.033898
Components1

How this topic connects Entity context

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Lamin

Top relations

related to A-type lamins · 15
Lamin → A-type, CaaX, Due, Expressed, Furthermore, Here, Isoform, LMNA, Prelamin, Some, The, These, This, Two, Unlike
related to B-type lamins · 14
Lamin → A-type, As, B-type, B1, B2, CaaX, Further, Furthermore, LMNB1, LMNB2, Other, Similar, They, This
related to history · 12
Lamin → After, Current, During, Further, Furthermore, However, IF, It, Lamins, Later, Studies, This
related to Hutchinson-Gilford progeria syndrome · 11
Lamin → Because, Current, FTIs, Furthermore, HGPS, Hutchinson-Gilford, LMNA, One, The, This, Those
related to Structure · 11
Lamin → As, C-terminal, However, IF, Lamins, NLS, Similar, The, The N-terminal, These, While
related to Apoptosis · 10
Lamin → Apoptosis, Apoptotic, As, B-type, B-types, DNA, Finally, Lamins, Studies, This
related to Maintenance of nuclear shape · 7
Lamin → Due, IF, Nuclei, SUN1/SUN2, These, They, This
related to Lamin A/C heart disease · 5
Lamin → As, Lamin A/C, Laminopathies, Some, These
related to Mitosis · 5
Lamin → After, DNA, During, MPF, This
related to Clinical significance · 4
Lamin → Collectively, Lamins, LMNA, Mutations

Important terminology Word statistics

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Important terminology

lamins nuclear proteins prelamin b-type cell found envelope laminopathies nucleus gene apoptosis structure a-type heart mitosis a- lmna studies posttranslational

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
atherosclerosisinstance ofhealth problems usually seen in older persons0.80text
high blood pressure occur at a much younger ageinstance ofhealth problems usually seen in older persons0.80text
sinus node dysfunctioninstance ofLaminopathies frequently cause heart rhythm problems at an early stage in the disease process including abnormally slow heart rhythms0.80text
atrioventricular blockinstance ofLaminopathies frequently cause heart rhythm problems at an early stage in the disease process including abnormally slow heart rhythms0.80text
and abnormally rapid heart rhythms such as ventricular tachycardiainstance ofLaminopathies frequently cause heart rhythm problems at an early stage in the disease process including abnormally slow heart rhythms0.80text
Laminrelated to A- and B-typesLamins0.60section
Laminrelated to A- and B-typesB-types0.60section
Laminrelated to A- and B-typesThese0.60section
Laminrelated to A-type laminsA-type0.60section
Laminrelated to A-type laminsExpressed0.60section
Laminrelated to A-type laminsLMNA0.60section
Laminrelated to A-type laminsTwo0.60section

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