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Vimentin: Function, Interactions & Clinical significance

Vimentin is a structural protein that in humans is encoded by the VIM gene. Its name comes from the Latin vimentum, meaning an osier, withy (array of flexible rods).

Language: English [EN]
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Vimentin topic overview

The analysis highlights Function, Interactions and Clinical significance as prominent areas in the source structure around Vimentin.

Related topics
56
Source areas
5
Connected nodes
61
Extracted relationships
139
Concept neighborhoods
18
Bridge connections
61

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 16 topics
Function · 15 topics
Interactions · 11 topics
Clinical significance · 8 topics
Structure · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
VIM, CTRCT30, HEL113, vimentin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GK4, 1GK6, 1GK7, 3G1E, 3KLT, 3S4R, 3SSU, 3SWK, 3TRT, 3UF1, 4MCY, 4MCZ, 4MD0, 4MD5, 4MDJ, 4YPC, 4YV3
Band
10p13 · 2 A1|2 10.04 cM
Bgee
ventricular zone · Descending thoracic aorta · right coronary artery · synovial membrane · spinal ganglia
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Vimentin connects Entity context

The extracted context around Vimentin shows recurring relationship patterns in the source. For example, Vimentin → astrocyte development, Bergmann glial cell differentiation, cell leading edge, cell projection, cellular response to interferon-gamma, cellular response to lipopolysaccharide, cellular response to muramyl dipeptide, cytokine-mediated signaling pathway, cytoplasm, cytoskeleton, cytosol, double-stranded RNA binding, extracellular exosome, extracellular matrix, focal adhesion, identical protein binding, intermediate filament, intermediate filament organization, intermediate filament-based process, keratin filament binding Another extracted example is Vimentin → ascending aorta, decidua, dermis, Descending thoracic aorta, endothelial cell of lymphatic vessel, external carotid artery, Gonadal ridge, internal carotid artery, left lung lobe, popliteal artery, right coronary artery, semi-lunar valve, spinal ganglia, stroma of bone marrow, synovial membrane, tibial arteries, tibial nerve, tunica media of zone of aorta, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Vimentin

Top relations

Gene ontology · 44
Vimentin → astrocyte development, Bergmann glial cell differentiation, cell leading edge, cell projection, cellular response to interferon-gamma, cellular response to lipopolysaccharide, cellular response to muramyl dipeptide, cytokine-mediated signaling pathway, cytoplasm, cytoskeleton, cytosol, double-stranded RNA binding, extracellular exosome, extracellular matrix, focal adhesion, identical protein binding, intermediate filament, intermediate filament organization, intermediate filament-based process, keratin filament binding
Bgee · 19
Vimentin → ascending aorta, decidua, dermis, Descending thoracic aorta, endothelial cell of lymphatic vessel, external carotid artery, Gonadal ridge, internal carotid artery, left lung lobe, popliteal artery, right coronary artery, semi-lunar valve, spinal ganglia, stroma of bone marrow, synovial membrane, tibial arteries, tibial nerve, tunica media of zone of aorta, ventricular zone
RNA expression pattern · 19
Vimentin → ascending aorta, decidua, dermis, Descending thoracic aorta, endothelial cell of lymphatic vessel, external carotid artery, Gonadal ridge, internal carotid artery, left lung lobe, popliteal artery, right coronary artery, semi-lunar valve, spinal ganglia, stroma of bone marrow, synovial membrane, tibial arteries, tibial nerve, tunica media of zone of aorta, ventricular zone
related to Clinical significance · 10
Vimentin → Anti-citrullinated, Barrett's, DNA, Downregulation, High, It, Methylation, SARS-CoV-2, See, Statistically
related to Function · 8
Vimentin → It, Moreover, On, Scientists, The, Therefore, This, Transgenic
related to Structure · 7
Vimentin → Eight, In, The, Two, ULF, ULFs, While
is a · 4
Vimentin → cytoskeletal component responsible for maintaining cell integrity, major cytoskeletal component of mesenchymal cells, structural protein that in humans is encoded by the VIM gene, type III intermediate filament
Band · 2
Vimentin → 10p13, 2 A1|2 10.04 cM
Chr. · 2
Vimentin → Chromosome 10 (human), Chromosome 2 (mouse)
End · 2
Vimentin → 13,587,637 bp, 17,237,593 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells gene cell protein found bp filament intermediate expressed chr human band also type proteins chromosome 10 vim cytoskeleton external

Vimentin relationships Subject–Predicate–Object triples

TTTA extracted 139 structured relationships around Vimentin. Examples in this analysis include Vimentin → Aliases → VIM, CTRCT30, HEL113, vimentin and Vimentin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GK4, 1GK6, 1GK7, 3G1E, 3KLT, 3S4R, 3SSU, 3SWK, 3TRT, 3UF1, 4MCY, 4MCZ, 4MD0, 4MD5, 4MDJ, 4YPC, 4YV3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
VimentinAliasesVIM, CTRCT30, HEL113, vimentin1.00infobox
VimentinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GK4, 1GK6, 1GK7, 3G1E, 3KLT, 3S4R, 3SSU, 3SWK, 3TRT, 3UF1, 4MCY, 4MCZ, 4MD0, 4MD5, 4MDJ, 4YPC, 4YV31.00infobox
VimentinBand10p131.00infobox
VimentinBand2 A1|2 10.04 cM1.00infobox
VimentinBgeeventricular zone1.00infobox
VimentinBgeeDescending thoracic aorta1.00infobox
VimentinBgeeright coronary artery1.00infobox
VimentinBgeesynovial membrane1.00infobox
VimentinBgeespinal ganglia1.00infobox
VimentinBgeepopliteal artery1.00infobox
VimentinBgeetibial arteries1.00infobox
VimentinBgeedecidua1.00infobox
VimentinBgeeascending aorta1.00infobox
VimentinBgeetibial nerve1.00infobox
VimentinBgeeendothelial cell of lymphatic vessel1.00infobox
VimentinBgeeleft lung lobe1.00infobox
VimentinBgeedermis1.00infobox
VimentinBgeeGonadal ridge1.00infobox
VimentinBgeeexternal carotid artery1.00infobox
VimentinBgeetunica media of zone of aorta1.00infobox
VimentinBgeestroma of bone marrow1.00infobox
VimentinBgeeinternal carotid artery1.00infobox
VimentinBgeesemi-lunar valve1.00infobox
VimentinBioGPSMore reference expression data1.00infobox
VimentinChr.Chromosome 10 (human)1.00infobox
VimentinChr.Chromosome 2 (mouse)1.00infobox
VimentinDatabasesNCBI: entry; OMA: entry1.00infobox
VimentinEnd17,237,593 bp1.00infobox
VimentinEnd13,587,637 bp1.00infobox
VimentinEnsemblENSG000000260251.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Vimentin bring nearby vocabulary together. In this analysis, examples include Cell, Found and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Vimentin
    • Cell
    • Found
    • Gene
    • Protein
    • Cells
    • Expressed
    • Also
    • Component
    • Cytoskeletal
    • Development
    • Forms
    • Normal
  • vimentin
    • Cell
    • Found
    • Gene
    • Protein
    • Cells
    • Expressed
    • Also
    • Component
    • Cytoskeletal
    • Development
    • Forms
    • Normal
  • structural protein
    • Vim
    • Cytoskeleton
    • Cytosol
    • Expressed
    • External
    • Mouse
    • Nucleus
    • Gene
    • Protein
    • Structural
    • Assembly
    • Component
  • gene
    • Location
    • Vim
    • Chromosome
    • Human
    • Bp
    • Chr
    • External
    • Mouse
    • Structural
    • Development
    • End
    • Function
  • cytoskeleton
    • Intermediate
    • Cytosol
    • External
    • Microtubules
    • Mouse
    • Nucleus
    • Structural
    • Assembly
    • Component
    • Development
    • End
    • Forms
  • cell lines
    • Vimentin
    • Component
    • Cytoskeletal
    • Function
    • Expressed
    • Intermediate
    • Filament
    • Protein
    • Cells
    • Found
    • Cytoskeleton
    • Cytosol
  • anti-citrullinated protein antibody
    • Expressed
    • Structural
    • Forms
    • Vim
    • Intermediate
    • Filament
    • Vimentin
    • Gene
    • Cell
    • Cytoskeleton
    • Cytosol
    • External
  • 3' utr of vimentin mrna
    • Cell
    • Found
    • Gene
    • Protein
    • Cells
    • Expressed
    • Also
    • Component
    • Cytoskeletal
    • Development
    • Forms
    • Normal

Connections between topic areas Semantic bridges

For Vimentin, one of the stronger structural bridges in this analysis connects Vimentin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
VimentinOverview · splits 45 ⟂ 17
VimentinFunction · splits 46 ⟂ 16
VimentinInteractions · splits 50 ⟂ 12
VimentinClinical significance · splits 53 ⟂ 9
VimentinStructure · splits 55 ⟂ 7

Map overview Semantic statistics

Vimentin

Nodes62
Edges61
Triples139
Avg. degree1.97
Density0.032258
Components1

Source & methodology

TTTA analyzes the structure around Vimentin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Vimentin · EN edition · Analysis: TopicsToTalkAbout

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