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Plakoglobin

Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. Plakoglobin is a member of the catenin protein family and homologous to β-catenin. Plakoglobin is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that…

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Aliases
JUP, ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB, Plakoglobin, junction plakoglobin, PG
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3IFQ
Band
17q21.2 · 11 D|11 63.47 cM
Bgee
skin of leg · skin of abdomen · mucosa of pharynx · nipple · gingival epithelium
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Plakoglobin

Nodes71
Edges70
Triples172
Avg. degree1.97
Density0.028169
Components1

How this topic connects Entity context

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Plakoglobin

Top relations

Gene ontology · 69
Plakoglobin → actin cytoskeleton, adherens junction, adherens junction assembly, adherens junction organization, alpha-catenin binding, apicolateral plasma membrane, bundle of His cell-Purkinje myocyte adhesion involved in cell communication, cadherin binding, catenin complex, cell adhesion, cell adhesion molecule binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication, cell junction, cell migration, cell-cell adhesion, cell-cell junction, cellular response to indole-3-methanol, cornification, cornified envelope, cytoplasm
Bgee · 20
Plakoglobin → apex of heart, corneal stroma, epithelium of stomach, esophagus, gingival epithelium, human penis, lip, mucosa of pharynx, muscle of thigh, nipple, pyloric antrum, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of leg, skin of thigh, stomach, vulva, yolk sac
RNA expression pattern · 20
Plakoglobin → apex of heart, corneal stroma, epithelium of stomach, esophagus, gingival epithelium, human penis, lip, mucosa of pharynx, muscle of thigh, nipple, pyloric antrum, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of leg, skin of thigh, stomach, vulva, yolk sac
related to Interactions · 15
Plakoglobin → APC, CDH1, CDH2, CDH3, CDH5, CTNNA1, CTNNB1, DSG2, DSP, MUC1, PKP2, PTPkappa, PTPrho, PTPRK, PTPRT
related to Clinical significance · 11
Plakoglobin → Affected, ARVD, ARVD/ARVC, Greek, It, JUP, Mutation, Naxos, The, These, This
related to Function · 5
Plakoglobin → Further, ICD, JUP, JUP-null, Transgenic
related to Structure · 5
Plakoglobin → C-terminal, E-cadherin, Human, N-terminal, The JUP
is a · 3
Plakoglobin → cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent ce…, member of the catenin family, member of the catenin protein family and homologous to β-catenin
Band · 2
Plakoglobin → 11 D|11 63.47 cM, 17q21.2
Chr. · 2
Plakoglobin → Chromosome 11 (mouse), Chromosome 17 (human)

Important terminology Word statistics

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Important terminology

cardiac also ventricular gene jup bp human desmosomes chr band protein right junction chromosome 17 adherens intercalated muscle arvd catenin

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PlakoglobinAliasesJUP, ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB, Plakoglobin, junction plakoglobin, PG1.00infobox
PlakoglobinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3IFQ1.00infobox
PlakoglobinBand17q21.21.00infobox
PlakoglobinBand11 D|11 63.47 cM1.00infobox
PlakoglobinBgeeskin of leg1.00infobox
PlakoglobinBgeeskin of abdomen1.00infobox
PlakoglobinBgeemucosa of pharynx1.00infobox
PlakoglobinBgeenipple1.00infobox
PlakoglobinBgeegingival epithelium1.00infobox
PlakoglobinBgeeskin of arm1.00infobox
PlakoglobinBgeehuman penis1.00infobox
PlakoglobinBgeevulva1.00infobox
PlakoglobinBgeeskin of thigh1.00infobox
PlakoglobinBgeeapex of heart1.00infobox
PlakoglobinBgeelip1.00infobox
PlakoglobinBgeeesophagus1.00infobox
PlakoglobinBgeecorneal stroma1.00infobox
PlakoglobinBgeeskin of back1.00infobox
PlakoglobinBgeemuscle of thigh1.00infobox
PlakoglobinBgeeskin of external ear1.00infobox
PlakoglobinBgeestomach1.00infobox
PlakoglobinBgeepyloric antrum1.00infobox
PlakoglobinBgeeepithelium of stomach1.00infobox
PlakoglobinBgeeyolk sac1.00infobox
PlakoglobinBioGPSMore reference expression data1.00infobox
PlakoglobinChr.Chromosome 17 (human)1.00infobox
PlakoglobinChr.Chromosome 11 (mouse)1.00infobox
PlakoglobinDatabasesNCBI: entry; OMA: entry1.00infobox
PlakoglobinEnd41,786,931 bp1.00infobox
PlakoglobinEnd100,288,589 bp1.00infobox

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