Plakoglobin

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Plakoglobin topic overview

The analysis highlights Function, Interactions and Clinical significance as prominent areas in the source structure around Plakoglobin.

Related topics: 65
Source areas: 5
Connected nodes: 70
Extracted relationships: 172
Concept neighborhoods: 21
Bridge connections: 70

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 22 topics

Interactions · 14 topics

Clinical significance · 11 topics

Overview · 11 topics

Structure · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: JUP, ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB, Plakoglobin, junction plakoglobin, PG
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3IFQ
Band: 17q21.2 · 11 D|11 63.47 cM
Bgee: skin of leg · skin of abdomen · mucosa of pharynx · nipple · gingival epithelium
BioGPS: More reference expression data
Chr.: Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Clinical significance

Interactions

Interact Protein-protein interaction
APC APC (gene)
CTNNA1 Catenin (cadherin-associated protein), alpha 1
CTNNB1 Beta-catenin
CDH1 CDH1 (gene)
CDH2
CDH3 CDH3 (gene)
CDH5 VE-cadherin
DSG2 Desmoglein 2
MUC1
PKP2
PTPRK
PTPRT
PDLIM3

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Plakoglobin connects Entity context

The extracted context around Plakoglobin shows recurring relationship patterns in the source. For example, Plakoglobin → actin cytoskeleton, adherens junction, adherens junction assembly, adherens junction organization, alpha-catenin binding, apicolateral plasma membrane, bundle of His cell-Purkinje myocyte adhesion involved in cell communication, cadherin binding, catenin complex, cell adhesion, cell adhesion molecule binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication, cell junction, cell migration, cell-cell adhesion, cell-cell junction, cellular response to indole-3-methanol, cornification, cornified envelope, cytoplasm Another extracted example is Plakoglobin → apex of heart, corneal stroma, epithelium of stomach, esophagus, gingival epithelium, human penis, lip, mucosa of pharynx, muscle of thigh, nipple, pyloric antrum, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of leg, skin of thigh, stomach, vulva, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 69

Plakoglobin → actin cytoskeleton, adherens junction, adherens junction assembly, adherens junction organization, alpha-catenin binding, apicolateral plasma membrane, bundle of His cell-Purkinje myocyte adhesion involved in cell communication, cadherin binding, catenin complex, cell adhesion, cell adhesion molecule binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication, cell junction, cell migration, cell-cell adhesion, cell-cell junction, cellular response to indole-3-methanol, cornification, cornified envelope, cytoplasm

Bgee · 20

Plakoglobin → apex of heart, corneal stroma, epithelium of stomach, esophagus, gingival epithelium, human penis, lip, mucosa of pharynx, muscle of thigh, nipple, pyloric antrum, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of leg, skin of thigh, stomach, vulva, yolk sac

RNA expression pattern · 20

related to Interactions · 15

Plakoglobin → APC, CDH1, CDH2, CDH3, CDH5, CTNNA1, CTNNB1, DSG2, DSP, MUC1, PKP2, PTPkappa, PTPrho, PTPRK, PTPRT

related to Clinical significance · 11

Plakoglobin → Affected, ARVD, ARVD/ARVC, Greek, It, JUP, Mutation, Naxos, The, These, This

related to Function · 5

Plakoglobin → Further, ICD, JUP, JUP-null, Transgenic

related to Structure · 5

Plakoglobin → C-terminal, E-cadherin, Human, N-terminal, The JUP

is a · 3

Plakoglobin → cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent ce…, member of the catenin family, member of the catenin protein family and homologous to β-catenin

Band · 2

Plakoglobin → 11 D|11 63.47 cM, 17q21.2

Chr. · 2

Plakoglobin → Chromosome 11 (mouse), Chromosome 17 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cardiac also ventricular gene jup bp human desmosomes chr band protein right junction chromosome 17 adherens intercalated muscle arvd catenin

Plakoglobin relationships Subject–Predicate–Object triples

TTTA extracted 172 structured relationships around Plakoglobin. Examples in this analysis include Plakoglobin → Aliases → JUP, ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB, Plakoglobin, junction plakoglobin, PG and Plakoglobin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3IFQ. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Plakoglobin	Aliases	JUP, ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB, Plakoglobin, junction plakoglobin, PG	1.00	infobox
Plakoglobin	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3IFQ	1.00	infobox
Plakoglobin	Band	17q21.2	1.00	infobox
Plakoglobin	Band	11 D\|11 63.47 cM	1.00	infobox
Plakoglobin	Bgee	skin of leg	1.00	infobox
Plakoglobin	Bgee	skin of abdomen	1.00	infobox
Plakoglobin	Bgee	mucosa of pharynx	1.00	infobox
Plakoglobin	Bgee	nipple	1.00	infobox
Plakoglobin	Bgee	gingival epithelium	1.00	infobox
Plakoglobin	Bgee	skin of arm	1.00	infobox
Plakoglobin	Bgee	human penis	1.00	infobox
Plakoglobin	Bgee	vulva	1.00	infobox
Plakoglobin	Bgee	skin of thigh	1.00	infobox
Plakoglobin	Bgee	apex of heart	1.00	infobox
Plakoglobin	Bgee	lip	1.00	infobox
Plakoglobin	Bgee	esophagus	1.00	infobox
Plakoglobin	Bgee	corneal stroma	1.00	infobox
Plakoglobin	Bgee	skin of back	1.00	infobox
Plakoglobin	Bgee	muscle of thigh	1.00	infobox
Plakoglobin	Bgee	skin of external ear	1.00	infobox
Plakoglobin	Bgee	stomach	1.00	infobox
Plakoglobin	Bgee	pyloric antrum	1.00	infobox
Plakoglobin	Bgee	epithelium of stomach	1.00	infobox
Plakoglobin	Bgee	yolk sac	1.00	infobox
Plakoglobin	BioGPS	More reference expression data	1.00	infobox
Plakoglobin	Chr.	Chromosome 17 (human)	1.00	infobox
Plakoglobin	Chr.	Chromosome 11 (mouse)	1.00	infobox
Plakoglobin	Databases	NCBI: entry; OMA: entry	1.00	infobox
Plakoglobin	End	41,786,931 bp	1.00	infobox
Plakoglobin	End	100,288,589 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Plakoglobin bring nearby vocabulary together. In this analysis, examples include Component, Desmosomes and Intercalated. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Plakoglobin
- Component
- Desmosomes
- Intercalated
- Gene
- Jup
- Cytoplasmic
- Function
- Wnt
- Catenin
- Expression
- Protein
- Signaling
plakoglobin
- Component
- Desmosomes
- Intercalated
- Gene
- Jup
- Cytoplasmic
- Function
- Wnt
- Catenin
- Expression
- Protein
- Signaling
protein
- Desmosome
- Ventricular
- External
- Cardiac
- Cytoplasmic
- Function
- Location
- Wnt
- Arrhythmogenic
- Band
- Cardiomyopathy
- Component
gene
- Jup
- Chromosome
- Location
- Human
- Bp
- Chr
- Junction
- External
- Function
- Band
- Protein
- Adherens
catenin
- Protein
- Ventricular
- External
- Cytoplasmic
- Desmosome
- Function
- Gamma-catenin
- Location
- Wnt
- Arrhythmogenic
- Band
- Cardiomyopathy
cytoplasmic
- Component
- Adherens
- Intercalated
- Function
- Junctions
- Structures
- Desmosomes
- Muscle
- External
- Desmosome
- Location
- Wnt
adherens junctions
- Junctions
- Cytoplasmic
- Component
- Desmosomes
- Intercalated
- Function
- Structures
- Cardiac
- Mice
- Muscle
- Gene
- Jup
cardiac muscle
- Muscle
- Desmosome
- Function
- Ventricular
- Arvd
- Intercalated
- Mice
- Cytoplasmic
- Cardiomyopathy
- Component
- Expression
- External

Connections between topic areas Semantic bridges

For Plakoglobin, one of the stronger structural bridges in this analysis connects Plakoglobin with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Plakoglobin — Function · splits 48 ⟂ 23

Plakoglobin — Interactions · splits 56 ⟂ 15

Plakoglobin — Overview · splits 59 ⟂ 12

Plakoglobin — Clinical significance · splits 59 ⟂ 12

Plakoglobin — Structure · splits 63 ⟂ 8

Map overview Semantic statistics

Plakoglobin

Nodes71

Edges70

Triples172

Avg. degree1.97

Density0.028169

Components1

Source & methodology

TTTA analyzes the structure around Plakoglobin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Plakoglobin · EN edition · Analysis: TopicsToTalkAbout