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Ectonucleotide pyrophosphatase/phosphodiesterase 1: Clinical significance, Function & Structure

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (PC-1, CD203a) is an enzyme that in humans is encoded by the ENPP1 gene.

Language: English [EN]
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Ectonucleotide pyrophosphatase/phosphodiesterase 1 topic overview

The analysis highlights Clinical significance, Function and Structure as prominent areas in the source structure around Ectonucleotide pyrophosphatase/phosphodiesterase 1.

Related topics
18
Source areas
5
Connected nodes
23
Extracted relationships
123
Concept neighborhoods
11
Bridge connections
23

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 6 topics
Function · 5 topics
Structure · 3 topics
Interactions · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.4.1
3.6.1.9
Aliases
ENPP1, ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1, Ectonucleotide pyrophosphatase/phosphodiesterase 1, CD203a
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2YS0
Band
6q23.2 · 10 A4|10 12.26 cM
Bgee
tibia · decidua · cartilage tissue · tail of epididymis · Achilles tendon

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Ectonucleotide pyrophosphatase/phosphodiesterase 1 connects Entity context

The extracted context around Ectonucleotide pyrophosphatase/phosphodiesterase 1 shows recurring relationship patterns in the source. For example, Ectonucleotide pyrophosphatase/phosphodiesterase 1 → 3'-phosphoadenosine 5'-phosphosulfate binding, 3'-phosphoadenosine 5'-phosphosulfate metabolic process, ATP binding, ATP metabolic process, basolateral plasma membrane, biomineral tissue development, calcium ion binding, catalytic activity, cell surface, cellular phosphate ion homeostasis, cellular response to insulin stimulus, cyclic-GMP-AMP hydrolase activity, endocytosis, exonuclease activity, extracellular region, extracellular space, generation of precursor metabolites and energy, hydrolase activity, immune response, inorganic diphosphate transport Another extracted example is Ectonucleotide pyrophosphatase/phosphodiesterase 1 → Achilles tendon, ankle, aortic valve, ascending aorta, body of femur, cartilage tissue, condyle, corpus epididymis, decidua, epithelium of lens, fossa, liver, right kidney, right lobe of liver, synovial joint, tail of epididymis, tendon of biceps brachii, tibia, transitional epithelium of urinary bladder, umbilical cord. Use these groups to spot repeated connection types before inspecting the individual relationships.

Ectonucleotide pyrophosphatase/phosphodiesterase 1

Top relations

Gene ontology · 55
Ectonucleotide pyrophosphatase/phosphodiesterase 1 → 3'-phosphoadenosine 5'-phosphosulfate binding, 3'-phosphoadenosine 5'-phosphosulfate metabolic process, ATP binding, ATP metabolic process, basolateral plasma membrane, biomineral tissue development, calcium ion binding, catalytic activity, cell surface, cellular phosphate ion homeostasis, cellular response to insulin stimulus, cyclic-GMP-AMP hydrolase activity, endocytosis, exonuclease activity, extracellular region, extracellular space, generation of precursor metabolites and energy, hydrolase activity, immune response, inorganic diphosphate transport
Bgee · 20
Ectonucleotide pyrophosphatase/phosphodiesterase 1 → Achilles tendon, ankle, aortic valve, ascending aorta, body of femur, cartilage tissue, condyle, corpus epididymis, decidua, epithelium of lens, fossa, liver, right kidney, right lobe of liver, synovial joint, tail of epididymis, tendon of biceps brachii, tibia, transitional epithelium of urinary bladder, umbilical cord
RNA expression pattern · 20
Ectonucleotide pyrophosphatase/phosphodiesterase 1 → Achilles tendon, ankle, aortic valve, ascending aorta, body of femur, cartilage tissue, condyle, corpus epididymis, decidua, epithelium of lens, fossa, liver, right kidney, right lobe of liver, synovial joint, tail of epididymis, tendon of biceps brachii, tibia, transitional epithelium of urinary bladder, umbilical cord
Band · 2
Ectonucleotide pyrophosphatase/phosphodiesterase 1 → 10 A4|10 12.26 cM, 6q23.2
Chr. · 2
Ectonucleotide pyrophosphatase/phosphodiesterase 1 → Chromosome 10 (mouse), Chromosome 6 (human)
End · 2
Ectonucleotide pyrophosphatase/phosphodiesterase 1 → 131,895,155 bp, 24,588,057 bp
related to Interactions · 2
Ectonucleotide pyrophosphatase/phosphodiesterase 1 → Ectonucleotide, Insulin
3.1.4.1 · 1
Ectonucleotide pyrophosphatase/phosphodiesterase 1 → ↗
3.6.1.9 · 1
Ectonucleotide pyrophosphatase/phosphodiesterase 1 → ↗
Aliases · 1
Ectonucleotide pyrophosphatase/phosphodiesterase 1 → ENPP1, ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1, Ectonucleotide pyrophosphatase/phosphodiesterase 1, CD203a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene pyrophosphatase phosphodiesterase chr human band chromosome enpp1 ectonucleotide location function enzyme mouse insulin pc-1 cd203a family member encoded

Ectonucleotide pyrophosphatase/phosphodiesterase 1 relationships Subject–Predicate–Object triples

TTTA extracted 123 structured relationships around Ectonucleotide pyrophosphatase/phosphodiesterase 1. Examples in this analysis include Ectonucleotide pyrophosphatase/phosphodiesterase 1 → 3.1.4.1 → ↗ and Ectonucleotide pyrophosphatase/phosphodiesterase 1 → Aliases → ENPP1, ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1, Ectonucleotide pyrophosphatase/phosphodiesterase 1, CD203a. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Ectonucleotide pyrophosphatase/phosphodiesterase 13.1.4.11.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 13.6.1.91.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1AliasesENPP1, ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1, Ectonucleotide pyrophosphatase/phosphodiesterase 1, CD203a1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2YS01.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Band6q23.21.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Band10 A4|10 12.26 cM1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeetibia1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeedecidua1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeecartilage tissue1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeetail of epididymis1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1BgeeAchilles tendon1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeetendon of biceps brachii1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeeliver1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeeright lobe of liver1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeesynovial joint1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeecorpus epididymis1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeeepithelium of lens1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeefossa1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeecondyle1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeetransitional epithelium of urinary bladder1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeebody of femur1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeeright kidney1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeeankle1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeeumbilical cord1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeeascending aorta1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Bgeeaortic valve1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1BioGPSMore reference expression data1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Chr.Chromosome 6 (human)1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1Chr.Chromosome 10 (mouse)1.00infobox
Ectonucleotide pyrophosphatase/phosphodiesterase 1DatabasesNCBI: entry; OMA: entry1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Ectonucleotide pyrophosphatase/phosphodiesterase 1 bring nearby vocabulary together. In this analysis, examples include Cd203a, Enzyme and Pc-1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Ectonucleotide pyrophosphatase/phosphodiesterase 1
    • Cd203a
    • Enzyme
    • Pc-1
    • Phosphodiesterase
    • Pyrophosphatase
    • Enpp1
    • Nucleotide
    • Gene
    • Activity
    • Arhr2
    • Encoded
    • Family
  • ectonucleotide pyrophosphatase/phosphodiesterase 1
    • Pyrophosphatase
    • Cd203a
    • Enzyme
    • Pc-1
    • Enpp1
    • Phosphodiesterase
    • Gene
    • Activity
    • Family
    • Member
    • Nucleotide
    • Receptor
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Phosphodiesterase
    • Pyrophosphatase
    • A4
    • Activity
    • Arhr2
    • End
    • Member
  • adenosine triphosphate
    • Atp
    • Diphosphate
    • A4
    • Activity
    • Adenosine
    • End
    • Family
    • Member
    • Mouse
    • Nucleotide
    • Protein
    • Receptor
  • function
    • Activity
    • Search
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Gene
    • Phosphodiesterase
    • Pyrophosphatase
    • A4
    • Adenosine
  • diphosphate
    • Triphosphate
    • Adenosine
    • End
    • Family
    • Member
    • Mouse
    • Nucleotide
    • Protein
    • Receptor
    • Search
    • Enpp1
    • Function
  • enzyme
    • Pc-1
    • Enpp1
    • Gene
    • Phosphodiesterase
    • Pyrophosphatase
    • Activity
    • Arhr2
    • Encoded
    • Family
    • Member
    • Search
    • Function
  • insulin resistance
    • Receptor
    • Phosphodiesterase
    • Pyrophosphatase
    • Diphosphate
    • Member
    • Mouse
    • Nucleotide
    • Protein
    • Search
    • Triphosphate
    • Location

Connections between topic areas Semantic bridges

For Ectonucleotide pyrophosphatase/phosphodiesterase 1, one of the stronger structural bridges in this analysis connects Ectonucleotide pyrophosphatase/phosphodiesterase 1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Ectonucleotide pyrophosphatase/phosphodiesterase 1Clinical significance · splits 17 ⟂ 7
Ectonucleotide pyrophosphatase/phosphodiesterase 1Function · splits 18 ⟂ 6
Ectonucleotide pyrophosphatase/phosphodiesterase 1Structure · splits 20 ⟂ 4
Ectonucleotide pyrophosphatase/phosphodiesterase 1Overview · splits 21 ⟂ 3
Ectonucleotide pyrophosphatase/phosphodiesterase 1Interactions · splits 21 ⟂ 3

Map overview Semantic statistics

Ectonucleotide pyrophosphatase/phosphodiesterase 1

Nodes24
Edges23
Triples123
Avg. degree1.92
Density0.083333
Components1

Source & methodology

TTTA analyzes the structure around Ectonucleotide pyrophosphatase/phosphodiesterase 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Ectonucleotide pyrophosphatase/phosphodiesterase 1 · EN edition · Analysis: TopicsToTalkAbout

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