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SDHB: Measurement, Function & Overview

Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the SDHB gene.

Language: English [EN]
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SDHB topic overview

The analysis highlights Measurement, Function and Overview as prominent areas in the source structure around SDHB.

Related topics
55
Source areas
4
Connected nodes
59
Extracted relationships
127
Concept neighborhoods
20
Bridge connections
59

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 24 topics
Function · 12 topics
Clinical significance · 10 topics
Structure · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.3.5.1
Aliases
SDHB, CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase complex iron sulfur subunit B, MC2DN4
Band
1p36.13 · 4|4 D3
Bgee
left ventricle · apex of heart · gastrocnemius muscle · muscle of thigh · mucosa of transverse colon
BioGPS
n/a
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SDHB connects Entity context

The extracted context around SDHB shows recurring relationship patterns in the source. For example, SDHB → 2 iron, 2 sulfur cluster binding, 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, aerobic dissimilation, electron transfer activity, electron transport chain, iron-sulfur cluster binding, membrane, metal ion binding, mitochondrial inner membrane, mitochondrial membranes, mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone), mitochondrion, nucleoplasm, oxidoreductase activity, plasma membrane, protein binding, respiratory chain complex II, respiratory electron transport chain, succinate dehydrogenase (ubiquinone) activity Another extracted example is SDHB → apex of heart, biceps brachii, cardiac muscle tissue of left ventricle, cardiac muscles, digastric muscle, gastrocnemius muscle, interventricular septum, left ventricle, mucosa of transverse colon, muscle of thigh, myocardium of ventricle, plantaris muscle, right auricle of heart, right lobe of liver, right ventricle, soleus muscle, sternocleidomastoid muscle, thoracic diaphragm, vastus lateralis muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

SDHB

Top relations

Gene ontology · 23
SDHB → 2 iron, 2 sulfur cluster binding, 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, aerobic dissimilation, electron transfer activity, electron transport chain, iron-sulfur cluster binding, membrane, metal ion binding, mitochondrial inner membrane, mitochondrial membranes, mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone), mitochondrion, nucleoplasm, oxidoreductase activity, plasma membrane, protein binding, respiratory chain complex II, respiratory electron transport chain, succinate dehydrogenase (ubiquinone) activity
Bgee · 19
SDHB → apex of heart, biceps brachii, cardiac muscle tissue of left ventricle, cardiac muscles, digastric muscle, gastrocnemius muscle, interventricular septum, left ventricle, mucosa of transverse colon, muscle of thigh, myocardium of ventricle, plantaris muscle, right auricle of heart, right lobe of liver, right ventricle, soleus muscle, sternocleidomastoid muscle, thoracic diaphragm, vastus lateralis muscle
RNA expression pattern · 19
SDHB → apex of heart, biceps brachii, cardiac muscle tissue of left ventricle, cardiac muscles, digastric muscle, gastrocnemius muscle, interventricular septum, left ventricle, mucosa of transverse colon, muscle of thigh, myocardium of ventricle, plantaris muscle, right auricle of heart, right lobe of liver, right ventricle, soleus muscle, sternocleidomastoid muscle, thoracic diaphragm, vastus lateralis muscle
related to Function · 13
SDHB → Citric Acid Cycle, Electrons, FAD, FADH2, Figure, Finally, Respiratory, SDH, SDHA, SDHC/SDHD, The SDH, This, Ubiquinone
related to Cancer · 9
SDHB → Currently, In, Malignancy, Malignant, Paragangliomas, SDHD, Sporadic, The, This
related to Structure · 7
SDHB → DNA, However, It, SDHA, SDHC, SDHD, The
related to Clinical significance · 6
SDHB → Germline, Less, Paraganglioma Type PGL4, Paragangliomas, The, When
related to RNA editing · 4
SDHB → ORF, R46X, The, This
related to External links · 3
SDHB → Archived, Database, Wayback Machine
Band · 2
SDHB → 1p36.13, 4|4 D3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

succinate protein gene ubiquinone complex sdhd sdh sdhc subunit human cell dehydrogenase bp sdha mitochondrial chr band electrons mutations iron

SDHB relationships Subject–Predicate–Object triples

TTTA extracted 127 structured relationships around SDHB. Examples in this analysis include SDHB → 1.3.5.1 → ↗ and SDHB → Aliases → SDHB, CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase complex iron sulfur subunit B, MC2DN4. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SDHB1.3.5.11.00infobox
SDHBAliasesSDHB, CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase complex iron sulfur subunit B, MC2DN41.00infobox
SDHBBand1p36.131.00infobox
SDHBBand4|4 D31.00infobox
SDHBBgeeleft ventricle1.00infobox
SDHBBgeeapex of heart1.00infobox
SDHBBgeegastrocnemius muscle1.00infobox
SDHBBgeemuscle of thigh1.00infobox
SDHBBgeemucosa of transverse colon1.00infobox
SDHBBgeeright ventricle1.00infobox
SDHBBgeeright auricle of heart1.00infobox
SDHBBgeeright lobe of liver1.00infobox
SDHBBgeevastus lateralis muscle1.00infobox
SDHBBgeebiceps brachii1.00infobox
SDHBBgeemyocardium of ventricle1.00infobox
SDHBBgeedigastric muscle1.00infobox
SDHBBgeeinterventricular septum1.00infobox
SDHBBgeeplantaris muscle1.00infobox
SDHBBgeesternocleidomastoid muscle1.00infobox
SDHBBgeecardiac muscles1.00infobox
SDHBBgeesoleus muscle1.00infobox
SDHBBgeethoracic diaphragm1.00infobox
SDHBBgeecardiac muscle tissue of left ventricle1.00infobox
SDHBBioGPSn/a1.00infobox
SDHBChr.Chromosome 1 (human)1.00infobox
SDHBChr.Chromosome 4 (mouse)1.00infobox
SDHBDatabasesNCBI: entry; OMA: entry1.00infobox
SDHBEnd17,054,032 bp1.00infobox
SDHBEnd140,706,504 bp1.00infobox
SDHBEnsemblENSG000001171181.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SDHB bring nearby vocabulary together. In this analysis, examples include Subunit, Complex and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • SDHB
    • Subunit
    • Complex
    • Gene
    • Protein
    • Iron
    • Succinate
    • Electrons
    • Mutations
    • Species
    • Acid
    • Paragangliomas
    • Sdha
  • sdhb
    • Subunit
    • Complex
    • Gene
    • Protein
    • Iron
    • Succinate
    • Electrons
    • Mutations
    • Species
    • Acid
    • Paragangliomas
    • Sdha
  • protein
    • Succinate
    • Sdhb
    • Ubiquinone
    • Gene
    • Membrane
    • Acid
    • Function
    • Sdha
    • Human
    • Subunit
    • Sdh
    • Band
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Sdhb
    • Ii
    • Iron-sulfur
    • Protein
    • Band
    • End
    • Mitochondrial
  • succinate dehydrogenase
    • Ii
    • Succinate
    • Complex
    • Iron-sulfur
    • Protein
    • Sdh
    • Also
    • Location
    • Mitochondrial
    • Species
    • Bp
    • Chr
  • iron-sulfur protein
    • Ii
    • Mitochondrial
    • Protein
    • Succinate
    • Subunit
    • Sdhb
    • Complex
    • Ubiquinone
    • Also
    • Band
    • End
    • Gene
  • succinate
    • Sdh
    • Protein
    • Ii
    • Mitochondrial
    • Complex
    • Sdha
    • Sdhb
    • Ubiquinone
    • Gene
    • Iron-sulfur
    • Also
    • Location
  • mitochondrial dna
    • Ii
    • Also
    • End
    • Membrane
    • Complex
    • Succinate
    • Ubiquinone
    • Gene
    • Protein
    • Band
    • Location
    • Species

Connections between topic areas Semantic bridges

For SDHB, one of the stronger structural bridges in this analysis connects SDHB with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SDHBOverview · splits 35 ⟂ 25
SDHBFunction · splits 47 ⟂ 13
SDHBClinical significance · splits 49 ⟂ 11
SDHBStructure · splits 50 ⟂ 10

Map overview Semantic statistics

SDHB

Nodes60
Edges59
Triples127
Avg. degree1.97
Density0.033333
Components1

Source & methodology

TTTA analyzes the structure around SDHB to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SDHB · EN edition · Analysis: TopicsToTalkAbout

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