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SDHD: Measurement, Structure & Clinical significance

Succinate dehydrogenase cytochrome b small subunit, mitochondrial (CybS), also known as succinate dehydrogenase complex subunit D (SDHD), is a protein that in humans is encoded by the SDHD gene. Names previously used for SDHD were PGL and PGL1. Succinate dehydrogenase is an important enzyme in both the citric acid cycle and the electron transport chain.…

Language: English [EN]
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SDHD topic overview

The analysis highlights Measurement, Structure and Clinical significance as prominent areas in the source structure around SDHD.

Related topics
46
Source areas
4
Connected nodes
50
Extracted relationships
117
Concept neighborhoods
25
Bridge connections
50

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 16 topics
Clinical significance · 14 topics
Function · 11 topics
Overview · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SDHD, CBT1, CII-4, CWS3, PGL, PGL1, QPs3, SDH4, cybS, succinate dehydrogenase complex subunit D, MC2DN3
Band
11q23.1 · 9|9 A5.3
Bgee
jejunal mucosa · rectum · kidney tubule · biceps brachii · mucosa of colon
BioGPS
n/a
Chr.
Chromosome 11 (human) · Chromosome 9 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SDHD connects Entity context

The extracted context around SDHD shows recurring relationship patterns in the source. For example, SDHD → biceps brachii, cardiac muscle tissue of left ventricle, cardiac muscles, digastric muscle, extraocular muscle, intercostal muscle, interventricular septum, jejunal mucosa, kidney tubule, mucosa of colon, mucosa of sigmoid colon, mucosa of transverse colon, myocardium of ventricle, rectum, right kidney, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, thoracic diaphragm Another extracted example is SDHD → Complex II, FAD, Fe-S, Following, Initially, O4, SDHA, SDHB, SDHC, SDHC/SDHD, Ser27, The, The O1, The SDHC/SDHD, This, Tyr83. Use these groups to spot repeated connection types before inspecting the individual relationships.

SDHD

Top relations

Bgee · 20
SDHD → biceps brachii, cardiac muscle tissue of left ventricle, cardiac muscles, digastric muscle, extraocular muscle, intercostal muscle, interventricular septum, jejunal mucosa, kidney tubule, mucosa of colon, mucosa of sigmoid colon, mucosa of transverse colon, myocardium of ventricle, rectum, right kidney, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, thoracic diaphragm
RNA expression pattern · 20
SDHD → biceps brachii, cardiac muscle tissue of left ventricle, cardiac muscles, digastric muscle, extraocular muscle, intercostal muscle, interventricular septum, jejunal mucosa, kidney tubule, mucosa of colon, mucosa of sigmoid colon, mucosa of transverse colon, myocardium of ventricle, rectum, right kidney, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, thoracic diaphragm
related to Function · 16
SDHD → Complex II, FAD, Fe-S, Following, Initially, O4, SDHA, SDHB, SDHC, SDHC/SDHD, Ser27, The, The O1, The SDHC/SDHD, This, Tyr83
Gene ontology · 14
SDHD → electron transfer activity, heme binding, integral component of membrane, membrane, metal ion binding, mitochondrial electron transport, succinate to ubiquinone, mitochondrial envelope, mitochondrial inner membrane, mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone), mitochondrion, succinate dehydrogenase (ubiquinone) activity, succinate dehydrogenase activity, tricarboxylic acid cycle, ubiquinone binding
related to Clinical significance · 13
SDHD → Andes, As, Because, Germline, Mutations, Notably, People, SDH, SDHAF2, SDHB, SDHC, Since, The
related to Structure · 8
SDHD → Complex II, SDHA, SDHB, SDHC, The, The SDHC/SDHD, The SDHD, There
related to External links · 6
SDHD → Archived, GeneReviews/NCBI/NIH/UW, Hereditary Paraganglioma-Pheochromocytoma SyndromesSDHD, HUGO Gene Nomenclature Committee, March, Wayback Machine
Band · 2
SDHD → 11q23.1, 9|9 A5.3
Chr. · 2
SDHD → Chromosome 11 (human), Chromosome 9 (mouse)
End · 2
SDHD → 112,120,016 bp, 50,515,112 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene succinate ubiquinone syndrome complex sdhc mutations bp protein dehydrogenase subunit electron chr human band chromosome 11 mitochondrial sdhb enzyme

SDHD relationships Subject–Predicate–Object triples

TTTA extracted 117 structured relationships around SDHD. Examples in this analysis include SDHD → Aliases → SDHD, CBT1, CII-4, CWS3, PGL, PGL1, QPs3, SDH4, cybS, succinate dehydrogenase complex subunit D, MC2DN3 and SDHD → Band → 11q23.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SDHDAliasesSDHD, CBT1, CII-4, CWS3, PGL, PGL1, QPs3, SDH4, cybS, succinate dehydrogenase complex subunit D, MC2DN31.00infobox
SDHDBand11q23.11.00infobox
SDHDBand9|9 A5.31.00infobox
SDHDBgeejejunal mucosa1.00infobox
SDHDBgeerectum1.00infobox
SDHDBgeekidney tubule1.00infobox
SDHDBgeebiceps brachii1.00infobox
SDHDBgeemucosa of colon1.00infobox
SDHDBgeeright ventricle1.00infobox
SDHDBgeemucosa of sigmoid colon1.00infobox
SDHDBgeemucosa of transverse colon1.00infobox
SDHDBgeeSkeletal muscle tissue of biceps brachii1.00infobox
SDHDBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
SDHDBgeeright kidney1.00infobox
SDHDBgeeinterventricular septum1.00infobox
SDHDBgeeextraocular muscle1.00infobox
SDHDBgeemyocardium of ventricle1.00infobox
SDHDBgeeintercostal muscle1.00infobox
SDHDBgeecardiac muscles1.00infobox
SDHDBgeedigastric muscle1.00infobox
SDHDBgeecardiac muscle tissue of left ventricle1.00infobox
SDHDBgeethoracic diaphragm1.00infobox
SDHDBgeesternocleidomastoid muscle1.00infobox
SDHDBioGPSn/a1.00infobox
SDHDChr.Chromosome 11 (human)1.00infobox
SDHDChr.Chromosome 9 (mouse)1.00infobox
SDHDDatabasesNCBI: entry; OMA: entry1.00infobox
SDHDEnd112,120,016 bp1.00infobox
SDHDEnd50,515,112 bp1.00infobox
SDHDEnsemblENSG000002043701.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SDHD bring nearby vocabulary together. In this analysis, examples include Gene, Mutations and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • SDHD
    • Gene
    • Mutations
    • Protein
    • Syndrome
    • Ii
    • Sdhc
    • Ubiquinone
    • Dimer
    • Hereditary
    • Associated
    • Succinate
    • Function
  • sdhd
    • Gene
    • Mutations
    • Protein
    • Syndrome
    • Ii
    • Sdhc
    • Ubiquinone
    • Dimer
    • Hereditary
    • Associated
    • Succinate
    • Function
  • gene
    • Sdhd
    • Syndrome
    • Associated
    • Protein
    • Mutations
    • Function
    • Location
    • Chromosome
    • Hereditary
    • Human
    • Variants
    • Bp
  • electron transport chain
    • Transport
    • Dehydrogenase
    • Dimer
    • Ii
    • Mitochondrial
    • Chain
    • Electron
    • Ubiquinone
    • Complex
    • Sdhc
    • Succinate
    • Function
  • protein complex
    • Ii
    • Mitochondrial
    • Dehydrogenase
    • Protein
    • Succinate
    • Sdhd
    • Function
    • Ubiquinone
    • Chain
    • Location
    • Chromosome
    • Dimer
  • complex ii
    • Mitochondrial
    • Ii
    • Dehydrogenase
    • Protein
    • Succinate
    • Dimer
    • Transport
    • Sdhd
    • Ubiquinone
    • Chain
    • Function
    • Location
  • protein
    • Succinate
    • Ii
    • Function
    • Sdhd
    • Gene
    • Ubiquinone
    • Chain
    • Location
    • Band
    • Chromosome
    • Dimer
    • Human
  • succinate dehydrogenase
    • Succinate
    • Complex
    • Mitochondrial
    • Protein
    • Chain
    • Function
    • Location
    • Chromosome
    • Human
    • Transport
    • Subunit
    • Bp

Connections between topic areas Semantic bridges

For SDHD, one of the stronger structural bridges in this analysis connects SDHD with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SDHDStructure · splits 34 ⟂ 17
SDHDClinical significance · splits 36 ⟂ 15
SDHDFunction · splits 39 ⟂ 12
SDHDOverview · splits 45 ⟂ 6

Map overview Semantic statistics

SDHD

Nodes51
Edges50
Triples117
Avg. degree1.96
Density0.039216
Components1

Source & methodology

TTTA analyzes the structure around SDHD to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Structure & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SDHD · EN edition · Analysis: TopicsToTalkAbout

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