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HDAC4

Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene.

Interactions, Function & Clinical significance

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Interactions

15 related topics

Function

9 related topics

Clinical significance

3 related topics

Overview

2 related topics

Key facts & relationships

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3.5.1.98
Aliases
HDAC4, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase 4, NEDCHID
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S
Band
2q37.3 · 1|1 D
Bgee
sural nerve · glutes · gastrocnemius muscle · tibialis anterior muscle · muscle of thigh
BioGPS
More reference expression data

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Overview

Function

Clinical significance

Interactions

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Map overview Semantic statistics

HDAC4

Nodes34
Edges33
Triples176
Avg. degree1.94
Density0.058824
Components1

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HDAC4

Top relations

Gene ontology · 77
HDAC4 → A band, actomyosin, B cell activation, B cell differentiation, cardiac muscle hypertrophy in response to stress, cellular response to mechanical stimulus, cellular response to parathyroid hormone stimulus, cellular response to tumor necrosis factor, chromatin binding, chromatin organization, chromatin remodeling, cytoplasm, cytosol, DNA binding, histone deacetylase activity, histone deacetylase binding, histone deacetylase complex, histone deacetylation, histone H3 deacetylation, histone H4 deacetylation
Bgee · 19
HDAC4 → blood, deltoid muscle, dentate gyrus of hippocampal formation granule cell, endothelial cell, gastrocnemius muscle, gastrula, glutes, granulocyte, interventricular septum, lip, muscle layer of sigmoid colon, muscle of thigh, muscle tissue, otic vesicle, Rostral migratory stream, skeletal muscle tissue, Skeletal muscle tissue of biceps brachii, sural nerve, tibialis anterior muscle
RNA expression pattern · 19
HDAC4 → blood, deltoid muscle, dentate gyrus of hippocampal formation granule cell, endothelial cell, gastrocnemius muscle, gastrula, glutes, granulocyte, interventricular septum, lip, muscle layer of sigmoid colon, muscle of thigh, muscle tissue, otic vesicle, Rostral migratory stream, skeletal muscle tissue, Skeletal muscle tissue of biceps brachii, sural nerve, tibialis anterior muscle
related to Interactions · 14
HDAC4 → BCL6, BTB, BTG2, CBX5, GATA1, HDAC3, MAPK1, MAPK3, MEF2C, Myocyte-specific, Nuclear, Testicular, YWHAB, YWHAE
related to Function · 13
HDAC4 → DNA, Furthermore, HDAC3, Histone, Histones, II, It, MEF2C, MEF2D, RbAp48, TGFbeta1-induced, The, This
related to External links · 6
HDAC4 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
related to Clinical significance · 3
HDAC4 → Harvard University, Reduced, Studies
Band · 2
HDAC4 → 1|1 D, 2q37.3
Chr. · 2
HDAC4 → Chromosome 1 (mouse), Chromosome 2 (human)
End · 2
HDAC4 → 239,401,654 bp, 92,123,421 bp

Important terminology Word statistics

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Important terminology

histone bp protein human deacetylase gene chr chromosome band also transcription location activity mouse dna factor function external encoded search

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
HDAC43.5.1.981.00infobox
HDAC4AliasesHDAC4, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase 4, NEDCHID1.00infobox
HDAC4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S1.00infobox
HDAC4Band2q37.31.00infobox
HDAC4Band1|1 D1.00infobox
HDAC4Bgeesural nerve1.00infobox
HDAC4Bgeeglutes1.00infobox
HDAC4Bgeegastrocnemius muscle1.00infobox
HDAC4Bgeetibialis anterior muscle1.00infobox
HDAC4Bgeemuscle of thigh1.00infobox
HDAC4Bgeemuscle layer of sigmoid colon1.00infobox
HDAC4Bgeeendothelial cell1.00infobox
HDAC4Bgeedeltoid muscle1.00infobox
HDAC4BgeeSkeletal muscle tissue of biceps brachii1.00infobox
HDAC4Bgeeblood1.00infobox
HDAC4Bgeeotic vesicle1.00infobox
HDAC4Bgeegranulocyte1.00infobox
HDAC4Bgeegastrula1.00infobox
HDAC4BgeeRostral migratory stream1.00infobox
HDAC4Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
HDAC4Bgeelip1.00infobox
HDAC4Bgeeinterventricular septum1.00infobox
HDAC4Bgeemuscle tissue1.00infobox
HDAC4Bgeeskeletal muscle tissue1.00infobox
HDAC4BioGPSMore reference expression data1.00infobox
HDAC4Chr.Chromosome 2 (human)1.00infobox
HDAC4Chr.Chromosome 1 (mouse)1.00infobox
HDAC4DatabasesNCBI: entry; OMA: entry1.00infobox
HDAC4End239,401,654 bp1.00infobox
HDAC4End92,123,421 bp1.00infobox

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