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Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene.
The analysis highlights Interactions, Function and Clinical significance as prominent areas in the source structure around HDAC4.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around HDAC4 shows recurring relationship patterns in the source. For example, HDAC4 → A band, actomyosin, B cell activation, B cell differentiation, cardiac muscle hypertrophy in response to stress, cellular response to mechanical stimulus, cellular response to parathyroid hormone stimulus, cellular response to tumor necrosis factor, chromatin binding, chromatin organization, chromatin remodeling, cytoplasm, cytosol, DNA binding, histone deacetylase activity, histone deacetylase binding, histone deacetylase complex, histone deacetylation, histone H3 deacetylation, histone H4 deacetylation Another extracted example is HDAC4 → blood, deltoid muscle, dentate gyrus of hippocampal formation granule cell, endothelial cell, gastrocnemius muscle, gastrula, glutes, granulocyte, interventricular septum, lip, muscle layer of sigmoid colon, muscle of thigh, muscle tissue, otic vesicle, Rostral migratory stream, skeletal muscle tissue, Skeletal muscle tissue of biceps brachii, sural nerve, tibialis anterior muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
histone bp protein human deacetylase gene chr chromosome band also transcription location activity mouse dna factor function external encoded search
TTTA extracted 176 structured relationships around HDAC4. Examples in this analysis include HDAC4 → 3.5.1.98 → ↗ and HDAC4 → Aliases → HDAC4, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase 4, NEDCHID. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| HDAC4 | 3.5.1.98 | ↗ | 1.00 | infobox |
| HDAC4 | Aliases | HDAC4, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase 4, NEDCHID | 1.00 | infobox |
| HDAC4 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S | 1.00 | infobox |
| HDAC4 | Band | 2q37.3 | 1.00 | infobox |
| HDAC4 | Band | 1|1 D | 1.00 | infobox |
| HDAC4 | Bgee | sural nerve | 1.00 | infobox |
| HDAC4 | Bgee | glutes | 1.00 | infobox |
| HDAC4 | Bgee | gastrocnemius muscle | 1.00 | infobox |
| HDAC4 | Bgee | tibialis anterior muscle | 1.00 | infobox |
| HDAC4 | Bgee | muscle of thigh | 1.00 | infobox |
| HDAC4 | Bgee | muscle layer of sigmoid colon | 1.00 | infobox |
| HDAC4 | Bgee | endothelial cell | 1.00 | infobox |
| HDAC4 | Bgee | deltoid muscle | 1.00 | infobox |
| HDAC4 | Bgee | Skeletal muscle tissue of biceps brachii | 1.00 | infobox |
| HDAC4 | Bgee | blood | 1.00 | infobox |
| HDAC4 | Bgee | otic vesicle | 1.00 | infobox |
| HDAC4 | Bgee | granulocyte | 1.00 | infobox |
| HDAC4 | Bgee | gastrula | 1.00 | infobox |
| HDAC4 | Bgee | Rostral migratory stream | 1.00 | infobox |
| HDAC4 | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| HDAC4 | Bgee | lip | 1.00 | infobox |
| HDAC4 | Bgee | interventricular septum | 1.00 | infobox |
| HDAC4 | Bgee | muscle tissue | 1.00 | infobox |
| HDAC4 | Bgee | skeletal muscle tissue | 1.00 | infobox |
| HDAC4 | BioGPS | More reference expression data | 1.00 | infobox |
| HDAC4 | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| HDAC4 | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| HDAC4 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| HDAC4 | End | 239,401,654 bp | 1.00 | infobox |
| HDAC4 | End | 92,123,421 bp | 1.00 | infobox |
The concept neighborhoods around HDAC4 bring nearby vocabulary together. In this analysis, examples include Histone, Protein and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For HDAC4, one of the stronger structural bridges in this analysis connects HDAC4 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around HDAC4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — HDAC4 · EN edition · Analysis: TopicsToTalkAbout