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Fas ligand (FasL, also known as CD95L or Apo-1L) is a type-II transmembrane protein in the tumor necrosis factor (TNF) superfamily. It binds to the Fas receptor (CD95) to induce apoptosis, and also activates non-apoptotic pathways such as NF-κB and MAPK. FasL exists in membrane-bound and soluble forms, and is primarily expressed by cytotoxic T…
Function, Interactions & Structure
Explore the main themes, entities and connections around Fas ligand. Start with the topic map, then use the sections below for research and deeper semantic analysis.
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High-confidence facts extracted from structured source data. Use them as anchors for further research.
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fasl fas immune receptor ligand apoptosis expression signaling cells protein apoptotic function also cell tumor factor bp non-apoptotic human soluble
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Fas ligand | Aliases | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand | 1.00 | infobox |
| Fas ligand | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MSV | 1.00 | infobox |
| Fas ligand | Band | 1q24.3 | 1.00 | infobox |
| Fas ligand | Band | 1 H2.1|1 69.95 cM | 1.00 | infobox |
| Fas ligand | Bgee | granulocyte | 1.00 | infobox |
| Fas ligand | Bgee | blood | 1.00 | infobox |
| Fas ligand | Bgee | lymph node | 1.00 | infobox |
| Fas ligand | Bgee | spleen | 1.00 | infobox |
| Fas ligand | Bgee | jejunal mucosa | 1.00 | infobox |
| Fas ligand | Bgee | mucosa of ileum | 1.00 | infobox |
| Fas ligand | Bgee | gallbladder | 1.00 | infobox |
| Fas ligand | Bgee | duodenum | 1.00 | infobox |
| Fas ligand | Bgee | rectum | 1.00 | infobox |
| Fas ligand | Bgee | bone marrow | 1.00 | infobox |
| Fas ligand | Bgee | blastocyst | 1.00 | infobox |
| Fas ligand | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| Fas ligand | Bgee | embryo | 1.00 | infobox |
| Fas ligand | Bgee | spermatid | 1.00 | infobox |
| Fas ligand | Bgee | placenta | 1.00 | infobox |
| Fas ligand | Bgee | decidua | 1.00 | infobox |
| Fas ligand | BioGPS | More reference expression data | 1.00 | infobox |
| Fas ligand | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| Fas ligand | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| Fas ligand | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Fas ligand | End | 172,666,876 bp | 1.00 | infobox |
| Fas ligand | End | 161,616,064 bp | 1.00 | infobox |
| Fas ligand | Ensembl | ENSG00000117560 | 1.00 | infobox |
| Fas ligand | Entrez | 356 | 1.00 | infobox |
| Fas ligand | External IDs | OMIM: 134638; MGI: 99255; GeneCards: FASLG | 1.00 | infobox |
| Fas ligand | Gene location (Human) | Gene location (Human)Chr.Chromosome 1 (human)Band1q24.3Start172,659,103 bpEnd172,666,876 bp | 1.00 | infobox |
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