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Fas ligand

Fas ligand (FasL, also known as CD95L or Apo-1L) is a type-II transmembrane protein in the tumor necrosis factor (TNF) superfamily. It binds to the Fas receptor (CD95) to induce apoptosis, and also activates non-apoptotic pathways such as NF-κB and MAPK. FasL exists in membrane-bound and soluble forms, and is primarily expressed by cytotoxic T…

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Aliases
FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MSV
Band
1q24.3 · 1 H2.1|1 69.95 cM
Bgee
granulocyte · blood · lymph node · spleen · jejunal mucosa
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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Fas ligand

Nodes42
Edges41
Triples176
Avg. degree1.95
Density0.047619
Components1

How this topic connects Entity context

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Fas ligand

Top relations

Gene ontology · 54
Fas ligand → activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, apoptotic signaling pathway, caveola, cell surface, cell-cell signaling, cellular chloride ion homeostasis, cytokine activity, cytokine-mediated signaling pathway, cytoplasmic vesicle, cytoplasmic vesicle lumen, death receptor binding, endosomal lumen acidification, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, immune response
Bgee · 16
Fas ligand → blastocyst, blood, bone marrow, decidua, duodenum, embryo, gallbladder, granulocyte, jejunal mucosa, lumbar subsegment of spinal cord, lymph node, mucosa of ileum, placenta, rectum, spermatid, spleen
RNA expression pattern · 16
Fas ligand → blastocyst, blood, bone marrow, decidua, duodenum, embryo, gallbladder, granulocyte, jejunal mucosa, lumbar subsegment of spinal cord, lymph node, mucosa of ileum, placenta, rectum, spermatid, spleen
related to Receptor · 15
Fas ligand → CD95, DcR3, Decoy, Fas, FasL, FasR, FasR-FasL, It, LIGHT, Many, Studies, The, The Fas, TL1A, TNF
related to Structure · 14
Fas ligand → Apo-1L, C-terminal, CD95L, Despite, Fas, FasL, II, It, MMP-7, N-terminal, The, The FasL, TNF, With
related to Function · 10
Fas ligand → CD95, DISC, FADD, Fas, Fas-associated, FasL, FasL-mediated, The, The DISC, The Fas
related to Expression · 9
Fas ligand → Active, CTLs, Fas, FasL, IFN-γ, IL-2, NK, The, TNF-α
related to Interactions · 8
Fas ligand → CASP8, EZR, FADD, Fas, FNBP1, FYN, Grb2, PACSIN2
related to Immune privilege · 7
Fas ligand → Fas, Fas-expressing, FasL, Immune-privileged, In, Likewise, These
Band · 2
Fas ligand → 1 H2.1|1 69.95 cM, 1q24.3

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Important terminology

fasl fas immune receptor ligand apoptosis expression signaling cells protein apoptotic function also cell tumor factor bp non-apoptotic human soluble

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Fas ligandAliasesFASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand1.00infobox
Fas ligandAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MSV1.00infobox
Fas ligandBand1q24.31.00infobox
Fas ligandBand1 H2.1|1 69.95 cM1.00infobox
Fas ligandBgeegranulocyte1.00infobox
Fas ligandBgeeblood1.00infobox
Fas ligandBgeelymph node1.00infobox
Fas ligandBgeespleen1.00infobox
Fas ligandBgeejejunal mucosa1.00infobox
Fas ligandBgeemucosa of ileum1.00infobox
Fas ligandBgeegallbladder1.00infobox
Fas ligandBgeeduodenum1.00infobox
Fas ligandBgeerectum1.00infobox
Fas ligandBgeebone marrow1.00infobox
Fas ligandBgeeblastocyst1.00infobox
Fas ligandBgeelumbar subsegment of spinal cord1.00infobox
Fas ligandBgeeembryo1.00infobox
Fas ligandBgeespermatid1.00infobox
Fas ligandBgeeplacenta1.00infobox
Fas ligandBgeedecidua1.00infobox
Fas ligandBioGPSMore reference expression data1.00infobox
Fas ligandChr.Chromosome 1 (human)1.00infobox
Fas ligandChr.Chromosome 1 (mouse)1.00infobox
Fas ligandDatabasesNCBI: entry; OMA: entry1.00infobox
Fas ligandEnd172,666,876 bp1.00infobox
Fas ligandEnd161,616,064 bp1.00infobox
Fas ligandEnsemblENSG000001175601.00infobox
Fas ligandEntrez3561.00infobox
Fas ligandExternal IDsOMIM: 134638; MGI: 99255; GeneCards: FASLG1.00infobox
Fas ligandGene location (Human)Gene location (Human)Chr.Chromosome 1 (human)Band1q24.3Start172,659,103 bpEnd172,666,876 bp1.00infobox

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