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Apoptosis (from Ancient Greek: ἀπόπτωσις, romanized: apóptōsis, lit. 'falling off') is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. Biochemical events lead to characteristic cellular changes (morphology) and death. These changes include blebbing, cell shrinkage…
Discovery and etymology, Activation mechanisms & Implication in disease
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cell cells death proteins apoptotic caspases pathway also protein cancer bcl-2 tnf caspase membrane activation pathways p53 mitochondria dna process
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Apoptosis | MeSH | D017209 | 1.00 | infobox |
| Apoptosis | causes | atrophy | 0.90 | text |
| Apoptosis | is a | highly regulated and controlled process that confers advantages during an organism's life cycle | 0.90 | text |
| Apoptosis | is a | multi-step | 0.90 | text |
| yeast | instance of | single-celled microorganisms | 0.80 | text |
| cytochrome c | instance of | The proapoptotic homodimers are required to make the mitochondrial membrane permeable for the release of caspase activators | 0.80 | text |
| SMAC | instance of | The proapoptotic homodimers are required to make the mitochondrial membrane permeable for the release of caspase activators | 0.80 | text |
| irradiation | instance of | APAF-1 cells are protected from apoptosis stimuli | 0.80 | text |
| membrane blebbing or nuclear fragmentation | instance of | a caspase 3 knock-out was characterized by ectopic cell masses in the brain and abnormal apoptotic features | 0.80 | text |
| DNA fragmentation | instance of | cellular markers | 0.80 | text |
| Herceptin | instance of | The addition of agents | 0.80 | text |
| Iressa | instance of | The addition of agents | 0.80 | text |
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