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Apoptosis

Apoptosis (from Ancient Greek: ἀπόπτωσις, romanized: apóptōsis, lit. 'falling off') is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. Biochemical events lead to characteristic cellular changes (morphology) and death. These changes include blebbing, cell shrinkage…

Discovery and etymology, Activation mechanisms & Implication in disease

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MeSH
D017209

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Overview

Discovery and etymology

Activation mechanisms

Negative regulators of apoptosis

Proteolytic caspase cascade: Killing the cell

Pathway knock-outs

Methods for distinguishing apoptotic from necrotic cells

Implication in disease

Plants

Caspase-independent apoptosis

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Map overview Semantic statistics

Apoptosis

Nodes184
Edges183
Triples243
Avg. degree1.99
Density0.01087
Components1

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Apoptosis

Top relations

related to External links · 39
Apoptosis → Accessed, Apoptosis Archived, Archived, Article, Bcl-2 Database Archived, Biochemistry, Caspase, Cell Biology Archived, Cell Death OrganizationApoptosis, Clip, CR, Cusabio, Database, Discovering Programmed Cell DeathThe, FAS, Finding Cancer's Self-Destruct Button, Info Apoptosis, Introduction, March, MiniCOPE Dictionary
related to Discovery and etymology · 31
Apoptosis → Aberdeen, Alastair Currie, Andrew Wyllie, BCL2, Boston, British Journal, Cancer, Carl Vogt, Currie, Currie's, Following, For, German, Greek, He, However, In, James Cormack, John Kerr, Kerr
related to Pathway knock-outs · 25
Apoptosis → Apaf-1, APAF-1 KO, APAF1, BAX-1, Casp, Casp3, CD95, FADD, Finally, However, IgG, IgM, In, KO, Many, Several, Since, SRBC, The, These
related to Hyperactive apoptosis · 16
Apoptosis → Alzheimer's, At, Bcl-2, BIM, Cancer, CD4, HIV, HIV-positive, In, Increased, Inverse Warburg, Moreover, Neurons, On, Parkinson's, The
related to Intrinsic pathway · 15
Apoptosis → Apaf-1, Apoptotic, ATP, Bak, Bax, Bax/Bak, During, Mitochondria, Nitric, Once, The, There, They, This, Without
related to Defective pathways · 11
Apoptosis → As, Defects, H460, In, NCI-H460, NF-κB, The, The X-linked, This, XIAP, XIAPs
related to HIV progression · 11
Apoptosis → AIDS, Bcl-2, CD4, Fas-mediated, HIV, In, One, Released, T-helper, The, This
related to Negative regulators of apoptosis · 10
Apoptosis → Akt, Bax, Bcl-2, BNIP3, FADD, IAPs, Many, Negative, NF-κB, The
has method · 9
Apoptosis → Bid, DNA, HMGB1, However, Label-free, Supernatant, There, These, Western
related to Inhibition · 9
Apoptosis → As, Cycle-regulating, IAP, Inhibition, It, Pathological, Some, The, Warburg

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Important terminology

cell cells death proteins apoptotic caspases pathway also protein cancer bcl-2 tnf caspase membrane activation pathways p53 mitochondria dna process

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ApoptosisMeSHD0172091.00infobox
Apoptosiscausesatrophy0.90text
Apoptosisis ahighly regulated and controlled process that confers advantages during an organism's life cycle0.90text
Apoptosisis amulti-step0.90text
yeastinstance ofsingle-celled microorganisms0.80text
cytochrome cinstance ofThe proapoptotic homodimers are required to make the mitochondrial membrane permeable for the release of caspase activators0.80text
SMACinstance ofThe proapoptotic homodimers are required to make the mitochondrial membrane permeable for the release of caspase activators0.80text
irradiationinstance ofAPAF-1 cells are protected from apoptosis stimuli0.80text
membrane blebbing or nuclear fragmentationinstance ofa caspase 3 knock-out was characterized by ectopic cell masses in the brain and abnormal apoptotic features0.80text
DNA fragmentationinstance ofcellular markers0.80text
Herceptininstance ofThe addition of agents0.80text
Iressainstance ofThe addition of agents0.80text

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