XIAP

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XIAP topic overview

The analysis highlights Function, Clinical significance and Discovery as prominent areas in the source structure around XIAP.

Related topics: 45
Source areas: 7
Connected nodes: 52
Extracted relationships: 158
Concept neighborhoods: 23
Bridge connections: 52

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 10 topics

Clinical significance · 8 topics

Overview · 8 topics

Discovery · 7 topics

Interactions · 7 topics

Inhibiting XIAP · 3 topics

Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.2.27: ↗
Aliases: XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, X-linked inhibitor of apoptosis
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1F9X, 1G3F, 1G73, 1I3O, 1I4O, 1I51, 1KMC, 1NW9, 1TFQ, 1TFT, 2ECG, 2JK7, 2KNA, 2OPY, 2OPZ, 2POI, 2POP, 2QRA,…
Band: X|X A4
Bgee: mucosa of ileum · buccal mucosa cell · myocardium of left ventricle · cardiac muscle tissue of right atrium · Achilles tendon
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Inhibitor protein
NAIP NAIP (gene)
RING zinc-finger domain RING finger domain
PCR Polymerase chain reaction
Cloning
BIR domains Inhibitor of apoptosis domain
Open reading frame

Structure

Function

Inhibiting XIAP

DIABLO Diablo homolog
HTRA2 HtrA serine peptidase 2
Tetrapeptide

Clinical significance

Cancer
Neurodegenerative disorders Neurodegenerative disorder
Autoimmunity
Tumor
Prostate cancer
Epithelium
Inflammatory bowel disease
X-linked lymphoproliferative disease type 2 X-linked lymphoproliferative disease

Interactions

Interact Protein-protein interaction
ALS2CR2
Caspase 7
MAGED1
MAP3K2
TAB1
XAF1

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How XIAP connects Entity context

The extracted context around XIAP shows recurring relationship patterns in the source. For example, XIAP → apoptotic process, cellular response to DNA damage stimulus, copper ion homeostasis, cysteine-type endopeptidase inhibitor activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytoplasm, cytosol, identical protein binding, inhibition of cysteine-type endopeptidase activity involved in apoptotic process, metal ion binding, mitotic spindle assembly, negative regulation of apoptotic process, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of peptidase activity, nucleoplasm, nucleus, peptidase inhibitor activity, positive regulation of canonical Wnt signaling pathway, positive regulation of protein linear polyubiquitination, positive regulation of protein ubiquitination Another extracted example is XIAP → Achilles tendon, buccal mucosa cell, cardiac muscle tissue of right atrium, cerebellar vermis, corpus epididymis, epithelium of colon, Gonadal ridge, habenula, human fetus, jejunal mucosa, left lung lobe, lobe of cerebellum, mucosa of ileum, myocardium of left ventricle, nasal epithelium, neural layer of retina, retinal pigment epithelium, right lung, seminal vesicula, tibialis anterior muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 31

XIAP → apoptotic process, cellular response to DNA damage stimulus, copper ion homeostasis, cysteine-type endopeptidase inhibitor activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytoplasm, cytosol, identical protein binding, inhibition of cysteine-type endopeptidase activity involved in apoptotic process, metal ion binding, mitotic spindle assembly, negative regulation of apoptotic process, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of peptidase activity, nucleoplasm, nucleus, peptidase inhibitor activity, positive regulation of canonical Wnt signaling pathway, positive regulation of protein linear polyubiquitination, positive regulation of protein ubiquitination

Bgee · 20

XIAP → Achilles tendon, buccal mucosa cell, cardiac muscle tissue of right atrium, cerebellar vermis, corpus epididymis, epithelium of colon, Gonadal ridge, habenula, human fetus, jejunal mucosa, left lung lobe, lobe of cerebellum, mucosa of ileum, myocardium of left ventricle, nasal epithelium, neural layer of retina, retinal pigment epithelium, right lung, seminal vesicula, tibialis anterior muscle

RNA expression pattern · 20

related to Discovery · 14

XIAP → Apoptosis Protein, BIR, IAP, IAPs, NAIP, Neuronal, NIAP, RING, The, The XIAP, Using PCR, With, X-linked Inhibitor, Xq24-25

related to Structure · 13

XIAP → Between, BIR, BIR-1, BIR-2, Firstly, IAP, In, RING, RING Finger, Secondly, Thirdly, UBA, XIAP/Caspase-7

related to Function · 12

XIAP → BIR, BIR2, BIR3, Caspases, E3, However, IAPs, RING Finger, Studies, The BIR2, The RING, When

related to Clinical significance · 11

XIAP → Apoptosis, Apoptotic, Defects, Deregulation, Drosophila, High, IAPs, In, Mutations, NCI-H460, X-linked

related to Inhibiting XIAP · 7

XIAP → DIABLO, HTRA2, Omi, Smac, Smac/DIABLO, The, This

related to Interactions · 7

XIAP → ALS2CR2, Caspase, Caspase-9, Diablo, MAGED1, MAP3K2, TAB1

is a · 2

XIAP → member of the inhibitor of apoptosis family of proteins, most potent human IAP protein currently identified

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein apoptosis domain iap iaps inhibitor gene caspase human chromosome activity x-linked cell apoptotic function ring also bp caspases diablo

XIAP relationships Subject–Predicate–Object triples

TTTA extracted 158 structured relationships around XIAP. Examples in this analysis include XIAP → 2.3.2.27 → ↗ and XIAP → Aliases → XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, X-linked inhibitor of apoptosis. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
XIAP	2.3.2.27	↗	1.00	infobox
XIAP	Aliases	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, X-linked inhibitor of apoptosis	1.00	infobox
XIAP	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1F9X, 1G3F, 1G73, 1I3O, 1I4O, 1I51, 1KMC, 1NW9, 1TFQ, 1TFT, 2ECG, 2JK7, 2KNA, 2OPY, 2OPZ, 2POI, 2POP, 2QRA,…	1.00	infobox
XIAP	Band	X\|X A4	1.00	infobox
XIAP	Bgee	mucosa of ileum	1.00	infobox
XIAP	Bgee	buccal mucosa cell	1.00	infobox
XIAP	Bgee	myocardium of left ventricle	1.00	infobox
XIAP	Bgee	cardiac muscle tissue of right atrium	1.00	infobox
XIAP	Bgee	Achilles tendon	1.00	infobox
XIAP	Bgee	nasal epithelium	1.00	infobox
XIAP	Bgee	jejunal mucosa	1.00	infobox
XIAP	Bgee	corpus epididymis	1.00	infobox
XIAP	Bgee	tibialis anterior muscle	1.00	infobox
XIAP	Bgee	epithelium of colon	1.00	infobox
XIAP	Bgee	left lung lobe	1.00	infobox
XIAP	Bgee	retinal pigment epithelium	1.00	infobox
XIAP	Bgee	neural layer of retina	1.00	infobox
XIAP	Bgee	Gonadal ridge	1.00	infobox
XIAP	Bgee	lobe of cerebellum	1.00	infobox
XIAP	Bgee	cerebellar vermis	1.00	infobox
XIAP	Bgee	habenula	1.00	infobox
XIAP	Bgee	right lung	1.00	infobox
XIAP	Bgee	seminal vesicula	1.00	infobox
XIAP	Bgee	human fetus	1.00	infobox
XIAP	BioGPS	More reference expression data	1.00	infobox
XIAP	Chr.	X chromosome (mouse)	1.00	infobox
XIAP	Databases	NCBI: entry; OMA: entry	1.00	infobox
XIAP	End	41,198,533 bp	1.00	infobox
XIAP	Ensembl	ENSG00000101966	1.00	infobox
XIAP	Entrez	331	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around XIAP bring nearby vocabulary together. In this analysis, examples include Apoptosis, Caspase and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

XIAP
- Apoptosis
- Caspase
- Protein
- Gene
- Domain
- Inhibits
- Result
- Cell
- Human
- Iap
- Inhibitor
- Activity
xiap
- Apoptosis
- Caspase
- Protein
- Gene
- Domain
- Inhibits
- Result
- Cell
- Human
- Iap
- Inhibitor
- Activity
protein
- Human
- Baculoviral
- Binding
- Humans
- Identified
- Also
- Apoptotic
- Chromosome
- Cell
- Iap
- X-linked
- Xiap
apoptotic
- Cell
- Baculoviral
- Humans
- Stops
- Death
- Function
- Inhibitor
- Iaps
- Band
- Birc4
- Mouse
- Protein
inhibitor of apoptosis
- Apoptosis
- Inhibitor
- X-linked
- Protein
- Birc4
- Mouse
- Activity
- Baculoviral
- Bp
- Chr
- Apoptotic
- Chromosome
inhibitor protein
- Apoptosis
- X-linked
- Birc4
- Mouse
- Baculoviral
- Bp
- Chr
- Human
- Protein
- Apoptotic
- Chromosome
- Cell
baculoviral iap repeat
- Apoptotic
- Cell
- Iap
- Inhibitor
- Band
- Birc4
- Mouse
- Protein
- Binding
- Bp
- Chr
- Humans
apoptosis
- Inhibitor
- Protein
- Activity
- Function
- X-linked
- Birc4
- Mouse
- Xiap
- Baculoviral
- Binding
- Bp
- Chr

Connections between topic areas Semantic bridges

For XIAP, one of the stronger structural bridges in this analysis connects XIAP with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

XIAP — Function · splits 42 ⟂ 11

XIAP — Overview · splits 44 ⟂ 9

XIAP — Clinical significance · splits 44 ⟂ 9

XIAP — Discovery · splits 45 ⟂ 8

XIAP — Interactions · splits 45 ⟂ 8

XIAP — Inhibiting XIAP · splits 49 ⟂ 4

XIAP — Structure · splits 50 ⟂ 3

Map overview Semantic statistics

XIAP

Nodes53

Edges52

Triples158

Avg. degree1.96

Density0.037736

Components1

Source & methodology

TTTA analyzes the structure around XIAP to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Discovery, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — XIAP · EN edition · Analysis: TopicsToTalkAbout