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XIAP

X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death. In humans, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome.

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2.3.2.27
Aliases
XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, X-linked inhibitor of apoptosis
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1F9X, 1G3F, 1G73, 1I3O, 1I4O, 1I51, 1KMC, 1NW9, 1TFQ, 1TFT, 2ECG, 2JK7, 2KNA, 2OPY, 2OPZ, 2POI, 2POP, 2QRA,…
Band
X|X A4
Bgee
mucosa of ileum · buccal mucosa cell · myocardium of left ventricle · cardiac muscle tissue of right atrium · Achilles tendon
BioGPS
More reference expression data

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Structure

Function

Inhibiting XIAP

Clinical significance

Interactions

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Map overview Semantic statistics

XIAP

Nodes53
Edges52
Triples158
Avg. degree1.96
Density0.037736
Components1

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XIAP

Top relations

Gene ontology · 31
XIAP → apoptotic process, cellular response to DNA damage stimulus, copper ion homeostasis, cysteine-type endopeptidase inhibitor activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytoplasm, cytosol, identical protein binding, inhibition of cysteine-type endopeptidase activity involved in apoptotic process, metal ion binding, mitotic spindle assembly, negative regulation of apoptotic process, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of peptidase activity, nucleoplasm, nucleus, peptidase inhibitor activity, positive regulation of canonical Wnt signaling pathway, positive regulation of protein linear polyubiquitination, positive regulation of protein ubiquitination
Bgee · 20
XIAP → Achilles tendon, buccal mucosa cell, cardiac muscle tissue of right atrium, cerebellar vermis, corpus epididymis, epithelium of colon, Gonadal ridge, habenula, human fetus, jejunal mucosa, left lung lobe, lobe of cerebellum, mucosa of ileum, myocardium of left ventricle, nasal epithelium, neural layer of retina, retinal pigment epithelium, right lung, seminal vesicula, tibialis anterior muscle
RNA expression pattern · 20
XIAP → Achilles tendon, buccal mucosa cell, cardiac muscle tissue of right atrium, cerebellar vermis, corpus epididymis, epithelium of colon, Gonadal ridge, habenula, human fetus, jejunal mucosa, left lung lobe, lobe of cerebellum, mucosa of ileum, myocardium of left ventricle, nasal epithelium, neural layer of retina, retinal pigment epithelium, right lung, seminal vesicula, tibialis anterior muscle
related to Discovery · 14
XIAP → Apoptosis Protein, BIR, IAP, IAPs, NAIP, Neuronal, NIAP, RING, The, The XIAP, Using PCR, With, X-linked Inhibitor, Xq24-25
related to Structure · 13
XIAP → Between, BIR, BIR-1, BIR-2, Firstly, IAP, In, RING, RING Finger, Secondly, Thirdly, UBA, XIAP/Caspase-7
related to Function · 12
XIAP → BIR, BIR2, BIR3, Caspases, E3, However, IAPs, RING Finger, Studies, The BIR2, The RING, When
related to Clinical significance · 11
XIAP → Apoptosis, Apoptotic, Defects, Deregulation, Drosophila, High, IAPs, In, Mutations, NCI-H460, X-linked
related to Inhibiting XIAP · 7
XIAP → DIABLO, HTRA2, Omi, Smac, Smac/DIABLO, The, This
related to Interactions · 7
XIAP → ALS2CR2, Caspase, Caspase-9, Diablo, MAGED1, MAP3K2, TAB1
is a · 2
XIAP → member of the inhibitor of apoptosis family of proteins, most potent human IAP protein currently identified

Important terminology Word statistics

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Important terminology

protein apoptosis domain iap iaps inhibitor gene caspase human chromosome activity x-linked cell apoptotic function ring also bp caspases diablo

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
XIAP2.3.2.271.00infobox
XIAPAliasesXIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, X-linked inhibitor of apoptosis1.00infobox
XIAPAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1F9X, 1G3F, 1G73, 1I3O, 1I4O, 1I51, 1KMC, 1NW9, 1TFQ, 1TFT, 2ECG, 2JK7, 2KNA, 2OPY, 2OPZ, 2POI, 2POP, 2QRA,…1.00infobox
XIAPBandX|X A41.00infobox
XIAPBgeemucosa of ileum1.00infobox
XIAPBgeebuccal mucosa cell1.00infobox
XIAPBgeemyocardium of left ventricle1.00infobox
XIAPBgeecardiac muscle tissue of right atrium1.00infobox
XIAPBgeeAchilles tendon1.00infobox
XIAPBgeenasal epithelium1.00infobox
XIAPBgeejejunal mucosa1.00infobox
XIAPBgeecorpus epididymis1.00infobox
XIAPBgeetibialis anterior muscle1.00infobox
XIAPBgeeepithelium of colon1.00infobox
XIAPBgeeleft lung lobe1.00infobox
XIAPBgeeretinal pigment epithelium1.00infobox
XIAPBgeeneural layer of retina1.00infobox
XIAPBgeeGonadal ridge1.00infobox
XIAPBgeelobe of cerebellum1.00infobox
XIAPBgeecerebellar vermis1.00infobox
XIAPBgeehabenula1.00infobox
XIAPBgeeright lung1.00infobox
XIAPBgeeseminal vesicula1.00infobox
XIAPBgeehuman fetus1.00infobox
XIAPBioGPSMore reference expression data1.00infobox
XIAPChr.X chromosome (mouse)1.00infobox
XIAPDatabasesNCBI: entry; OMA: entry1.00infobox
XIAPEnd41,198,533 bp1.00infobox
XIAPEnsemblENSG000001019661.00infobox
XIAPEntrez3311.00infobox

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