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APAF1

Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene.

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Function

13 related topics

Interactions

5 related topics

Structure

1 related topics

Key facts & relationships

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Aliases
APAF1, APAF-1, CED4, apoptotic peptidase activating factor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C15, 1CWW, 1CY5, 1Z6T, 2P1H, 2YGS, 3J2T, 3YGS, 4RHW, 3JBT
Band
12q23.1 · 10 C2|10 45.47 cM
Bgee
monocyte · ventricular zone · blood · bone marrow cell · ganglionic eminence
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 10 (mouse)

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Interactions

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Map overview Semantic statistics

APAF1

Nodes23
Edges22
Triples111
Avg. degree1.91
Density0.086957
Components1

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APAF1

Top relations

Gene ontology · 44
APAF1 → activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, ADP binding, ageing, apoptosome, apoptotic process, apoptotic signaling pathway, ATP binding, brain development, cardiac muscle cell apoptotic process, cell differentiation, cellular response to transforming growth factor beta stimulus, cysteine-type endopeptidase activator activity involved in apoptotic process, cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, forebrain development, glial cell apoptotic process
Bgee · 19
APAF1 → Achilles tendon, blood, bone marrow cell, dermis, epithelium of colon, ganglionic eminence, gastrula, granulocyte, ileum, jejunum, migratory enteric neural crest cell, monocyte, otic vesicle, stroma of bone marrow, testicle, trabecular bone, ureter, vas deferens, ventricular zone
RNA expression pattern · 19
APAF1 → Achilles tendon, blood, bone marrow cell, dermis, epithelium of colon, ganglionic eminence, gastrula, granulocyte, ileum, jejunum, migratory enteric neural crest cell, monocyte, otic vesicle, stroma of bone marrow, testicle, trabecular bone, ureter, vas deferens, ventricular zone
related to Interactions · 3
APAF1 → APIP, BCL2-like, HSPA4
related to Structure · 3
APAF1 → CARD, Greek, Rossman
Band · 2
APAF1 → 10 C2|10 45.47 cM, 12q23.1
Chr. · 2
APAF1 → Chromosome 10 (mouse), Chromosome 12 (human)
End · 2
APAF1 → 91,082,770 bp, 98,735,433 bp
Aliases · 1
APAF1 → APAF1, APAF-1, CED4, apoptotic peptidase activating factor 1
Available structures · 1
APAF1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C15, 1CWW, 1CY5, 1Z6T, 2P1H, 2YGS, 3J2T, 3YGS, 4RHW, 3JBT

Important terminology Word statistics

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Important terminology

human bp gene chr band protein chromosome 12 apoptosome apoptotic factor location caspase-9 mouse binding activating function search 735 433

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
APAF1AliasesAPAF1, APAF-1, CED4, apoptotic peptidase activating factor 11.00infobox
APAF1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C15, 1CWW, 1CY5, 1Z6T, 2P1H, 2YGS, 3J2T, 3YGS, 4RHW, 3JBT1.00infobox
APAF1Band12q23.11.00infobox
APAF1Band10 C2|10 45.47 cM1.00infobox
APAF1Bgeemonocyte1.00infobox
APAF1Bgeeventricular zone1.00infobox
APAF1Bgeeblood1.00infobox
APAF1Bgeebone marrow cell1.00infobox
APAF1Bgeeganglionic eminence1.00infobox
APAF1Bgeeepithelium of colon1.00infobox
APAF1Bgeegranulocyte1.00infobox
APAF1BgeeAchilles tendon1.00infobox
APAF1Bgeetrabecular bone1.00infobox
APAF1Bgeetesticle1.00infobox
APAF1Bgeedermis1.00infobox
APAF1Bgeemigratory enteric neural crest cell1.00infobox
APAF1Bgeeureter1.00infobox
APAF1Bgeejejunum1.00infobox
APAF1Bgeevas deferens1.00infobox
APAF1Bgeeotic vesicle1.00infobox
APAF1Bgeestroma of bone marrow1.00infobox
APAF1Bgeegastrula1.00infobox
APAF1Bgeeileum1.00infobox
APAF1BioGPSMore reference expression data1.00infobox
APAF1Chr.Chromosome 12 (human)1.00infobox
APAF1Chr.Chromosome 10 (mouse)1.00infobox
APAF1DatabasesNCBI: entry; OMA: entry1.00infobox
APAF1End98,735,433 bp1.00infobox
APAF1End91,082,770 bp1.00infobox
APAF1EnsemblENSG000001208681.00infobox

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