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Protein phosphatase 2: Drug discovery, Structure and function & Overview

Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. Its serine/threonine phosphatase activity has a broad substrate specificity and diverse cellular…

Language: English [EN]
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Protein phosphatase 2 topic overview

The analysis highlights Drug discovery, Structure and function and Overview as prominent areas in the source structure around Protein phosphatase 2.

Related topics
17
Source areas
3
Connected nodes
20
Extracted relationships
11
Concept neighborhoods
13
Bridge connections
20

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics
Drug discovery · 5 topics
Structure and function · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Domains
InterPro
EC number
3.1.3.16
HGNC
9299
Locus
Chr. 5 q23-q31
NCBI gene
5515
OMIM
176915

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure and function

Drug discovery

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Protein phosphatase 2 connects Entity context

The extracted context around Protein phosphatase 2 shows recurring relationship patterns in the source. For example, Protein phosphatase 2 → InterPro Another extracted example is Protein phosphatase 2 → 3.1.3.16. Use these groups to spot repeated connection types before inspecting the individual relationships.

Protein phosphatase 2

Top relations

Domains · 1
Protein phosphatase 2 → InterPro
EC number · 1
Protein phosphatase 2 → 3.1.3.16
HGNC · 1
Protein phosphatase 2 → 9299
Locus · 1
Protein phosphatase 2 → Chr. 5 q23-q31
NCBI gene · 1
Protein phosphatase 2 → 5515
OMIM · 1
Protein phosphatase 2 → 176915
RefSeq · 1
Protein phosphatase 2 → NM_002715
Search for · 1
Protein phosphatase 2 → Search forStructuresSwiss-modelDomainsInterPro
Structures · 1
Protein phosphatase 2 → Swiss-model
Symbol · 1
Protein phosphatase 2 → PPP2CA

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pp2a protein subunit phosphatase activity catalytic manganese ppp2ca subunits pp2 also proteins active site gene n-terminus c-terminus methylated leucine microcystin

Protein phosphatase 2 relationships Subject–Predicate–Object triples

TTTA extracted 11 structured relationships around Protein phosphatase 2. Examples in this analysis include Protein phosphatase 2 → Domains → InterPro and Protein phosphatase 2 → EC number → 3.1.3.16. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Protein phosphatase 2DomainsInterPro1.00infobox
Protein phosphatase 2EC number3.1.3.161.00infobox
Protein phosphatase 2HGNC92991.00infobox
Protein phosphatase 2LocusChr. 5 q23-q311.00infobox
Protein phosphatase 2NCBI gene55151.00infobox
Protein phosphatase 2OMIM1769151.00infobox
Protein phosphatase 2RefSeqNM_0027151.00infobox
Protein phosphatase 2Search forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
Protein phosphatase 2StructuresSwiss-model1.00infobox
Protein phosphatase 2SymbolPPP2CA1.00infobox
Protein phosphatase 2UniProtP677751.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Protein phosphatase 2 bring nearby vocabulary together. In this analysis, examples include Protein, Activity and Eukaryotic. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Ppp2ca
    • 2iae
    • C-terminus
    • Carboxyl
    • Chr
    • Group
    • Leucine
    • Methylated
    • Microcystin
    • N-terminus
    • Pdb
    • Active
  • active site
    • Manganese
    • Site
    • Ions
    • Microcystin
    • Two
    • 2iae
    • C-terminus
    • Carboxyl
    • Chr
    • Gene
    • Group
    • Leucine
  • Protein phosphatase 2
    • Protein
    • Activity
    • Eukaryotic
    • Enzyme
    • Functions
    • Gene
    • Heterotrimeric
    • Pp2a
    • Also
    • Pp2
    • Ppp2ca
    • Subunit
  • protein phosphatase 2
    • Protein
    • Activity
    • Eukaryotic
    • Enzyme
    • Functions
    • Gene
    • Heterotrimeric
    • Pp2a
    • Also
    • Pp2
    • Ppp2ca
    • Subunit
  • protein phosphatase
    • Protein
    • Activity
    • Eukaryotic
    • Enzyme
    • Functions
    • Gene
    • Heterotrimeric
    • Pp2a
    • Also
    • Pp2
    • Ppp2ca
    • Subunit
  • serine/threonine phosphatase
    • Protein
    • Activity
    • Eukaryotic
    • Enzyme
    • Functions
    • Gene
    • Heterotrimeric
    • Pp2a
    • Also
    • Pp2
    • Ppp2ca
    • Catalytic
  • manganese
    • Active
    • Site
    • Ions
    • Microcystin
    • Two
    • 2iae
    • Chr
    • Methylated
    • N-terminus
    • Pdb
    • Required
    • Ppp2ca
  • enzyme
    • Gene
    • Q23-q31
    • Pp2
    • Pp2a
    • Ppp2ca
    • Regulatory
    • Phosphatase
    • Subunits
    • Catalytic
    • Protein
    • Subunit

Connections between topic areas Semantic bridges

For Protein phosphatase 2, one of the stronger structural bridges in this analysis connects Protein phosphatase 2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Protein phosphatase 2 — Overview · splits 11 ⟂ 10
Protein phosphatase 2 — Drug discovery · splits 15 ⟂ 6
Protein phosphatase 2 — Structure and function · splits 17 ⟂ 4

Map overview Semantic statistics

Protein phosphatase 2

Nodes21
Edges20
Triples11
Avg. degree1.9
Density0.095238
Components1

Source & methodology

TTTA analyzes the structure around Protein phosphatase 2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Drug discovery, Structure and function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Protein phosphatase 2 · EN edition · Analysis: TopicsToTalkAbout

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