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Osteopontin

Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). The murine ortholog is Spp1. Osteopontin is a SIBLING (glycoprotein) that was first…

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Aliases
SPP1, BNSP, BSPI, ETA-1, OPN, secreted phosphoprotein 1, Osteopontin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3CXD, 3DSF
Band
4q22.1 · 5 E5|5 50.68 cM
Bgee
gallbladder · middle frontal gyrus · inferior ganglion of vagus nerve · C1 segment · periodontal fiber
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 5 (mouse)

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Overview

Structure

Isoforms

Tissue distribution

Regulation

Function

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Map overview Semantic statistics

Osteopontin

Nodes128
Edges127
Triples211
Avg. degree1.98
Density0.015625
Components1

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Osteopontin

Top relations

Gene ontology · 32
Osteopontin → androgen catabolic process, biomineral tissue development, cell adhesion, cell differentiation, cell projection, cellular response to testosterone stimulus, cytokine activity, decidualization, embryo implantation, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix binding, extracellular matrix disassembly, extracellular matrix organization, extracellular region, extracellular space, Golgi apparatus, inflammatory response, negative regulation of collateral sprouting of intact axon in response to injury, ossification
Bgee · 20
Osteopontin → beta cell, body of femur, C1 segment, calvaria, corpus callosum, decidua, gallbladder, gastrula, human kidney, inferior ganglion of vagus nerve, lactiferous gland, middle frontal gyrus, periodontal fiber, pons, right kidney, stria vascularis, stroma of bone marrow, subthalamic nucleus, tibiofemoral joint, vestibular sensory epithelium
RNA expression pattern · 20
Osteopontin → beta cell, body of femur, C1 segment, calvaria, corpus callosum, decidua, gallbladder, gastrula, human kidney, inferior ganglion of vagus nerve, lactiferous gland, middle frontal gyrus, periodontal fiber, pons, right kidney, stria vascularis, stroma of bone marrow, subthalamic nucleus, tibiofemoral joint, vestibular sensory epithelium
related to Biomineralization · 17
Osteopontin → ASARM, Asp, Contiguous, Glu, In, N-Glycosylated, OPN, PHEX, Ser, SIBLINGs, Small Integrin Binding LIgand, Stenciling Principle, Such, This, TNAP, X-linked, XLH
related to Cancer · 17
Osteopontin → Although, Antiosteopontin, At, Because PDAC, CA19, CD44, However, IL-17, IPMN, It, MMP, OPN, PC, PDAC, This, Thus, VEGF
related to Allergy and asthma · 13
Osteopontin → BALF, BHR, DCs, Expression, Furthermore, In, Opn, Opn-s, OVA/Alum, Th2-promoting, Th2-suppressing, The, These
related to Regulation · 13
Osteopontin → Bsp, Cbfa1, Col1α1, D3, Different, Hypocalcemia, OPN, OPN Runx2, Osx, Regulation, Runx2, This, VDRE
related to Bone remodeling · 9
Osteopontin → Ca10, Collagen, Loss, OH, OPN, PO4, RGD, Specifically, The
related to External links · 8
Osteopontin → Medicine Medical Subject Headings, MeSH, National Library, Overview, P10451, PDB, PDBe-KB, UniProt
related to Structure · 8
Osteopontin → All, Exons, It, OPN, SPP1, The, The OPN, UTR

Important terminology Word statistics

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Important terminology

opn cells also protein bone cell expression gene disease expressed including role extracellular human immune spp1 function macrophages levels found

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
OsteopontinAliasesSPP1, BNSP, BSPI, ETA-1, OPN, secreted phosphoprotein 1, Osteopontin1.00infobox
OsteopontinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3CXD, 3DSF1.00infobox
OsteopontinBand4q22.11.00infobox
OsteopontinBand5 E5|5 50.68 cM1.00infobox
OsteopontinBgeegallbladder1.00infobox
OsteopontinBgeemiddle frontal gyrus1.00infobox
OsteopontinBgeeinferior ganglion of vagus nerve1.00infobox
OsteopontinBgeeC1 segment1.00infobox
OsteopontinBgeeperiodontal fiber1.00infobox
OsteopontinBgeesubthalamic nucleus1.00infobox
OsteopontinBgeepons1.00infobox
OsteopontinBgeehuman kidney1.00infobox
OsteopontinBgeebeta cell1.00infobox
OsteopontinBgeecorpus callosum1.00infobox
OsteopontinBgeecalvaria1.00infobox
OsteopontinBgeebody of femur1.00infobox
OsteopontinBgeestroma of bone marrow1.00infobox
OsteopontinBgeetibiofemoral joint1.00infobox
OsteopontinBgeelactiferous gland1.00infobox
OsteopontinBgeevestibular sensory epithelium1.00infobox
OsteopontinBgeedecidua1.00infobox
OsteopontinBgeegastrula1.00infobox
OsteopontinBgeeright kidney1.00infobox
OsteopontinBgeestria vascularis1.00infobox
OsteopontinBioGPSMore reference expression data1.00infobox
OsteopontinChr.Chromosome 4 (human)1.00infobox
OsteopontinChr.Chromosome 5 (mouse)1.00infobox
OsteopontinDatabasesNCBI: entry; OMA: entry1.00infobox
OsteopontinEnd87,983,532 bp1.00infobox
OsteopontinEnd104,588,916 bp1.00infobox

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