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Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). The murine ortholog is Spp1. Osteopontin is a SIBLING (glycoprotein) that was first…
The analysis highlights Function, Clinical significance and Tissue distribution as prominent areas in the source structure around Osteopontin.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Osteopontin shows recurring relationship patterns in the source. For example, Osteopontin → androgen catabolic process, biomineral tissue development, cell adhesion, cell differentiation, cell projection, cellular response to testosterone stimulus, cytokine activity, decidualization, embryo implantation, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix binding, extracellular matrix disassembly, extracellular matrix organization, extracellular region, extracellular space, Golgi apparatus, inflammatory response, negative regulation of collateral sprouting of intact axon in response to injury, ossification Another extracted example is Osteopontin → beta cell, body of femur, C1 segment, calvaria, corpus callosum, decidua, gallbladder, gastrula, human kidney, inferior ganglion of vagus nerve, lactiferous gland, middle frontal gyrus, periodontal fiber, pons, right kidney, stria vascularis, stroma of bone marrow, subthalamic nucleus, tibiofemoral joint, vestibular sensory epithelium. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
opn cells also protein bone cell expression gene disease expressed including role extracellular human immune spp1 function macrophages levels found
TTTA extracted 211 structured relationships around Osteopontin. Examples in this analysis include Osteopontin → Aliases → SPP1, BNSP, BSPI, ETA-1, OPN, secreted phosphoprotein 1, Osteopontin and Osteopontin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3CXD, 3DSF. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Osteopontin | Aliases | SPP1, BNSP, BSPI, ETA-1, OPN, secreted phosphoprotein 1, Osteopontin | 1.00 | infobox |
| Osteopontin | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3CXD, 3DSF | 1.00 | infobox |
| Osteopontin | Band | 4q22.1 | 1.00 | infobox |
| Osteopontin | Band | 5 E5|5 50.68 cM | 1.00 | infobox |
| Osteopontin | Bgee | gallbladder | 1.00 | infobox |
| Osteopontin | Bgee | middle frontal gyrus | 1.00 | infobox |
| Osteopontin | Bgee | inferior ganglion of vagus nerve | 1.00 | infobox |
| Osteopontin | Bgee | C1 segment | 1.00 | infobox |
| Osteopontin | Bgee | periodontal fiber | 1.00 | infobox |
| Osteopontin | Bgee | subthalamic nucleus | 1.00 | infobox |
| Osteopontin | Bgee | pons | 1.00 | infobox |
| Osteopontin | Bgee | human kidney | 1.00 | infobox |
| Osteopontin | Bgee | beta cell | 1.00 | infobox |
| Osteopontin | Bgee | corpus callosum | 1.00 | infobox |
| Osteopontin | Bgee | calvaria | 1.00 | infobox |
| Osteopontin | Bgee | body of femur | 1.00 | infobox |
| Osteopontin | Bgee | stroma of bone marrow | 1.00 | infobox |
| Osteopontin | Bgee | tibiofemoral joint | 1.00 | infobox |
| Osteopontin | Bgee | lactiferous gland | 1.00 | infobox |
| Osteopontin | Bgee | vestibular sensory epithelium | 1.00 | infobox |
| Osteopontin | Bgee | decidua | 1.00 | infobox |
| Osteopontin | Bgee | gastrula | 1.00 | infobox |
| Osteopontin | Bgee | right kidney | 1.00 | infobox |
| Osteopontin | Bgee | stria vascularis | 1.00 | infobox |
| Osteopontin | BioGPS | More reference expression data | 1.00 | infobox |
| Osteopontin | Chr. | Chromosome 4 (human) | 1.00 | infobox |
| Osteopontin | Chr. | Chromosome 5 (mouse) | 1.00 | infobox |
| Osteopontin | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Osteopontin | End | 87,983,532 bp | 1.00 | infobox |
| Osteopontin | End | 104,588,916 bp | 1.00 | infobox |
The concept neighborhoods around Osteopontin bring nearby vocabulary together. In this analysis, examples include Disease, Expression and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Osteopontin, one of the stronger structural bridges in this analysis connects Osteopontin with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Osteopontin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Tissue distribution, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Osteopontin · EN edition · Analysis: TopicsToTalkAbout