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Osteopontin: Function, Clinical significance & Tissue distribution

Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). The murine ortholog is Spp1. Osteopontin is a SIBLING (glycoprotein) that was first…

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Osteopontin topic overview

The analysis highlights Function, Clinical significance and Tissue distribution as prominent areas in the source structure around Osteopontin.

Related topics
120
Source areas
7
Connected nodes
127
Extracted relationships
211
Concept neighborhoods
31
Bridge connections
127

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 43 topics
Function · 35 topics
Tissue distribution · 19 topics
Overview · 16 topics
Isoforms · 4 topics
Regulation · 2 topics
Structure · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SPP1, BNSP, BSPI, ETA-1, OPN, secreted phosphoprotein 1, Osteopontin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3CXD, 3DSF
Band
4q22.1 · 5 E5|5 50.68 cM
Bgee
gallbladder · middle frontal gyrus · inferior ganglion of vagus nerve · C1 segment · periodontal fiber
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 5 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Isoforms

Tissue distribution

Regulation

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Osteopontin connects Entity context

The extracted context around Osteopontin shows recurring relationship patterns in the source. For example, Osteopontin → androgen catabolic process, biomineral tissue development, cell adhesion, cell differentiation, cell projection, cellular response to testosterone stimulus, cytokine activity, decidualization, embryo implantation, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix binding, extracellular matrix disassembly, extracellular matrix organization, extracellular region, extracellular space, Golgi apparatus, inflammatory response, negative regulation of collateral sprouting of intact axon in response to injury, ossification Another extracted example is Osteopontin → beta cell, body of femur, C1 segment, calvaria, corpus callosum, decidua, gallbladder, gastrula, human kidney, inferior ganglion of vagus nerve, lactiferous gland, middle frontal gyrus, periodontal fiber, pons, right kidney, stria vascularis, stroma of bone marrow, subthalamic nucleus, tibiofemoral joint, vestibular sensory epithelium. Use these groups to spot repeated connection types before inspecting the individual relationships.

Osteopontin

Top relations

Gene ontology · 32
Osteopontin → androgen catabolic process, biomineral tissue development, cell adhesion, cell differentiation, cell projection, cellular response to testosterone stimulus, cytokine activity, decidualization, embryo implantation, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix binding, extracellular matrix disassembly, extracellular matrix organization, extracellular region, extracellular space, Golgi apparatus, inflammatory response, negative regulation of collateral sprouting of intact axon in response to injury, ossification
Bgee · 20
Osteopontin → beta cell, body of femur, C1 segment, calvaria, corpus callosum, decidua, gallbladder, gastrula, human kidney, inferior ganglion of vagus nerve, lactiferous gland, middle frontal gyrus, periodontal fiber, pons, right kidney, stria vascularis, stroma of bone marrow, subthalamic nucleus, tibiofemoral joint, vestibular sensory epithelium
RNA expression pattern · 20
Osteopontin → beta cell, body of femur, C1 segment, calvaria, corpus callosum, decidua, gallbladder, gastrula, human kidney, inferior ganglion of vagus nerve, lactiferous gland, middle frontal gyrus, periodontal fiber, pons, right kidney, stria vascularis, stroma of bone marrow, subthalamic nucleus, tibiofemoral joint, vestibular sensory epithelium
related to Biomineralization · 17
Osteopontin → ASARM, Asp, Contiguous, Glu, In, N-Glycosylated, OPN, PHEX, Ser, SIBLINGs, Small Integrin Binding LIgand, Stenciling Principle, Such, This, TNAP, X-linked, XLH
related to Cancer · 17
Osteopontin → Although, Antiosteopontin, At, Because PDAC, CA19, CD44, However, IL-17, IPMN, It, MMP, OPN, PC, PDAC, This, Thus, VEGF
related to Allergy and asthma · 13
Osteopontin → BALF, BHR, DCs, Expression, Furthermore, In, Opn, Opn-s, OVA/Alum, Th2-promoting, Th2-suppressing, The, These
related to Regulation · 13
Osteopontin → Bsp, Cbfa1, Col1α1, D3, Different, Hypocalcemia, OPN, OPN Runx2, Osx, Regulation, Runx2, This, VDRE
related to Bone remodeling · 9
Osteopontin → Ca10, Collagen, Loss, OH, OPN, PO4, RGD, Specifically, The
related to External links · 8
Osteopontin → Medicine Medical Subject Headings, MeSH, National Library, Overview, P10451, PDB, PDBe-KB, UniProt
related to Structure · 8
Osteopontin → All, Exons, It, OPN, SPP1, The, The OPN, UTR

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

opn cells also protein bone cell expression gene disease expressed including role extracellular human immune spp1 function macrophages levels found

Osteopontin relationships Subject–Predicate–Object triples

TTTA extracted 211 structured relationships around Osteopontin. Examples in this analysis include Osteopontin → Aliases → SPP1, BNSP, BSPI, ETA-1, OPN, secreted phosphoprotein 1, Osteopontin and Osteopontin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3CXD, 3DSF. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
OsteopontinAliasesSPP1, BNSP, BSPI, ETA-1, OPN, secreted phosphoprotein 1, Osteopontin1.00infobox
OsteopontinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3CXD, 3DSF1.00infobox
OsteopontinBand4q22.11.00infobox
OsteopontinBand5 E5|5 50.68 cM1.00infobox
OsteopontinBgeegallbladder1.00infobox
OsteopontinBgeemiddle frontal gyrus1.00infobox
OsteopontinBgeeinferior ganglion of vagus nerve1.00infobox
OsteopontinBgeeC1 segment1.00infobox
OsteopontinBgeeperiodontal fiber1.00infobox
OsteopontinBgeesubthalamic nucleus1.00infobox
OsteopontinBgeepons1.00infobox
OsteopontinBgeehuman kidney1.00infobox
OsteopontinBgeebeta cell1.00infobox
OsteopontinBgeecorpus callosum1.00infobox
OsteopontinBgeecalvaria1.00infobox
OsteopontinBgeebody of femur1.00infobox
OsteopontinBgeestroma of bone marrow1.00infobox
OsteopontinBgeetibiofemoral joint1.00infobox
OsteopontinBgeelactiferous gland1.00infobox
OsteopontinBgeevestibular sensory epithelium1.00infobox
OsteopontinBgeedecidua1.00infobox
OsteopontinBgeegastrula1.00infobox
OsteopontinBgeeright kidney1.00infobox
OsteopontinBgeestria vascularis1.00infobox
OsteopontinBioGPSMore reference expression data1.00infobox
OsteopontinChr.Chromosome 4 (human)1.00infobox
OsteopontinChr.Chromosome 5 (mouse)1.00infobox
OsteopontinDatabasesNCBI: entry; OMA: entry1.00infobox
OsteopontinEnd87,983,532 bp1.00infobox
OsteopontinEnd104,588,916 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Osteopontin bring nearby vocabulary together. In this analysis, examples include Disease, Expression and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Osteopontin
    • Disease
    • Expression
    • Gene
    • Spp1
    • Macrophages
    • Expressed
    • Protein
    • Cells
    • Dendritic
    • Diseases
    • Regulation
    • Function
  • osteopontin
    • Disease
    • Expression
    • Gene
    • Spp1
    • Macrophages
    • Expressed
    • Protein
    • Cells
    • Dendritic
    • Diseases
    • Regulation
    • Function
  • bone
    • Extracellular
    • Expressed
    • Matrix
    • Regulation
    • Spp1
    • Gene
    • Osteopontin
    • Protein
    • Opn
    • Activation
    • Bp
    • Chr
  • extracellular structural protein
    • Matrix
    • Regulation
    • Spp1
    • Human
    • Expressed
    • Mouse
    • Function
    • Gene
    • Cell
    • Extracellular
    • Protein
    • Band
  • chromosome 4
    • Bp
    • Chr
    • Band
    • Human
    • Gene
    • Implantation
    • Mouse
    • Regulation
    • Spp1
    • Function
    • Cytokine
    • Diseases
  • bone marrow
    • Extracellular
    • Expressed
    • Matrix
    • Regulation
    • Spp1
    • Gene
    • Osteopontin
    • Protein
    • Opn
    • Activation
    • Bp
    • Chr
  • programmed cell death
    • Opn
    • Cytokine
    • Colitis
    • Inflammatory
    • Function
    • Expressed
    • Gene
    • Protein
    • Bp
    • Chr
    • Chromosome
    • Implantation
  • bone remodeling
    • Extracellular
    • Expressed
    • Matrix
    • Regulation
    • Spp1
    • Gene
    • Osteopontin
    • Protein
    • Opn
    • Activation
    • Bp
    • Chr

Connections between topic areas Semantic bridges

For Osteopontin, one of the stronger structural bridges in this analysis connects Osteopontin with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
OsteopontinClinical significance · splits 84 ⟂ 44
OsteopontinFunction · splits 92 ⟂ 36
OsteopontinTissue distribution · splits 108 ⟂ 20
OsteopontinOverview · splits 111 ⟂ 17
OsteopontinIsoforms · splits 123 ⟂ 5
OsteopontinRegulation · splits 125 ⟂ 3

Map overview Semantic statistics

Osteopontin

Nodes128
Edges127
Triples211
Avg. degree1.98
Density0.015625
Components1

Source & methodology

TTTA analyzes the structure around Osteopontin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Tissue distribution, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Osteopontin · EN edition · Analysis: TopicsToTalkAbout

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