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Olanzapine

Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. It is also sometimes used off-label in cancer patients for treatment of chemotherapy-induced nausea and vomiting and as an appetite stimulant. For schizophrenia, it can be used for both new-onset disease and…

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N05AH03 (WHO)
Bioavailability
60–65%
CAS Number
132539-06-1 Y
ChEBI
CHEBI:7735 Y

Topics to explore

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Overview

Medical uses

Adverse effects

Overdose

Interactions

Pharmacology

Chemical synthesis

Society and culture

Research

Advanced semantic analysis

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Map overview Semantic statistics

Olanzapine

Nodes155
Edges154
Triples136
Avg. degree1.99
Density0.012903
Components1

How this topic connects Entity context

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Olanzapine

Top relations

has effect · 17
Olanzapine → Although, APDs, Despite, Drug Administration, Extrapyramidal, FDA, It, Mental Health, National Institute, Of, One, SMD, Studies, The, The US Food, There, These
related to Legal status · 12
Olanzapine → December, Intramuscular, January, Long-term, Maintaining, March, November, Oral, September, Short-term, Treatment, US FDA
related to Interactions · 9
Olanzapine → Although, Another, Carbamazepine, CYP1A2, CYP2D6, Drugs, LSD, Probenecid, UGT
related to Bipolar disorder · 8
Olanzapine → Anxiety Treatments, Care Excellence, Health, It, Mood, National Institute, Other, The Network
related to Post-injection delirium/sedation syndrome · 8
Olanzapine → Although, FDA, Most, PDSS, Postinjection, The, This, Using
Legal status · 7
Olanzapine → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, EU: Rx-only, NZ: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Medical uses · 6
Olanzapine → FDA, In, It, Lybalvi, More, Symbyax
related to Overdose · 5
Olanzapine → Death, Fatalities, No, SSRIs, Symptoms
related to Chemical synthesis · 4
Olanzapine → Co, Eli Lilly, In, The
related to Pharmacodynamics · 3
Olanzapine → D2, HT2A, Investigation

Important terminology Word statistics

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Important terminology

may treatment schizophrenia effects risk disorder bipolar also side weight gain used associated lilly use patients zyprexa antipsychotic symptoms people

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Olanzapine3D model (JSmol)Interactive image1.00infobox
OlanzapineAHFS/Drugs.comMonograph1.00infobox
OlanzapineATC codeN05AH03 (WHO)1.00infobox
OlanzapineBioavailability60–65%1.00infobox
OlanzapineCAS Number132539-06-1 Y1.00infobox
OlanzapineChEBICHEBI:7735 Y1.00infobox
OlanzapineChEMBLChEMBL715 Y1.00infobox
OlanzapineChemSpider10442212 Y1.00infobox
OlanzapineCompTox Dashboard (EPA)DTXSID90233881.00infobox
OlanzapineDrug classAtypical antipsychotic1.00infobox
OlanzapineDrugBankDB00334 Y1.00infobox
OlanzapineECHA InfoCard100.125.3201.00infobox
OlanzapineElimination half-life33 hours, 51.8 hours (elderly)1.00infobox
OlanzapineExcretionUrine (57%; 7% as unchanged drug), faeces (30%)1.00infobox
OlanzapineFormulaC17H20N4S1.00infobox
OlanzapineIUPHAR/BPS471.00infobox
OlanzapineKEGGD00454 Y1.00infobox
OlanzapineLegal statusAU: S4 (Prescription only)1.00infobox
OlanzapineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
OlanzapineLegal statusCA: ℞-only1.00infobox
OlanzapineLegal statusNZ: Rx-only1.00infobox
OlanzapineLegal statusUK: POM (Prescription only)1.00infobox
OlanzapineLegal statusUS: ℞-only1.00infobox
OlanzapineLegal statusEU: Rx-only1.00infobox
OlanzapineLicense dataUS DailyMed: Olanzapine1.00infobox
OlanzapineMedlinePlusa6012131.00infobox
OlanzapineMelting point195 °C (383 °F)1.00infobox
OlanzapineMetabolismLiver (direct glucuronidation and CYP1A2 mediated oxidation)1.00infobox
OlanzapineMolar mass312.44 g·mol−11.00infobox
OlanzapinePregnancy categoryAU: C1.00infobox

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