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Probenecid: History & Applications

Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia.

Language: English [EN]
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Probenecid topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Probenecid.

Related topics
37
Source areas
6
Connected nodes
43
Extracted relationships
55
Concept neighborhoods
17
Bridge connections
43

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Drug interactions · 13 topics
Pharmacology · 10 topics
Adverse effects · 5 topics
Overview · 4 topics
Medical uses · 3 topics
History · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
M04AB01 (WHO)
CAS Number
57-66-9 Y
ChEMBL
ChEMBL897 Y
ChemSpider
4742 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Drug interactions

Pharmacology

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Probenecid connects Entity context

The extracted context around Probenecid shows recurring relationship patterns in the source. For example, Probenecid → In, Inhibition, OAT, Pannexin, This Another extracted example is Probenecid → Historically, In, OAT, Penicillins, Probenicid. Use these groups to spot repeated connection types before inspecting the individual relationships.

Probenecid

Top relations

related to Pharmacodynamics · 5
Probenecid → In, Inhibition, OAT, Pannexin, This
related to Pharmacokinetics · 5
Probenecid → Historically, In, OAT, Penicillins, Probenicid
related to history · 4
Probenecid → During World War II, International Olympic Committee's, January, This
has effect · 3
Probenecid → Life-threatening, Mild, Theoretically
related to Drug interactions · 2
Probenecid → In, Some
3D model (JSmol) · 1
Probenecid → Interactive image
AHFS/Drugs.com · 1
Probenecid → Monograph
ATC code · 1
Probenecid → M04AB01 (WHO)
CAS Number · 1
Probenecid → 57-66-9 Y
ChEMBL · 1
Probenecid → ChEMBL897 Y

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

excretion gout used acid drugs urine penicillin uric concentration drug effects use also plasma kidneys interactions hyperuricemia name probalan increase

Probenecid relationships Subject–Predicate–Object triples

TTTA extracted 55 structured relationships around Probenecid. Examples in this analysis include Probenecid → 3D model (JSmol) → Interactive image and Probenecid → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Probenecid3D model (JSmol)Interactive image1.00infobox
ProbenecidAHFS/Drugs.comMonograph1.00infobox
ProbenecidATC codeM04AB01 (WHO)1.00infobox
ProbenecidCAS Number57-66-9 Y1.00infobox
ProbenecidChEMBLChEMBL897 Y1.00infobox
ProbenecidChemSpider4742 Y1.00infobox
ProbenecidCompTox Dashboard (EPA)DTXSID90211881.00infobox
ProbenecidDrugBankDB01032 Y1.00infobox
ProbenecidECHA InfoCard100.000.3131.00infobox
ProbenecidElimination half-life2-6 hours (dose: 0.5-1 g)1.00infobox
ProbenecidExcretionkidney (77-88%)1.00infobox
ProbenecidFormulaC13H19NO4S1.00infobox
ProbenecidIUPHAR/BPS43571.00infobox
ProbenecidKEGGD00475 Y1.00infobox
ProbenecidLegal statusIn general: ℞ (Prescription only)1.00infobox
ProbenecidMedlinePlusa6823951.00infobox
ProbenecidMolar mass285.36 g·mol−11.00infobox
ProbenecidProtein binding75-95%1.00infobox
ProbenecidPubChem CID49111.00infobox
ProbenecidRoutes of administrationBy mouth1.00infobox
ProbenecidTrade namesProbalan1.00infobox
ProbenecidUNIIPO572Z79171.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Probenecid bring nearby vocabulary together. In this analysis, examples include Excretion, Acid and Uric. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Probenecid
    • Excretion
    • Acid
    • Uric
    • Drugs
    • Used
    • Increase
    • Interactions
    • Plasma
    • Concentration
    • Penicillin
    • Antibiotics
    • Competitively
  • probenecid
    • Excretion
    • Acid
    • Uric
    • Drugs
    • Used
    • Increase
    • Interactions
    • Plasma
    • Concentration
    • Penicillin
    • Antibiotics
    • Competitively
  • uric acid
    • Uric
    • Kidney
    • Name
    • Probalan
    • Urine
    • Probenecid
    • Excretion
    • Gout
    • Competitively
    • Inhibits
    • Elimination
    • Hyperuricemia
  • drug interactions
    • Elimination
    • Excretion
    • Use
    • Drugs
    • Due
    • Kidney
    • Name
    • Penicillins
    • Primarily
    • Probalan
    • Turn
    • Used
  • gout
    • Hyperuricemia
    • Primarily
    • Oat
    • Proximal
    • Used
    • Competitively
    • Elimination
    • Inflammation
    • Inhibits
    • Kidney
    • Name
    • Penicillins
  • urine
    • Excretion
    • Uric
    • Acid
    • Increases
    • Medication
    • Name
    • Penicillins
    • Probalan
    • Renal
    • Also
    • Oat
    • Plasma
  • adverse effects
    • Elimination
    • Hyperuricemia
    • Kidney
    • Name
    • Primarily
    • Probalan
    • Renal
    • Excretion
    • Interactions
    • Plasma
    • Drug
    • Gout
  • hyperuricemia
    • Primarily
    • Elimination
    • Kidney
    • Name
    • Probalan
    • Used
    • Effects
    • Interactions
    • Drug
    • Drugs
    • Probenecid

Connections between topic areas Semantic bridges

For Probenecid, one of the stronger structural bridges in this analysis connects Probenecid with Drug interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ProbenecidDrug interactions · splits 30 ⟂ 14
ProbenecidPharmacology · splits 33 ⟂ 11
ProbenecidAdverse effects · splits 38 ⟂ 6
ProbenecidOverview · splits 39 ⟂ 5
ProbenecidMedical uses · splits 40 ⟂ 4
ProbenecidHistory · splits 41 ⟂ 3

Map overview Semantic statistics

Probenecid

Nodes44
Edges43
Triples55
Avg. degree1.95
Density0.045455
Components1

Source & methodology

TTTA analyzes the structure around Probenecid to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Probenecid · EN edition · Analysis: TopicsToTalkAbout

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