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P21

p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2. p21 represents a major target of p53 activity and thus is associated with linking DNA…

Function, Interactions & Clinical significance

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Function

17 related topics

Interactions

13 related topics

Clinical significance

8 related topics

Regulation

5 related topics

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Aliases
CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AXC, 2ZVV, 2ZVW, 4RJF, 5E0U
Band
6p21.2 · 17 A3.3|17 15.12 cM
Bgee
stromal cell of endometrium · gastric mucosa · vena cava · left uterine tube · beta cell
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 17 (mouse)

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Overview

Function

Regulation

Clinical significance

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

P21

Nodes57
Edges56
Triples235
Avg. degree1.96
Density0.035088
Components1

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P21

Top relations

Gene ontology · 75
P21 → animal organ regeneration, cell cycle, cellular response to amino acid starvation, cellular response to DNA damage stimulus, cellular response to extracellular stimulus, cellular response to gamma radiation, cellular response to heat, cellular response to ionizing radiation, cellular response to UV-B, cellular senescence, cyclin binding, cyclin-dependent protein kinase activating kinase activity, cyclin-dependent protein kinase holoenzyme complex, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cytokine-mediated signaling pathway, cytoplasm, cytosol, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Bgee · 20
P21 → ascending aorta, beta cell, calvaria, Descending thoracic aorta, endothelial cell of lymphatic vessel, epithelium of stomach, esophagus, gastric mucosa, hair follicle, left uterine tube, lip, molar, popliteal artery, pyloric antrum, saphenous vein, skin of external ear, stroma of bone marrow, stromal cell of endometrium, tibial arteries, vena cava
RNA expression pattern · 20
P21 → ascending aorta, beta cell, calvaria, Descending thoracic aorta, endothelial cell of lymphatic vessel, epithelium of stomach, esophagus, gastric mucosa, hair follicle, left uterine tube, lip, molar, popliteal artery, pyloric antrum, saphenous vein, skin of external ear, stroma of bone marrow, stromal cell of endometrium, tibial arteries, vena cava
related to CDK inhibition · 17
P21 → C-terminal, CDK, CDK1, CDK2, CDK4/6, CIP/KIP CDK, CIP1/WAF1, CKI, Cy1, Cy2, Experiments, Follow, G0/quiescent, G1, N-terminal, Specifically, The
related to External links · 16
P21 → CDKN1A, Cyclin-Dependent, Drosophila, Human Cyclin-dependent, Inhibitor, Kinase, Medicine Medical Subject Headings, MeSH, National Library, Overview, P38936, PDB, PDBe-KB, The Interactive FlyCDKN1A, UCSC Genome Browser, UniProt
related to p53 dependent response · 16
P21 → CDK2, DNA, Dulcic, E/CDK2, El-Deiry, G1, G2, Moreover, Notably, Recent, S-phase, Spencer, Studies, Taken, WAF1, Working
related to Interactions · 13
P21 → CCNE1, CDK, CIZ1, CUL4A, DDB1, DTL, GADD45A, GADD45G, HDAC, Nrf2BCCIP, PCNA, PIM1, TK1
related to Degradation · 12
P21 → CRL4Cdt2, DNA, E3, G1, G1/S, PCNA, Recent, S-phase, SCFSkp2, Specifically, Studies, UV
related to Clinical significance · 11
P21 → B2/B3, CD4, Cytoplasmic, DFS, Disease-Free Survival, HIV, OS, TNM, When, WHO, World Health Organization
related to PCNA inhibition · 7
P21 → As, DNA, NER, PCNA, PIP-box, S-phase DNA, Specifically

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Important terminology

cell cycle dna human p53 gene damage response inhibitor bp cdk2 activity arrest protein cdkn1a dependent also cyclin-dependent kinase g1

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
P21AliasesCDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A1.00infobox
P21Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AXC, 2ZVV, 2ZVW, 4RJF, 5E0U1.00infobox
P21Band6p21.21.00infobox
P21Band17 A3.3|17 15.12 cM1.00infobox
P21Bgeestromal cell of endometrium1.00infobox
P21Bgeegastric mucosa1.00infobox
P21Bgeevena cava1.00infobox
P21Bgeeleft uterine tube1.00infobox
P21Bgeebeta cell1.00infobox
P21Bgeeascending aorta1.00infobox
P21Bgeesaphenous vein1.00infobox
P21Bgeepopliteal artery1.00infobox
P21Bgeetibial arteries1.00infobox
P21BgeeDescending thoracic aorta1.00infobox
P21Bgeestroma of bone marrow1.00infobox
P21Bgeecalvaria1.00infobox
P21Bgeemolar1.00infobox
P21Bgeepyloric antrum1.00infobox
P21Bgeelip1.00infobox
P21Bgeeesophagus1.00infobox
P21Bgeehair follicle1.00infobox
P21Bgeeepithelium of stomach1.00infobox
P21Bgeeskin of external ear1.00infobox
P21Bgeeendothelial cell of lymphatic vessel1.00infobox
P21BioGPSMore reference expression data1.00infobox
P21Chr.Chromosome 6 (human)1.00infobox
P21Chr.Chromosome 17 (mouse)1.00infobox
P21DatabasesNCBI: entry; OMA: entry1.00infobox
P21End36,687,339 bp1.00infobox
P21End29,319,701 bp1.00infobox

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